Tetrodotoxin-induced conduction blockade is prolonged by hyaluronic acid with and without bupivacaine

Acta Anaesthesiologica Scandinavica

Volumn 48, Issue 1, 2004, Pages 128-134

  Stevens, M F ^a   Hoppe, M ^a   Holthusen, H ^a   Lipfert, P ^a  

^a UNIVERSITY HOSPITAL DÜSSELDORF   (Germany)

Author keywords

Aortic nerve; Bupivacaine; Hyaluronic acid; Rabbit; Tetrodotoxin

Indexed keywords

BUPIVACAINE; HYALURONIC ACID; TETRODOTOXIN; CARBON DIOXIDE; LOCAL ANESTHETIC AGENT;

ANESTHETIC RECOVERY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA NERVE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG SAFETY; NERVE BLOCK; NERVE CONDUCTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RABBIT; SPIKE WAVE; WOUND CLOSURE; ANIMAL; BLOOD; DRUG EFFECTS; DRUG POTENTIATION; HEMODYNAMICS; NERVE CELL; OXYGEN CONSUMPTION; PATHOLOGY; TOXICITY;

ANESTHETICS, LOCAL; ANIMALS; BUPIVACAINE; CARBON DIOXIDE; DRUG SYNERGISM; HEMODYNAMIC PROCESSES; HYALURONIC ACID; NERVE BLOCK; NEURONS; OXYGEN CONSUMPTION; RABBITS; TETRODOTOXIN; HEMODYNAMICS;

EID: 85052488869     PISSN: 00015172     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1399-6576.2004.00269.x     Document Type: Article

References (25)

1. Lipfert P, Beyer G, Lömm M. Local anesthetic action of tetrodotoxin (TTX) on natural spike activity of rabbit aortic nerve. Reg Anaesth 1989; 12: 69-75.
2. Adams HJ, Blair MR, Takman BH. The local anesthetic activity of tetrodotoxin alone and in combination with vasoconstrictors and local anesthetics. Anesth Analg 1976; 55: 568-73.
3. Covino BG. Ultralong-acting local anesthetic agents. Anesthesiology 1981; 54: 263-4.
4. Kohane DS, Yieh J, Lu NT, Langer R, Strichartz GR, Berde CB. A re-examination of tetrodotoxin for prolonged duration local anesthesia. Anesthesiology 1998; 89: 119-31.
5. Hassan HG, Akerman B, Renck H, Lindberg B, Lindquist B. Effects of adjuvants to local anaesthetics on their duration -III. Experimental studies of hyaluronic acid. Acta Anaesthesiol Scand 1985; 29: 384-8.
6. Loewe S. The problem of synergism and antagonism of combined drugs. Arzneimittelforsch 1953; 3: 285-90.
7. de Jong RH. Local Anesthetics, 1st edn. St. Louis: Mosby, 1994.
8. Sakura S, Bollen AW, Ciriales R, Drasner K. Local anesthetic neurotoxicity does not result from blockade of voltage-gated sodium channels. Anesth Analg 1995; 81: 338-46.
9. Myers RR, Kalichman MW, Reisner LS, Powell HC. Neurotoxicity of local anesthetics: altered perineurial permeability, edema, and nerve fiber injury. Anesthesiology 1986; 64: 29-35.
10. Lipfert P, Seitz RJ, Arndt JO. Studies of local anesthetic action on natural spike activity in the aortic nerve of cats. Anesthesiology 1987; 66: 210-3.
11. Arndt JO, Morgenstern J, Samodelov L. The physiologically relevant information regarding systemic blood pressure encoded in the carotid sinus baroreceptor discharge pattern. J Physiol (Lond) 1977; 268: 775-91.
12. Seitz RJ, Lipfert P, Willrich A, Himmelmann F. Toxic effects of triethyldodecylammoniumbromide (TEA-C12) on myelinated nerve fibers and blood-nerve barrier in the mouse. Brain Res 1989; 74: 293-302.
13. Thoren P, Jones JV. Characteristics of aortic baroreceptor C-fibres in the rabbit. Acta Physiol Scand 1977; 99: 448-56.
14. Keynes RD, Greeff NG, Forster IC, Bekkers JM. The effect of tetrodotoxin on the sodium gating current in the squid giant axon. Proc R Soc Lond Biol Sci 1991; 246: 135-40.
15. Gissen AJ, Covino BG, Gregus J. Differential sensitivity of fast and slow fibers in mammalian nerve 3. Effect of etidocaine and bupivacaine on fast/slow fibers. Anesth Analg 1982; 61: 570-5.
16. Gissen AJ, Covino BG, Gregus J. Differential sensitivity of fast and slow fibers in mammalian nerve 2. Margin of safety for nerve transmission. Anesth Analg 1982; 61: 561-9.
17. Rosenblatt RM. Dextran as a local anesthetic adjuvant: its history and current status. Reg Anesth Pain Med 1981; 6: 108-11.
18. Doherty MM, Hughes PJ, Korszniak NV, Charman WN. Prolongation of lidocaine-induced epidural anesthesia by medium molecular weight hyaluronic acid formulations: pharmacodynamic and pharmacokinetic studies in the rabbit. Anesth Analg 1995; 80: 740-6.
19. Aberg G, Friberger P, Sydnes G. Studies on the duration of local anaesthesia. A possible mechanism for the prolonging effect of dextran on the duration of infiltration anaesthesia. Acta Pharmacol Toxicol 1978; 42: 88-92.
20. Johansson A, Hassan H, Renck H. Effects of adjuvants to local anaesthetics on their duration - IV. Effects of hyaluronic acid added to bupivacaine or prilocaine on the duration of nerve blockade in man. Acta Anaesthesiol Scand 1985; 29: 736-8.
21. Renck H, Hassan HG, Lindberg B, Akerman B. Effects of macromolecular adjuvants on the duration of prilocaine. Acta Anaesthesiol Scand 1988; 32: 355-64.
22. Kohane DS, Lu NT, Cairns BE, Berde CB. Effects of adrenergic agonists and antagonists on tetrodotoxin-induced nerve block. Reg Anesth Pain Med 2001; 26: 239-45.
23. Lipfert P, Seitz RJ, Arndt JO. Ultralong-lasting; nerve block: triethyldodecyl ammonium bromide is probably a neurotoxin rather than a local anesthetic. Anesthesiology 1987; 67: 896-904.
24. Stevens MF, Novotny GE, Lipfert P. Inactivation of baro-afferents leads to loss of barosensitivity without changes in nerve morphology. J Auton Nerv Syst 1998; 68: 125-34.
25. Mackenzie CF, Smalley AJ, Barnas GM, Park SG. Tetrodotoxin infusion: nonventilatory effects and role in toxicity models. Acad Emerg Med 1996; 3: 1106-12.