Comparison of the transcellular transport of FDG and D-glucose by the kidney epithelial cell line, LLC-PK1

Nuclear Medicine Communications

Volumn 31, Issue 2, 2010, Pages 141-146

  Kobayashi, Masato ^a,b   Shikano, Naoto ^c   Nishii, Ryuichi ^d   Kiyono, Yasushi ^b   Araki, Hiroyo ^a   Nishi, Kodai ^a   Oh, Myungmi ^b   Okudaira, Hiroyuki ^a   Ogura, Masato ^c   Yoshimoto, Mitsuyoshi ^e   Okazawa, Hidehiko ^b   Fujibayashi, Yasuhisa ^b   Kawai, Keiichi ^a,b  

^a KANAZAWA UNIVERSITY   (Japan)

^b UNIVERSITY OF FUKUI   (Japan)

^c IBARAKI PREFECTURAL UNIVERSITY OF HEALTH SCIENCES   (Japan)

^d UNIVERSITY OF FUKUI   (Japan)

^e NATIONAL CANCER CENTER   (Japan)

Author keywords

D glucose; Fluoro 2 deoxy D glucose; Kidney epithelial cell line LLC PK1; Renal proximal tubule; Transcellular transport

Indexed keywords

CARBON 14; FLUORODEOXYGLUCOSE; GLUCOSE; GLUCOSE TRANSPORTER; MANNITOL; ORGANIC ANION TRANSPORTER; ORGANIC CATION TRANSPORTER; PHLORETIN; PHLORIZIN; PHOSPHATE BUFFERED SALINE; PROBENECID; SODIUM GLUCOSE COTRANSPORTER; SODIUM ION; TETRYLAMMONIUM BROMIDE; TRITIUM;

ANIMAL CELL; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; EPITHELIUM CELL; INCUBATION TIME; KIDNEY EPITHELIUM; KIDNEY PROXIMAL TUBULE; NONHUMAN; TRANSCYTOSIS;

BIOLOGICAL TRANSPORT; CELL LINE; EPITHELIAL CELLS; FLUORODEOXYGLUCOSE F18; GLUCOSE; GLUCOSE TRANSPORT PROTEINS, FACILITATIVE; KIDNEY; KIDNEY TUBULES, PROXIMAL; ORGANIC ANION TRANSPORTERS; ORGANIC CATION TRANSPORT PROTEINS; RADIOISOTOPES; SODIUM-GLUCOSE TRANSPORT PROTEINS; TIME FACTORS;

EID: 75149131704     PISSN: 01433636     EISSN: None     Source Type: Journal    
DOI: 10.1097/MNM.0b013e328333bcf5     Document Type: Article

References (33)

1. Som P, Atkins HL, Bandoypadyay D, Fowler JS, MacGregor RR, Matsui K, et al. A fluorinated glucose analog, 2-fluoro-2-deoxy-D-glucose (F-18): nontoxic tracer for rapid tumor detection. J Nucl Med 1980; 21:670-675.
2. Kumar R, Jana S. Positron emission tomography: an advanced nuclear medicine imaging technique from research to clinical practice. Methods Enzymol 2004; 385:3-19.
3. Hustinx R, Benard F, Alavi A. Whole-body FDG-PET imaging in the management of patients with cancer. Semin Nucl Med 2002; 32:35-46.
4. Burgman P, Odonoghue JA, Humm JL, Ling CC. Hypoxia-induced increase in FDG uptake in MCF7 cells. J Nucl Med 2001; 42:170-175.
5. von Forstner C, Egberts JH, Ammerpohl O, Niedzielska D, Buchert R, Mikecz P, et al. Gene expression patterns and tumor uptake of 18F-FDG, 18F-FLT, and 18F-FEC in PET/MRI of an orthotopic mouse xenotransplantation model of pancreatic cancer. J Nucl Med 2008; 49:1362-1370.
6. Nguyen XC, So Y, Chung JH, Lee WW, Park SY, Kim SE. High correlations between primary tumours and loco-regional metastatic lymph nodes in nonsmall- cell lung cancer with respect to glucose transporter type 1-mediated 2-deoxy-2-F18-fluoro-D-glucose uptake. Eur J Cancer 2008; 44:692-698.
7. Yamamoto T, Seino Y, Fukumoto H, Koh G, Yano H, Inagaki N, et al. Over-expression of facilitative glucose transporter genes in human cancer. Biochem Biophys Res Commun 1990; 170:223-230.
8. Younes M, Lechago LV, Somoano JR, Mosharaf M, Lechargo J. Wide expression of the human erythrocyte glucose transporter Glut1 in human cancers. Cancer Res 1996; 56:1164-1167.
9. Weber G. Enzymology of cancer cells. (second of two parts). N Engl J Med 1977; 296:541-551. (Pubitemid 8038324)
10. Monakov NK, Neistadt EL, Shavlovskii MM, Shvartsman AL, Neifakh SA. Physicochemical properties and isoenzyme composition of hexokinase from normal and malignant human tissues. J Natl Cancer Inst 1978; 61:27-33.
11. Medina RA, Owen GI. Glucose transporters: expression, regulation and cancer. Biol Res 2002; 35:9-26.
12. Wood IS, Trayhurn P. Glucose transporters (GLUT and SGLT): expanded families of sugar transport proteins. Br J Nutr 2003; 89:3-9.
13. Sacktor B. Sodium-coupled hexose transport. Kidney Int 1989; 36:342-350.
14. Silverman M. Glucose transport in the kidney. Biochim Biophys Acta 1976; 457:303-351.
15. Ohta T, Isselbacher KJ, Rhoads DB. Regulation of glucose transporters in LLC-PK1 cells: effects of D-glucose and monosaccharides. Mol Cell Biol 1990; 10:6491-6499.
16. Hediger MA, Coady MJ, Ikeda TS,Wright EM. Expression cloning and cDNA sequencing of the Na+/glucose co-transporter. Nature 1987; 330:379-381.
17. Carruthers A. Facilitated diffusion of glucose. Physiol Rev 1990; 70:1135-1176.
18. Cheung PT, Hammerman MR. Na+-independent D-glucose transport in rabbit renal basolateral membranes. Am J Physiol 1988; 254:F711-718.
19. Miller JH, Mullin JM, McAvoy E, Kleinzeller A. Polarity of transport of 2-deoxy-D-glucose and D-glucose by cultured renal epithelia (LLC-PK1). Biochim Biophys Acta 1992; 1110:209-217.
20. Mullin JM, Weibel J, Diamond L, Kleinzeller A. Sugar transport in the LLC-PK1 renal epithelial cell line: similarity to mammalian kidney and the influence of cell density. J Cell Physiol 1980; 104:375-389.
21. Rabito CA, Ausiello DA. Na+-dependent sugar transport in a cultured epithelial cell line from pig kidney. J Membr Biol 1980; 54:31-38.
22. Rabito CA. Localization of the Na+-sugar cotransport system in a kidney epithelial cell line (LLC PK1). Biochim Biophys Acta 1981; 649:286-296.
23. Imaoka T, Kusuhara H, Adachi-Akahane S, Hasegawa M, Morita N, Endou H, Sugiyama Y. The renal-specific transporter mediates facilitative transport of organic anions at the brush border membrane of mouse renal tubules. J Am Soc Nephrol 2004; 15:2012-2022.
24. Urakami Y, Kimura N, Okuda M, Masuda S, Katsura T, Inui K. Transcellular transport of creatinine in renal tubular epithelial cell line LLC-PK1. Drug Metab Pharmacokinet 2005; 20:200-205.
25. Pritchard JB, Miller DS. Mechanisms mediating renal secretion of organic anions and cations. Physiol Rev 1993; 73:765-796.
26. Sekine T, Watanabe N, Hosoyamada M, Kanai Y, Endou H. Expression cloning and characterization of a novel multispecific organic anion transporter. J Biol Chem 1997; 272:18526-18529.
27. Moran JK, Lee HB, Blaufox MD. Optimization of urinary FDG excretion during PET imaging. J Nucl Med 1999; 40:1352-1357.
28. Shikano N, Kawai K, Nakajima S, Kubodera A, Kubota N, Ishikawa N, Saji H. Transcellular transport of radioiodinated 3-iodo-a-methyl-L-tyrosine across monolayers of kidney epithelial cell line LLC-PK1. Ann Nucl Med 2004; 18:227-234. (Pubitemid 38899672)
29. Shikano N, Kawai K, Nakajima S, Kubodera A, Kubota N, Ishikawa N, Saji H. Transcellular transport of 4-iodo-L-meta-tyrosine via system L across monolayers of kidney epithelial cell line LLC-PK1. Nucl Med Biol 2004; 31:477-482. (Pubitemid 38490747)
30. Kiyono Y, Yamashita T, Doi H, Kuge Y, Katsura T, Inui K, et al. Is MIBG a substrate of P-glycoprotein? Eur J Nucl Med Mol imaging 2007; 34:448-452.
31. Kosuda S, Fisher S, Wahl RL. Animal studies on the reduction and/or dilution of 2-deoxy-2-[18F]fluoro-D-glucose (FDG) activity in the urinary system. Ann Nucl Med 1997; 11:213-218.
32. Thorens B. Glucose transporters in the regulation of intestinal, renal, and liver glucose fluxes. Am J Physiol 1996; 270:G541-53.
33. Kleinzeller A, McAvoy EM, McKibbin RD. Active renal hexose transport structural requirements. Biochim Biophys Acta 1980; 600:513-520.