Transcellular transport of radioiodinated 3-iodo-α-methyl-L-tyrosine across monolayers of kidney epithelial cell line LLC-PK1

Annals of Nuclear Medicine

Volumn 18, Issue 3, 2004, Pages 227-234

  Shikano, Naoto ^a   Kawai, Keiichi ^b   Nakajima, Syuichi ^a   Kubodera, Akiko ^c   Kubota, Nobuo ^a   Ishikawa, Nobuyoshi ^a   Saji, Hideo ^d  

^a IBARAKI PREFECTURAL UNIVERSITY OF HEALTH SCIENCES   (Japan)

^b KANAZAWA UNIVERSITY   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

^d KYOTO UNIVERSITY   (Japan)

Author keywords

3 iodo methyl L tyrosine; Amino acid transport; Epithelial cell line; System L

Indexed keywords

2 AMINOBICYCLO[2.2.1]HEPTANE 2 CARBOXYLIC ACID; 2 METHYL 2 METHYLAMINOPROPIONIC ACID; CARBOXYLIC ACID DERIVATIVE; COLLAGEN; IODINE 123; METIROSINE; METIROSINE I 123; PHOSPHATE BUFFERED SALINE; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

AMINO ACID TRANSPORT; ANIMAL CELL; APICAL MEMBRANE; ARTICLE; BASOLATERAL MEMBRANE; CELL TRANSPORT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACCUMULATION; INCUBATION TIME; INHIBITION KINETICS; KIDNEY EPITHELIUM; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE ABSORPTION; MEMBRANE FILTER; MONOLAYER CULTURE; NONHUMAN; PH MEASUREMENT; POROSITY; PRIORITY JOURNAL; QUANTITATIVE DIAGNOSIS; RADIOIODINATION; REGULATORY MECHANISM; SODIUM TRANSPORT; SOLUBILITY; SWINE; TRANSCYTOSIS;

EID: 3142590521     PISSN: 09147187     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02985004     Document Type: Article

References (27)

1. Kawai K, Fujibayashi Y, Saji H, Yonekura Y, Konishi J, Kubodera A, et al. A strategy for study of cerebral amino acid transport using iodine-123-labeled amino acid radiopharmaceutical: 3-iodo-alpha-methyl-L-tyrosine. J Nucl Med 1991; 32: 819-824.
2. 123I-3-iodo-alpha-methyl-L-tyrosine. Ann Nucl Med 1992; 6: 169-175.
3. 125I]iodo-α-methyl-L-tyrosine transport via human L-type amino acid transporter 1. Nucl Med Biol 2003; 30: 31-37.
4. 123I]iodo-L-α- methyl-L-tyrosine: uptake mechanisms and clinical applications. Nucl Med Biol 2002; 29: 625-631.
5. 123I]iodo-L-α-methlyl tyrosine transport in rat C6 glioma cells. Eur J Nucl Med 1999; 26: 1274-1278.
6. 123I]IMT) transport in human GOS3 glioma cells. Nucl Med Biol 2001; 28: 293-297.
7. 123I]IMT) transport into human Ewing's sarcoma cells in vitro. Nucl Med Biol 2001; 28: 123-128.
8. Shikano N, Kawai K, Flores II LG, Nishii R, Kubota N, Ishikawa N, et al. An artificial amino acid 4-iodo-L-metatyrosine: Biodistribution and excretion via kidney. J Nucl Med 2003; 44: 625-631.
9. Jager PL, Vaalburg W, Pruim J, de Vries EG, Langen KJ, Piers DA. Radiolabeled amino acids: basic aspects and clinical applications in oncology. J Nucl Med 2001; 42: 432-445.
10. 1) with characteristics of proximal tubular cells. Am J Physiol 1986; 250: F734-743.
11. 1). J Biol Chem 1983; 258: 2543-2547.
12. 1 and MDCK cells. J Cell Physiol 1985; 123: 144-150.
13. 1. In Vitro 1976; 12: 670-677.
14. 1. Nippon Jinzo Gakkai Shi 1996; 38: 435-440.
15. Krummeich C, Holschbach M, Stocklin G. Direct n.c.a. electrophilic radioiodination of tyrosine analogues: their in vivo stability and brain-uptake in mice. Appl Radiat Isot 1994; 45: 929-935.
16. Christensen HN. Role of amino acid transport and counter-transport in nutrition and metabolism. Physiol Rev 1990; 70: 43-77.
17. Chairoungdua A, Segawa H, Kim JY, Miyamoto K, Haga J, Fukui Y, et al. Identification of an amino acid transporter associated with the cystinuria-related type II membrane glycoprotein. J Biol Chem 1999; 274: 28845-28848.
18. Maenz DD, Patience JF. L-Threonine transport of pigjejunal brush border membrane. J Biol Chem 1992; 267: 22079-22086.
19. +- dependent transporter for alanine, glutamine, leucine and phenylalanine in brush-border membrane vesicles from bovine kidney. Biochem Biophys Acta 1987; 899: 176-184.
20. Palacin M, Estevenz R, Bertran E, Zorano A. Molecular biology of mammalian plasma membrane amino acid transports. Physiol Rev 1998; 78: 969-1054.
21. +/monocarboxylate transporters. J Biol Chem 2001; 276: 17221-17228.
22. 125I]iodo-L-tyrosine into U266 human myeloma cells: Evidence for System T transport. Nucl Med Biol 2001; 28: 129-134.
23. Kanai Y, Segawa H, Miyamoto K, Uchino H, Takeda E, Endou H. Expression cloning and characterization of a transporter for large neutral amino acids activated by heavy chain of 4F2 antigen (CD98). J Biol Chem 1998; 273: 23629-23632.
24. +-independent neutral amino acid transporter with broad substrate selectivity. J Biol Chem 1999; 274: 19745-19751.
25. Soares-da-silva P, Serrao MP. Molecular modulation of inward and outward apical transporters of L-dopa in cells. Am J Physiol Renal Physiol 2000; 279: F736-746.
26. Shotwell MA, Jayme DW, Kilberg M, Oxender DL. Neutral amino acid transport system in Chinese hamster ovary cells. J Biol Chem 1981; 256: 5422-5427.
27. Sepulveda FV, Pearson JD. Characterization of neutral amino acid uptake by cultured epithelial cells from pig kidney. J Cell Physiol 1982; 112: 182-188.