Influence of lactose addition to gentamicin-loaded acrylic bone cement on the kinetics of release of the antibiotic and the cement properties

Acta Biomaterialia

Volumn 6, Issue 3, 2010, Pages 804-811

  Frutos, Gloria ^a   Pastor, José Ygnacio ^b   Martínez, Noelia ^b   Virto, María Rosa ^a   Torrado, Susana ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^b UNIVERSIDAD POLITÉCNICA DE MADRID   (Spain)

Author keywords

Acrylic bone cement; Drug release; Mathematical modelling; Mechanical behaviour

Indexed keywords

ANTIBIOTICS; BONE; BONE CEMENT; CONTROLLED DRUG DELIVERY; DENSITY (SPECIFIC GRAVITY); DISSOLUTION; ESTERS; FRACTURE; FRACTURE TOUGHNESS; POROSITY; SUGARS; SULFUR COMPOUNDS; TARGETED DRUG DELIVERY; TENSILE STRENGTH;

ACRYLIC BONE CEMENTS; ANTIBIOTIC GENTAMICIN; CEMENT PROPERTIES; DRUG RELEASE; GENTAMICIN SULFATES; KINETICS OF RELEASE; MATHEMATICAL MODELING; MECHANICAL BEHAVIOR; POLY(METHYL METHACRYLATE); POLY-METHYL METHACRYLATES;

BENDING STRENGTH;

GENTAMICIN; GENTAMICIN BONE CEMENT; LACTOSE;

ARTICLE; CHEMICAL COMPOSITION; DENSITY; DIFFUSION; DISSOLUTION; DRUG RELEASE; ELUTION; FLEXURAL STRENGTH; FRACTURE TOUGHNESS; MECHANICS; POROSITY; PRIORITY JOURNAL; SPECTROPHOTOMETER; TENSILE STRENGTH; YOUNG MODULUS;

EID: 75149117670     PISSN: 17427061     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.actbio.2009.08.028     Document Type: Article

References (35)

1. Charnley J. Anchorage of the femoral head prosthesis to the shaft of the femur. J Bone Joint Surg 43B (1960) 28-30
2. Tunney M.M., Jones D.S., and Gorman S.P. Methacrylate polymers and copolymers as urinary tract biomaterials: resistance to encrustation and microbial adhesion. Int J Pharm 151 (1997) 121-126
3. Kühn K.D. Bone cements (2000), Springer Verlag, Berlin
4. Sabokbar A., Fujikawa Y., Murray D.W., and Athanason N.A. Radiopaque agents in bone cement increase bone resorption. J Bone Joint Surg 79B (1997) 129-134
5. Lazaraus M., Cuckler J., Schummacher H., Ducheyne P., and Baker D.G. Comparison of the inflammatory response to particulate polymethylmethacrylate debris with and without barium sulphate. J Orthop Res 12 (1994) 532-541
6. Hernández L., Fernández M., Collía F., Gurruchaga M., and Goñi I. Preparation of acrylic cements for vertebroplasty with bismuth salicylate as radiopaque agent. Biomaterials 27 (2006) 100-107
7. Welch A.B. Antibiotics in acrylic bone cement. In vitro studies. J Biomed Mater Res 12 (1978) 679-700
8. van de Belt H., Neut D., Uges D.R.A., Schenk W., van Horn J.R., van der Mei H.C., et al. Surface roughness, porosity and wettability of gentamicin-loaded bone cements and their antibiotic release. Biomaterials 21 (2000) 1981-1987
9. Krasko M.Y., Golenser J., Nyska A., Nyska M., Brin Y.S., and Domb A.J. Gentamicin extended release from an injectable polymeric implant. J Control Release 117 (2007) 90-96
10. Frutos Cabanillas P., Díez Peña E., Barrales-Rienda J.M., and Frutos G. Validation and in vitro characterization of antibiotic-loaded bone cement release. Int J Pharm 209 (2000) 15-26
11. Virto M.R., Frutos P., Torrado S., and Frutos G. Gentamicin release from modified acrylic bone cements with lactose and hydroxypropylmethylcellulose. Biomaterials 24 (2003) 79-87
12. Link D.P., van den Dolder J., Jurgens W.J.F.M., Wolke J.G.C., and Jansen J.A. Mechanical evaluation of implanted calcium phosphate cement incorporated with PLGA microparticles. Biomaterials 27 (2006) 4941-4947
13. Torrado S., Frutos P., and Frutos G. Gentamicin bone cements: characterisation and release (in vitro and in vivo assays). Int J Pharm 217 (2001) 57-69
14. Frutos P., Díez Peña E., Frutos G., and Barrales-Rienda J.M. Release of gentamicin sulphate from a modified commercial bone cement. Effect of (2-hydroxyethyl methacrylate) comonomer and poly(N-vinyl-2-pyrrolidone) additive on release mechanism and kinetics. Biomaterials 23 (2002) 3787-3797
15. Díez Peña E., Frutos G., Frutos P., and Barrales-Rienda J.M. Gentamicin sulphate release from a modified commercial acrylic bone cement. I: Influence of the gentamicin concentration on the release process mechanism. Chem Pharm Bull 9 (2002) 1201-1208
16. Klein R.W., Scott C.P., and Higham P.A. The strength of acrylic bone cement cured under thumb pressure. Biomaterials 25 (2004) 943-947
17. ® P acrylic bone cement and experimental variants. Acta Biomater 3 (2007) 970-979
18. Washburn E.W. The dynamics of capillary flow. Phys Rev 17 (1921) 273
19. Thimoshenko S.P. Strength of materials. Part II. 3rd ed. (1956), D. van Nostrand, Princeton, NJ
20. Guinea G., Pastor J.Y., Planas J., and Elices M. Stress intensity factor, compliance and CMOD for general three-point-bend beam. Int J Fracture 89 (1998) 103-116
21. S-PLUS 6. Data analysis products division. Seattle, WA: MathSoft; 2001.
22. Arnold J.C. The effects of diffusion on environmental stress crack initiation in PMMA. J Mater Sci 33 (1998) 5193-5204
23. Xiangyang L. Environmental stress cracking resistance of a new copolymer of bisphenol-A. Polym Degrad Stabil 90 (2005) 44-52
24. Mehta K.A., Kislalioglu M.S., Phauapradit W., Malick A.W., and Shah N.H. Effect of formulation and process variables on porosity parameters and release rates from a multi-unit erosion matrix of a poorly soluble drug. J Control Release 63 (2000) 201-211
25. Ries M.D., Young E., Al-Marashi L., Goldstein P., Hetherington A., Prie T., et al. In vivo behaviour of acrylic bone cement in total hip arthroplasty. Biomaterials 27 (2006) 256-261
26. Puska M.A., Kokkari A.K., Närhi T.O., and Vallittu P.K. Mechanical properties of oligomer-modified acrylic bone cement. Biomaterials 24 (2003) 417-425
27. Cervantes-Uc J.M., Vázquez-Torres H., Cauich-Rodríguez J.V., Vázquez-Lasa B., and San Roman del Barrio J. Comparative study on properties of acrylic bone cements prepared with either aliphatic or aromatic functionalised methacrylates. Biomaterials 26 (2005) 4063-4072
28. Perkins M., Ebbens S.J., Hayes S., Roberts C.J., Madden C.E., Luk S.Y., et al. Elastic modulus measurements from individual lactose particles using atomic force microscopy. Int J Pharm 332 (2007) 168-175
29. Mark H.F. Encyclopedia of polymers science and technology, vol. 12. 3rd ed. (2004), John Wiley & Sons, San Francisco, CA
30. Ezrin M., and Lavigne G. Unexpected and unusual failures of polymeric materials. Eng Fail Anal 14 (2007) 1153-1165
31. Vila M.M., Ginebra M.P., Gil F.J., and Planell J.A. Effect of porosity and environment on the mechanical properties of acrylic bone cement modified with acrylonitrile-butadiene-styrene particles. Part I: Fracture toughness. J Biomed Mater Res (Appl Biomater) 48 (1999) 121-127
32. van Hooy-Cortjens C.S.J., Govaert L.E., Spoelstra A.B., Bulstra S.K., Wetzels G.M.R., and Koole L.H. Mechanical behaviour of a new acrylic radiopaque iodine-containing bone cement. Biomaterials 25 (2004) 2657-2667
33. Ezrin M. Plastics failure guide: cause and prevention (1996), Hanser-Gardner Publications, Cincinnati, OH
34. Wright D.C. Environmental stress cracking of plastics (2001), Smithers Rapra Technology, Shrewsbury
35. Vuorinen A., Dyer S.R., Lassila L.V.J., and Vallittu P. Effect of a rigid rod polymer filler on mechanical properties of poly-methyl methacrylate denture base material. Dent Mater 24 (2008) 708-713