Histopathological diagnosis of hydatidiform mole: Contemporary features and clinical implications

Fetal and Pediatric Pathology

Volumn 29, Issue 1, 2010, Pages 1-16

  Sebire, N J ^a  

^a CHARING CROSS HOSPITAL   (United Kingdom)

Author keywords

Choriocarcinoma; Complete mole; HCG; Hydatidiform mole; Miscarriage; Partial mole; Trophoblast

Indexed keywords

ANTINEOPLASTIC AGENT; ORAL CONTRACEPTIVE AGENT;

CHORIOCARCINOMA; CLINICAL FEATURE; COMPLETE HYDATIDIFORM MOLE; CONCEPTION; DISEASE COURSE; FIRST TRIMESTER PREGNANCY; GENETIC ANALYSIS; GENETICS; HISTOLOGY; HISTOPATHOLOGY; HUMAN; HYDATIDIFORM MOLE; IMMUNOHISTOCHEMISTRY; MATERNAL AGE; MORPHOLOGY; PARTIAL HYDATIDIFORM MOLE; PLACENTAL SITE TROPHOBLASTIC TUMOR; PRIORITY JOURNAL; RECURRENCE RISK; REVIEW; SECOND TRIMESTER PREGNANCY; SPONTANEOUS ABORTION; TROPHOBLAST; TROPHOBLASTIC DISEASE; TROPHOBLASTIC TUMOR; VILLOUS DYSMORPHISM; VILLOUS TROPHOBLAST HYPERPLASIA;

FEMALE; HUMANS; HYDATIDIFORM MOLE; PREGNANCY; UTERINE NEOPLASMS;

EID: 75149115093     PISSN: 15513815     EISSN: 15513823     Source Type: Journal    
DOI: 10.3109/15513810903266138     Document Type: Review

References (57)

1. Kim S. Epidemiology. In Gestational Trophoblastic Disease, Hancock BW, Newlands ES, Berkowitz RS, eds. London: Chapman & Hall, 27-42, 1997.
2. Sebire NJ, Foskett M, Fisher RA, Rees H, Seckl M, Newlands E. Risk of partial and complete hydatidiform molar pregnancy in relation to maternal age. BJOG 109:99-102, 2002.
3. Seckl MJ, Fisher RA, Salerno G, Rees H, Paradinas FJ, Foskett M, Newlands ES. Choriocarcinoma and partial hydatidiform moles. Lancet 356:36-39, 2000.
4. Kajii T, Ohama K. Androgenetic origin of hydatidiform mole. Nature 268:633-634, 1977.
5. Jacobs PA, Hunt PA, Matsuura JS, Wilson CC, Szulman AE. Complete and partial hydatidiform mole in Hawaii: cytogenetics, morphology and epidemiology. Br J Obstet Gynaecol 89:258-266, 1982.
6. Lawler SD, Povey S, Fisher RA, Pickthall VJ. Genetic studies on hydatidiform moles. II. The origin of complete moles. Ann Hum Genet 46:209-222, 1982.
7. Fisher RA, Povey S, Jeffreys AJ, Martin CA, Patel I, Lawler SD. Frequency of heterozygous complete hydatidiform moles, estimated by locus-specific minisatellite and Y chromosome-specific probes. Hum Genet 8:259-263, 1989.
8. Fisher RA, Khatoon R, Paradinas FJ, Roberts AP, Newlands ES. Repetitive complete hydatidiform mole can be biparental in origin and either male or female. Hum Reprod 15:594-598, 2000.
9. Szulman AE, Surti U. The syndromes of hydatidiform mole. I. Cytogenetic and morphologic correlations. Am J Obstet Gynecol 131:665-671, 1978. (Pubitemid 8364343)
10. Lawler SD, Fisher RA, Pickthall VJ, Povey S, Evans MW. Genetic studies on hydatidiform moles. I. The origin of partial moles. Cancer Genet Cytogenet 5:309-320, 1982.
11. Jacobs PA, Szulman AE, Funkhouser J, Matsuura JS, Wilson CC. Human triploidy: relationship between parental origin of the additional haploid complement and development of partial hydatidiform mole. Ann Hum Genet 46:223-231, 1982.
12. Zaragoza MV, Surti U, Redline RW, Millie E, Chakravarti A, Hassold TJ. Parental origin and phenotype of triploidy in spontaneous abortions: predominance of diandry and association with the partial hydatidiform mole. Am J Hum Genet 66:1807-1820, 2000.
13. Fisher RA, Hodges MD, Newlands ES. Familial recurrent hydatidiform mole: a review. J Reprod Med 49:595-601, 2004.
14. Helwani MN, Seoud M, Zahed L, Zaatari G, Khalil A, Slim R. A familial case of recurrent hydatidiform molar pregnancies with biparental genomic contribution. Hum Genet 105:112-115, 1999.
15. Sensi A, Gualandi F, Pittalis MC, Calabrese O, Falciano F, Maestri I, Bovicelli L, Calzolari E. Mole maker phenotype: possible narrowing of the candidate region. Eur J Hum Genet 8:641-644, 2000.
16. Hodges MD, Rees HC, Seckl MJ, Newlands ES, Fisher RA. Genetic refinement and physical mapping of a biparental complete hydatidiformmole locus on chromosome 19q13.4. J MedGenet 40:e95, 2003.
17. Panichkul PC, Al-Hussaini TK, Sierra R, Kashork CD, Popek EJ, Stockton DW, Van den Veyver IB. Recurrent biparental hydatidiform mole: additional evidence for a 1.1-Mb locus in 19q13.4 and candidate gene analysis. J Soc Gynecol Invest 12:376-383, 2005.
18. Zhao J, Moss J, Sebire NJ, Cui QC, Seckl MJ, Xiang Y, Fisher RA. Analysis of the chromosomal region 19q13.4 in two Chinese families with recurrent hydatidiform mole. Hum Reprod 21:536-541, 2006.
19. Fisher RA, Khatoon R, Paradinas FJ, Roberts AP, Newlands ES. Repetitive complete hydatidiform mole can be biparental in origin and either male or female. Hum Reprod 15:594-598, 2000.
20. Judson H, Hayward BE, Sheridan E, Bonthron DT. A global disorder of imprinting in the human female germ line. Nature 416:539-542, 2002.
21. Moglabey YB, Kircheisen R, Seoud M, El Mogharbel N, Van Den Veyver I, Slim R. Genetic mapping of a maternal locus responsible for familial hydatidiform moles. Hum Mol Genet 8:667-671, 1999.
22. Murdoch S, Djuric U, Mazhar B, Seoud M, Khan R, Kuick R, Bagga R, Kircheisen R, Ao A, Ratti B, Hanash S, Rouleau GA, Slim R. Mutations in NALP7 cause recurrent hydatidiform moles and reproductive wastage in humans. Nat Genet 38:300-302, 2006.
23. Sebire NJ, Foskett M, Fisher RA, Lindsay I, Seckl MJ. Persistent gestational trophoblastic disease is rarely, if ever, derived from non-molar first-trimester miscarriage. Med Hypoth 64:689-693, 2005.
24. Bagshawe KD, Dent J, Webb J. Hydatidiform mole in England and Wales 1973-1983. Lancet 2:673-677, 1986.
25. Sebire NJ, Fisher RA, FoskettM, Rees H, SecklMJ, Newlands ES. Risk of recurrent hydatidiform mole and subsequent pregnancy outcome following complete or partial hydatidiform molar pregnancy. BJOG 110:22-26, 2003.
26. Bracken MB. Incidence and aetiology of hydatidiform mole: an epidemiological review. Br J Obstet Gynaecol 94:1123-1135, 1987.
27. Sebire NJ, Foskett M, Fisher RA, Rees H, Seckl M, Newlands ES. Risk of partial and complete hydatidiform mole in relation to maternal age. BJOG 109:99-102, 2002.
28. Gemer O, Segal S, Kopmar A, Sassoon E. The current clinical presentation of complete molar pregnancy. Arch Gynecol Obstet 264:33-34, 2000.
29. Johns JN, Greenwold S, Buckley E, Jauniaux E. A prospective study of ultrasound screening for molar pregnancies in missed miscarriages. Ultrasound Obstet Gynecol 25:493-497, 2005.
30. Fowler DJ, Lindsay I, Seckl MJ, Sebire NJ. Routine pre-evacuation ultrasound diagnosis of hydatidiform mole: experience of <1,000 Cases from a regional referral centre. Ultrasound Obstet Gynaecol 27:56-60, 2006.
31. Sebire NJ, Fisher RA, Rees HC. Histopathological diagnosis of partial and complete hydatidiform mole in the first trimester of pregnancy. Pediatr Dev Pathol 6:69-77, 2003.
32. Sebire NJ, Makrydimas G, Agnantis NJ, Zagorianakou N, Rees H, Fisher RA. Updated diagnostic criteria for partial and complete hydatidiform moles in early pregnancy. Anticancer Res 3:1723-1728, 2003.
33. Sebire NJ, Rees H. Diagnosis of gestational trophoblastic disease in early pregnancy. Cur Diagn Pathol 8:430-440, 2003.
34. Szulman AE, Surti U. The syndromes of hydatidiform mole. II. Morphologic evolution of the complete and partial mole. Am J Obstet Gynecol 132:20-27, 1978. (Pubitemid 8397361)
35. Kajii T, Kurashige H, Ohama K, Uchino F. XY and XX complete moles: clinical and morphological correlations. Am J Obstet Gynecol 150:57-64, 1984.
36. Fisher RA, Paradinas FJ, Soteriou BA, Foskett M, Newlands ES. Diploid hydatidiform moles with fetal red blood cells in molar villi. 2-Genetics.J Pathol 181:189-195, 1997.
37. Paradinas FJ, Fisher RA, Browne P, Newlands ES. Diploid hydatidiform moles with fetal red blood cells in molar villi.1. Pathology, incidence, and prognosis. J Pathol 181:183-188, 1997.
38. Paradinas FJ. The histological diagnosis of hydatidiform moles. Curr Diagn Pathol 1:24-31, 1994.
39. Sebire NJ, Rees H, Paradinas F, Fisher R, Foskett M, Seckl M, Newlands E. Extravillus endovascular implantation site trophoblast invasion is abnormal in complete versus partial molar pregnancies. Placenta 22:725-728, 2001.
40. Cheung, ANY, Ngan HYS, Chen WZ et al. The significance of the proliferating cell nuclear antigen in human trophoblastic disease: an immunohistochemical study. Histopathology 22:565-568, 1993.
41. Suresh, UR, Hale RJ, Fox H, Buckley CH. Use of proliferation cell nuclear antigen immunoreactivity for distinguishing hydropic abortions from partial hydatidiform moles. J Clin Pathol 46:48-50, 1993.
42. Olvera M, Harris S, Amezcua CA, McCourty A, Rezk S, Koo C, Felix JC, Brynes RK. Immunohistochemical expression of cell cycle proteins E2F-1, Cdk-2, Cyclin E, p27 (kip1) and Ki-67 in normal placenta and gestational trophoblastic disease. Mod Pathol 14:1036-1042, 2001.
43. Castrillon DH, Sun D, Weremowicz S, Fisher RA, Crum CP, Genest DR. Discrimination of complete hydatidiform mole from its mimics by immunohistochemistry of the paternally imprinted gene product p57KIP2. Am J Surg Pathol 25:1225-1230, 2001.
44. Fisher RA, Hodges MD, Rees HC, Sebire NJ, Seckl MJ, Newlands ES, Genest DR, Castrillon DH. The maternally transcribed gene p57(KIP2) (CDNK1C) is abnormally expressed in both androgenetic and biparental complete hydatidiform moles. Hum Mol Genet 11:3267-3272, 2002.
45. Sebire NJ, Lindsay I, Fisher RA. Recent advances in gestational trophoblastic neoplasia. Curr Diagn Pathol 13:210-221, 2007.
46. Fisher RA, Newlands ES. Rapid diagnosis and classification of hydatidiform moles using the polymerase chain reaction. Am J Obstet Gynecol 168:563-569, 1993.
47. Osada H, Iitsuka Y, Matsui H, Sekiya S. A complete hydatidiform mole coexisting with a normal fetus was confirmed by variable number tandem repeat (VNTR) polymorphism analysis using polymerase chain reaction. Gynecol Oncol 56:90-93, 1995.
48. Makrydimas G, Sebire NJ, Thornton SE, Zagorianakou N, Lolis D, Fisher RA. Complete hydatidiform mole and normal live birth: a novel case of confined placental mosaicism: case report. Hum Reprod 17:2459-2463, 2002.
49. Paradinas FJ. Pathology. In Gestational Trophoblastic Disease, Hancock BW, Newlands ES, Berkowitz RS, eds. London: Chapman & Hall, 43-76, 1997.
50. Burton JL, Lidbury EA, Gillespie AM, Tidy JA, Smith O, Lawry J, Hancock BW, Wells M. Overdiagnosis of hydatidiform mole in early tubal ectopic pregnancy. Histopathology 38:409-417, 2001.
51. Sebire NJ, Lindsay I, Fisher RA, Savage P, Seckl MJ. Overdiagnosis of complete and partial hydatidiform mole in tubal ectopic pregnancies. Int J Gynecol Pathol 24:260-264, 2005.
52. Sebire NJ, Foskett M, Paradinas FJ, Fisher RA, Francis RJ, Short D, Newlands ES, Seckl MJ. Outcome of twin pregnancies with complete hydatidiform mole and healthy co-twin. Lancet 359:2165-2166, 2002.
53. Surti U, Hill LM, Dunn J, Prosen T, Hoffner L. Twin pregnancy with a chimeric androgenetic and biparental placenta in one twin displaying placental mesenchymal dysplasia phenotype. Prenat Diagn 25:1048-1056, 2005.
54. Kaiser-Rogers KA, McFadden DE, Livasy CA, Dansereau J, Jiang R, Knops JF, Lefebvre L, Rao KW, Robinson WP. Androgenetic/biparental mosaicism causes placental mesenchymal dysplasia. J Med Genet 43:187-192, 2006.
55. Sebire NJ, Foskett M, Short D, Savage P, Stewart W, Thomson M, Seckl MJ. Shortened duration of human chorionic gonadotrophin surveillance following complete or partial hydatidiform mole: evidence for revised protocol of a UK regional trophoblastic disease unit. BJOG 114:760-762, 2007.
56. Royal College of Obstetricians and Gynaecologists. The Management of Early Pregnancy Loss. Clinical Guideline No. 25. London, UK: RCOG Press, 2000.
57. Tidy JA, Hancock BW, Newlands ES. The Management of Gestational Trophoblastic Neoplasia. Royal College of Obstetricians and Gynaecologists. Clinical Guideline No. 38. London, UK: RCOG press, Feb 2004.