The role of mutations in core protein of hepatitis B virus in liver fibrosis

Virology Journal

Volumn 6, Issue , 2009, Pages

  Mohamadkhani, Ashraf ^a,b   Jazii, Ferdous Rastgar ^a   Poustchi, Hossein ^b   Nouraein, Omidreza ^a   Abbasi, Shahsanam ^a   Sotoudeh, Masoud ^b   Montazeri, Ghodratollah ^b  

^a NATIONAL INSTITUTE OF GENETIC ENGINEERING AND BIOTECHNOLOGY   (Iran)

^b TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; CORE PROTEIN; VIRUS DNA; EPITOPE; MICROSOMAL AMINOPEPTIDASE;

ADULT; ARTICLE; B LYMPHOCYTE; CARBOXY TERMINAL SEQUENCE; CLINICAL ARTICLE; CYTOTOXIC T LYMPHOCYTE; HELPER CELL; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; LIVER FIBROSIS; NONHUMAN; PROTEIN PHOSPHORYLATION; BLOOD; GENETICS; IMMUNOLOGY; LIVER CIRRHOSIS; MALE; MUTATION; VIROLOGY;

HEPATITIS B VIRUS;

ADULT; ANTIGENS, CD13; DNA, VIRAL; EPITOPES, T-LYMPHOCYTE; HEPATITIS B VIRUS; HEPATITIS B, CHRONIC; HUMANS; LIVER CIRRHOSIS; MALE; MUTATION; T-LYMPHOCYTES, CYTOTOXIC; VIRAL CORE PROTEINS;

EID: 74949142947     PISSN: None     EISSN: 1743422X     Source Type: Journal    
DOI: 10.1186/1743-422X-6-209     Document Type: Article

References (32)

1. Hepatitis B: evolving epidemiology and implications for control. HS Margolis MJ Alter SC Hadler, Semin Liver Dis 1991 11 84 92 10.1055/s-2008- 1040427 1832236
2. Reassessment of the role of hepatitis B and C viruses in postnecrotic cirrhosis and chronic hepatitis in southern Iran. KB Lankarani I Nabipoor, Irn J Med Sci 1999 24 117 121
3. The global impact of hepatic fibrosis and end-stage liver disease. YS Lim WR Kim, Clin Liver Dis 2008 12 733 746 10.1016/j.cld.2008.07.007 18984463
4. Hepadnaviruses. C Seeger W Mason F Zoulim, Fields virology Philadelphia: Lippincott Williams & Wilkins, Knipe DM, Howley PM, 2007 2977 3029
5. The arginine-rich domain of the hepatitis B virus core protein is required for pregenome encapsidation and productive viral positive-strand DNA synthesis but not for virus assembly. M Nassal, J Virol 1992 66 4107 4116 1602535
6. Clinical significance of precore and core promoter mutations in genotype D hepatitis B-related chronic liver disease. H Poustchi A Mohamadkhani S Bowden G Montazeri A Ayres P Revill GC Farrell S Locarnini J George R Malekzadeh, J Viral Hepat 2008 15 753 760 10.1111/j.1365-2893.2008.00998.x 18507754
7. The crystal structure of the human hepatitis B virus capsid. SA Wynne RA Crowther AG Leslie, Mol Cell 1999 3 771 780 10.1016/S1097-2765(01)80009-5 10394365
8. A protease-sensitive hinge linking the two domains of the hepatitis B virus core protein is exposed on the viral capsid surface. M Seifer DN Standring, J Virol 1994 68 5548 5555 7520091
9. Phosphorylation in the carboxyl-terminal domain of the capsid protein of hepatitis B virus: evaluation with a monoclonal antibody. A Machida H Ohnuma F Tsuda A Yoshikawa Y Hoshi T Tanaka S Kishimoto Y Akahane Y Miyakawa M Mayumi, J Virol 1991 65 6024 6030 1717713
10. Localization of the C terminus of the assembly domain of hepatitis B virus capsid protein: implications for morphogenesis and organization of encapsidated RNA. A Zlotnick N Cheng SJ Stahl JF Conway AC Steven PT Wingfield, Proc Natl Acad Sci USA 1997 94 9556 9561 10.1073/pnas.94.18.9556 9275161
11. A structural model for maturation of the hepatitis B virus core. AM Roseman JA Berriman SA Wynne PJ Butler RA Crowther, Proc Natl Acad Sci USA 2005 102 15821 15826 10.1073/pnas.0504874102 16247012
12. Reverse transcription-associated dephosphorylation of hepadnavirus nucleocapsids. DH Perlman EA Berg PB O'Connor CE Costello J Hu, Proc Natl Acad Sci USA 2005 102 9020 9025 10.1073/pnas.0502138102 15951426
13. An assessment of the effect of hepatitis B vaccine in decreasing the amount of hepatitis B disease in Italy. G La Torre N Nicolotti C de Waure G Chiaradia ML Specchia A Mannocci W Ricciardi, Virol J 2008 5 84 10.1186/1743-422X-5-84 18652653
14. Rous-Whipple Award Lecture. Viruses, immunity, and cancer: lessons from hepatitis B. FV Chisari, Am J Pathol 2000 156 1117 1132 10751335
15. HBV core particles as a carrier for B cell/T cell epitopes. P Pumpens E Grens, Intervirology 2001 44 98 114 10.1159/000050037 11509871
16. High rate of mutations in the hepatitis B core gene during the immune clearance phase of chronic hepatitis B virus infection. H Bozkaya B Ayola AS Lok, Hepatology 1996 24 32 37 10.1002/hep.510240107 8707278
17. Cytotoxic T lymphocyte responses and CTL epitope escape mutation in HBsAg, anti-HBe positive individuals. SI Khakoo R Ling I Scott AI Dodi TJ Harrison GM Dusheiko JA Madrigal, Gut 2000 47 137 143 10.1136/gut.47.1.137 10861276
18. Core mutations in patients with acute episodes of chronic HBV infection are associated with the emergence of new immune recognition sites and the development of high IgM anti-HBc index values. A Alexopoulou G Baltayiannis C Eroglu T Nastos SP Dourakis AJ Archimandritis P Karayiannis, J Med Virol 2009 81 34 41 10.1002/jmv.21337 19031457
19. Molecular epidemiology and immunology of hepatitis B virus infection-an update. P Pumpens E Grens M Nassal, Intervirology 2002 45 218 232 10.1159/000067915 12566704
20. Identification of immunodominant T cell epitopes of the hepatitis B virus nucleocapsid antigen. C Ferrari A Bertoletti A Penna A Cavalli A Valli G Missale M Pilli P Fowler T Giuberti FV Chisari, et al. J Clin Invest 1991 88 214 222 10.1172/JCI115280 1711541
21. Natural variants of cytotoxic epitopes are T-cell receptor antagonists for antiviral cytotoxic T cells. A Bertoletti A Sette FV Chisari A Penna M Levrero M De Carli F Fiaccadori C Ferrari, Nature 1994 369 407 410 10.1038/369407a0 8196768
22. Long-term outcome after spontaneous HBeAg seroconversion in patients with chronic hepatitis B. YS Hsu RN Chien CT Yeh IS Sheen HY Chiou CM Chu YF Liaw, Hepatology 2002 35 1522 1527 10.1053/jhep.2002.33638 12029639
23. Histological grading and staging of chronic hepatitis. K Ishaka A Baptistab L Bianchic F Callead JD Grootee F Gudatf, J Hepatology 1995 22 696 699 10.1016/0168-8278(95)80226-6
24. Cellular apoptosis induced by replication of hepatitis B virus: possible link between viral genotype and clinical outcome. YW Lu TL Tan J Zhang WN Chen, Virol J 2007 4 117 10.1186/1743-422X-4-117 17973991
25. The origins of eukariotic gene structure. M Lynch, Mol Biol Evol 2006 23 450 468 10.1093/molbev/msj050 16280547
26. Hepatitis B virus DNA replication is coordinated by core protein serine phosphorylation and HBx expression. M Melegari SK Wolf RJ Schneider, J Virol 2005 79 9810 9820 10.1128/JVI.79.15.9810-9820.2005 16014942
27. The origins of protein phosphorylation. P Cohen, Nat Cell Biol 2002 4 127 130 10.1038/ncb0502-e127 11988757
28. Regulation of hepadnavirus reverse transcription by dynamic nucleocapsid phosphorylation. SH Basagoudanavar DH Perlman J Hu, J Virol 2007 81 1641 1649 10.1128/JVI.01671-06 17135319
29. An enzyme-linked immunosorbent assay with monoclonal antibodies for the determination of phosphorylated hepatitis B core protein (p21c) in serum. S Usuda H Okamoto F Tsuda T Tanaka Y Miyakawa M Mayumi, J Virol Methods 1998 72 95 103 10.1016/S0166-0934(98)00019-6 9672136
30. Precore/core mutations of hepatitis B virus in hepatocellular carcinomas developed on noncirrhotic livers. M Minami K Poussin M Kew T Okanoue C Brechot P Paterlini, Gastroenterology 1996 111 691 700 10.1053/gast.1996.v111.pm8780574 8780574
31. Evidence for selection of hepatitis B mutants after liver transplantation through peripheral blood mononuclear cell infection. A Brind J Jiang D Samuel M Gigou C Feray C Brechot D Kremsdorf, J Hepatol 1997 26 228 235 10.1016/S0168-8278(97)80035-9 9059940
32. Hepatitis B virus core protein stimulates the proteasome-mediated degradation of viral X protein. JH Kim S Kang J Kim BY Ahn, J Virol 2003 77 7166 7173 10.1128/JVI.77.13.7166-7173.2003 12805415