Cytotoxic T lymphocyte responses and CTL epitope escape mutation in HBsAg, anti-HBe positive individuals

Gut

Volumn 47, Issue 1, 2000, Pages 137-143

  Khakoo, S I ^a   Ling, R ^a   Scott, I ^c   Dodi, A I ^c   Harrison, T J ^a   Dusheiko, G M ^a   Madrigal, J A ^b,c  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c ROYAL FREE HOSPITAL   (United Kingdom)

Author keywords

Cytotoxicity; Hepatitis B core antigen; Hepatitis B virus; HLA; Mutant

Indexed keywords

ALANINE AMINOTRANSFERASE; ALPHA INTERFERON; AMINO ACID; CELL DNA; EPITOPE; HEPATITIS B CORE ANTIGEN; HEPATITIS B SURFACE ANTIGEN; HEPATITIS B(E) ANTIBODY; HLA ANTIGEN CLASS 1; HLA ANTIGEN CLASS 2; IMMUNOGLOBULIN M;

ADULT; ALLELE; AMINO ACID SEQUENCE; AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; CYTOTOXICITY; FEMALE; GENE MUTATION; GENETIC TRANSFECTION; HEPATITIS B; HEPATITIS B VIRUS; HLA SYSTEM; HUMAN; HUMAN CELL; HUMAN TISSUE; LYMPHOCYTE PROLIFERATION; MALE; PRIORITY JOURNAL; SEQUENCE ANALYSIS; VIRAL GENETICS; VIRUS MUTANT;

ADULT; AMINO ACID SEQUENCE; CARRIER STATE; CELL CULTURE TECHNIQUES; CELL LINE; CYTOTOXICITY, IMMUNOLOGIC; EPITOPES, T-LYMPHOCYTE; FEMALE; HEPATITIS B ANTIBODIES; HEPATITIS B E ANTIGENS; HEPATITIS B SURFACE ANTIGENS; HEPATITIS B, CHRONIC; HISTOCOMPATIBILITY ANTIGENS CLASS I; HLA-A ANTIGENS; HUMANS; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; MUTATION; T-LYMPHOCYTES, CYTOTOXIC; TRANSFECTION;

EID: 0033918173     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.47.1.137     Document Type: Article

References (39)

1. 1 Wells RS, Parham P. HLA class I genes: structure and diversity. In: Browning MJ, McMichael AJ, editors. HLA and MHC: genes, molecules and functions. Oxford: BIOS Scientific Publishers Ltd, 1996:79-96.
2. 2 Lau JYN, Bird GLA, Naoumov NV, et al. Hepatic HLA antigen display in chronic hepatitis B virus infection: Relation to hepatic expression of HBV genome/gene products and liver histology. Dig Dis Sci 1993;38:888-95.
3. 3 Paul RG, Roodman ST, Campbell CR, et al. HLA class I antigen expression as a measure of response to antiviral therapy of chronic hepatitis B. Hepatology 1991;13:820-5.
4. 4 Pignatelli M, Water J, Lever AML, et al. HLA class I antigens on hepatocyte membrane: Increased expression during interferon therapy of chronic hepatitis B. Hepatology 1986;6:349-53.
5. 5 Bertoletti A, Chisari FV, Penna A, et al. Definition of a minimal optimal cytotoxic T-cell epitope within the hepatitis B virus nucleocapsid protein. J Virol 1993;67:2376-80.
6. 6 Nayersina R, Fowler P, Guilhot S, et al. HLA A2 restricted cytotoxic T lymphocyte responses to multiple hepatitis B surface antigen epitopes during hepatitis B virus infection. J Immunol 1994;150:4659-71.
7. 7 Rehermann B, Fowler P, Sidney J, et al. The cytotoxic T lymphocyte response to multiple hepatitis B virus polymerase epitopes during and after acute viral hepatitis. J Exp Med 1995;181:1047-58.
8. 8 Missale G, Redeker A, Person J, et al. HLA-A31- and HLA-Aw68.1-restricted cytotoxic T cell responses to a single hepatitis B virus nucleocapsid epitope during acute viral hepatitis. J Exp Med 1993;177:751-62.
9. + cytotoxic T lymphocytes. J Clin Invest 1996;97:577-84.
10. 10 Rehermann B, Lau D, Hoofnagle JH, et al. Cytotoxic T lymphocyte responsiveness after resolution of chronic hepatitis B virus infection. J Clin Invest 1996;97:1655-65.
11. 11 Rehermann B, Ferrari C, Pasquinelli C, et al. The hepatitis B virus persists for decades after patients' recovery from acute viral hepatitis despite active maintenance of a cytotoxic T-lymphocyte response. Nat Med 1996;2:1104-8.
12. 12 Mota AH, Fainboim H, Terg R, et al. Association of chronic active hepatitis and HLA B35 in patients with hepatitis B virus. Tissue Antigens 1987;30:238-40.
13. 13 Sampliner RE, Bias WB, Carney E, et al. HLA antigens and HBV infection: evaluation in the chronic carrier state and in a large family. Tissue Antigens 1981;18:247-51.
14. 14 Thursz MR, Kwiatkowski D, Allsopp CEM, et al. Association between an MHC class II allele and clearance of hepatitis B virus in the Gambia. N Engl J Med 1995;332:1065-9.
15. 15 van Hattum J, Schreuder GM, Schalm SW. HLA antigens in patients with various courses after hepatitis B virus infection. Hepatology 1987;7:11-14.
16. 16 Guo H, Jardetzky TS, Garrett TPJ, et al. Different length peptides bind to HLA-Aw68 similarly at their ends but bulge out in the middle. Nature 1992;360:364-6.
17. 17 Kaneko S, Miller RH, Feinstone SM, et al. Detection of serum hepatitis B virus DNA in patients with chronic hepatitis using the polymerase chain reaction assay. Proc Natl Acad Sci USA 1989;86:312-16.
18. 18 Khakoo SI, Soni PN, Brown D, et al. A clinical evaluation of a new method for HBV DNA quantitation in patients with chronic hepatitis B. J Med Virol 1996;50:112-16.
19. 19 Carman WF, Korula J, Wallace L, et al. Fulminant reactivation of hepatitis B due to envelope protein mutant that escaped detection by monoclonal HBsAg ELISA. Lancet 1995;345:1406-7.
20. 20 Kavathas P, Bach FH, DeMars R. Gamma ray induced loss of expression of HLA and glyoxylase I alleles in lymhpoblastoid cells. Proc Natl Acad Sci USA 1980;77:4251.
21. 21 Storkus WJ, Alexander J, Payne JA, et al. Reversal of natural killing susceptibility in target cells expressing transfected class I HLA genes. Proc Natl Acad Sci USA 1989;86: 2361-4.
22. 22 Zemmour J, Little AM, Schendel DJ, et al. The HLA-A,B "negative" mutant cell line CIR expresses a novel HLA-B35 allele, which also has a point mutation in the translation initiation codon. J Immunol 1992;148:1941-8.
23. 23 Vaudin M, Wolstenholme AJ, Tsiquaye KN, et al. The complete nucleotide sequence of the genome of a hepatitis B virus isolated from a naturally infected chimpanzee. J Gen Virol 1988;69:1383-9.
24. 24 Ono Y, Onda H, Sasada R, et al. The complete nucleotide sequences of the cloned hepatitis B virus DNA; subtype adr and adw. Nucleic Acid Res 1983;11:1747-57.
25. 25 Koenig S, Conley AJ, Brewah YA, et al. Transfer of HIV-1-specific cytotoxic T lymphocytes to an AIDS patient leads to selection for mutant HIV variants and subsequent disease progression. Nat Med 1995;1:330-6.
26. 26 de Campos-Lima PO, Gavioli R, Zhang QJ, et al. 1993. HLA-A11 epitope loss isolates of Epstein-Barr virus from a highly A11+ population. Science 1993;260:98-100.
27. 27 Pircher H, Moskophidis D, Rohrer U, et al. Viral escape by selection of cytotoxic T cell-resistant virus varíants in vivo. Nature 1990;346:629-33.
28. 28 Bertoletti A, Sette A, Scaccaglia P, et al. Natural variants of cytotoxic epitopes are T cell receptor antagonists for anti-viral cytotoxic T cells. Nature 1994;369:407-10.
29. 29 Rehermann B, Pasquinelli C, Mosier SM, et al. Hepatitis B virus (HBV) sequence variation in cytotoxic T lymphocyte epitopes is not common in patients with chronic HBV infection. J Clin Invest 1995;96:1527-34.
30. 30 Derso A, Boxall EA, Tarlow MJ, et al. Transmission of HBsAg from mother to infant. BMJ 1978;1:949-52.
31. 31 Lee SD, Lo KJ, Wu JC, et al. Prevention of maternal-infant hepatitis B virus transmission by immunization: the role of serum hepatitis B virus DNA. Hepatology 1986;6:369-73.
32. 32 Bozkaya H, Ayola B, Lok ASF. High rate of mutations in the hepatitis B core gene during the immune clearance phase of chronic hepatitis B virus infection. Hepatology 1996;24: 32-7.
33. 33 Carman WF, Boner W, Fattovich G, et al. Hepatitis B core protein mutations are concentrated in B cell epitopes during clinical remission. J Infect Dis 1997;175:1093-100.
34. 34 Gunther S, Paulij W, Meisel H, et al. Analysis of hepatitis B virus populations in an interferon-u-treated patient reveals predominant mutations in the c-gene and changing e-antigenicity. Virology 1998;244:146-60.
35. 35 Garboczi DN, Ghosh P, Utz U, et al. Structure of the complex between human T-cell receptor, viral peptide and HLA-A2. Nature 1996;384:134-41.
36. 36 Garrett TPJ, Saper MA, Bjorkrnan PJ, et al. Specificity pockets for the side chains of peptide antigens in HLA-Aw68. Nature 1989;342:692-6.
37. 37 Birnbaum F, Nassal M. Hepatitis B virus nucleocapsid assembly: primary structure requirements in the core protein. J Virol 1990;64:3319-30.
38. 38 Nassal M. The arginine-rich domain of the hepatitis B virus core protein is required for pregenome encapsidation and productive viral positive-strand DNA synthesis but not for virus assmebly. J Virol 1992;66:4107-16.
39. 39 Zoulim F, Seeger C. Reverse transcription in hepatitis B viruses is primed by a tyrosine residue of the polymerase. J Virol 1994;68:6-13.