Development of pH- and enzyme-controlled, colon-targeted, pulsed delivery system of a poorly water-soluble drug: Preparation and in vitro evaluation

Drug Development and Industrial Pharmacy

Volumn 36, Issue 1, 2010, Pages 81-92

  Lai, Huiming ^a   Lin, Ke ^a   Zhang, Wenbin ^b   Zhang, Zhirong ^a   Jie, Liu ^a   Wu, Yuna ^a   He, Qin ^a  

^a SICHUAN UNIVERSITY   (China)

^b SICHUAN CANCER HOSPITAL   (China)

Author keywords

mannanase medium; Colon targeting; Human fecal; PH and enzyme controlled; Rat cecal content

Indexed keywords

2 HYDROXYPROPYL BETA CYCLODEXTRIN; ALCOHOL; BETA CYCLODEXTRIN; BETA MANNOSIDASE; CARBOXYMETHYLCELLULOSE; DODECYL SULFATE SODIUM; EUDRAGIT; GUAR GUM; LACTOSE; LANSOPRAZOLE; MAGNESIUM STEARATE; MANNITOL; POLOXAMER; POLYSACCHARIDE; POLYSORBATE 80; POVIDONE; SODIUM CARBOXYMETHYL STARCH; STARCH; TALC; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CECUM; COLON; CONTROLLED STUDY; CORROSION; DRUG DEGRADATION; DRUG DELIVERY SYSTEM; DRUG SOLUBILITY; DRUG SYNTHESIS; DRUG TARGETING; ENTERIC COATED TABLET; FECES; FEMALE; HUMAN; INTESTINE FLUID; INTESTINE TRANSIT TIME; MALE; NONHUMAN; PH; PULSATILE DRUG RELEASE; RAT; SIMULATION; TABLET COMPRESSION; TABLET DISINTEGRATION; TABLET FORMULATION; TABLET FRIABILITY; TABLET HARDNESS; TABLET THICKNESS;

2-PYRIDINYLMETHYLSULFINYLBENZIMIDAZOLES; ADOLESCENT; ADULT; AGE FACTORS; AGED; ANIMALS; BETA-MANNOSIDASE; CHILD; CHILD, PRESCHOOL; COLON; DRUG DELIVERY SYSTEMS; EXCIPIENTS; FEMALE; GALACTANS; GASTROINTESTINAL TRANSIT; HUMANS; HYDROGEN-ION CONCENTRATION; MALE; MANNANS; MICROSCOPY, ELECTRON, SCANNING; MIDDLE AGED; PLANT GUMS; POLYMETHACRYLIC ACIDS; RATS; RATS, WISTAR; SEX FACTORS; SOLUBILITY; YOUNG ADULT;

EID: 74949127656     PISSN: 03639045     EISSN: 15205762     Source Type: Journal    
DOI: 10.3109/03639040903092335     Document Type: Article

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