Cholestasis and regulation of genes related to drug metabolism and biliary transport in rat liver following treatment with cyclosporine a and sirolimus (rapamycin)

Pharmacology and Toxicology

Volumn 89, Issue 3, 2001, Pages 133-139

  Bramow, Stephan ^a   Ott, Peter ^a   Thomsen Nielsen, Finn ^d   Bangert, Kristian ^b   Tygstrup, Niels ^a   Dalhoff, Kim ^c  

^a Department of Hepatology ^*  (Denmark)

^b Clinical Biochemistry KB   (Denmark)

^c Rigshospitalet   (Denmark)

^d ODENSE UNIVERSITY HOSPITAL   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; BILIRUBIN; CARRIER PROTEIN; CYCLOSPORIN A; CYTOCHROME P450; CYTOCHROME P450 1A2; CYTOCHROME P450 2E1; CYTOCHROME P450 3A; GAMMA GLUTAMYLTRANSFERASE; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; GLUTATHIONE TRANSFERASE; MESSENGER RNA; PENTOXYRESORUFIN DEALKYLASE; RAPAMYCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BILE FLOW; CHOLESTASIS; CONTROLLED STUDY; DRUG METABOLISM; DRUG TRANSPORT; GENE CONTROL; GENE EXPRESSION; HEPATOBILIARY SYSTEM; IMMUNOSUPPRESSIVE TREATMENT; LIVER CELL; LIVER FUNCTION TEST; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT;

ANIMALS; CARRIER PROTEINS; CHOLESTASIS; CYCLOSPORINE; CYTOCHROME P-450 ENZYME SYSTEM; DRUG INTERACTIONS; GENE EXPRESSION REGULATION; GLUTATHIONE; IMMUNOSUPPRESSIVE AGENTS; LIVER; LIVER FUNCTION TESTS; LIVER TRANSPLANTATION; MALE; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SIROLIMUS;

EID: 0034802547     PISSN: 09019928     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0773.2001.890304.x     Document Type: Article

References (5)

1. Adesnik, M., S. Bar Nun, F. Maschio, M. Zunich, A. Lippman & E. Bard: Mechanism of induction of cytochrome P-450 by phenobarbital. J. Biol Chem. 1981, 256, 10340-10345.
2. Bohme, M., M. Muller, I. Leier, G. Jedlitschky & D. Keppler: Cholestasis caused by inhibition of the adenosine triphosphate-dependent bile salt transport in rat liver. Gastroenterology 1994, 107, 255-265.
3. Brawn, P. C., S. S. Thorgeirsson & J. A. Silverman: Cloning and regulation of the rat mdr2 gene. Nucleic Acids Res 1993, 21, 3885-3891.
4. Buchler, M., J. Konig, M. Brom, J. Kartenbeck, H. Spring, T. Horie & D. Keppler: cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats. J Biol Chem 1996, 271, 15091-15098.
5. Carrella, M., D. Feldman, S. Cogoi, A. Csillaghy & P. A. Weinhold: Enhancement of mdr2 gene transcription mediates the biliary transfer of phosphatidylcholine supplied by an increased biosynthesis in the pravastatin-treated rat. Hepatology 1999, 29, 1825-1832.