The natural compound ascorbigen modulates NADPH-quinone oxidoreductase (NQO1) mRNA and enzyme activity levels in cultured liver cells and in laboratory rats

Annals of Nutrition and Metabolism

Volumn 53, Issue 2, 2008, Pages 122-128

  Wagner, Anika E ^a   Hug, Hubert ^b   Gössl, Richard ^b   Riss, Georges ^b   Mussler, Bernd ^b   Elste, Volker ^b   Rimbach, Gerald ^a   Barella, Luca ^b  

^a UNIVERSITY OF KIEL   (Germany)

^b Research and Development   (Switzerland)

Author keywords

Antioxidant response element; Ascorbigen; NADPH quinone oxidoreductase; NFE2 related factor 2; Sulforaphane

Indexed keywords

ASCORBIC ACID; ASCORBIGEN; ENZYME; ENZYME ACTIVATOR; MESSENGER RNA; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE QUINONE OXIDOREDUCTASE; SULFORAPHANE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG EFFICACY; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RAT; WISTAR RAT;

ANIMALS; ASCORBIC ACID; CELL LINE; CYTOPROTECTION; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INDUCTION; HUMANS; INDOLES; LIVER; MALE; NAD(P)H DEHYDROGENASE (QUINONE); NADPH DEHYDROGENASE; RATS; RATS, WISTAR; RNA, MESSENGER; SIGNAL TRANSDUCTION;

ANIMALIA; BRASSICA; RATTUS; RATTUS NORVEGICUS;

EID: 55449128294     PISSN: 02506807     EISSN: None     Source Type: Journal    
DOI: 10.1159/000170887     Document Type: Article

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