Highly enantioselective titanium-catalyzed cyanation of imines at room temperature

Organic Letters

Volumn 12, Issue 2, 2010, Pages 264-267

  Seayad, Abdul Majeed ^a   Ramalingam, Balamurugan ^a   Yoshinaga, Kazuhiko ^b   Nagata, Takushi ^b   Chai, Christina L L ^a  

^a INSTITUTE OF CHEMICAL AND ENGINEERING SCIENCES   (Singapore)

^b Mitsui Chemicals Asia Pacific Ltd   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

IMINE; NITRILE; ORGANOMETALLIC COMPOUND; TITANIUM;

ARTICLE; CATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; STEREOISOMERISM; SYNTHESIS; TEMPERATURE;

CATALYSIS; IMINES; MOLECULAR STRUCTURE; NITRILES; ORGANOMETALLIC COMPOUNDS; STEREOISOMERISM; TEMPERATURE; TITANIUM;

EID: 74949115001     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol902540h     Document Type: Article

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51. 4. The hydrolysis was confirmed by the formation of n-BuOH with concomitant decrease in the concentration of water as measured by in situ IR. The hydrolysis is generally faster, and a major part of hydrolysis takes place within 15 minutes. Hydrated inorganic salts can also be used for partial hydrolysis.
52. The beneficial effect of alcohols as additives is well known in the literature, and generally i-PrOH is used.
53. See Supporting Information for details.