A new chiral catalyst for the enantioselective Strecker synthesis of α-amino acids

Organic Letters

Volumn 6, Issue 26, 2004, Pages 5027-5029

  Huang, Jinkun ^a   Corey, E J ^a  

^a HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLYL COMPOUND; ALPHA AMINO ACID; AMMONIA; HYDROGEN CYANIDE;

ARTICLE; CATALYST; CHEMICAL REACTION; CHIRALITY; DIHYDROXYLATION; ENANTIOSELECTIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; STRECKER SYNTHESIS;

AMINO ACIDS; CATALYSIS; MOLECULAR STRUCTURE; QUATERNARY AMMONIUM COMPOUNDS; STEREOISOMERISM;

EID: 12344276522     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol047698w     Document Type: Article

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40. Pure N-allylimines were prepared by combining the corresponding aldehyde, magnesium sulfate, and allylamine in benzene at room temperature, removing solvent and distilling in vacuo. The imines were stored at -20°C (freezer) until use.
41. +], 619.3396; found, 619.3386.
42. 3N). Enantiomeric excess was determined by GC or HPLC analysis of the N-trifluoroacetyl α-amino nitriles using a chiral column as described in ref 9.