Increased integrin α5β1 heterodimer formation and reduced c-Jun expression are involved in integrin β1 overexpression-mediated cell growth arrest

Journal of Cellular Biochemistry

Volumn 109, Issue 2, 2010, Pages 383-395

  Fang, Zhengyu ^a,b   Yao, Wantong ^a   Fu, Yi ^a   Wang, Li Ying ^a   Li, Zengxia ^a   Yang, Yong ^a   Shi, Yinghong ^a   Qiu, Shuangjian ^a   Fan, Jia ^a   Zha, Xiliang ^a  

^a FUDAN UNIVERSITY   (China)

^b PEKING UNIVERSITY   (China)

Author keywords

1 integrins; c Jun; Cell cycle arrest; Extracellular matrix (ECM); p21Cip1; Sp1

Indexed keywords

BETA1 INTEGRIN; PROTEIN C JUN; PROTEIN P21; PROTEIN P27; VERY LATE ACTIVATION ANTIGEN 5; ALPHA5 INTEGRIN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYCLIN DEPENDENT KINASE INHIBITOR 1B; TRANSCRIPTION FACTOR SP1;

ARTICLE; CANCER CELL CULTURE; CELL CYCLE ARREST; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; BINDING SITE; BIOSYNTHESIS; CELL PROLIFERATION; GENETICS; METABOLISM; PROTEIN MULTIMERIZATION; TRANSCRIPTION INITIATION; TUMOR CELL LINE; UPREGULATION;

ANTIGENS, CD29; BINDING SITES; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLIN-DEPENDENT KINASE INHIBITOR P27; EXTRACELLULAR MATRIX; HUMANS; INTEGRIN ALPHA5; INTEGRIN ALPHA5BETA1; PROTEIN MULTIMERIZATION; PROTO-ONCOGENE PROTEINS C-JUN; SP1 TRANSCRIPTION FACTOR; TRANSCRIPTIONAL ACTIVATION; UP-REGULATION;

EID: 74949101844     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.22416     Document Type: Article

References (49)

1. Arnaout MA, Goodman SL, Xiong JP. 2002. Coming to grips with integrin binding to ligands. Curr Opin Cell Biol 14:641-651.
2. Berry MG, Goode AW, Puddefoot JR, Vinson GP, Carpenter R. 2003. Integrin beta1-mediated invasion of human breast cancer cells: An ex vivo assay for invasiveness. Breast Cancer 10:214-219.
3. Blystone SD, Graham IL, Lindberg FP, Brown EJ. 1994. Integrin alpha v beta 3 differentially regulates adhesive and phagocytic functions of the fibronectin receptor alpha 5 beta 1. J Cell Biol 127:1129-1137.
4. Blystone SD, Slater SE, Williams MP, Crow MT, Brown EJ. 1999. A molecular mechanism of integrin crosstalk: alphavbeta3 suppression of calcium/ calmodulin-dependent protein kinase II regulates alpha5beta1 function. J Cell Biol 145:889-897.
5. Brakebusch C, Fassler R. 2005. beta 1 integrin function in vivo: Adhesion, migration and more. Cancer Metastasis Rev 24:403-411.
6. Brakebusch C, Hirsch E, Potocnik A, Fassler R. 1997. Genetic analysis of beta1 integrin function: confirmed, new and revised roles for a crucial family of cell adhesion molecules. J Cell Sci 110(Pt 23):2895-2904.
7. Bu X, Le C, Jia F, Guo X, Zhang L, Zhang B, Wu M, Wei L. 2008. Synergistic effect of mTOR inhibitor rapamycin and fluorouracil in inducing apoptosis and cell senescence in hepatocarcinoma cells. Cancer Biol Ther 7:392-396.
8. Cheresh DA, Stupack DG. 2002. Integrin-mediated death: An explanation of the integrin-knockout phenotype? Nat Med 8:193-194.
9. Clark EA, Brugge JS. 1995. Integrins and signal transduction pathways: The road taken. Science 268:233-239.
10. Cordes N. 2006. Integrin-mediated cell-matrix interactions for prosurvival and antiapoptotic signaling after genotoxic injury. Cancer Lett 242:11-19.
11. Diaz-Gonzalez F, Forsyth J, Steiner B, Ginsberg MH. 1996. Trans-dominant inhibition of integrin function. Mol Biol Cell 7:1939-1951.
12. Fang Z, Fu Y, Liang Y, Li Z, Zhang W, Jin J, Yang Y, Zha X. 2007. Increased expression of integrin beta1 subunit enhances p21WAF1/Cip1 transcription through the Sp1 sites and p300-mediated histone acetylation in human hepatocellular carcinoma cells. J Cell Biochem 101:654-664.
13. Fassler R, Rohwedel J, Maltsev V, Bloch W, Lentini S, Guan K, Gullberg D, Hescheler J, Addicks K, Wobus AM. 1996. Differentiation and integrity of cardiac muscle cells are impaired in the absence of beta 1 integrin. J Cell Sci 109(Pt 13):2989-2999.
14. Feltri ML, Graus Porta D, Previtali SC, Nodari A, Migliavacca B, Cassetti A, Littlewood-Evans A, Reichardt LF, Messing A, Quattrini A, Mueller U, Wrabetz L. 2002. Conditional disruption of beta 1 integrin in Schwann cells impedes interactions with axons. J Cell Biol 156:199-209.
15. Frisch SM, Ruoslahti E. 1997. Integrins and anoikis. Curr Opin Cell Biol 9:701-706.
16. Fu Y, Fang Z, Liang Y, Zhu X, Prins P, Li Z, Wang L, Sun L, Jin J, Yang Y, Zha X. 2007. Overexpression of integrin beta1 inhibits proliferation of hepatocellular carcinoma cell SMMC-7721 through preventing Skp2-dependent degradation of p27 via PI3K pathway. J Cell Biochem 102:704-718.
17. Gartel AL, Radhakrishnan SK. 2005. Lost in transcription: p21 repression, mechanisms, and consequences. Cancer Res 65:3980-3985.
18. Grose R, Hutter C, Bloch W, Thorey I, Watt FM, Fassler R, Brakebusch C, Werner S. 2002. A crucial role of beta 1 integrins for keratinocyte migration in vitro and during cutaneous wound repair. Development 129:2303-2315.
19. Gui GP, Wells CA, Yeomans P, Jordan SE, Vinson GP, Carpenter R. 1996. Integrin expression in breast cancer cytology: A novel predictor of axillary metastasis. Eur J Surg Oncol 22:254-258.
20. Hansen MB, Nielsen SE, Berg K. 1989. Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill. J Immunol Methods 119:203-210.
21. Irie A. 2005. Integrin family. Jpn J Clin Med 63(Suppl 8):142-145.
22. Kardassis D, Papakosta P, Pardali K, Moustakas A. 1999. c-Jun transactivates the promoter of the human p21(WAF1/Cip1) gene by acting as a superactivator of the ubiquitous transcription factor Sp1. J Biol Chem 274:29572-29581.
23. Ke JJ, Shao QS, Ling ZQ. 2006. Expression of E-selectin, integrin beta1 and immunoglobulin superfamily member in human gastric carcinoma cells and its clinicopathologic significance. World J Gastroenterol 12:3609-3611.
24. Kim H, Kokkotou E, Na X, Rhee SH, Moyer MP, Pothoulakis C, Lamont JT. 2005. Clostridium difficile toxin A-induced colonocyte apoptosis involves p53-dependent p21(WAF1/CIP1) induction via p38 mitogen-activated protein kinase. Gastroenterology 129:1875-1888.
25. Kobayashi K, Tsukamoto I. 2001. Prolonged Jun N-terminal kinase (JNK) activation and the upregulation of p53 and p21(WAF1/CIP1) preceded apoptosis in hepatocytes after partial hepatectomy and cisplatin. Biochim Biophys Acta 1537:79-88.
26. Kolomeichuk SN, Bene A, Upreti M, Dennis RA, Lyle CS, Rajasekaran M, Chambers TC. 2008. Induction of apoptosis by vinblastine via c-Jun autoamplification and p53-independent down-regulation of p21WAF1/CIP1. Mol Pharmacol 73:128-136.
27. Li Y, Xing G, Wang Q, Li M, Wei H, Fan G, Chen J, Yang X, Wu C, Chen H, He F. 2001. Hepatopoietin acts as an autocrine growth factor in hepatoma cells. DNA Cell Biol 20:791-795.
28. Li Y, Dowbenko D, Lasky LA. 2002. AKT/PKB phosphorylation of p21Cip/ WAF1 enhances protein stability of p21Cip/WAF1 and promotes cell survival. J Biol Chem 277:11352-11361.
29. Liang YL, Lei TW, Wu H, Su JM, Wang LY, Lei QY, Zha XL. 2003. S-phase delay in human hepatocellular carcinoma cells induced by overexpression of integrin beta1. World J Gastroenterol 9:1689-1696.
30. Liang YL, Fu Y, Chen SG, Cai XM, Su JM, Jin JW, Ma DZ, Li ZX, Zhang W, Zha X. 2004. Integrin beta1 subunit overexpressed in the SMMC-7721 cells regulates the promoter activity of p21(CIP1) and enhances its transcription. FEBS Lett 558:107-113.
31. Lin J, Zhu MH, Qu JH, Ni CR, Li FM. 2005. Hepatitis B virus and deletion of its COOH-terminal forty amino acids: Proliferative impact on hepatoma cell line SMMC-7721. Zhonghua Bing Li Xue Za Zhi 34:592-595.
32. Masumoto A, Arao S, Otsuki M. 1999. Role of beta1 integrins in adhesion and invasion of hepatocellular carcinoma cells. Hepatology 29:68-74.
33. Nejjari M, Hafdi Z, Dumortier J, Bringuier AF, Feldmann G, Scoazec JY. 1999. alpha6beta1 integrin expression in hepatocarcinoma cells: Regulation and role in cell adhesion and migration. Int J Cancer 83:518-525.
34. Oshita F, Kameda Y, Hamanaka N, Saito H, Yamada K, Noda K, Mitsuda A. 2004. High expression of integrin beta1 and p53 is a greater poor prognostic factor than clinical stage in small-cell lung cancer. Am J Clin Oncol 27:215-219.
35. Ozaki I, Yamamoto K, Mizuta T, Kajihara S, Fukushima N, Setoguchi Y, Morito F, Sakai T. 1998. Differential expression of laminin receptors in human hepatocellular carcinoma. Gut 43:837-842.
36. Ruoslahti E. 1996. Integrin signaling and matrix assembly. Tumour Biol 17:117-124.
37. Schwartz MA, Ginsberg MH. 2002. Networks and crosstalk: Integrin signalling spreads. Nat Cell Biol 4:E65-E68.
38. Simon KO, Nutt EM, Abraham DG, Rodan GA, Duong LT. 1997. The alphavbeta3 integrin regulates alpha5beta1-mediated cell migration toward fibronectin. J Biol Chem 272:29380-29389.
39. Stupack DG, Puente XS, Boutsaboualoy S, Storgard CM, Cheresh DA. 2001. Apoptosis of adherent cells by recruitment of caspase-8 to unligated integrins. J Cell Biol 155:459-470.
40. Tang CW, Tang LP, Wang CH. 2002. Effects of combination of octreotide and aspirin on proliferation of human hepatocellular carcinoma. Ai Zheng 21:383-387.
41. Torimura T, Ueno T, Kin M, Inuzuka S, Sugawara H, Tamaki S, Tsuji R, Sujaku K, Sata M, Tanikawa K. 1997. Coordinated expression of integrin alpha6beta1 and laminin in hepatocellular carcinoma. Hum Pathol 28:1131-1138.
42. Varner JA, Emerson DA, Juliano RL. 1995. Integrin alpha 5 beta 1 expression negatively regulates cell growth: reversal by attachment to fibronectin. Mol Biol Cell 6:725-740.
43. Volpes R, van den Oord JJ, Desmet VJ. 1993. Integrins as differential cell lineage markers of primary liver tumors. Am J Pathol 142:1483-1492.
44. Walker JL, Assoian RK. 2005. Integrin-dependent signal transduction regulating cyclin D1 expression and G1 phase cell cycle progression. Cancer Metastasis Rev 24:383-393.
45. Walker JL, Fournier AK, Assoian RK. 2005. Regulation of growth factor signaling and cell cycle progression by cell adhesion and adhesion-dependent changes in cellular tension. Cytokine Growth Factor Rev 16:395-405.
46. Wang CH, Tsao YP, Chen HJ, Chen HL, Wang HW, Chen SL. 2000. Transcriptional repression of p21((Waf1/Cip1/Sdi1)) gene by c-jun through Sp1 site. Biochem Biophys Res Commun 270:303-310.
47. Yang JT, Rayburn H, Hynes RO. 1993. Embryonic mesodermal defects in alpha 5 integrin-deficient mice. Development 119:1093-1105.
48. Yao M, Zhou XD, Zha XL, Shi DR, Fu J, He JY, Lu HF, Tang ZY. 1997. Expression of the integrin alpha5 subunit and its mediated cell adhesion in hepatocellular carcinoma. J Cancer Res Clin Oncol 123:435-440.
49. Ye Z, Wang X, Hao S, Zhong J, Xiang J, Yang J. 2006. Oncolytic adenovirus-mediated E1A gene therapy induces tumor-cell apoptosis and reduces tumor angiogenesis leading to inhibition of hepatocellular carcinoma growth in animal model. Cancer Biother Radiopharm 21:225-234.