A comparative study on conformation and ligand binding of the neuronal uncoupling proteins

Biochemistry

Volumn 49, Issue 3, 2010, Pages 512-521

  Ivanova, Marina V ^a   Hoang, Tuan ^a   McSorley, Fern R ^a   Krnac, Gabriela ^a   Smith, Matthew D ^a   Jelokhani Niaraki, Masoud ^a  

^a WILFRID LAURIER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

, INHIBITOR; CD AND FLUORESCENCE SPECTROSCOPY; CENTRAL NERVOUS SYSTEMS; COMPARATIVE STUDIES; FUNCTIONAL PROPERTIES; HELICAL CONFORMATION; LIGAND BINDING; MICROENVIRONMENTS; MOLAR RATIO; NERVOUS SYSTEM; NUCLEOTIDE BINDING; NUCLEOTIDE-BINDING SITES; PHOSPHOLIPID VESICLES; PRIMARY SEQUENCES; PROTEOLIPOSOMES; PROTON TRANSPORT; PURINE NUCLEOTIDES; SMALL UNILAMELLAR VESICLE; SPECTROSCOPIC STUDIES; STRUCTURAL INFORMATION; UNCOUPLING PROTEINS;

BINDING ENERGY; FATTY ACIDS; FLUORESCENCE; FLUORESCENCE SPECTROSCOPY; LIPID BILAYERS; LIPOSOMES; NUCLEOTIDES; PHOSPHOLIPIDS; PROTEINS; SOAPS (DETERGENTS); SPECTROSCOPIC ANALYSIS;

CONFORMATIONS;

COENZYME A; FATTY ACID; GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATE; HEXAHISTIDINE; LIPOSOME; MITOCHONDRIAL PROTEIN; OLEOYLPALMITOYLLECITHIN; PALMITOYLOLEOYLPHOSPHATIDYLGLYCEROL; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLGLYCEROL; PROTEIN INHIBITOR; PURINE NUCLEOTIDE; TRYPTOPHAN; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN; UNCOUPLING PROTEIN 1; UNCOUPLING PROTEIN 2; UNCOUPLING PROTEIN 3; UNCOUPLING PROTEIN 4; UNCOUPLING PROTEIN 5;

AMINO ACID SEQUENCE; ARTICLE; CENTRAL NERVOUS SYSTEM; CIRCULAR DICHROISM; COMPARATIVE STUDY; FLUORESCENCE SPECTROSCOPY; LIGAND BINDING; LIPID BILAYER; NERVE CELL; NONHUMAN; NUCLEOTIDE BINDING SITE; PHOSPHOLIPID VESICLE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN FUNCTION; PROTEIN LIPID INTERACTION; PROTEIN STRUCTURE; PROTEOLIPOSOME; PROTON TRANSPORT; SEQUENCE ANALYSIS; ULTRAVIOLET SPECTROSCOPY;

AMINO ACID SEQUENCE; BINDING SITES; HUMANS; ION CHANNELS; KINETICS; LIGANDS; MEMBRANE TRANSPORT PROTEINS; MITOCHONDRIAL PROTEINS; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; NEURONS; SEQUENCE ALIGNMENT; SPECTROMETRY, FLUORESCENCE;

EID: 74949093836     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi901742g     Document Type: Article

References (34)

1. Echtay, K. S. (2007) Mitochondrial uncoupling proteins - what is their physiological role? Free Radical Biol. Med. 43, 1351-1371.
2. Krauss, S., Zhang, C. Y., and Lowell, B. B. (2005) The mitochondrial uncoupling protein homologues. Nat. Rev. Mol. Cell Biol. 6, 248-261.
3. Fleury, C., Neverova, M., Collins, S., Raimbault, S., Champigny, O., Levi-Meyrueis, C., Bouillaud, F., Selding, M. F., Surwit, R. S., Ricquier, D., and Warden, C. H. (1997) Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia. Nat. Rev. Genet. 15, 269-272.
4. Mao, W., Yu, X. X., Zhong, A., Li, W., Brush, J., Sherwood, S. W., Adams, S. H., and Pan, G. (1999) UCP4, a novel brain-specific mitochondrial protein that reduces membrane potential in mammalian cells. FEBS Lett. 443, 326-330.
5. Sanchis, D., Fleury, C., Chomiki, N., Goubern, M., Huang, Q., Neverova, M., Grégoire, F., Easlick, J., Raimbault, S., Lévi-Meyrueis, C., Miroux, B., Collins, S., Seldin, M., Richard, D., Warden, C., Bouillaud, F., and Ricquier, D. (1998) BMCP1, a novel mitochondrial carrier with high expression in the central nervous system of humans and rodents, and respiration uncoupling activity in recombinant yeast. J. Biol. Chem. 273, 34611-34615.
6. Andrews, Z. B., Diano, S., and Horvath, T. L. (2005) Mitochondrial uncoupling proteins in the CNS: in support of function and survival. Nat. Rev. Neurosci. 6, 829-840.
7. Chan, S. L., Liu, D., Kyriazis, G. A., Bagsiyao, P., Ouyang, X., and Mattson,M. P. (2006) Mitochondrial uncoupling protein-4 regulates calcium homeostasis and sensitivity to store depletion-induced apoptosis in neuronal cells. J. Biol. Chem. 281, 37391-37403.
8. Andrews, Z. B., Liu, Z.-W., Walllingford, N., Erion, D. M., Borok, E., Friedman, J. M., Tschop, M. H., Shanabrough, M., Cline, G., Shulman, G., Coppola, A., Gao, X.-B., Horvath, T. L., and Diano, S. (2008) UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals. Nature 454, 846-851.
9. Conti, B., Sugama, S., Lucero, J., Winsky-Sommerer, R., Wirz, S. A., Maher, P., Andrews, Z., Barr, A. M., Morale, M., Paneda, C., Pemberton, J., Gaidarova, S., Behrens, M. M., Beal, F., Sanna, P. P., Horvath, T. L., and Bartfai, T. (2005) Uncoupling protein 2 protects dopaminergic neurons from acute1,2,3,6-methyl-phenyltetrahydropyridine toxicity. J. Neurochem. 93, 493-501.
10. Echtay, K. S., Winkler, E., Bienengraeber, M., and Klingenberg, M. (2000) Site-directed mutagenesis identifies residues in uncoupling protein (UCP1) involved in three different functions. Biochemistry 39, 3311-3317.
11. Jelokhani-Niaraki, M., Ivanova, M. V., McIntyre, B. L., Newman, C. L., McSorley, F. R., Young, E. K., and Smith,M. D. (2008) A CD study of uncoupling protein-1 and its transmembrane and matrixloop domains. Biochem. J. 411, 593-603.
12. Klingenberg, M., and Huang, S. G. (1999) Structure and function of the uncoupling protein from brown adipose tissue. Biochim. Biophys. Acta 1415, 271-296.
13. Keller, P. A.,Lehr, L.,Giacobino, J.-P.,Charnay, Y., Assimacopoulos- Jeannet, F., and Giovannini, N. (2005) Cloning, ontogenesis, and localization of an atypical uncoupling protein 4 in Xenopus laevis. Physiol. Genomics 22, 339-345.
14. Hanák, P., and Ježek, P. (2001) Mitochondrial uncoupling proteins and phylogenesis - UCP4 as the ancestral uncoupling protein. FEBS Lett. 495, 137-141.
15. Echtay, K. S., Liu, Q., Caskey, T., Winkler, E., Frischmuth, K., Bienengreber, M., and Klingenberg, M. (1999) Regulation of UCP3 by nucleotides is different from regulation of UCP1. FEBS Lett. 450, 8-12.
16. Compton, L. A., and Johnson, W. C. (1986) Analysis of protein circular dichroism spectra for secondary structure using a simple matrix multiplication. Anal. Biochem. 155, 155-167.
17. Johnson, W. C. (1999) Analyzing protein circular dichroism spectra for accurate secondary structures. Proteins: Struct., Funct., Genet. 35, 307-312.
18. Whitmore, L., and Wallace, B. A. (2004) DICHROWEB: an online server for protein secondary structure analyses from circular dichroism spectroscopic data. Nucleic Acids Res. 32, W668-673.
19. Lees, J. G., Miles, A. J., Wien, F., and Wallace, B. A. (2006) A reference database for circular dichroism spectroscopy covering fold and secondary structure space. Bioinformatics 22, 1955-1962.
20. Douette, P., Navet, R., Bouillenne, F., Brans, A., Sluse-Goffart, C., Matagne, A., and Sluse, F. E. (2004) Secondary-structure characterization by far-UV CD of highly purified uncoupling protein 1 expressed in yeast. Biochem. J. 380, 139-145.
21. Rial, E., Muga, A., Valpuesta, J. M., Arrondo, J.-L.R., and Goni, F. M. (1990) Infrared spectroscopic studies of detergent-solubilized uncoupling protein from brown-adipose-tissue mitochondria. Eur. J. Biochem. 188, 83-89.
22. Pebay-Peyroula, E., Dahout-Gonzalez, C., Kahn, R., Trézé guet, V., Lauquin, G.J.-M., and Brandolin, G. (2003) Structure of mitochondrial ADP/ATP carrier in complex with carboxyatractyloside. Nature 426, 39-44.
23. Skulachev, V. P. (1999) Anion carriers in fatty acid-mediated physiological uncoupling. J. Bioenerg. Biomembr. 31, 431-445.
24. O'Neil, M. J. (2006) The Merck Index, 14th ed., Merck & Co., Whitehouse Station, NJ.
25. Mao, D., and Wallace, B. A. (1984) Differential light scattering and absorption flattening optical effects are minimal in the circular dichroism spectra of small unilamellar vesicles. Biochemistry 23, 2667-2673.
26. Klingenberg, M., and Appel, M. (1989) The uncoupling protein dimer can form a disulfide cross-link between the mobile C-terminal SH groups. Eur. J. Biochem. 180, 123-131.
27. Wallace, B. A., Lees, J. G., Orry, A. J. W., Lobley, A., and Janes, R. W. (2003) Analyses of circular dichroism spectra of membrane proteins. Protein Sci. 12, 875-884.
28. Park, K., Perczel, A., and Fasman, G. D. (1992) Differentiation between transmembrane helices and peripheral helices by the deconvolution of circular dichroism spectra of membrane proteins. Protein Sci. 1, 1032-1049.
29. Fasman, G. D., Ed. (1996) Circular dichroism and the conformational analysis of biomolecules, Chapters 2-4, Plenum Press, New York.
30. Fasman, G. D., Ed. (1989) Prediction of protein structure and the principles of protein conformation, Chapters 11 and 18, Plenum Press, New York.
31. Taira, J., Jelokhani-Niaraki, M., Osada, S., Kato, F., and Kodama, H. (2008) Ion-channel formation assisted by electrostatic interhelical interactions in covalently dimerized amphiphilic helical peptides. Biochemistry 47, 3705-3714.
32. Voet, D., and Voet, J.G. (2004) Biochemistry: biomolecules, mechanisms of enzyme action and metabolism, 2nd ed., Vol. 1, Chapters 1, 4, 16, 17, and 22, John Wiley and Sons, New York.
33. Eftink, M. R. (1997) Fluorescence methods for studying equilibrium macromolecule-ligand interactions. Methods Enzymol. 278, 221-257.
34. Chenna, R., Sugawara, H., Koike, T., Lopez, R., Gibson, T. J., Higgins, D. G., and Thompson, J. D. (2003) Multiple sequence alignment with the clustal series of programs. Nucleic Acids Res. 31, 3497-500.