Regulation of the cGMP-cPKG pathway and large-conductance Ca 3+-activated K+ channels in uterine arteries during the ovine ovarian cycle

American Journal of Physiology - Endocrinology and Metabolism

Volumn 298, Issue 2, 2010, Pages

  Khan, Liaqat H ^a   Rosenfeld, Charles R ^a   Liu, Xiao Tie ^a   Magness, Ronald R ^b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

Estrogen; Guanylyl cyclase; Protein kinase G; Uterine blood flow

Indexed keywords

CYCLIC GMP; CYCLIC GMP DEPENDENT PROTEIN KINASE; ESTROGEN; GONADOTROPIN; GUANYLATE CYCLASE; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; PROGESTERONE; PROSTAGLANDIN F2 ALPHA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEVICE REMOVAL; EWE; FEMALE; FOLLICULAR PHASE; GONADOTROPIN BLOOD LEVEL; IMMUNOHISTOCHEMISTRY; LUTEAL PHASE; MECHANICAL PROBE; NONHUMAN; OVARY CYCLE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RADIOIMMUNOASSAY; SHEEP; SIGNAL TRANSDUCTION; SMOOTH MUSCLE; STOICHIOMETRY; UPREGULATION; UTERINE ARTERY; UTERUS BLOOD FLOW; WESTERN BLOTTING;

ANIMALS; CYCLIC GMP; CYCLIC GMP-DEPENDENT PROTEIN KINASES; ESTROUS CYCLE; FEMALE; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; NITRIC OXIDE; OVARIAN FOLLICLE; OVULATION; SECOND MESSENGER SYSTEMS; SHEEP; SIGNAL TRANSDUCTION; STATISTICS, NONPARAMETRIC; UTERINE ARTERY; UTERUS;

EID: 74949087431     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00375.2009     Document Type: Article

References (51)

1. Carnegie JA, Robertson HA. Conjugated and unconjugated estrogens in fetal and maternal fluids of the pregnant ewe: a possible role for estrone sulfate during early pregnancy. Biol Reprod 19: 202-211, 1978.
2. Chang S, Hypolite JA, Velez M, Changolkar A, Wein AJ, Chacko S, DiSanto ME. Downregulation of cGMP-dependent protein kinase-1 activity in the corpus cavernosum smooth muscle of diabetic rabbits. Am J Physiol Regul Integr Comp Physiol 287: R950-R960, 2004.
3. Chen L, Shipston MJ. Cloning of potassium channel splice variants from tissues and cells. Methods Mol Biol 491: 35-60, 2009.
4. Darkow DJ, Lu L, White RE. Estrogen relaxation of coronary artery smooth muscle is mediated by nitric oxide and cGMP. Am J Physiol Heart Circ Physiol 272: H2765-H2773, 1997.
5. Davis MJ, Hill MA. Signaling mechanisms underlying the vascular myogenic response. Physiol Rev 79: 387-423, 1999.
6. Ford SP. Control of uterine and ovarian blood flow throughout the estrous cycle and pregnancy of ewes, sows and cows. J Anim Sci 55, Suppl 2: 32-42, 1982.
7. Ford SP, Christenson RK, Chenault JR. Patterns of blood flow to the uterus and ovaries of ewes during the period of luteal regression. J Anim Sci 49: 1510-1516, 1979.
8. Ghatta S, Nimmagadda D, Xu X, O'Rourke ST. Large-conductance, calcium-activated potassium channels: structural and functional implications. Pharmacol Ther 110: 103-116, 2006.
9. Gibson TC, Phernetton TM, Wiltbank MC, Magness RR. Development and use of an ovarian synchronization model to study the effects of endogenous estrogen and nitric oxide on uterine blood flow during ovarian cycles in sheep. Biol Reprod 70: 1886-1894, 2004.
10. Greiss FC Jr, Anderson SG. Effect of ovarian hormones on the uterine vascular bed. Am J Obstet Gynecol 107: 829-836, 1970.
11. Greiss FC Jr, Anderson SG. Uterine vascular changes during the ovarian cycle. Am J Obstet Gynecol 103: 629-640, 1969.
12. Hansel W, Convey EM. Physiology of the estrous cycle. J Anim Sci 57, Suppl 2: 404-424, 1983.
13. Hartshorne DJ, Hirano K. Interactions of protein phosphatase type 1, with a focus on myosin phosphatase. Mol Cell Biochem 190: 79-84, 1999.
14. 2+ binding and channel opening in large conductance (BK) potassium channels. J Gen Physiol 120: 267-305, 2002.
15. Killam AP, Rosenfeld CR, Battaglia FC, Makowski EL, Meschia G. Effect of estrogens on the uterine blood flow of oophorectomized ewes. Am J Obstet Gynecol 115: 1045-1052, 1973.
16. + channels in vascular smooth muscle cells. J Smooth Muscle Res 44: 65-81, 2008.
17. Ledoux J, Werner ME, Brayden JE, Nelson MT. Calcium-activated potassium channels and the regulation of vascular tone. Physiology (Bethesda) 21: 69-78, 2006.
18. Magness RR, Phernetton TM, Gibson TC, Chen DB. Uterine blood flow responses to ICI 182,780 in ovariectomized oestradiol-17β-treated, intact follicular and pregnant sheep. J Physiol 565: 71-83, 2005.
19. Magness RR, Rosenfeld CR. Local and systemic estradiol-17β: effects on uterine and systemic vasodilation. Am J Physiol Endocrinol Metab 256: E536-E542, 1989.
20. Magness RR, Rosenfeld CR, Carr BR. Protein kinase C in uterine and systemic arteries during ovarian cycle and pregnancy. Am J Physiol Endocrinol Metab 260: E464-E470, 1991.
21. Magness RR, Sullivan JA, Li Y, Phernetton TM, Bird IM. Endothelial vasodilator production by uterine and systemic arteries. VI. Ovarian and pregnancy effects on eNOS and NO(x). Am J Physiol Heart Circ Physiol 280: H1692-H1698, 2001.
22. Markee JE. Rhythmic vascular uterine changes. Am J Physiol 100: 32-29, 1932.
23. + channels in arteries from reproductive tissues. Am J Physiol Heart Circ Physiol 289: H1417-H1427, 2005.
24. Orio P, Rojas P, Ferreira G, Latorre R. New disguises for an old channel: MaxiK channel β-subunits. News Physiol Sci 17: 156-161, 2002.
25. Orstavik S, Natarajan V, Tasken K, Jahnsen T, Sandberg M. Characterization of the human gene encoding the type 1α and type 1β cGMP-dependent protein kinase (PRKG1). Genomics 42: 311-318, 1997.
26. Reynolds LP, Magness RR, Ford SP. Uterine blood flow during early pregnancy in ewes: interaction between the conceptus and the ovary bearing the corpus luteum. J Anim Sci 58: 423-429, 1984.
27. Roman-Ponce H, Caton D, Thatcher WW, Lehrer R. Uterine blood flow in relation to endogenous hormones during estrous cycle and early pregnancy. Am J Physiol Regul Integr Comp Physiol 245: R843-R849, 1983.
28. Rosenfeld CR. The Uterine Circulation. Ithaca, NY: Perinatology, 1989.
29. Rosenfeld CR, Chen C, Roy T, Liu X. Estrogen selectively up-regulates eNOS and nNOS in reproductive arteries by transcriptional mechanisms. J Soc Gynecol Investig 10: 205-215, 2003.
30. 2β-induced rises in uterine blood flow in ovine pregnancy. Am J Physiol Heart Circ Physiol 281: H422-H431, 2001.
31. Rosenfeld CR, Cox BE, Roy T, Magness RR. Nitric oxide contributes to estrogen-induced vasodilation of the ovine uterine circulation. J Clin Invest 98: 2158-2166, 1996.
32. Rosenfeld CR, Killam AP, Battaglia FC, Makowski EL, Meschia G. Effect of estradiol-17β, on the magnitude and distribution of uterine blood flow in nonpregnant, oophorectomized ewes. Pediatr Res 7: 139-148, 1973.
33. + channel expression and cGMP-dependent signaling in uterine vascular smooth muscle. Am J Physiol Heart Circ Physiol 296: H1878-H1887, 2009.
34. Rosenfeld CR, Morriss FH Jr, Battaglia FC, Makowski EL, Meschia G. Effect of estradiol-17β on blood flow to reproductive and nonreproductive tissues in pregnant ewes. Am J Obstet Gynecol 124: 618-629, 1976.
35. Rosenfeld CR, Morriss FH Jr, Makowski EL, Meschia G, Battaglia FC. Circulatory changes in the reproductive tissues of ewes during pregnancy. Gynecol Invest 5: 252-268, 1974.
36. + channels regulate basal uteroplacental blood flow in ovine pregnancy. J Soc Gynecol Investig 12: 402-408, 2005.
37. Rosenfeld CR, White RE, Roy T, Cox BE. Calcium-activated potassium channels and nitric oxide coregulate estrogen-induced vasodilation. Am J Physiol Heart Circ Physiol 279: H319-H328, 2000.
38. + channels contribute to vascular function in nonpregnant human uterine arteries. Reprod Sci 15: 651-660, 2008.
39. Salhab WA, Shaul PW, Cox BE, Rosenfeld CR. Regulation of types I and III NOS in ovine uterine arteries by daily and acute estrogen exposure. Am J Physiol Heart Circ Physiol 278: H2134-H2142, 2000.
40. Salkoff L, Butler A, Ferreira G, Santi C, Wei A. High-conductance potassium channels of the SLO family. Nat Rev Neurosci 7: 921-931, 2006.
41. 2 subunit. J Gen Physiol 130: 117-131, 2007.
42. Somlyo AP, Somlyo AV. Signal transduction and regulation in smooth muscle. Nature 372: 231-236, 1994.
43. Sprague BJ, Phernetton TM, Magness RR, Chesler NC. The effects of ovarian cycle and pregnancy on uterine vascular impedance and uterine artery mechanics. Europ J Obstet Gynecol Reprod Bio 144: S184-S191, 2009.
44. Surks HK. cGMP-dependent protein kinase 1 and smooth muscle relaxation: a tale of two isoforms. Circ Res 101: 1078-1080, 2007.
45. Tamura N, Itoh H, Ogawa Y, Nakagawa O, Harada M, Chun TH, Suga S, Yoshimasa T, Nakao K. cDNA cloning and gene expression of human type 1α cGMP-dependent protein kinase. Hypertension 27: 552-557, 1996.
46. Tang KM, Wang GR, Lu P, Karas RH, Aronovitz M, Heximer SP, Kaltenbronn KM, Blumer KJ, Siderovski DP, Zhu Y, Mendelsohn ME. Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure. Nat Med 9: 1506-1512, 2003.
47. + channels. J Biol Chem 282: 24485-24489, 2007.
48. Vagnoni KE, Shaw CE, Phernetton TM, Meglin BM, Bird IM, Magness RR. Endothelial vasodilator production by uterine and systemic arteries. III. Ovarian and estrogen effects on NO synthase. Am J Physiol Heart Circ Physiol 275: H1845-H1856, 1998.
49. Valverde MA, Rojas P, Amigo J, Cosmelli D, Orio P, Bahamonde MI, Mann GE, Vergara C, Latorre R. Acute activation of Maxi-K channels (hSlo) by estradiol binding to the β subunit. Science 285: 1929-1931, 1999.
50. Van Buren GA, Yang DS, Clark KE. Estrogen-induced uterine vasodilatation is antagonized by L-nitroarginine methyl ester, an inhibitor of nitric oxide synthesis. Am J Obstet Gynecol 167: 828-833, 1992.
51. Ca channels through a cGMP-dependent mechanism. Circ Res 77: 936-942, 1995.