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Volumn 5, Issue 1, 2010, Pages 130-139

Novel imatinib derivatives with altered specificity between Bcr-Abl and FMS, KIT, and PDGF receptors

(12) Skobridis, Konstantinos a Kinigopoulou, Maria a Theodorou, Vassiliki a Giannousi, Emilia a Russell, Alison b Chauhan, Rakhee b Sala, Roberta b Brownlow, Nicola b Kiriakidis, Serafim c Domin, Jan b Tzakos, Andreas G a Dibb, Nick J b

a UNIVERSITY OF IOANNINA (Greece)

b IMPERIAL COLLEGE LONDON (United Kingdom)

c UNIVERSITY OF OXFORD (United Kingdom)

Author keywords

Drug design; Imatinib; Kinase inhibitors; Oncogenes; Synthesis

Indexed keywords

IMATINIB; N [2 METHYL 3 (4 PYRIDIN 2 YLPYRIMIDIN 2 YLAMINO)PHENYL] 3,5 DINITROBENZAMIDE; N [2 METHYL 3 (4 PYRIDIN 3 YLPYRIMIDIN 2 YLAMINO)PHENYL] 3,5 DINITROBENZAMIDE; N [2 METHYL 3 (4 PYRIDIN 4 YLPYRIMIDIN 2 YLAMINO)PHENYL] 3,5 DINITROBENZAMIDE; N [2 METHYL 4 (4 PYRIDIN 3 YLPYRIMIDIN 2 YLAMINO)PHENYL] 3,5 DINITROBENZAMIDE; N [2 METHYL 5 (4 PYRIDIN 2 YLPYRIMIDIN 2 YLAMINO)PHENYL] 3,5 DINITROBENZAMIDE; N [2 METHYL 5 (4 PYRIDIN 3 YLPYRIMIDIN 2 YLAMINO)PHENYL] 2 CHLORO 3 NITROBENZAMIDE; N [2 METHYL 5 (4 PYRIDIN 3 YLPYRIMIDIN 2 YLAMINO)PHENYL] 2 CHLORO 4 NITROBENZAMIDE; N [2 METHYL 5 (4 PYRIDIN 3 YLPYRIMIDIN 2 YLAMINO)PHENYL] 2 CHLORO 5 NITROBENZAMIDE; N [2 METHYL 5 (4 PYRIDIN 3 YLPYRIMIDIN 2 YLAMINO)PHENYL] 2 FLUORO 5 NITROBENZAMIDE; N [2 METHYL 5 (4 PYRIDIN 3 YLPYRIMIDIN 2 YLAMINO)PHENYL] 2 METHYL 3 NITROBENZAMIDE; N [2 METHYL 5 (4 PYRIDIN 3 YLPYRIMIDIN 2 YLAMINO)PHENYL] 2 METHYL 5 NITROBENZAMIDE; N [2 METHYL 5 (4 PYRIDIN 3 YLPYRIMIDIN 2 YLAMINO)PHENYL] 3 NITROBENZAMIDE; N [2 METHYL 5 (4 PYRIDIN 3 YLPYRIMIDIN 2 YLAMINO)PHENYL] 3,5 DINITROBENZAMIDE; N [2 METHYL 5 (4 PYRIDIN 3 YLPYRIMIDIN 2 YLAMINO)PHENYL] 4 CHLORO 3 NITROBENZAMIDE; N [2 METHYL 5 (4 PYRIDIN 3 YLPYRIMIDIN 2 YLAMINO)PHENYL] 4 FLUORO 3 NITROBENZAMIDE; N [2 METHYL 5 (4 PYRIDIN 3 YLPYRIMIDIN 2 YLAMINO)PHENYL] 4 METHYL 3 NITROBENZAMIDE; N [2 METHYL 5 (4 PYRIDIN 3 YLPYRIMIDIN 2 YLAMINO)PHENYL] 4 NITRO 2 TRIFLUOROMETHYLBENZAMIDE; N [2 METHYL 5 (4 PYRIDIN 3 YLPYRIMIDIN 2 YLAMINO)PHENYL] 4 NITRO 3 TRIFLUOROMETHYLBENZAMIDE; N [2 METHYL 5 (4 PYRIDIN 3 YLPYRIMIDIN 2 YLAMINO)PHENYL] 4 NITROBENZAMIDE; N [2 METHYL 5 (4 PYRIDIN 3 YLPYRIMIDIN 2 YLAMINO)PHENYL]BENZAMIDE; N [2 METHYL 5 (4 PYRIDIN 4 YLPYRIMIDIN 2 YLAMINO)PHENYL] 3,5 DINITROBENZAMIDE; N [4 METHYL 3 (4 PYRIDIN 3 YLPYRIMIDIN 2 YLAMINO)PHENYL] 2 CHLORO 3 NITROBENZAMIDE; N [4 METHYL 3 (4 PYRIDIN 3 YLPYRIMIDIN 2 YLAMINO)PHENYL] 2 CHLORO 4 NITROBENZAMIDE; N [4 METHYL 3 (4 PYRIDIN 3 YLPYRIMIDIN 2 YLAMINO)PHENYL] 2 FLOURO 5 NITROBENZAMIDE; N [4 METHYL 3 (4 PYRIDIN 3 YLPYRIMIDIN 2 YLAMINO)PHENYL] 3,5 DINITROBENZAMIDE; N [4 METHYL 3 (4 PYRIDIN 3 YLPYRIMIDIN 2 YLAMINO)PHENYL] 4 CHLORO 3 NITROBENZAMIDE; N [4 METHYL 3 (4 PYRIDIN 3 YLPYRIMIDIN 2 YLAMINO)PHENYL] 4 FLOURO 3 NITROBENZAMIDE; N [4 METHYL 3 (4 PYRIDIN 3 YLPYRIMIDIN 2 YLAMINO)PHENYL] 4 NITRO 2 TRIFLUOROMETHYLBENZAMIDE; N [4 METHYL 3 (4 PYRIDIN 3 YLPYRIMIDIN 2 YLAMINO)PHENYL] 4 NITRO 3 TRIFLUOROMETHYLBENZAMIDE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG INHIBITION; DRUG SOLUBILITY; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

ANIMALS; ANTINEOPLASTIC AGENTS; BINDING SITES; CELL LINE, TUMOR; COMPUTER SIMULATION; DRUG DESIGN; FUSION PROTEINS, BCR-ABL; HUMANS; K562 CELLS; MICE; PHOSPHORYLATION; PIPERAZINES; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-KIT; PYRIMIDINES; RECEPTOR, MACROPHAGE COLONY-STIMULATING FACTOR; RECEPTORS, PLATELET-DERIVED GROWTH FACTOR; SUBSTRATE SPECIFICITY;

EID: 74849135229 PISSN: 18607179 EISSN: 18607187 Source Type: Journal
DOI: 10.1002/cmdc.200900394 Document Type: Article

Times cited : (17)

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