Structure of Trypanosoma brucei glutathione synthetase: Domain and loop alterations in the catalytic cycle of a highly conserved enzyme

Molecular and Biochemical Parasitology

Volumn 170, Issue 2, 2010, Pages 93-99

  Fyfe, Paul K ^a   Alphey, Magnus S ^a   Hunter, William N ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

ATP grasp; Glutathione; Glutathione synthetase; Trypanosoma brucei; Trypanothione; X ray structure

Indexed keywords

DIMER; GLUTATHIONE; GLUTATHIONE SYNTHASE;

ARTICLE; CATALYSIS; CONFORMATIONAL TRANSITION; CONSERVATION BIOLOGY; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME STRUCTURE; LIGAND BINDING; NONHUMAN; ORTHOLOGY; PRIORITY JOURNAL; PROTEIN DOMAIN; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY; STRUCTURAL HOMOLOGY; TRYPANOSOMA BRUCEI;

AMINO ACID SEQUENCE; ANIMALS; CATALYTIC DOMAIN; CONSERVED SEQUENCE; CRYSTALLOGRAPHY, X-RAY; GLUTATHIONE; GLUTATHIONE SYNTHASE; HUMANS; METABOLIC NETWORKS AND PATHWAYS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; PROTOZOAN PROTEINS; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY, AMINO ACID; TRYPANOSOMA BRUCEI BRUCEI;

HOMO SAPIENS; SACCHAROMYCES; TRYPANOSOMA BRUCEI;

EID: 74849132388     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molbiopara.2009.12.011     Document Type: Article

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