An unbiased sensitivity analysis reveals important parameters controlling periodicity of circadian clock

Biotechnology and Bioengineering

Volumn 105, Issue 2, 2010, Pages 250-259

  Xie, Zhi ^a,b   Kulasiri, Don ^a   Samarasinghe, Sandhya ^a   Qian, Jiang ^b  

^a LINCOLN UNIVERSITY   (New Zealand)

^b JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Circadian clock; Genetic regulatory networks; Mathematical model; Parameter estimation; Sensitivity analysis; Systems biology

Indexed keywords

BIOCHEMICAL MODEL; BIOCHEMICAL SYSTEMS; CIRCADIAN CLOCK; COMPUTATIONAL APPROACH; GENETIC REGULATORY NETWORKS; IN-VIVO; KINETIC MODELS; MODEL PARAMETERS; PARAMETRIC SENSITIVITY; RELATIVE IMPORTANCE; SENSITIVITY OF PARAMETERS; UNKNOWN VALUES;

BIOLOGY; CLOCKS; COMPUTER SIMULATION; MATHEMATICAL MODELS; PARAMETER ESTIMATION;

SENSITIVITY ANALYSIS;

ACCURACY; ARTICLE; CIRCADIAN RHYTHM; CONTROLLED STUDY; DROSOPHILA; GENE; MATHEMATICAL MODEL; NONHUMAN; PER GENE; SENSITIVITY ANALYSIS; TIM GENE;

ANIMALS; BIOLOGICAL CLOCKS; CIRCADIAN RHYTHM; DROSOPHILA; GENE REGULATORY NETWORKS; MODELS, BIOLOGICAL; SYSTEMS BIOLOGY;

EID: 74849130143     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.22540     Document Type: Article

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