p53 levels positively correlate with carotid intima-media thickness in patients with subclinical atherosclerosis

Clinical Cardiology

Volumn 32, Issue 12, 2009, Pages 705-710

  Chen, Wenqiang ^a   Wang, Fen ^b   Li, Zongxin ^a   Huang, Xiaobo ^a   Wang, Ningqun ^a   Dong, Zhizhi ^a   Sun, Ping ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b Oriental Hospital   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; INTERCELLULAR ADHESION MOLECULE 1; PROTEIN P53; VASCULAR CELL ADHESION MOLECULE 1;

ADULT; ARTERIAL WALL THICKNESS; ARTICLE; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; B SCAN; CARDIOVASCULAR RISK; CAROTID ARTERY; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTIPLE REGRESSION; PROTEIN EXPRESSION; RISK FACTOR;

AGE FACTORS; BIOLOGICAL MARKERS; CAROTID ARTERIES; CASE-CONTROL STUDIES; CORONARY ARTERY DISEASE; E-SELECTIN; FEMALE; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; MALE; MIDDLE AGED; RISK FACTORS; SEVERITY OF ILLNESS INDEX; TUMOR SUPPRESSOR PROTEIN P53; TUNICA INTIMA; TUNICA MEDIA; VASCULAR CELL ADHESION MOLECULE-1;

EID: 74849117681     PISSN: 01609289     EISSN: 19328737     Source Type: Journal    
DOI: 10.1002/clc.20639     Document Type: Article

References (40)

1. O'Leary DH, Polak JF, Kronmal RA, et al. Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular Health Study Collaborative Research Group. N Engl J Med. 1999;340:14-22.
2. Minamino T, Miyauchi H, Yoshida T, et al. Endothelial cell senescence in human atherosclerosis role of telomere in endothelial dysfunction. Circulation. 2002;105:1541-1544.
3. Brandes RP, Fleming I, Busse R. Endothelial aging. Cardiovasc Res. 2005;66:286-294.
4. Fenton M, Barker S, Kurz DJ, et al. Cellular senescence after single and repeated balloon catheter denudations of rabbit carotid arteries. Arterioscler Thromb Vasc Biol. 2001;21:220-226.
5. Liao S, Curci JA, Kelley BJ, et al. Accelerated replicative senescence of medial smooth muscle cells derived from abdominal aortic aneurysms compared to the adjacent inferior mesenteric artery. J Surg Res. 2000;92:85-95.
6. Sherr CJ, DePinho RA. Cellular senescence: mitotic clock or culture shock? Cell. 2000;102:407-410.
7. Satyanarayana A,Wiemann SU, Buer J, et al. Telomere shortening impairs organ regeneration by inhibiting cell cycle re-entry of a subpopulation of cells. EMBO J. 2003;22:4003-4013.
8. Donehower LA. Does p53 affect organismal aging? J Cell Physiol. 2002;192:23-33.
9. Lavezzi AM, Milei J, Grana DR, et al. Expression of c-fos, p53 and PCNA in the unstable atherosclerotic carotid plaque. Int J Cardiol. 2003;92:59-63.
10. Aoki M, Morishita R, Matsushita H, et al. Inhibition of the p53 tumor suppressor gene results in growth of human aortic vascular smooth muscle cells. Potential role of p53 in regulation of vascular smooth muscle cell growth. Hypertension. 1999;34: 192-200.
11. Mancini GB, Dahlöf B, Díez J. Surrogate markers for cardiovascular disease: structural markers. Circulation. 2004;109:IV22-30.
12. Martinet W, Knaapen MW, De Meyer GR, et al. Elevated levels of oxidative DNA damage and DNA repair enzymes in human atherosclerotic plaques. Circulation. 2002;106:927-932.
13. Ihling C, Haendeler J, Menzel G, et al. Co-expression of p53 and MDM2 in human atherosclerosis: implications for the regulation of cellularity of atherosclerotic lesions. J Pathol. 1998;185: 303-312.
14. Saito H, Papaconstantinou J. Age-associated differences in cardiovascular inflammatory gene induction during endotoxic stress. J BiolChem. 2001;276:29307-29312.
15. European Society of Hypertension-European Society of Cardiology Guidelines Committee. 2003 European Society of Hypertension-European Society of Cardiology Guidelines for the Management of Arterial Hypertension. J Hypertens. 2003;21: 1011-1053.
16. Stenger JE, Mayr GA, Mann K, et al. Formation of stable p53 homotetramers and multiples of tetramers. Mol Carcinog. 1992;52:102-106.
17. Geng YJ. Biologic effect and molecular regulation of vascular apoptosis in atherosclerosis. Curr Atheroscler Rep. 2001;3:234-242.
18. Saam T, Yuan C, Chu B, et al. Predictors of carotid atherosclerotic plaque progression as measured by noninvasive magnetic resonance imaging. Atherosclerosis. 2007;194:e34-42.
19. Lutgens E, de Muinck ED, Kitslaar PJ, et al. Biphasic pattern of cell turnover characterizes the progression from fatty streaks to ruptured human atherosclerotic plaques. Cardiovasc Res. 1999;41:473-479.
20. van Vlijmen BJ, Gerritsen G, Franken AL, et al. Macrophage p53 deficiency leads to enhanced atherosclerosis in APOE* 3-Leiden transgenic mice. Circ Res. 2001;88:780-786.
21. Mercer J, Mahmoudi M, Bennett M. DNA damage, p53, apoptosis and vascular disease. Mutat Res. 2007;621:75-86.
22. Tabas I. p53 and atherosclerosis. Circ Res. 2001;88:747-749.
23. Sanz-González SM, Barquín L, García-Cao I, et al. Increased p53 gene dosage reduces neointimal thickening induced by mechanical injury but has no effect on native atherosclerosis. Cardiovasc Res. 2007;75:803-812.
24. Ihling C, Haendeler J, Menzel G, et al. Co-expression of p53 and MDM2 in human atherosclerosis: implications for the regulation of cellularity of atherosclerotic lesions. J Pathol. 1998;185: 303-312.
25. Scheinman M, Ascher E, Levi GS, et al. p53 gene transfer to the injured rat carotid artery decreases neointimal formation. J Vasc Surg. 1999;29:360-369.
26. George SJ, Angelini GD, Capogrossi MC, et al. Wild-type p53 gene transfer inhibits neointima formation in human saphenous vein by modulation of smooth muscle cell migration and induction of apoptosis. Gene Ther. 2001;8:668-676.
27. Matsushita H, Morishita R, Aoki M, et al. Transfection of antisense p53 tumor suppressor gene oligodeoxynucleotides into rat carotid artery results in abnormal growth of vascular smooth muscle cells. Circulation. 2000;101:1447-1452.
28. Ihling C, Menzel G, Wellens E, et al. Topographical association between the cyclin-dependent kinases inhibitor P21, p53 accumulation, and cellular proliferation in human atherosclerotic tissue. Arterioscler Thromb Vasc Biol. 1997;17:2218-2224.
29. Kinscherf R, Claus R, Wagner M, et al. Apoptosis caused by oxidized LDL is manganese superoxide dismutase and p53 dependent. FASEB J. 1998;12:461-467.
30. Lewis JM, Truong TN, Schwartz MA. Integrins regulate the apoptotic response to DNA damage through modulation of p53. Proc Natl Acad Sci USA. 2002;99:3627-3632.
31. Gorgoulis VG, Zacharatos P, Kotsinas A, et al. p53 activates ICAM-1 (CD54) expression in an NF-kappaB-independent manner. EMBO J. 2003;22:1567-1578.
32. Huo Y, Ley K. Adhesion molecules and atherogenesis. Acta Physiol Scand. 2001;173:35-43.
33. Tzoulaki I, Murray GD, Lee AJ, et al. C-reactive protein, interleukin-6, and soluble adhesion molecules as predictors of progressive peripheral atherosclerosis in the General Population Edinburgh Artery Study. Circulation. 2005;112:976-983.
34. Zhou X, Perez F, Han K, et al. Clonal senescence alters endothelial ICAM-1 function. Mech Ageing Dev. 2006;127:779-785.
35. Mercer J, Mahmoudi M, Bennett M. DNA damage, p53, apoptosis and vascular disease. Mutat Res. 2007;621:75-86.
36. Yuan Y, Verna LK, Wang NP, et al. Cholesterol enrichment upregulates intercellular adhesion molecule-1 in human vascular endothelial cells. Biochim Biophys Acta. 2001;1534:139-148.
37. Gorgoulis VG, Pratsinis H, Zacharatos P, et al. p53-dependent ICAM-1 overexpression in senescent human cells identified in atherosclerotic lesions. Lab Invest. 2005;85:502-511.
38. Tanaka Y, Nomi M, Fujii K, et al. Intercellular adhesion molecule 1 underlies the functional heterogeneity of synovial cells in patients with rheumatoid arthritis: involvement of cell cycle machinery. Arthritis Rheum. 2000;43:2513-2522.
39. Aupperle KR, Boyle DL, Hendrix M, et al. Regulation of synoviocyte proliferation, apoptosis, and invasion by the p53 tumor suppressor gene. Am J Pathol. 1998;152:1091-1098.
40. Vaishnaw AK, McNally JD, Elkon KB. Apoptosis in the rheumatic diseases. Arthritis Rheum. 1997;40:1917-1927.