Gene expression modulation of rat liver cholesterol metabolism by oleoyl-estrone

Obesity Research and Clinical Practice

Volumn 4, Issue 1, 2010, Pages

  Romero, Maria del Mar ^a,b   Esteve, Montserrat ^a,b   Alemany, Marià ^a,b   Fernández López, José Antonio ^a,b  

^a UNIVERSITY OF BARCELONA   (Spain)

^b Instituto de Salud Carlos III   (Spain)

Author keywords

ABC transporter A1; Cholesterol 7 hydroxylase; LDL receptor; Liver cholesterol metabolism; Oleoyl estrone

Indexed keywords

ABC TRANSPORTER A1; APOLIPOPROTEIN A1; APOLIPOPROTEIN E; BILE ACID; CHOLESTEROL; CHOLESTEROL 7ALPHA MONOOXYGENASE; ESTRONE DERIVATIVE; ESTRONE OLEATE; HYDROXYMETHYLGLUTARYL COENZYME A SYNTHASE; LIVER X RECEPTOR; LOW DENSITY LIPOPROTEIN RECEPTOR; MEVALONIC ACID; RNA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE ACID SYNTHESIS; CHOLESTEROL METABOLISM; CONTROLLED STUDY; DRUG MECHANISM; DRUG RESPONSE; GENE EXPRESSION REGULATION; LIPID OXIDATION; LIVER METABOLISM; MALE; NONHUMAN; OBESITY; PRIORITY JOURNAL; RAT;

RATTUS;

EID: 74849108810     PISSN: 1871403X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.orcp.2009.09.001     Document Type: Article

References (35)

1. Sanchis D., Balada F., Grasa M.M., Virgili J., Peinado J., Monserrat C., et al. Oleoyl-estrone induces the loss of body fat in rats. Int J Obes 20 (1996) 588-594
2. Virgili J., Casals I., Peinado-Onsurbe J., Esteve M., Julve J., Fernández-López J.A., et al. Distribution of oleoyl-estrone in rat plasma lipoproteins. Horm Metab Res 31 (1999) 597-601
3. Sanchis D., Balada F., Picó C., Grasa M.M., Virgili J., Farrerons C., et al. Rats receiving the slimming agent oleoyl-estrone in liposomes Merlin-2; decrease food intake but maintain thermogenesis. Arch Physiol Biochem 105 (1997) 663-672
4. Grasa M.M., Cabot C., Esteve M., Yubero P., Masanés R.M., Blay M., et al. Daily oral oleoyl-estrone gavage induces a dose-dependent loss of fat in Wistar rats. Obes Res 9 (2001) 202-209
5. Remesar X., Guijarro P., Torregrosa C., Grasa M.M., López J., Fernández-López J.A., et al. Oral oleoyl-estrone induces the rapid loss of body fat in Zucker lean rats fed a hyperlipidic diet. Int J Obes 24 (2000) 1405-1412
6. Remesar X., Fernández-López J.A., Blay M.T., Savall P., Salas A., Díaz-Silva M., et al. Effect of oral oleoyl-estrone on adipose tissue composition in male rats. Int J Obes 26 (2002) 1092-1102
7. Salas A., Remesar X., and Esteve M. Oleoyl-estrone treatment activates apoptotic mechanisms in white adipose tissue. Life Sci 80 (2007) 293-298
8. Blay M., Peinado-Onsurbe J., Grasa M.M., Díaz-Silva M., Fernández-López J.A., Remesar X., et al. Effect of oral oleoyl-estrone treatment on plasma lipoproteins and tissue lipase and lipase activities of Zucker lean and obese female rats. Int J Obes 26 (2002) 618-626
9. Salas A., Esteve M., Grasa M.M., and Remesar X. Rats treated with oleoyl-oestrone maintain glucidic homeostasis: comparisons with a pair-fed model. Br J Nutr 94 (2005) 738-745
10. Felber J.P., and Golay A. Regulation of nutrient metabolism and energy expenditure. Metabolism 44 Suppl. 2 (1995) 4-9
11. Federspil G., de Palo C.B., Zago E., Zaccaria M., and Scandellari C. Spontaneous fasting hypoglycemia: basal levels of plasma free fatty acids and glycerol, blood ketone bodies, serum cholesterol and plasma growth hormone. Diab Métab 4 (1978) 35-38
12. Westerterp K. How rats economize-energy loss in starvation. Physiol Zool 50 (1977) 331-362
13. Ma S.W.Y., and Foster DO. Starvation-induced changes in metabolic-rate, blood-flow, and regional energy-expenditure in rats. Can J Physiol Pharmacol 64 (1986) 1252-1258
14. Matamala J.C., Gianotti N., Pericás J., Quevedo S., Roca P., and Palou A. Changes induced by fasting and dietetic obesity in thermogenic parameters of rat brown adipose tissue mitochondrial subpopulations. Biochem J 319 (1996) 529-534
15. Cabot C., Salas A., Ferrer-Lorente R., Savall P., Remesar X., Fernández-López J.A., et al. Short-term oral oleoyl-estrone treatment increases plasma cholesterol turnover in the rat. Int J Obes 29 (2005) 534-539
16. Kawashiri M.A., Maugeais C., and Rader D.J. High-density lipoprotein metabolism: molecular targets for new therapies for atherosclerosis. Curr Atheroscler Rep 2 (2000) 363-372
17. Vlahcevic Z.R., Heuman D.M., and Hylemon PB. Regulation of bile acid synthesis. Hepatology 13 (1991) 590-600
18. Stroes E. Statins and LDL-cholesterol lowering: an overview. Curr Med Res Opin 21 Suppl. 6 (2005) S9-16
19. Romero M.M., Esteve M., and Alemany M. Combined effects of oral oleoyl-estrone and limited food intake on body composition of young overweight male rats. Int J Obes 30 (2006) 1149-1156
20. Folch J., Lees M., and Sloane-Stanley GH. A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 226 (1957) 497-509
21. Romero M.M., Grasa M.M., Esteve M., Fernández-López J.A., and Alemany M. Semiquantitative RT-PCR measurement of gene expression in rat tissues including a correction for varying cell size and number. Nutr Metab 4 (2007) 26
22. Romero MM, Fernández-López JA, Esteve M, Alemany. Gene expression modulation of liver energy metabolism by oleoyl-estrone in overweight rats. Biosci Rep 2009; doi:101042/BSR20080182.
23. Soutar A.K., Harders-Spengel K., Wade D.P., and Knight BL. Detection and quantitation of low density lipoprotein (LDL) receptors in human liver by ligand blotting, immunoblotting, and radioimmunoassay. LDL receptor protein content is correlated with plasma LDL cholesterol concentration. J Biol Chem 261 (1986) 17127-17133
24. Yang T., Espenshade P.J., Wright M.E., Yabe D., Gong Y., Aebersold R., et al. Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER. Cell 110 (2000) 489-500
25. Horton J.D., Goldstein J.L., and Brown MS. SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J Clin Invest 109 (2002) 1125-1131
26. Cabot C., Grasa M.M., Masanés R.M., Matteis R., Cinti S., Fernández-López J.A., et al. Oleoyl-estrone does not have direct estrogenic effects on rats. Life Sci 69 (2001) 749-761
27. di Croce L., Bruscalupi G., and Trentalance A. Independent behavior of rat liver LDL receptor and HMGCoA reductase under estrogen treatment. Biochem Biophys Res Commun 224 (1996) 345-350
28. Li Y.C., Wang D.P., and Chiang J.Y. Regulation of cholesterol 7 alpha-hydroxylase in the liver. Cloning, sequencing, and regulation of cholesterol 7 alpha-hydroxylase mRNA. J Biol Chem 265 (1990) 12012-12019
29. Pikuleva I.A. Cytochrome P450s and cholesterol homeostasis. Pharmacol Ther 112 (2006) 761-773
30. Pandak W.M., Vlahcevic Z.R., Heuman D.M., Redford K.S., Chiang J.Y., and Hylemon P.B. Effects of different bile salts on steady-state mRNA levels and transcriptional activity of cholesterol 7 alpha-hydroxylase. Hepatology 19 (1994) 941-947
31. Cheema S.K., Cikaluk D., and Agellon L.B. Dietary fats modulate the regulatory potential of dietary cholesterol on cholesterol 7 alpha-hydroxylase gene expression. J Lipid Res 38 (1997) 315-323
32. Repa J.J., Turley S.D., Lobaccaro J.A., Medina J., Li L., Lustig K., et al. Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers. Science 289 (2000) 1524-1529
33. Lehmann J.M., Kliewer S.A., Moore L.B., Smith-Oliver T.A., Oliver B.B., Su J.L., et al. Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway. J Biol Chem 272 (1997) 3137-3140
34. Chiang J.Y., Kimmel R., and Stroup D. Regulation of cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription by the liver orphan receptor (LXRalpha). Gene 262 (2001) 257-265
35. Crestani M., de Fabiani E., Caruso D., Mitro N., Gilardi F., Vigil Chacon A.B., et al. LXR (liver X receptor) and HNF-4 (hepatocyte nuclear factor-4): key regulators in reverse cholesterol transport. Biochem Soc Trans 32 (2004) 92-96