Preparation and in vitro evaluation of indomethacin loaded solid lipid microparticles

Acta Pharmaceutica Sciencia

Volumn 51, Issue 3, 2009, Pages 203-210

  Erdal, M Sedef ^a   Güngör, Sevgi ^a   Özsoy, Yildiz ^a   Araman, Ahmet ^a  

^a ISTANBUL UNIVERSITY   (Turkey)

Author keywords

Glyceryl behenate; Labrasol ; Lipid microparticles; Sucrose ester; Tween 80

Indexed keywords

DRUG CARRIER; GLYCEROL BEHENATE; INDOMETACIN; LABRASOL; POLYSORBATE 80; SOLID LIPID NANOPARTICLE; SUCROSE ESTER DERIVATIVE; SURFACTANT;

ARTICLE; CRYSTAL STRUCTURE; DISPERSION; DRUG FORMULATION; DRUG RELEASE; DRUG SOLUBILITY; EVALUATION; FREEZE DRYING; HEATING; IN VITRO STUDY; INFRARED SPECTROSCOPY; PARTICLE SIZE; REFLECTOMETRY; SCANNING ELECTRON MICROSCOPE; SURFACE PROPERTY;

EID: 74749103323     PISSN: 13072080     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Ayala-Bravo H.A., Quintanar-Guerrero, D., Naik, A. and Kalia, Y.N., Cornejo-Bravo, J.M., Ganem-Quintanar, A. (2003). Effects of sucrose oleate and sucrose laureate on in vivo human stratum corneum permeability. Pharm. Res. 20: 1267-1273.
2. Bahl, D. and Bogner, R.H. (2006).Amorphization of indomethacin by co-grinding with neusilin US2: Amorphization kinetics, physical stability and mechanism. Pharm. Res. 23: 2317-2325.
3. Becirevic-Lacan M. (1994). Inclusion complexation of indomethacin with cyclodextrins in solution and in the solid state. STP Pharm. Sci. 4: 282-286
4. Biswanath S.A. and Mondal U.K. (1998).Evaluation of indomethacin loaded polymethylmethacrylate microparticles. Pharm. Pharmacol. Commun. 4: 515-519.
5. Bolzinger M.A., Carduner T.C. and Poelman M.C. (1998).Bicontinuous sucrose ester microemulsion: A new vehicle for topical delivery of niflumic acid. Int. J. Pharm. 176: 39-45.
6. Castelli F., Puglia C., Sarpietro M.G., Rizza L. and Bonina F. (2005).Characterization of indomethacin loaded lipid nanoparticles by differential scanning calorimetry. Int. J. Pharm. 304: 231-238.
7. Chauhan B., Shimpi S. and Paradkar A. (2005).Preparation and characterization of etoricoxib solid dispersions using lipid carriers by spray drying technique. AAPS Pharm.Sci.Tech. 6: 405-412.
8. Freitas C., Müller R.H. (1998).Spray-drying of solid lipid nanoparticles (SLN™). Eur. J. Pharm. Biopharm. 46: 145-151.
9. Higuchi, T. (1963). Mechanisms of sustained-action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices. J. Pharm. Sci. 52: 1145-1149.
10. Huang, J., Wigent, R.J., Bentzley, C.M. and Schwartz J.B. (2006). Nifedipine solid dispersion in microparticles of ammonio methacrylate copolymer and ethylcellulose binary blend for controlled drug delivery. Effect of drug loading on release kinetics. Int. J. Pharm. 319: 44-54.
11. Jannin V., Musakhanian J. and Marchaud D. (2008). Approaches for the development of solid and semi solid lipid based formulations. Adv. Drug. Del. Rew. 60: 734-746.
12. Jaspart S., Bertholet P., Piel G., Dogne J.M., Delattre L. and Evrard B. (2007). Solid lipid microparticles as a sustained release system for pulmonary drug delivery. Eur. J. Pharm. Biopharm. 65: 47-56.
13. Jenning V., Schaefer-Korting M. and Gohla S. (2000). Vitamin A loaded solid lipid nanoparticles for topical use: drug release properties. J. Cont. Rel. 66: 115-126.
14. Kalava B.S., Demirel M., Yazan Y. (2005). Physicochemical characterization and dissolution properties of cinnarizine solid dispersions. T. J. Pharm. Sci. 2: 51-62.
15. Matthew, O., McCauley, J. and Cohen, E. (1984). Analytical Profiles of Drug Substances. 13: 211-238.
16. Mühlen A., Schwarz, C. and Mehnert W. (1998). Solid lipid nanoparticles for controlled delivery, drug release and release mechanism. Eur. J. Pharm. Biopharm. 45: 149-155.
17. Qi S., Gryczke A., Belton P. and Craig D.Q.M. (2008). Characterization of solid dispersions of paracetamol and Eudragit E prepared by hot melt extrusion using thermal, microthermal and spectroscopic analysis. Int. J. Pharm. 354: 158-167.
18. Reithmeyer H., Herrmann J., Göpferich A. (2001). Development and characterization of lipid microparticles as a drug carrier for somatostatin. Int. J. Pharm. 218:133-143.
19. Sanna V., Kirschwink N., Gustin P., Gavini E., Roland I., Delattre L. and Evrard B. (2003). Preparation and in vivo toxicity study of solid lipid microparticles as carrier for pulmonary administration. AAPS Pharm. Sci. 5: 1-7.
20. Soultani S., Ognier S., Engasser J.M. and Ghoul M. (2003). Comparative study of some surface active properties of fructose esters and commercial sucrose esters. Coll Surfaces A: Physicochem. Eng. Aspects 227: 35-44.
21. Sweetman, S.C. (2005), Martindale, The Extra Pharmacopoeia, 34rd Ed., The Pharmaceutical Press, London, p.47.
22. Thevenin M.A., Grossiord J.L. and Poelman M.C. (1996). Sucrose esters/cosurfactant microemulsion systems for transdermal delivery: assessment of bicontinuous structures. Int. J. Pharm. 137: 177-186.
23. Tursilli R., Piel G., Delattre L. and Scalia S. (2007). Solid lipid microparticles containing the sunscreen agent, octyl-dimethylminobenzoate: Effect of the vehicle. Eur. J. Pharm Biopharm. 66: 483-487.
24. Ullrich, S., Metz, H. and Maeder K. (2008). Sucrose ester nanodispersions: Microviscosity and viscoelastic properties. Eur. J. Pharm. Biopharm. 70: 550-555.
25. Vasconcelos T., Sarmento B. and Costa P. (2007). Solid dispersions as strategy to improve oral bioavailability of poor water soluble drugs. Drug Discovery Today 12: 1068-1075.
26. Youan B.C., Hussain A. and Nguyen N.T. (2003). Evaluation of sucrose esters as alternative surfactants in microencapsulation of proteins by the solvent evaporation method. AAPS Pharm. Sci. 5: 1-9.
27. Zajc N., Obreza A., Bele M. and Srcic, S. (2005). Physical properties and dissolution behaviour of nifedipine/ mannitol solid dispersions prepared by hot melt method. Int. J. Pharm. 291: 51-58.