The molecular basis of longevity, and clinical implications

Maturitas

Volumn 65, Issue 2, 2010, Pages 87-91

  Marques, Francine Z ^a   Markus, M Andrea ^a   Morris, Brian J ^a  

^a Bosch Institute   (Australia)

Author keywords

DNA damage; Enalapril; Genome stability; Mitochondria; Reactive oxygen species; Sirtuins; Telomerase

Indexed keywords

DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; INSULIN; MICRORNA; RAPAMYCIN; RESVERATROL; SIRTUIN; SOMATOMEDIN C; SPERMIDINE;

AGING; CALORIC RESTRICTION; GENE; LIFESPAN; LONGEVITY; MAMMAL; NONHUMAN; REVIEW;

AGING; ANIMALS; BIOLOGICAL MARKERS; GENE EXPRESSION REGULATION; LONGEVITY; SIGNAL TRANSDUCTION; STEM CELLS; TELOMERE;

ANIMALIA; MAMMALIA;

EID: 74749091222     PISSN: 03785122     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.maturitas.2009.12.008     Document Type: Review

References (49)

1. Ljubuncic P., and Reznick A.Z. The evolutionary theories of aging revisited-a mini-review. Gerontology 55 (2009) 205-216
2. Russell S.J., and Kahn C.R. Endocrine regulation of ageing. Nat Rev Mol Cell Biol 8 (2007) 681-691
3. Hoeijmakers J.H. DNA damage, aging, and cancer. N Engl J Med 361 (2009) 1475-1485
4. Garinis G.A., Uittenboogaard L.M., Stachelscheid H., et al. Persistent transcription-blocking DNA lesions trigger somatic growth attenuation associated with longevity. Nat Cell Biol 11 (2009) 604-615
5. Finkel T., Serrano M., and Blasco M.A. The common biology of cancer and ageing. Nature 448 (2007) 767-774
6. Morris B. A forkhead in the road to longevity: the molecular basis of lifespan becomes clearer. J Hypertens 23 (2005) 1285-1309
7. Hedrick S.M. The cunning little vixen: FoxO and the cycle of life and death. Nat Immunol 10 (2009) 1057-1063
8. Finkel T., Deng C.X., and Mostoslavsky R. Recent progress in the biology and physiology of sirtuins. Nature 460 (2009) 587-591
9. Renault V.M., Rafalski V.A., Morgan A.A., et al. FoxO3 regulates neural stem cell homeostasis. Cell Stem Cell 5 (2009) 527-539
10. Westerheide S.D., Anckar J., Stevens Jr. S.M., Sistonen L., and Morimoto R.I. Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1. Science 323 (2009) 1063-1066
11. Imai SI. "Clocks" in the NAD world: NAD as a metabolic oscillator for the regulation of metabolism and aging. Biochim Biophys Acta 2009. doi:10.1016/j.bbapap.2009.10.024.
12. Schonbrun M., Laor D., Lopez-Maury L., Bahler J., Kupiec M., and Weisman R. Tor complex 2 controls gene silencing, telomere length maintenance, and survival under DNA-damaging conditions. Mol Cell Biol 29 (2009) 4584-4594
13. Murga M., Bunting S., Montana M.F., et al. A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging. Nat Genet 41 (2009) 891-898
14. Benigni A., Corna D., Zoja C., et al. Disruption of the Ang II type 1 receptor promotes longevity in mice. J Clin Invest 119 (2009) 524-530
15. de Magalhaes J.P., Budovsky A., Lehmann G., et al. The human ageing genomic resources: online databases and tools for biogerontologists. Aging Cell 8 (2009) 65-72
16. Ladiges W., Van Remmen H., Strong R., et al. Lifespan extension in genetically modified mice. Aging Cell 8 (2009) 346-352
17. de Magalhaes J.P., Curado J., and Church G.M. Meta-analysis of age-related gene expression profiles identifies common signatures of aging. Bioinformatics 25 (2009) 875-881
18. Zahn J.M., Poosala S., Owen A.B., et al. AGEMAP: a gene expression database for aging in mice. PLoS Genet 3 (2007) e201
19. Calvanese V., Lara E., Kahn A., and Fraga M.F. The role of epigenetics in aging and age-related diseases. Ageing Res Rev 8 (2009) 268-276
20. Liang R., Bates D.J., and Wang E. Epigenetic control of microRNA expression and aging. Curr Genomics 10 (2009) 184-193
21. Menghini R., Casagrande V., Cardellini M., et al. MicroRNA 217 modulates endothelial cell senescence via silent information regulator 1. Circulation 120 (2009) 1524-1532
22. Ibanez-Ventoso C., and Driscoll M. MicroRNAs in C. elegans aging: molecular insurance for robustness?. Curr Genomics 10 (2009) 144-153
23. Sinclair D.A., and Oberdoerffer P. The ageing epigenome: damaged beyond repair?. Ageing Res Rev 8 (2009) 189-198
24. Wagner W., Bork S., Horn P., et al. Aging and replicative senescence have related effects on human stem and progenitor cells. PLoS One 4 (2009) e5846
25. Lorbeck MT, Singh N, Zervos A, et al. The histone demethylase Dmel\Kdm4A controls genes required for life span and male-specific sex determination in Drosophila. Gene 2009. doi:10.1016/j.gene.2009.09.007.
26. Khrapko K., and Vijg J. Mitochondrial DNA mutations and aging: devils in the details?. Trends Genet 25 (2009) 91-98
27. Addabbo F., Montagnani M., and Goligorsky M.S. Mitochondria and reactive oxygen species. Hypertension 53 (2009) 885-892
28. Perez V.I., Van Remmen H., Bokov A., Epstein C.J., Vijg J., and Richardson A. The overexpression of major antioxidant enzymes does not extend the lifespan of mice. Aging Cell 8 (2009) 73-75
29. Artal-Sanz M., and Tavernarakis N. Prohibitin couples diapause signalling to mitochondrial metabolism during ageing in C. elegans. Nature 461 (2009) 793-797
30. von Figura G., Hartmann D., Song Z., and Rudolph K.L. Role of telomere dysfunction in aging and its detection by biomarkers. J Mol Med 87 (2009) 1165-1171
31. Tomas-Loba A., Flores I., Fernandez-Marcos P.J., et al. Telomerase reverse transcriptase delays aging in cancer-resistant mice. Cell 135 (2008) 609-622
32. Jiang H., Schiffer E., Song Z., et al. Proteins induced by telomere dysfunction and DNA damage represent biomarkers of human aging and disease. Proc Natl Acad Sci USA 105 (2008) 11299-11304
33. Njajou O.T., Hsueh W.C., Blackburn E.H., et al. Association between telomere length, specific causes of death, and years of healthy life in health, aging, and body composition, a population-based cohort study. J Gerontol A Biol Sci Med Sci 64 (2009) 860-864
34. Sharpless N.E., and DePinho R.A. How stem cells age and why this makes us grow old. Nat Rev Mol Cell Biol 8 (2007) 703-713
35. Inomata K., Aoto T., Binh N.T., et al. Genotoxic stress abrogates renewal of melanocyte stem cells by triggering their differentiation. Cell 137 (2009) 1088-1099
36. Lescai F., Marchegiani F., and Franceschi C. Pon1 is a longevity gene: results of a meta-analysis. Ageing Res Rev 8 (2009) 277-284
37. Di Bona D., Vasto S., Capurso C., et al. Effect of interleukin-6 polymorphisms on human longevity: a systematic review and meta-analysis. Ageing Res Rev 8 (2009) 36-42
38. Willcox B.J., Donlon T.A., He Q., et al. FOXO3A genotype is strongly associated with human longevity. Proc Natl Acad Sci USA 105 (2008) 13987-13992
39. Bishop N.A., and Guarente L. Genetic links between diet and lifespan: shared mechanisms from yeast to humans. Nat Rev Genet 8 (2007) 835-844
40. Colman R.J., Anderson R.M., Johnson S.C., et al. Caloric restriction delays disease onset and mortality in rhesus monkeys. Science 325 (2009) 201-204
41. Markus M.A., and Morris B.J. Resveratrol in prevention and treatment of common clinical conditions of aging. Clin Interv Aging 3 (2008) 331-339
42. Marques F.Z., Markus M.A., Morris B.J., and Resveratrol:. Cellular actions of a potent natural chemical that confers a diversity of health benefits. Int J Biochem Cell Biol 41 (2009) 2125-2128
43. Harrison D.E., Strong R., Sharp Z.D., et al. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature 460 (2009) 392-395
44. Greer E.L., Banko M.R., and Brunet A. AMP-activated protein kinase and FoxO transcription factors in dietary restriction-induced longevity. Ann N Y Acad Sci 1170 (2009) 688-692
45. Selman C., Tullet J.M., Wieser D., et al. Ribosomal protein s6 kinase 1 signaling regulates mammalian life span. Science 326 (2009) 140-144
46. Cox L.S., and Mattison J.A. Increasing longevity through caloric restriction or rapamycin feeding in mammals: common mechanisms for common outcomes?. Aging Cell 8 (2009) 607-613
47. Vellai T., Takacs-Vellai K., Sass M., and Klionsky D.J. The regulation of aging: does autophagy underlie longevity?. Trends Cell Biol 19 (2009) 487-494
48. Eisenberg T., Knauer H., Schauer A., et al. Induction of autophagy by spermidine promotes longevity. Nat Cell Biol 11 (2009) 1305-1314
49. Santos E.L., de Picoli Souza K., da Silva E.D., et al. Long term treatment with ace inhibitor enalapril decreases body weight gain and increases life span in rats. Biochem Pharmacol 78 (2009) 951-958