Real-time PCR analysis of genes encoding tumor antigens in esophageal tumors and a cancer vaccine

Cancer Immunity

Volumn 9, Issue , 2009, Pages

  Weinert, Brian T ^a   Krishnadath, Kausilia K ^b   Milano, Francesca ^b   Pedersen, Ayako W ^a   Claesson, Mogens H ^a   Zocca, Mai Britt ^a  

^a DanDrit Biotech A/S   (Denmark)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

5 aza 2 deoxycytidine; Esophageal cancer; Human; MelCancerVac ; PCR; Tumor antigen

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; CANCER VACCINE; MELANOMA ANTIGEN; MELCANCERVAC; TUMOR ANTIGEN; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CANCER CLASSIFICATION; CANCER STAGING; CELL CLONE; CELL LYSATE; CLINICAL ARTICLE; CONTROLLED STUDY; ESOPHAGUS BIOPSY; ESOPHAGUS CARCINOMA; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SQUAMOUS CELL CARCINOMA; VACCINE PRODUCTION;

EID: 74749086000     PISSN: None     EISSN: 14249634     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Milano F, Krishnadath KK. Novel therapeutic strategies for treating esophageal adenocarcinoma: the potential of dendritic cell immu-notherapy and combinatorial regimens. Hum Immunol 2008; 69: 614-624. (PMID: 18703104)
2. Khushalani N. Cancer of the esophagus and stomach. Mayo Clin Proc 2008; 83: 712-722. (PMID: 18533089)
3. Haier J, Owzcareck M, Guller U, Spagnoli GC, Bürger H, Senninger N, Kocher T. Expression of MAGE-A cancer/testis antigens in esophageal squamous cell carcinomas. Anticancer Res 2006; 26: 2281-2287. (PMID: 16821603)
4. Kan T, Yamasaki S, Kondo K, Teratani N, Kawabe A, Kaganoi J, Meltzer SJ, Imamura M, Shimada Y. A new specific gene expression in squamous cell carcinoma of the esophagus detected using repre-sentational difference analysis and cDNA microarray. Oncology 2006; 70: 25-33. (PMID: 16446548)
5. Akcakanat A, Kanda T, Tanabe T, Komukai S, Yajima K, Nakagawa S, Ohashi M, Hatakeyama K. Heterogeneous expression of GAGE, NY-ESO-1, MAGE-A and SSX proteins in esophageal cancer: Impli-cations for immunotherapy. Int J Cancer 2006; 118: 123-128. (PMID: 16003736)
6. Simpson AJ, Caballero OL, Jungbluth A, Chen YT, Old LJ. Cancer/ testis antigens, gametogenesis and cancer. Nat Rev Cancer 2005; 5: 615-625. (PMID: 16034368)
7. Burgdorf SK, Fischer A, Claesson MH, Kirkin AF, Dzhandzhugazyan KN, Rosenberg J. Vaccination with melanoma lysate-pulsed dendritic cells, of patients with advanced colorectal carcinoma: report from a phase I study. J Exp Clin Cancer Res 2006; 25: 201-206. (PMID: 16918131)
8. Burgdorf SK, Fischer A, Myschetzky PS, Munksgaard SB, Zocca MB, Claesson MH, Rosenberg J. Clinical responses in patients with advanced colorectal cancer to a dendritic cell based vaccine. Oncol Rep 2008; 20: 1305-1311. (PMID: 19020707)
9. Scanlan MJ, Simpson AJ, Old LJ. The cancer/testis genes: review, standardization, and commentary. Cancer Immun 2004; 4: 1. URL: http://www.cancerimmunity.org/v4p1/031220.htm
10. Roman-Gomez J, Jimenez-Velasco A, Agirre X, Castillejo JA, Navarro G, San Jose-Eneriz E, Garate L, Cordeu L, Cervantes F, Prosper F, Heiniger A, Torres A. Epigenetic regulation of human cancer/testis antigen gene, HAGE, in chronic myeloid leukemia. Haematologica 2007; 92: 153-162. (PMID: 17296563)
11. Fukutomi S, Seki N, Koda K, Miyazaki M. Identification of methyla-tion-silenced genes in colorectal cancer cell lines: genomic screen-ing using oligonucleotide arrays. Scand J Gastroenterol 2007; 42: 1486-1494. (PMID: 17994469)
12. Calabrò L, Fonsatti E, Altomonte M, Pezzani L, Colizzi F, Nanni P, Gattei V, Sigalotti L, Maio M. Methylation-regulated expression of cancer testis antigens in primary effusion lymphoma: immunother-apeutic implications. J Cell Physiol 2005; 202: 474-477. (PMID: 15389591)
13. Zendman AJ, Ruiter DJ, van Muijen GN. Cancer/testis-associated genes: identification, expression profile, and putative function. J Cell Physiol 2003; 194: 272-288. (PMID: 12548548)
14. van der Bruggen P, Traversari C, Chomez P, Lurquin C, De Plaen E, Van den Eynde B, Knuth A, Boon T. A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma. Science 1991; 254: 1643-1647. (PMID: 1840703)
15. Valmori D, Dutoit V, Liénard D, Rimoldi D, Pittet MJ, Champagne P, Ellefsen K, Sahin U, Speiser D, Lejeune F, Cerottini JC, Romero P. Naturally occurring human lymphocyte antigen-A2 restricted CD8+ T-cell response to the cancer testis antigen NY-ESO-1 in mel-anoma patients. Cancer Res 2000; 60: 4499-4506. (PMID: 10969798)
16. Rescigno M, Avogadri F, Curigliano G. Challenges and prospects of immunotherapy as cancer treatment. Biochim Biophys Acta 2007; 1776: 108-123. (PMID: 17720322)
17. Copier J, Dalgleish AG, Britten CM, Finke LH, Gaudernack G, Gnjatic S, Kallen K, Kiessling R, Schuessler-Lenz M, Singh H, Tal-madge J, Zwierzina H, Håkansson L. Improving the efficacy of can-cer immunotherapy. Eur J Cancer 2009; 45: 1424-1431. (PMID: 19167214)
18. Romero P. Current state of vaccine therapies in non-small-cell lung cancer. Clin Lung Cancer 2008; 9 Suppl 1: S28-S36. (PMID: 18540532)
19. Singh R, Bandyopadhyay D. MUC1: a target molecule for cancer therapy. Cancer Biol Ther 2007; 6: 481-486. (PMID: 18027437)
20. Savage PA, Vosseller K, Kang C, Larimore K, Riedel E, Wojnoonski K, Jungbluth AA, Allison JP. Recognition of a ubiquitous self anti-gen by prostate cancer-infiltrating CD8+ T lymphocytes. Science 2008; 319: 215-220. (PMID: 18187659)
21. Hofmann O, Caballero OL, Stevenson BJ, Chen YT, Cohen T, Chua R, Maher CA, Panji S, Schaefer U, Kruger A, Lehvaslaiho M, Carn-inci P, Hayashizaki Y, Jongeneel CV, Simpson AJ, Old LJ, Hide W. Genome-wide analysis of cancer/testis gene expression. Proc Natl Acad Sci U S A 2008; 105: 20422-20427. (PMID: 19088187)
22. Bredenbeck A, Hollstein VM, Trefzer U, Sterry W, Walden P, Losch FO. Coordinated expression of clustered cancer/testis genes encoded in a large inverted repeat DNA structure. Gene 2008; 415: 68-73. (PMID: 18395366)
23. Milano F, Rygiel AM, Buttar N, Bergman JJ, Sondermeijer C, van Baal JW, ten Brinke A, Kapsenberg M, van Ham SM, Peppelen-bosch MP, Krishnadath KK. An ex vivo readout for evaluation of dendritic cell-induced autologous cytotoxic T lymphocyte responses against esophageal cancer. Cancer Immunol Immunother 2007; 56: 1967-1977. (PMID: 17564704)
24. Weber J, Salgaller M, Samid D, Johnson B, Herlyn M, Lassam N, Treisman J, Rosenberg SA. Expression of the MAGE-1 tumor anti-gen is up-regulated by the demethylating agent 5-aza-2′-deoxycyti-dine. Cancer Res 1994; 54: 1766-1771. (PMID: 7511051)
25. Adair SJ, Hogan KT. Treatment of ovarian cancer cell lines with 5- aza-2′-deoxycytidine upregulates the expression of cancer-testis antigens and class I major histocompatibility complex-encoded molecules. Cancer Immunol Immunother 2009; 58: 589-601. (PMID: 18791715)
26. Serrano A, Garcia A, Abril E, Garrido F, Ruiz-Cabello F. Methylated CpG points identified within MAGE-1 promoter are involved in gene repression. Int J Cancer 1996; 68: 464-470. (PMID: 8945617)
27. Wang Z, Zhang Y, Ramsahoye B, Bowen D, Lim SH. Sp17 gene expression in myeloma cells is regulated by promoter methylation. Br J Cancer 2004; 91: 1597-1603. (PMID: 15381930)
28. Tang H, Goldberg E. Homo sapiens lactate dehydrogenase c (Ldhc) gene expression in cancer cells is regulated by transcription factor Sp1, CREB, and CpG island methylation. J Androl 2009; 30: 157-167. (PMID: 18930904)
29. Woloszynska-Read A, James SR, Link PA, Yu J, Odunsi K, Karpf AR. DNA methylation-dependent regulation of BORIS/CTCFL expres-sion in ovarian cancer. Cancer Immun 2007; 7: 21. URL: http:// www.cancerimmunity.org/ v7p21/071122.htm
30. Wischnewski F, Pantel K, Schwarzenbach H. Promoter demethyla-tion and histone acetylation mediate gene expression of MAGE-A1, -A2, -A3, and -A12 in human cancer cells. Mol Cancer Res 2006; 4: 339-349. (PMID: 16687489)
31. Yao X, Hu JF, Li T, Yang Y, Sun Z, Ulaner GA, Vu TH, Hoffman AR. Epigenetic regulation of the taxol resistance-associated gene TRAG- 3 in human tumors. Cancer Genet Cytogenet 2004; 151: 1-13. (PMID: 15120907)
32. Cho B, Lee H, Jeong S, Bang YJ, Lee HJ, Hwang KS, Kim HY, Lee YS, Kang GH, Jeoung DI. Promoter hypomethylation of a novel cancer/testis antigen gene CAGE is correlated with its aberrant expression and is seen in premalignant stage of gastric carcinoma. Biochem Biophys Res Commun 2003; 307: 52-63. (PMID: 12849980)
33. Ghoshal K, Bai S. DNA methyltransferases as targets for cancer therapy. Drugs Today (Barc) 2007; 43: 395-422. (PMID: 17612710)
34. Oki Y, Issa JP. Review: recent clinical trials in epigenetic therapy. Rev Recent Clin Trials 2006; 1: 169-182. (PMID: 18473969)
35. Coral S, Sigalotti L, Covre A, Nicolay HJ, Natali PG, Maio M. 5- AZA-2'-deoxycytidine in cancer immunotherapy: a mouse to man story. Cancer Res 2007; 67: 2900-2901. (PMID: 17363616)