Homo sapiens lactate dehydrogenase c (Ldhc) gene expression in cancer cells is regulated by transcription factor Sp1, CREB, and CpG island methylation

Journal of Andrology

Volumn 30, Issue 2, 2009, Pages 157-167

  Tang, Huanghui ^a   Goldberg, Erwin ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Cancer testis antigen; DNA methylation; Promoter

Indexed keywords

BIOLOGICAL MARKER; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYTOSINE; DNA; GUANINE; LACTATE DEHYDROGENASE (CYTOCHROME); TRANSCRIPTION FACTOR SP1;

ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; GENE EXPRESSION REGULATION; GENETIC CONSERVATION; HUMAN; HUMAN CELL; HUMAN TISSUE; MELANOMA CELL; PRIORITY JOURNAL; PROMOTER REGION; PROSTATE TUMOR; PROTEIN ANALYSIS; PROTEIN INDUCTION; PYROSEQUENCING; QUANTITATIVE ANALYSIS; SEQUENCE ANALYSIS; TRANSCRIPTION REGULATION;

BASE SEQUENCE; CELL LINE, TUMOR; CPG ISLANDS; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DNA METHYLATION; ELECTROPHORETIC MOBILITY SHIFT ASSAY; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; L-LACTATE DEHYDROGENASE; MALE; MOLECULAR SEQUENCE DATA; NEOPLASMS; PROMOTER REGIONS, GENETIC; PROTEIN KINASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSCRIPTION, GENETIC;

EID: 62649125299     PISSN: 01963635     EISSN: None     Source Type: Journal    
DOI: 10.2164/jandrol.108.005785     Document Type: Article

References (33)

1. Antequera FJ, Boyes J, Bird A. High levels of de novo methylation and altered chromatin structure at CpG islands in cell lines. Cell. 1990;62:503-514.
2. Bastian PJ, Yegnasubramanian S, Palapattu GS, Rogers CG, Lin X, De Marzo AM, Nelson WG. Molecular biomarker in prostate cancer: the role of CpG island hypermethylation. Eur Urol. 2004:46:698-708.
3. Bonny C, Cooker LA, Goldberg E. Deoxyribonucleic acids-protein interactions and expression of the human testis-specific lactate dehydrogenase promoter: transcription factor Sp1 plays a major role. Biol Reprod. 1998:58:754-759.
4. Cameron EE, Bachman KE, Myohanen S, Herman JG, Baylin SB. Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer. Nat Genet. 1999;21:103-107.
5. Chen YT, Scanlan MJ, Sahin U, Tureci O, Gure AO, Tsang S, Williamson B, Stockert E, Pfreundschuh M, Old LJ. A testicular antigen aberrantly expressed in human cancers detected by autologous antibody screening. Proc Natl Acad Sci U S A. 1997;94:1914-1918.
6. Clark SJ, Harrison J, Paul CL, Frommer M. High sensitivity mapping of methylated cytosines. Nucleic Acids Res. 1994;22:2990-2997.
7. De Smet C, Loriot A, Boon T. Promoter-dependent mechanism leading to selective hypomethylation within the 5′ region of gene MAGE-A1 in tumor cells. Mol Cell Biol. 2004;24:4781-4790.
8. De Smet C, Lurquin C. Lethe B, Martelange V, Boon T. DNA methylation is the primary silencing mechanism for a set of germ line- and tumor-specific genes with a CpG-rich promoter. Mol Cell Biol. 1999:19:7327-7335.
9. Deng G, Chen A, Hong J, Chae HS, Kim YS. Methylation of CpG in a small region of the hMLH1 promoter invariably correlates with the absence of gene expression. Cancer Res. 1999;59:2029-2033.
10. Ellinger J, Bastian PJ, Jurgan T, Biermann K, Kahl P, Heukamp LC, Wernert N, Muller SC, von Ruecker A. CpG island hypermethylation at multiple gene sites in diagnosis and prognosis of prostate cancer. J Urol. 2008;71:161-167.
11. Emami KH, Burke TW, Smale ST. Sp1 activation of a TATA-less promoter requires a species-specific interaction involving transcription factor IID. Nucleic Acids Res. 1998:26:839-846.
12. Gonzalgo ML, Havashida T, Bender CM, Pao MM, Tsai YC, Gonzales FA, Nguyen HD, Nguyen TT, Jones PA. The role of DNA methylation in expression of the p19/p16 locus in human bladder cancer cell lines. Cancer Res. 1998;58:1245-1252.
13. Hintz M, Goldberg E. Immunohistochemical location of LDH-X during spermatogeriesis in mouse testes. Dev Biol. 1977;57:375-384.
14. Jaenisch R, Bird A. Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat Genet. 2003;33(suppl):245-254.
15. Jones PA, Baylin SB. The fundamental role of epigenetic events in cancer. Nat Rev Genet. 2002;3:415-428.
16. Jones PL, Veenstra GJC, Wade PA, Vermaak D, Kass SU, Landsberger N, Strouboulis J, Wolffe AP. Methylation DNA and MeCP2 recruit historic deacetylase to repress transcription. Nat Genet. 1998:19:187-191.
17. Kalejs M. Erenpreisa J. Cancer/testis antigens and gametogenesis: a review and "brain-storming" session. Cancer Cell Int. 2005;5:4.
18. Koslowski M, Tureci O, Bell C, Krause P, Lehr HA, Brunner J, Seitz G, Nestle FO, Huber C, Sahin U. Multiple splice variants of lactate dehydrogenase C selectively expressed in human cancer. Cancer Res. 2002;62:6750-6755.
19. Lim JH, Kim SP, Gabrielson E, Park YB, Park JW, Kwon TK. Activation of human cancer/testis antigen gene, XAGE-1 in tumor cells is correlated with CpG island hypomethylation. Int J Cancer. 2005;116:200-206.
20. Mirmohammads A, Marini A, Nambiar S, Hassan M, Tannapfel A. Ruzicka T, Hengge UR. Epigenetic silencing of the PTEN gene in melanoma. Cancer Res. 2006;66(13):6546-6552.
21. Miyakura Y, Sugano K, Konishi F, Ichikawa A, Maekawa M, Shitoh K, Igarashi S, Kotake K, Koyama Y, Nagai H. Extensive methylation of hMLH1 promoter region predominates in proximal colon cancer with microsatellite instability. Gastroenterology. 1001:121:1300-1309.
22. Nan X, Ng HH, Johnson CA, Laherty CD, Turner BM, Eisenman RN, Bird A. Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a historic deacetylase complex. Nature. 1998393:386-389.
23. Old LJ. Cancer/testis (CT) antigens - a new link between gametogenesis and cancer. Cancer Immun. 2001;1:1.
24. Shim H, Dolde C, Lewis BC, Wu CS, Dang G, Jungmann RA, Dalla-Favera R, Dang CV. c-Myc transactivation of LDH-A: implications for tumor metabolism and growth. Proc Natl Acad Sci U S A. 1997; 94:6658-6663.
25. Somboonthum P, Ohta H, Yamada S, Onishi M, Ike A, Nishimune Y, Nozaki M. cAMP-responsive clement in TATA-less core promoter is essential for haploid-specific gene expression in mouse testis. Nucleic Acids Res. 2005;33:3401-3411.
26. Szyf M, Campbell PM, Detich N, Ou JN, Hamm S, Bovenzi V. The role of active demethylation in cancer and its therapeutic potential. In: Szyf M ed. DNA Methylation and Cancer Therapy. New York, NY: Springer-Verlag; 2005:255.
27. Takai D, Jones PA. Comprehensive analysis of CpG islands in human chromosomes 21 and 22. Proc Natl Acad Sci U S A. 2002;99: 3740-3745.
28. Tang HH, Kung A, Goldberg E. Regulation of murine lactate dehydrogenase C (Ldhc) gene expression. Biol Reprod. 2008;78: 455-461.
29. Tost J, Dunker J, Glynne Gut Y. Analysis and quantification of multiple methylation variable positions in CpG islands by Pyrosequencing™. Biotechniques. 2003;35:152-156.
30. van der Bruggen P, Traversari C, Chomez P, Lurquin C, De Plaen E, Van den EB, Knuth A, Boon T. A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma. Science. 1991:254:1643-1647.
31. Weis L, Reinberg D. Accurate positioning of RNA polymerase II on a natural TATA-less promoter is independent of TATA-binding-protein-associated factors and initiator-binding proteins. Mol Cell Biol. 1997;17:2973-2984.
32. Zendman AJ, Ruiter DJ, Van Muijen GNP. Cancer/testis-associated genes: identification, expression profile, and putative function. J Cell Physiol. 2003:194:272-288.
33. Zlatanova J, Caiafa P, Van Holde K. Linker histone binding and displacement: versatile mechanism for transcription regulation. FASEB J. 2000;14:1697-1704.