Recognition of a ubiquitous self antigen by prostate cancer-infiltrating CD8+ T lymphocytes

Science

Volumn 319, Issue 5860, 2008, Pages 215-220

  Savage, Peter A ^a   Vosseller, Keith ^b   Kang, Chulho ^c   Larimore, Kevin ^c   Riedel, Elyn ^a   Wojnoonski, Kathleen ^a   Jungbluth, Achim A ^d   Allison, James P ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d LUDWIG INSTITUTE FOR CANCER RESEARCH   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE H4; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; T LYMPHOCYTE RECEPTOR; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN;

ANTIGEN; CANCER; CYTOLOGY; DETECTION METHOD; IMMUNITY; RECOGNITION; REPRODUCTIVE DISORDER; TUMOR;

AMINO ACID SEQUENCE; ANTIGEN EXPRESSION; ANTIGEN RECOGNITION; ARTICLE; CD8+ T LYMPHOCYTE; COMPLEMENTARITY DETERMINING REGION; HUMAN; IMMUNODETECTION; IMMUNOTHERAPY; LYMPHOCYTE SUBPOPULATION; LYMPHOCYTIC INFILTRATION; MAJOR HISTOCOMPATIBILITY COMPLEX; MOLECULAR RECOGNITION; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROSTATE ADENOCARCINOMA; PROSTATE CANCER; TREATMENT RESPONSE; TUMOR ASSOCIATED LEUKOCYTE;

ADENOCARCINOMA; ADOPTIVE TRANSFER; ANIMALS; ANTIGEN PRESENTATION; ANTIGENS, NEOPLASM; AUTOANTIGENS; CD8-POSITIVE T-LYMPHOCYTES; CELL LINE; EPITOPES, T-LYMPHOCYTE; HISTONES; HYBRIDOMAS; LYMPHOCYTES, TUMOR-INFILTRATING; MALE; MICE; MICE, TRANSGENIC; PEPTIDE FRAGMENTS; PROSTATIC NEOPLASMS; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA;

MUS;

EID: 38149035080     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1148886     Document Type: Article

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17. - cell lines were a gift from N. Shastri. We thank M. LaRusso, S. Schwab, and G. Hammer for technical assistance; H. Erdjument-Bromage for mass spectrometry analysis; I. Leiner for peptide/MHC tetramer production; and S. Quezada, E. Corse, C. Sumen, D. Raulet, N. Shastri, and D. Allis for helpful discussion. P.A.S. was supported by a postdoctoral fellowship from the Damon Runyon Cancer Research Fund. J.P.A. is the David H. Koch Chair for Immunological Studies and was supported by grants from the Howard Hughes Medical Institute, the National Cancer Institute/NIH, the Prostate Cancer Foundation, and the David H. Koch Foundation.