Controllable expansion of primary cardiomyocytes by reversible immortalization

Human Gene Therapy

Volumn 20, Issue 12, 2009, Pages 1687-1696

  Zhang, Yue ^a   Nuglozeh, Edem ^a   Touré, Fatouma ^a   Schmidt, Ann Marie ^a   Vunjak Novakovic, Gordana ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA ACTIN; CALCIUM; CONNEXIN 43; CRE RECOMBINASE; LENTIVIRUS VECTOR; TELOMERASE REVERSE TRANSCRIPTASE; TRANSCRIPTION FACTOR NKX2.5; TROPONIN I; VIMENTIN;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL EXPANSION; CELL IMMORTALIZATION; CELL PROLIFERATION; CELL STRUCTURE; CELL THERAPY; CONTROLLED STUDY; FEASIBILITY STUDY; GENE; GENETIC TRANSDUCTION; HEART MUSCLE CELL; IN VITRO STUDY; NEWBORN; NONHUMAN; PHENOTYPE; PROTEIN EXPRESSION; RAT; TAG GENE;

ACTINS; ANIMALS; ANTIGENS, POLYOMAVIRUS TRANSFORMING; CELL DIFFERENTIATION; CELL LINE, TRANSFORMED; CONNEXIN 43; HIV; HOMEODOMAIN PROTEINS; HUMANS; INTEGRASES; MYOCYTES, CARDIAC; NUCLEAR PROTEINS; PHENOTYPE; PROTO-ONCOGENE PROTEINS; RATS; REPRESSOR PROTEINS; TELOMERASE; TISSUE ENGINEERING; TRANSCRIPTION FACTORS; TRANSDUCTION, GENETIC; TROPONIN;

RATTUS; SIMIAN VIRUS 40;

EID: 74549219812     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/hum.2009.057     Document Type: Article

References (40)

1. Ai, Z., Fischer, A., Spray, D.C., Brown A.M., and Fishman, G.I. (2000). Wnt-1 regulation of connexin43 in cardiac myocytes. J. Clin. Invest. 105, 161-171.
2. Ali, S.H., and DeCaprio, J.A. (2001). Cellular transformation by SV40 large T antigen: Interaction with host proteins. Semin. Cancer Biol. 11, 15-23.
3. Caldwell, M.A., He, X., and Svendsen, C.N. (2005). 5-Bromo-2'- deoxyuridine is selectively toxic to neuronal precursors in vitro. Eur. J. Neurosci. 22, 2965-2970.
4. Coons, J.C., and Seidl, E. (2007). Cardiovascular pharmacother-apy update for the intensive care unit. Crit. Care Nurs. Q. 30, 44-57.
5. Cudré-Mauroux, C., Occhiodoro, T., Knig, S., Salmon, P., Bern-heim, L., and Trono, D. (2003). Lentivector-mediated transfer of Bmi-1 and telomerase in muscle satellite cells yields a Du-chenne myoblast cell line with long-term genotypic and phe-notypic stability. Hum. Gene Ther. 14, 1525-1533.
6. Fender, P., Schoehn, G., Perron-Sierra, F., Tucker, G.C., and Lortat-Jacob, H. (2008). Adenovirus dodecahedron cell attachment and entry are mediated by heparan sulfate and in-tegrins and vary along the cell cycle. Virology 371, 155-164.
7. Gerecht-Nir, S., Radisic, M., Park, H., Cannizzaro, C., Boublik, J., Langer, R., and Vunjak-Novakovic, G. (2006). Biophysical regulation during cardiac development and application to tissue engineering. Int. J. Dev. Biol. 50, 233-243.
8. Hahn, W.C., Counter, C.M., Lundberg, A.S., Beijersbergen, R.L., Brooks, M.W., and Weinberg, R.A. (1999). Creation of human tumour cells with defined genetic elements.Nature 400,464-468.
9. Hashimoto, N., Kiyono, T., Wada, M.R., Shimizu, S., Yasumoto, S., and Inagawa, M. (2006). Immortalization of human myo-genic progenitor cell clone retaining multipotentiality. Bio-chem. Biophys. Res. Commun. 348, 1383-1388.
10. Jacobs, J.J., Kieboom, K., Marino, S., DePinho, R.A., and van Lohuizen, M. (1999). The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus. Nature 397, 164-168.
11. Kehat, I., Khimovich, L., Caspi, O., Gepstein, A., Shofti, R., Arbel, G., Huber, I., Satin, J., Itskovitz-Eldor, J., and Gepstein, L. (2004). Electromechanical integration of cardiomyocytes derived from human embryonic stem cells. Nat. Biotechnol. 22, 1282-1289. (Pubitemid 39341201)
12. Kirkpatrick, J.N., Vannan, M.A., Narula, J., and Lang, R.M. (2007). Echocardiography in heart failure: Applications, utility, and new horizons J. Am. Coll. Cardiol. 50, 381-396.
13. Kobayashi, N., Noguchi, H., Westerman, K.A., Watanabe, T., Matsumura, T., Totsugawa, T., Fujiwara, T., Leboulch, P., and Tanaka, N. (2001). Cre=loxP-based reversible immortalization of human hepatocytes. Cell Transplant. 10, 383-386.
14. Kowolik, C.M., Liang, S., Yu, Y., and Yee, J.K. (2004). Cre-mediated reversible immortalization of human renal proximal tubular epithelial cells. Oncogene 23, 5950-5957.
15. LaFramboise, W.A., Scalise, D., Stoodley, P., Graner, S.R., Guthrie, R.D., Magovern, J.A., and Becich, M.J. (2007). Cardiac fibroblasts influence cardiomyocyte phenotype in vitro. Am. J. Physiol. Cell Physiol. 292, C1799-C1808.
16. Li, Y., Pong, R.C., Bergelson, J.M., Hall, M.C., Sagalowsky, A.I., Tseng, C.P., Wang, Z., and Hsieh, J.T. (1999). Loss of adeno-viral receptor expression in human bladder cancer cells: A potential impact on the efficacy of gene therapy. Cancer Res. 59, 325-330.
17. Lokuta, A., Kirby, M.S., Gaa, S.T., Lederer, W.J., and Rogers, T.B. (1994). On establishing primary cultures of neonatal rat ventricular myocytes for analysis over long periods. J. Cardiovasc. Electrophysiol. 5, 50-62.
18. Long, C.S., Kariya, K., Karns, L., and Simpson, P.C. (1990). Trophic factors for cardiac myocytes. J. Hypertens. Suppl. 8, S219-S224.
19. Mauritz, C., Schwanke, K., Reppel, M., Neef, S., Katsirntaki, K., Maier, L.S., Nguemo, F., Menke, S., Haustein, M., Hescheler, J., Hasenfuss, G., and Martin, U. (2008). Generation of functional murine cardiac myocytes from induced pluripotent stem cells. Circulation 118, 507-517.
20. Miragoli, M., Gaudesius, G., and Rohr, S. (2006). Electrotonic modulation of cardiac impulse conduction by myofibroblasts. Circ. Res. 98, 801-810.
21. + progenitor cells lead to cardiac, smooth muscle, and endothelial cell diversification. Cell 127, 1151-1165.
22. Naghavi, M.H., Hatziioannou, T., Gao, G., and Goff, S.P. (2005). Overexpression of fasciculation and elongation protein z-1 (FEZ1) induces a post-entry block to retroviruses in cultured cells. Genes Dev. 19, 1105-1115.
23. Nakamura, T., Feng, Z., Honda, T., Nomura, Y., Kitajima, T., and Umezu, M. (2008). Comparison of mRNA expression of transcriptional factors and intercalated disk constituent proteins between in vivo and cultured cardiomyocytes. J. Artif. Organs 11, 134-140.
24. Narazaki, G., Uosaki, H., Teranishi, M., Okita, K., Kim, B., Mat-suoka, S., Yamanaka, S., and Yamashita, J.K. (2008). Directed and systematic differentiation of cardiovascular cells from mouse induced pluripotent stem cells. Circulation 118, 498-506.
25. Narushima, M., Kobayashi, N., Okitsu, T., Tanaka, Y., Li, S.A., Chen, Y., Miki, A., Tanaka, K., Nakaji, S., Takei, K., Gutierrez, A.S., Rivas-Carrillo, J.D., Navarro-Alvarez, N., Jun, H.S., Westerman, K.A., Noguchi, H., Lakey, J.R., Leboulch, P., Tanaka, N., and Yoon, J.W. (2005). A human beta-cell line for transplantation therapy to control type 1 diabetes. Nat. Bio-technol. 23, 1274-1282.
26. Noguchi, H., Kobayashi, N., Westerman, K.A., Sakaguchi, M., Okitsu, T., Totsugawa, T., Watanabe, T., Matsumura, T., Fujiwara, T., Ueda, T., Miyazaki, M., Tanaka, N., and Le-boulch, P. (2002). Controlled expansion of human endothelial cell populations by Cre-loxP-based reversible immortalization. Hum. Gene Ther. 13, 321-334.
27. Orlic, D., Kajstura, J., Chimenti, S., Jakoniuk, I., Anderson, S.M., Li, B., Pickel, J., McKay, R., Nadal-Ginard, B., Bodine, D.M., Leri, A., and Anversa, P. (2001). Bone marrow cells regenerate infarcted myocardium. Nature 410, 701-705.
28. Radisic, M., Marsano, A., Maidhof, R., Wang, Y., and Vunjak-Novakovic, G. (2008). Cardiac tissue engineering using per-fusion bioreactor systems. Nat. Protoc. 3, 719-738.
29. Rybkin, I.I., Markham, D.W., Yan, Z., Bassel-Duby, R., Williams, R.S., and Olson, E.N. (2003). Conditional expression of SV40 T-antigen in mouse cardiomyocytes facilitates an inducible switch from proliferation to differentiation. J. Biol. Chem. 278, 15927-15934.
30. Salmon, P., Oberholzer, J., Occhiodoro, T., Morel, P., Lou, J., and Trono, D. (2000). Reversible immortalization of human primary cells by lentivector-mediated transfer of specific genes. Mol. Ther. 2, 404-414.
31. Schultz, L.B., Chehab, N.H., Malikzay, A., and Halazonetis, T.D. (2000). p53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks. J. Cell Biol. 151, 1381-1390.
32. Simpson, P., and Savion, S. (1982). Differentiation of rat myo-cytes in single cell cultures with and without proliferating nonmyocardial cells: Cross-striations, ultrastructure, and chronotropic response to isoproterenol. Circ. Res. 50, 101-116.
33. Smalley, M.J., and Dale, T.C. (1999). Wnt signalling in mammalian development and cancer. Cancer Metastasis Rev. 18, 215-230.
34. Takahashi, K., and Yamanaka, S. (2006). Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126, 663-676.
35. Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K., and Yamanaka, S. (2007). Induction of pluripo-tent stem cells from adult human fibroblasts by defined factors. Cell 131, 861-872.
36. Tandon, N., Cannizzaro, C., Chao, P.H., Maidhof, R., Marsano, A., Au, H.T., Radisic, M., and Vunjak-Novakovic, G. (2009). Electrical stimulation systems for cardiac tissue engineering. Nat. Protoc. 4, 155-173.
37. Westerman, K.A., and Leboulch, P. (1996). Reversible immortalization of mammalian cells mediated by retroviral transfer and site-specific recombination. Proc. Natl. Acad. Sci. U.S.A. 93, 8971-8976.
38. Xia, Z., Dickens, M., Raingeaud, J., Davis, R.J., and Greenberg, M.E. (1995). Opposing effects of ERK and JNK-p38 MAP ki-nases on apoptosis. Science 270, 1326-1331.
39. Yamada, K., Green, K.G., Samarel, A.M., and Saffitz, J.E. (2005). Distinct pathways regulate expression of cardiac electrical and mechanical junction proteins in response to stretch. Circ. Res. 97, 346-353.
40. + embryonic-stem-cell-derived population. Nature 453, 524-528.