Cre/loxP-based reversible immortalization of human hepatocytes

Cell Transplantation

Volumn 10, Issue 4-5, 2001, Pages 383-386

  Kobayashi, N ^a   Noguchi, H ^a   Westerman, K A ^b   Watanabe, T ^a   Matsumura, T ^a   Totsugawa, T ^a   Fujiwara, T ^a   Leboulch, P ^b   Tanaka, N ^a  

^a OKAYAMA UNIVERSITY MEDICAL SCHOOL   (Japan)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Cre loxP system; Human hepatocytes; Reversible immortalization; Simian virus 40 large T antigen

Indexed keywords

RECOMBINASE; VIRUS LARGE T ANTIGEN; VIRUS VECTOR;

ADENOVIRUS; CELL IMMORTALIZATION; CONFERENCE PAPER; CONTROLLED STUDY; GENE EXPRESSION; GENETIC RECOMBINATION; HUMAN; HUMAN CELL; LIVER CELL; LIVER CELL CULTURE; LIVER PARENCHYMA; LIVER TRANSPLANTATION; PRIORITY JOURNAL; SIMIAN VIRUS 40;

EID: 0034873041     PISSN: 09636897     EISSN: None     Source Type: Journal    
DOI: 10.3727/000000001783986558     Document Type: Conference Paper

References (8)

1. Treatment of the Crigler-Najjar syndrome type I with hepatocyte transplantation
2. Efficient gene activation system on mammalian cell chromosomes using recombinant adenovirus producing Cre recombinase
3. Transplantation of highly differentiated immortalized human hepatocytes to treat acute liver failure
4. Prevention of acute liver failure in rats with reversibly immortalized human hepatocytes
5. Reversible cell immortalization with Cre-loxP system
6. Bacteriophage P1 site-specific recombination I. Recombination between loxP sites
7. Hepatocyte transplantation as a bridge to orthotopic liver transplantation in terminal liver failure
8. Reversible immortalization of mammalian cells mediated by retroviral transfer and site-specific recombination