Oxidative markers, nitric oxide and homocysteine alteration in hypercholesterolimic rats: Role of atorvastatine and cinnamon

International Journal of Clinical and Experimental Medicine

Volumn 2, Issue 3, 2009, Pages 254-265

  Amin, Kamal A ^a   Abd El Twab, Thanaa M ^b  

^a Beni Suef University   (Egypt)

^b Beni Suef University   (Egypt)

Author keywords

Cinnamon; Homocystein; Hypercholesterolemia; Nitric oxide; Oxidative stress atorvastatin

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; ATORVASTATIN; CATALASE; CHOLESTEROL; CINNAMON EXTRACT; GLUTATHIONE; HIGH DENSITY LIPOPROTEIN; HOMOCYSTEINE; LIVER ENZYME; LOW DENSITY LIPOPROTEIN; MALONALDEHYDE; NITRIC OXIDE; SUPEROXIDE DISMUTASE; TRIACYLGLYCEROL;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CARDIOVASCULAR FUNCTION; CHOLESTEROL BLOOD LEVEL; CINNAMON; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; HYPERCHOLESTEROLEMIA; HYPERLIPIDEMIA; LIPOPROTEIN BLOOD LEVEL; LIVER PROTECTION; MALE; NONHUMAN; OXIDATIVE STRESS; RAT; TRIACYLGLYCEROL BLOOD LEVEL;

CINNAMOMUM VERUM; RATTUS;

EID: 74549217179     PISSN: None     EISSN: 19405901     Source Type: Journal    
DOI: None     Document Type: Article

References (59)

1. Dietschy JM, Turley SD, Spady DK. Role of liver in the maintenance of cholesterol and low density lipoprotein homeostasis in different animal species, including humans. J Lipid Res 1993; 34: 1637-1659.
2. Grigore L, Norata GD, Catapano AL. Inhibition of synthesis and absorption of cholesterol: A new option in managing hypercholesterolemia, International Congress Series 2007; 1303: 121-128.
3. Stokes KY, Cooper D, Tailor A, Granger DN. Hypercholesterolemia promotes inflammation and microvascular dysfunction: role of nitric oxide and superoxide. Free Radic Biol Med 2002; 33: 1026-1036.
4. Davi G., Alessandrini P, Mezzetti A, Minotti G, Bucciarelli T, Costantini F, Cipollone F, et al. In vivo formation of 8-Epi-prostaglandin F2 alpha is increased in hypercholesterolemia. Arterio-scler Thromb Vasc Biol 1997; 17: 3230-5.
5. Deepa PR, Varalakshmi, P. Atheroprotective effect of exogenous heparin-derivative treatment on the aortic disturbances and lipo-protein oxidation in hypercholesterolemic diet fed rats. Clin Chim Acta 2005; 355:119-130.
6. Guemouri L, Artur Y, Herbeth B. Biological variability of superoxide dismutase, glutathione peroxidase, and catalase in blood. Clin Chem 1991; 7: 1932-37.
7. Sasaki S, Kuwahara N, Kunitomo K, Harada S, Yamada T, Azuma A, et al. Effects of atorvastatin on oxidized low density lipoprotein, low-density lipoprotein subfraction distribution, and remnant lipoprotein in patients with mixed hyperlipoproteinemia. Am J Cardiol 2002; 89(4): 386-9.
8. Von Haehling S, Anker SD, Bassenge E. Statins and the role of nitric oxide in chronic heart failure. Heart Fail Rev 2003 ; 8:99-106.
9. Jayaprakasha GK, Rao LJ, Sakaraiah KK. Volatile constituents from Cinnamomum zeylanicum fruit stalks and their antioxidant activities. Journal of Agriculture and Food Chemistry 2003; 51: 4344-4348.
10. Wang R, Wang R, Yang B. Extraction of essential oils from cinnamon leaves and identification of their volatile compound com-position. Innovative Food Science and Emer-genging Technologies 2008; 10: 289-292.
11. Singh G, Maurya S, deLampasona MP, Catalan CN. A comparison of chemical, antioxidant and antimicrobial studies of cinnamon leaf and bark volatile oils, oleoresins and their consti-tuents. Food and Chem Toxicol 2007; 45: 1650-61.
12. Kim SH, Hyun SH, Choung SY. Anti-diabetic effect of cinnamon extract on blood glucose in db/db mice. J Ethnopharmacol 2006; 104: 119-123.
13. Pengzhan Y, Ning L, Xiguang L, Gefei Z, Quanbin Z, Pengcheng L. Antihyperlipidemic effects of different molecular weight sulfated polysaccharides from Ulva Pertusa (Chloro-phyta.) Pharmacological Research 2003; 48: 543-549.
14. Kreydiyyeh SI, Usta J, Copti R. Effect of cinnamon, clove and some of their consti-tuents on the Na+-K+-ATPase activity and alanine absorption in the rat jejunum. Food Chem Toxicol 2000; 038:755-62.
15. Kannappan S, Jayaraman T, Rajasekar P, Ravichandran MK, Anuradha CV. Cinnamon bark extract improves glucose metabolism and lipid profile in the fructose-fed rat. Singapore Med J 2006; 47(10): 858-863.
16. AL-Rawi MM, Maisaa M. Efficacy of oat bran (Avena sativa L.) in comparison with atorva-statin in treatment of hypercholesterolemia in albino rat liver.The Egyptian J. of Hospital Med. 2007; 29: 511- 521.
17. Deeg R, Ziegenohrm Kinetic enzymatic method for automated determination of total chole-sterol in serum. J Clin Chem 1983; 29(10): 1798-1802.
18. Fossati P, Prencipe L. Serum triglycerides determined colourimetrically with an enzyme that produces hydrogen peroxide. Clin Chem 1982; 28(1): 2077-80.
19. Friendewald WT. Estimation of the concentration of low-density lipoprotein cholesterol in plasma without use of the preparative ultra-centrifuge. Clin Chem 1972; 8: 499-502.
20. Burstein M, Selvenick H R, Morfin R. Rapid method for the isolation of lipoproteins from human serum by precipitation with polyanions. J Lipid Res 1970; 11: 583-595.
21. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979; 95(2):351-8.
22. Beutler E, Duron O, Kelly BM. Improved method for determination of blood glutathione. J Lab Clin Med 1963; 61:882-8.
23. Cohen G, Dembiec D, Marcus J. 1970 Measurment of catalase activity in tissue. Analytical Biochemistry 1970; 34: 30-38.
24. Marklund S, Marklund G. Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for super-oxide dismutase. Eur J Biochem 1974; 47(3): 469-74.
25. Kar M, Mishra D. Catalase, peroxidase and polyphenoloxidase activities during rice leaf senescence. Plant Physiology 1976; 57: 315-319.
26. Miranda, K.M., Espey, M.G., Wink, D.A. A rapid, simplex Trophometric method for simultaneous detection of nitrate and nitrite. Nitric oxide Biol Chem 2001; 5:62-71.
27. Araki A, Sako Y. Determination of free and total homocysteine in human serum by high-performance liquid chromatography with fluorence detection. J chromatography 1987; 422:43-52.
28. Xu G, Pan LX, Li H, Shang Q, Honda A, Shefer S. Dietary cholesterol stimulates CYP7A1 in rats because farnesoid X receptor is not activated. Am. J. Physiol. Gastrointest. Liver Physiol 2004; 286:G730-G735.
29. Yang TT, Koo MW. Chinese green tea lowers cholesterol level through an increase in fecal lipid excretion. Life Sci 2000; 66:411-423.
30. Martinez LO, Jacquet S, Terce F, Collet X, Perret B, Barbaras R. New insight on the molecular mechanisms of high-density lipoprotein cellular interactions. Cellular and Molecular Life Sciences 2004; 61: 2343-2360.
31. Shepherd J. Lipids in health and disease, Biochem. Soc Trans 2004; 32:1051-56.
32. Steiner G. The need for a different cholesterol lowering drug, Can J Clin Pharmacol 2003; 10: (SupplA) 4A-6A.
33. Khan A, Safdar M, Khan MA, Khattak KN, Anderson RA. Cinnamon improves glucose and lipids of people with type 2 diabetes. Diabetes Care 2003; 26:3215-8.
34. Lee JS, Jeon SM, Park EM, Huh TL, Kwon OS, Lee MK, Choi MS. Cinnamate supplementation enhances hepatic lipid metabolism and anti-oxidant defense systems in high cholesterol-fed rats. J Med Food 2003; 6(3): 183-91.
35. Sheng X, Zhang Y, Gong Z, Huang C, Zang YQ. Improved Insulin Resistance and Lipid Metabolism by Cinnamon Extract through Activation of Peroxisome Proliferator Activated Receptors. PPAR Research 2008; 2008: 581348.
36. Bolkent S, Yanardag R, Bolkent S, Doger MM. Beneficial effects of combined treatment with niacin and chromium on the liver of hyperlipemic rats. Biological Trace Element Research. 2004; 01: 219-230.
37. Martinet W, Knaapen MW, De Meyer GR, Herman AG, Kockx MM. Oxidative DNA damage and repair in experimental atherosclerosis are reversed by dietary lipid lowering. Circ Res 2001; 88: 733- 9.
38. Sakabe K, Fukuda N, Fukuda Y, Wakayama K, Nada T, Morishita S, Shinohara H, Tamura Y, Gender differences in short-term effects of atorvastatin on lipid profile, fibrinolytic parameters, and endothelial function. Nutr Metab Cardiovasc Dis. 2008; 18(3):182-8.
39. Bolayirli IM, Aslan M, Balci H, Altug T, Hacibekiroglu M, Seven A. Effect of atorva-statin therapy on hypercholesterolemic rabbits with respect to oxidative stress, nitric oxide pathway and homocysteine. Life Sci 2007; 81(2):121-7.
40. Sakabe K, Fukuda N, Wakayama K, Nada T, Shinohara H, Tamura Y. Effects of atorvastatin therapy on the low-density lipoprotein subfraction, remnant-like particles cholesterol, and oxidized low-density lipoprotein within 2 weeks in hypercholesterolemic patients. Circ J 2003; 67: 866-70.
41. John S, Schneider MP, Delles C, Jacobi J, Schmieder RE. Lipid-independent effects of statins on endothelial function and bioavaila-bility of nitric oxide in hypercholesterolemic patients. Am Heart J 2005; 149(3):473.
42. Qin B, Nagasaki M, Ren M, Bajotto G, Oshida Y, Sato Y. Cinnamon extract prevents the insulin resistance induced by high-fructose diet. Horm Metab Res 2004; 36(2):119-25.
43. Sanyal A. Non alcoholic steatohepatitis. Indian J Gastroenterol 2001; 20(suppl): C64-C70.
44. Mahfouz MM, Kummerow FA. Cholesterol-rich diets have different effects on lipid peroxidetion, cholesterol oxides, and antioxidant enzymes in rats and rabbits. J Nutr Biochem 2000; 11: 293- 302.
45. Wassmann S, Laufs U, Müller K, Konkol C, Ahlbory K, Bäumer AT, Linz W, Böhm M, Nickenig G. Cellular antioxidant effects of atorvastatin in vitro and in vivo. Arterioscler Thromb Vasc Biol 2002; 22(2):300-5.
46. Endres M, Laufs U, Huang Z, Nakamura T, Huang P, Moskowitz MA, Liao JK. Stroke protection by 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors mediated by endothelial nitric oxide synthase. Proc. Natl Acad. Sci USA 1998; 95(15):8880-5.
47. Szilvassy Z, Csont T, Pali T, Droy-Lefaix MT, Ferdinandy P. Nitric oxide, peroxynitrite and cGMP in atherosclerosis-induced hypertension in rabbits: benifecial effects of cicletanine, J of Vascular Research 2001; 38(1): 39-46.
48. Barua RS, Ambrose JA, Srivastava S, DeVoe MC, Eales-Reynolds LJ. Reactive oxygen species are involved in smoking-induced dysfunction of nitric oxide biosynthesis and upregulation of endothelial nitric oxide synthase: an in vitro demonstration in human coronary artery endothelial cells. Circulation 2003; 13, 107(18):2342-7.
49. Böger RH. The emerging role of asymmetric dimethylarginine as anovel cardiovascular risk factor, Cardiovascular research, 2003; 59. 824-833.
50. Ferretti G, Bacchetti T, Marotti E, Curatola G. Effect of homocystienylation on human high density lipoproteins: a correlation with paraoxo-nase activity. Metabolism 2003; 52 (2) pp. 146-151.
51. Stühlinger MC, Tsao PS, Her JH, Kimoto M, Balint RF, Cooke JP. Homocysteine impairs the nitric oxide synthase pathway role of asymmetric dimethylarginine, Circulation, 2001; 104: 2569-2575.
52. Shai M, Stampfer J, Ma JE, Manson SE, Hankison C, Cannussio J, Selhub G, Curhan Rimm EB. Homocysteine as a risk factor for coronary heart diseases and its association with inflammatory biomarkers, lipids and dietary factors. Atherosclerosis, 2004; 177 (2): 375-381.
53. Obeid R, Herrmann W. Homocysteine and lipids: S-adenosyl methionine as a key intermediate. FEBS Lett. 2009; 17,583(8):1215-25.
54. Signorello MG, Segantin A, Passalacqua M, Leoncini G. Homocysteine decreases platelet NO level via protein kinase C activation. Nitric Oxide 2009; 20(2):104-13.
55. Fogari R, Preti P, Zoppi A, Lazzari P, Corradi L, Fogari E, Ciccarelli L, Derosa G. Effects of amlodipine-atorvastatin combination on inflammation markers and insulin sensitivity in normocholesterolemic obese hypertensive patients. Eur J Clin Pharmacol 2006; 62:817-22.
56. Rajamannan NM, Sabramaniam M, Stock SR, Stone NJ, Springett M, Ignatiev KI, McConnel JP, Singh RJ, Bonow RO, Spelsberg TC. Atorvastatin inhibits calcification and enhances nitric oxide synthase production in the hypercholesterolemic aortic valve. Heart, 2005; 91(6): 806-810.
57. Broadhurst CL, Polansky MM, Anderson RA. Insulin like biological activity of culinary and medicinal plant aqueous extracts in vitro. J Agric Food Chem 2000; 48:849-852.
58. Tyagi N Gillespie W, Vacek JC, Sen U, Tyagi SC, Lominadze D. Activation of GABA-A receptor ameliorates homocysteine-induced MMP-9 activation by ERK pathway. J Cell Physiol 2009; 220(1):257-66.
59. Vizzardi E, Bonadei I, Zanini G, Frattini S, Fiorina C, Raddino R, Dei Cas L. Homocysteine and heart failure: an overview. Recent Pat Cardiovasc Drug Discov. 2009; 4(1):15-21.