Brugada syndrome: Insights of ST elevation, arrhythmogenicity, and risk stratification from experimental observations

Heart Rhythm

Volumn 6, Issue 11 SUPPL., 2009, Pages

  Morita, Hiroshi ^a,b   Zipes, Douglas P ^a   Wu, Jiashin ^c  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b OKAYAMA UNIVERSITY   (Japan)

^c UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

Action potential; Brugada syndrome; Fragmented QRS; Heterogeneity; Right ventricular outflow tract; T wave alternans; Temperature sensitivity; Ventricular tachycardia

Indexed keywords

BETA CAROTENE; CALCIUM CHANNEL; CITROXANTHIN; DRUG DERIVATIVE; SODIUM CHANNEL;

ANIMAL; BODY TEMPERATURE; BRUGADA SYNDROME; ELECTROCARDIOGRAPHY; GENETICS; HEART ARRHYTHMIA; HEART FUNCTION TEST; HEART MUSCLE CONDUCTION SYSTEM; HEART VENTRICLE; HUMAN; PATHOPHYSIOLOGY; PHYSIOLOGY; REVIEW; RISK ASSESSMENT;

ANIMALS; ARRHYTHMIAS, CARDIAC; BETA CAROTENE; BODY TEMPERATURE; BRUGADA SYNDROME; CALCIUM CHANNELS; ELECTROCARDIOGRAPHY; ELECTROPHYSIOLOGIC TECHNIQUES, CARDIAC; HEART CONDUCTION SYSTEM; HEART VENTRICLES; HUMANS; RISK ASSESSMENT; SODIUM CHANNELS;

EID: 74549188843     PISSN: 15475271     EISSN: 15563871     Source Type: Journal    
DOI: 10.1016/j.hrthm.2009.07.018     Document Type: Conference Paper

References (59)

1. Antzelevitch C, Brugada P, Borggrefe M, et al. Brugada syndrome: report of the second consensus conference. Heart Rhythm 2005;2:429-440.
2. Keller DI, Huang H, Zhao J, et al. A novel SCN5A mutation, F1344S, identified in a patient with Brugada syndrome and fever-induced ventricular fibrillation. Cardiovasc Res 2006;70:521-529.
3. Morita H, Morita ST, Nagase S, et al. Ventricular arrhythmia induced by sodium channel blocker in patients with Brugada syndrome. J Am Coll Cardiol 2003; 42:1624-1631.
4. Matsuo K, Kurita T, Inagaki M, et al. The circadian pattern of the development of ventricular fibrillation in patients with Brugada syndrome. Eur Heart J 1999;20:465-470.
5. Noda T, Shimizu W, Taguchi A, et al. ST-segment elevation and ventricular fibrillation without coronary spasm by intracoronary injection of acetylcholine and/or ergonovine maleate in patients with Brugada syndrome. J Am Coll Cardiol 2002;40:1841-1847.
6. Takigawa M, Noda T, Shimizu W, et al. Seasonal and circadian distributions of ventricular fibrillation in patients with Brugada syndrome. Heart Rhythm 2008; 5:1523-1527.
7. Morita H, Fukushima-Kusano K, Nagase S, et al. Site-specific arrhythmogenesis in patients with Brugada syndrome. J Cardiovasc Electrophysiol 2003;14:373-379.
8. Brugada J, Brugada R, Antzelevitch C, Towbin J, Nademanee K, Brugada P. Long-term follow-up of individuals with the electrocardiographic pattern of right bundle-branch block and ST-segment elevation in precordial leads V1 to V3. Circulation 2002;105:73-78.
9. Priori SG, Napolitano C, Gasparini M, et al. Natural history of Brugada syndrome: insights for risk stratification and management. Circulation 2002;105: 1342-1347.
10. Fish JM, Antzelevitch C. Role of sodium and calcium channel block in unmasking the Brugada syndrome. Heart Rhythm 2004;1:210-217.
11. Aiba T, Shimizu W, Hidaka I, et al. Cellular basis for trigger and maintenance of ventricular fibrillation in the Brugada syndrome model: high-resolution optical mapping study. J Am Coll Cardiol 2006;47:2074-2085.
12. Morita H, Zipes DP, Lopshire J, Morita ST, Wu J. T wave alternans in an in vitro canine tissue model of Brugada syndrome. Am J Physiol Heart Circ Physiol 2006;291:H421-428.
13. Morita H, Zipes DP, Morita ST, Wu J. Differences in arrhythmogenicity between the canine right ventricular outflow tract and anteroinferior right ventricle in a model of Brugada syndrome. Heart Rhythm 2007;4:66-74.
14. Morita H, Zipes DP, Morita ST, Wu J. Temperature modulation of ventricular arrhythmogenicity in a canine tissue model of Brugada syndrome. Heart Rhythm 2007;4:188-197.
15. Kurita T, Shimizu W, Inagaki M, et al. The electrophysiologic mechanism of ST-segment elevation in Brugada syndrome. J Am Coll Cardiol 2002;40:330-334.
16. Nagase S, Kusano KF, Morita H, et al. Longer repolarization in the epicardium at the right ventricular outflow tract causes type 1 ECG in patients with Brugada syndrome. J Am Coll Cardiol 2008;51:1154-1161.
17. Morita H, Zipes DP, Fukushima-Kusano K, et al. Repolarization heterogeneity in the right ventricular outflow tract: correlation with ventricular arrhythmias in Brugada patients and in an in vitro canine Brugada model. Heart Rhythm 2008;5:725-733.
18. Sah R, Ramirez RJ, Oudit GY, et al. Regulation of cardiac excitation-contraction coupling by action potential repolarization: role of the transient outward potassium current (I(to)). J Physiol 2003;546:5-18.
19. Calloe K, Cordeiro JM, Di Diego JM, et al. A transient outward potassium current activator recapitulates the electrocardiographic manifestations of Brugada syndrome. Cardiovasc Res 2009;81:686-694.
20. Boukens BJ, Christoffels VM, Coronel R, Moorman AF. Developmental basis for electrophysiological heterogeneity in the ventricular and outflow tract myocardium as a substrate for life-threatening ventricular arrhythmias. Circ Res 2009;104:19-31.
21. Hisamatsu K, Kusano KF, Morita H, et al. Relationships between depolarization abnormality and repolarization abnormality in patients with Brugada syndrome: using body surface signal-averaged electrocardiography and body surface maps. J Cardiovasc Electrophysiol 2004;15:870-876.
22. Di Diego JM. Cordeiro JM, Goodrow RJ, et al. Ionic and cellular basis for the predominance of the Brugada syndrome phenotype in males. Circulation 2002; 106:2004-2011.
23. van der Heyden MA, Wijnhoven TJ, Opthof T. Molecular aspects of adrenergic modulation of the transient outward current. Cardiovasc Res 2006;71:430-442.
24. Shimizu W, Matsuo K, Kokubo Y, et al. Sex hormone and gender difference- role of testosterone on male predominance in Brugada syndrome. J Cardiovasc Electrophysiol 2007;18:415-421.
25. Tan HL, Bezzina CR, Smits JP, Verkerk AO, Wilde AA. Genetic control of sodium channel function. Cardiovasc Res 2003;57:961-973.
26. Chen Q, Kirsch GE, Zhang D, et al. Genetic basis and molecular mechanism for idiopathic ventricular fibrillation. Nature 1998;392:293-296.
27. Wang Q, Shen J, Splawski I, et al. SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome. Cell 1995;80:805-811.
28. Grant AO, Carboni MP, Neplioueva V, et al. Long QT syndrome, Brugada syndrome, and conduction system disease are linked to a single sodium channel mutation. J Clin Invest 2002;110:1201-1209.
29. + current and causes inherited arrhythmias. Circulation 2007;116:2260-2268.
30. Watanabe H, Koopmann TT, Le Scouarnec S, et al. Sodium channel beta1 subunit mutations associated with Brugada syndrome and cardiac conduction disease in humans. J Clin Invest 2008;118:2260-2268.
31. Abriel H. Roles and regulation of the cardiac sodium channel Nav1.5: recent insights from experimental studies. Cardiovasc Res 2007;76:381-389.
32. Bezzina CR, Shimizu W, Yang P, et al. Common sodium channel promoter haplotype in Asian subjects underlies variability in cardiac conduction. Circulation 2006;113:338-344.
33. Antzelevitch C, Pollevick GD, Cordeiro JM, et al. Loss-of-function mutations in the cardiac calcium channel underlie a new clinical entity characterized by ST-segment elevation, short QT intervals, and sudden cardiac death. Circulation 2007;115:442-449.
34. Mohler PJ, Le Scouarnec S, Denjoy I, et al. Defining the cellular phenotype of "ankyrin-B syndrome" variants: human ANK2 variants associated with clinical phenotypes display a spectrum of activities in cardiomyocytes. Circulation 2007;115:432-441.
35. Verkerk AO, Wilders R, Schulze-Bahr E. Role of sequence variations in the human ether-a-go-go-related gene (HERG, KCNH2) in the Brugada syndrome. Cardiovasc Res 2005;68:441-453.
36. Barajas-Martinez H, Hu D, Burashnikov E, Antzelevitch C. Novel mutation in the KCNQ1 associated with Brugada syndrome. Circulation 2008;118:S332 (abstract).
37. Delpón E, Cordeiro JM, Núñez L, et al. Functional Effects of KCNE3 mutation and its role in the development of Brugada syndrome. Circ Arrhythm Electrophysiol 2008;1:209-218.
38. Yokokawa M, Noda T, Okamura H, et al. Comparison of long-term follow-up of electrocardiographic features in Brugada syndrome between the SCN5Apositive probands and the SCN5A-negative probands. Am J Cardiol 2007;100: 649-655.
39. Schwartz PJ, Priori SG, Spazzolini C, et al. Genotype-phenotype correlation in the long QT syndrome. Gene-specific triggers for life-threatening arrhythmias. Circulation 2001;103:89-95.
40. Smits JP, Eckardt L, Probst V, et al. Genotype-phenotype relationship in Brugada syndrome: electrocardiographic features differentiate SCN5A-related patients from non-SCN5A-related patients. J Am Coll Cardiol 2002; 40:350-356.
41. Morita H, Fukushima KK, Miura D, et al. Fragmented QRS as a marker of conduction abnormality and a predictor of prognosis of Brugada syndrome. Circulation 2008;118:1697-1704.
42. Morita H, Nagase S, Miura D, et al. Differential effects of cardiac sodium channel mutations on the initiation of ventricular arrhythmias in patients with Brugada syndrome. Heart Rhythm 2009;6:487-492.
43. 2+ channel current in rat ventricular myocytes by terfenadine. Circ Res 1997;81:202-210.
44. Nishizaki M, Sakurada H, Ashikaga T, et al. Effects of glucose-induced insulin secretion on ST segment elevation in the Brugada syndrome. J Cardiovasc Electrophysiol 2003;14:243-249.
45. Morita H, Zipes DP, Morita ST, Lopshire JC, Wu J. Epicardial ablation eliminates ventricular arrhythmias in an experimental model of Brugada syndrome. Heart Rhythm 2009;6:665-671.
46. Brugada P, Brugada J. Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome. J Am Coll Cardiol 1992;20:1391-1396.
47. Kanda M, Shimizu W, Matsuo K, et al. Electorophysiologic characteristics and implications of induced ventricular fibrillation in symptomatic patients with Brugada syndrome. J Am Coll Cardiol 2002;39:1799-1805.
48. Morita H, Takenaka-Morita S, Fukushima-Kusano K, et al. Risk stratification for asymptomatic patients with Brugada syndrome. Circ J 2003;67:312-316.
49. Nagase S, Kusano KF, Morita H, et al. Epicardial electrogram of the right ventricular outflow tract in patients with the Brugada syndrome: using the epicardial lead. J Am Coll Cardiol 2002;39:1992-1995.
50. Coronel R, Casini S, Koopmann TT, et al. Right ventricular fibrosis and conduction delay in a patient with clinical signs of Brugada syndrome: a combined electrophysiological, genetic, histopathologic, and computational study. Circulation 2005;112:2769-2777.
51. Schwartz PJ, Malliani A. Electrical alternation of the T wave. Clinical and experimental evidence of its relationship with the sympathetic nervous system and with the long QT syndrome. Am Heart J 1975;89:45-50.
52. Morita H, Jiashin Wu, Zipes DP. The QT syndrome: long and short. Lancet 2008;372:750-763.
53. Saura D, García-Alberola A, Carrillo P, Pascual D, Martínez-Sánchez J, Valdés M. Brugada-like electrocardiographic pattern induced by fever. Pacing Clin Electrophysiol 2002;25:856-859.
54. Wakita R, Watanabe I, Okumura Y, et al. Brugada-like electrocardiographic pattern unmasked by fever. Jpn Heart J 2004;45:163-167.
55. Mok NS, Priori SG, Napolitano C, Chan NY, Chahine M, Baroudi G. A newly characterized SCN5A mutation underlying Brugada syndrome unmasked by hyperthermia. J Cardiovasc Electrophysiol 2003;14:407-411.
56. Mori A, Kusano KF, Nagase S, Nakamura K, Morita H, Ohe T. Clinical impact of the hot-bath test in patients with Brugada syndrome. Circulation 2008;118: S674 (abstract).
57. Paul M, Gerss J, Schulze-Bahr E, et al. Role of programmed ventricular stimulation in patients with Brugada syndrome: a meta-analysis of worldwide published data. Eur Heart J 2007;28:2126-2133.
58. Castro Hevia J, Antzelevitch C, Tornes Barzaga F, et al. Tpeak-Tend and Tpeak-Tend dispersion as risk factors for ventricular tachycardia/ventricular fibrillation in patients with the Brugada syndrome. J Am Coll Cardiol 2006;47: 1828-1834.
59. Takagi M, Yokoyama Y, Aonuma K, et al. Clinical characteristics and risk stratification in symptomatic and asymptomatic patients with Brugada syndrome: multicenter study in Japan. J Cardiovasc Electrophysiol 2007;18:1244-1251.