The immunologic basis for gastrointestinal food allergy

Current Opinion in Gastroenterology

Volumn 25, Issue 6, 2009, Pages 521-526

  MacDonald, Thomas T ^a   Di Sabatino, Antonio ^b  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b UNIVERSITY OF PAVIA   (Italy)

Author keywords

Oral tolerance; Regulatory T cell; Weaning

Indexed keywords

ALLERGEN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN E; PREBIOTIC AGENT; PROBIOTIC AGENT;

CLINICAL TRIAL; DESENSITIZATION; EXPOSURE; FOOD ALLERGY; FOOD INTAKE; HUMAN; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; IMMUNOPATHOLOGY; IMMUNOTHERAPY; MILK; PATHOPHYSIOLOGY; REGULATORY T LYMPHOCYTE; REVIEW; SENSITIZATION;

ADULT; ALLERGENS; ANAPHYLAXIS; CHILD; DESENSITIZATION, IMMUNOLOGIC; FOOD HYPERSENSITIVITY; GASTROINTESTINAL TRACT; HUMANS; PREBIOTICS; PROBIOTICS; T-LYMPHOCYTES; TIME FACTORS;

EID: 74549182232     PISSN: 02671379     EISSN: None     Source Type: Journal    
DOI: 10.1097/MOG.0b013e3283306236     Document Type: Review

References (46)

1. Scott H, Rognum TO, Midtvedt T, Brandtzaeg P. Age-related changes of human serum antibodies to dietary and colonic bacterial antigens measured by an enzyme-linked immunosorbent assay. Acta Pathol Microbiol Immunol Scand C 1985; 93:65-70.
2. Nagata S, McKenzie C, Pender SLF, et al. Human Peyer's patch T cells are sensitised to dietary antigen and display a T helper cell type 1 cytokine profile. J Immunol 2000; 165:5315-5321.
3. Latcham F, Merino F, Lang A, et al. A consistent pattern of minor immunodeficiency and subtle enteropathy in children with multiple food allergy. J Pediatr 2003; 143:39-47.
4. DeBrosse CW, Rothenberg ME. Allergy and eosinophil-associated gastrointestinal disorders (EGID). Curr Opin Immunol 2008; 20:703-708.
5. Markowitz JE, Spergel JM, Ruchelli E, Liacouras CA. Elemental diet is an effective treatment for eosinophilic esophagitis in children and adolescents. Am J Gastroenterol 2003; 98:777-782.
6. Iacono G, Ravelli A, Di Prima L, et al. Colonic lymphoid nodular hyperplasia in children: relationship to food hypersensitivity. Clin Gastroenterol Hepatol 2007; 5:361-366.
7. Janzi M, Kull I, Sjóberg R, et al. Selective IgA deficiency in early life: association to infections and allergic diseases during childhood. Clin Immunol 2009 [Epub ahead of print].
8. Zitnik SE, Rüschendorf F, Mü ller S, et al. IL13 variants are associated with total serum IgE and early sensitization to food allergens in children with atopic dermatitis. Pediatr Allergy Immunol 2009 [Epub ahead of print].
9. O'Regan GM, Sandilands A, McLean WH, et al. Filaggrin in atopic dermatitis. J Allergy Clin Immunol 2008; 122:689-693.
10. Marenholz I, Kerscher T, Bauerfeind A, et al. An interaction between filaggrin mutations and early food sensitization improves the prediction of childhood asthma. J Allergy Clin Immunol 2009; 123:911-916.
11. Lack G, Fox D, Northstone K, et al. Factors associated with the development of peanut allergy. N Engl J Med 2003; 348:977-985.
12. Greer FR, Sicherer SH, Burks AW. American Academy of Pediatrics Committee on Nutrition; American Academy of Pediatrics Section on Allergy and Immunology, Effects of early nutritional interventions on the development of atopic disease in infants and children: the role of maternal dietary restriction, breastfeeding, timing of introduction of complementary foods, and hydrolyzed formulas. Pediatrics 2008; 121:183-191.
13. Mihrshahi S, Ampon R, Webb K, et al. The association between infant feeding practices and subsequent atopy among children with a family history of asthma. Clin Exp Allergy 2007; 37:671-679.
14. Filipiak B, Zutavern A, Koletzko S, et al. Solid food introduction in relation to eczema: results from a four-year prospective birth cohort study. J Pediatr 2007; 151:352-358.
15. Zutavern A, Brockow I, Schaaf B, et al. Timing of solid food introduction in relation to eczema, asthma, allergic rhinitis, and food and inhalant sensitization at the age of 6 years: results from the prospective birth cohort study LISA. Pediatrics 2008; 121:44-52.
16. Snijders BE, Thijs C, van Ree R, van den Brandt PA. Age at first introduction of cow milk products and other food products in relation to infant atopic manifestations in the first 2 years of life: the KOALA Birth Cohort Study. Pediatrics 2008; 122:115-122.
17. Venter C, Pereira B, Voigt K, et al. Factors associated with maternal dietary intake, feeding and weaning practices, and the development of food hypersensitivity in the infant. Pediatr Allergy Immunol 2009; 20:320-327.
18. Fox TA, Sasieni P, du Toit G, et al. Household peanut consumption as a risk factor for the development of peanut allergy. J Allergy and Clin Immunol 2009; 122:417-423.
19. Du Toit G, Katz Y, Sasieni P, et al. Early consumption of peanuts in infancy is associated with a low prevalence of peanut allergy. J Allergy and Clin Immunol 2008; 122:984-991. A very interesting study in which it is suggested that the low incidence of peanut allergy in Israel may be due to oral tolerance elicited by the early introduction into the infant diet.
20. Prescott SL, Smith P, Tang M, et al. The importance of early complementary feeding in the development of oral tolerance: concerns and controversies. Pediatr Allergy Immunol 2008; 19:375-380. An excellent brief review on why current infant feeding practices may be increasing rather than decreasing atopy. This study suggests that there may be a critical window between 4 and 6 months when tolerance can be achieved.
21. Ozcan E, Notarangelo LD, Geha RD. Primary immune deficiencies with aberrant IgE production. J Allergy Clin Immunol 2008; 122:1054-1062.
22. + regulatory T cells in children who have outgrown cow's milk allergy. J Exp Med 2004; 199:1679-1688.
23. +)CD127(lo/-) regulatory T cell function. J Allergy Clin Immunol 2008; 121:1460-1466.
24. Shreffler WG, Wanich N, Moloney M, et al., Association of allergenspecific regulatory T cells with the onset of clinical tolerance to milk protein. J Allergy and Clin Immunol. 2009, 123:43-52. An in-vitro study, which suggests that having higher number of Tregs is a favorable prognostic indicator for mild food allergy and recovery.
25. Nowak-Wegrzyn A, Bloom KA, Sicherer SH, et al. Tolerance to extensively heated milk in children with cow's milk allergy. J Allergy Clin Immunol 2008; 122:342-347.
26. Meglio P, Bartone E, Plantamura M, et al. A protocol for oral desensitization in children with IgE-mediated cow's milk allergy. Allergy 2004; 59:980-987.
27. Meglio P, Giampietro PG, Gianni S, Galli E. Oral desensitization in children with immunoglobulin E-mediated cow's milk allergy: follow-up at 4 yr and 8 months. Pediatr Allergy Immunol 2008; 19:412-419.
28. Longo G, Barbi E, Berti I, et al. Specific oral tolerance induction in children with very severe cow's milk-induced reactions. J Allergy Clin Immunol 2008; 121:343-347. An interesting study in which feeding graded doses of cows milk induced tolerance in 36% of cow's milk allergic children.
29. Skripak JM, Nash SD, Rowley H, et al. A randomized, double-blind, placebocontrolled study of milk oral immunotherapy for cow's milk allergy. J Allergy and Clin Immunol 2008; 122:1154-1160. A small study of 20 cows milk allergic children, two-thirds of whom underwent oral tolerization to cow's milk. The protocol allowed children to tolerate a much higher amount of cow's milk.
30. Fernández-Rivas M, Garrido Fernández S, Nadal JA, et al. Randomized double-blind, placebo-controlled trial of sublingual immunotherapy with a Pru p 3 quantified peach extract. Allergy 2009; 64:876-883.
31. Buchanan AD, Green TD, Jones SM, et al. Egg oral immunotherapy in nonanaphylactic children with egg allergy. J Allergy Clin Immunol 2007; 119:199-205.
32. Burks AW, Jones SM. Egg oral immunotherapy in nonanaphylactic children with egg allergy: follow-up. J Allergy Clin Immunol 2008; 121:270-271.
33. Kalliomá ki M, Salminen S, Arvilommi H, et al. Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial. Lancet 2001; 357: 1076-1079.
34. Osborn DA, Sinn JKH. Probiotics in infants for prevention of allergic disease and food hypersensitivity. Cochrane Database Syst Rev 2007: CD006475. A meta-analysis of the ability of probiotics to prevent eczema in children which is not supportive of the general notion.
35. Boyle RJ, Bath-Hextall BJ, Leonardi-Bee J, et al. Prebiotics for treating eczema. Cochrane Database Syst Rev 2009:CD006135.
36. Arslanoglu S, Moro GE, Schmitt J, et al. Early dietary intervention with a mixture of prebiotic oligosaccharides reduces the incidence of allergic manifestations and infections during the first two years of life. J Nutr 2008; 138:1091-1095. A study which claims that feeding prebiotics to infants reduces allergies.
37. Ozbek OY, Ozcay F, Avci Z, et al. Food allergy after liver transplantation in children: a prospective study. Pediatr Allergy Immunol 2009 [Epub ahead of print].
38. Arikan C, Kilic M, Tokat Y, Aydogdu SL. Allergic disease after pediatric liver transplantation with systemic tacrolimus and cyclosporine a therapy. Transplant Proc 2003; 35:3039-3041.
39. Levy Y, Davidovits M, Cleper R, Shapiro R. New-onset posttransplantation food allergy in children: is it attributable only to the immunosuppressive protocol? Pediatr Transplant 2009; 13:63-69.
40. + T cells for IgE response to a dietary antigen develop in the liver. J Allergy Clin Immnuol 2003; 111:375-1385.
41. Skripak JM, Wood RA. Mammalian milk allergy: avoidance strategies and oral desensitization. Curr Opin Allergy Clin Immunol 2009; 9:259-264.
42. Skripak JM, Sampson HA. Towards a cure for food allergy. Immunol 2008; 20:690-696. A good review that puts forward the notion that food allergies may be a treatable condition other than by allergen avoidance.
43. Haahtela T, von Hertzen L, Má kelá M, Hannuksela M, Allergy Programme Working Group. Finnish Allergy Programme 2008-2018: time to act and change the course. Allergy 2008; 63:634-645. Description of the massive effort ongoing in Finland to reduce allergies.
44. Eigenmann PA, Beyer K, Wesley Burks A, et al. An iPAC summary and future trends. Pediatr Allergy Immunol 2008; 19:26-39.
45. Kummeling I, Mills EN, Clausen M, et al. The EuroPrevail surveys on the prevalence of food allergies in children and adults: background and study methodology. Allergy 2009 [Epub ahead of print].
46. Riffelmann F. Anti IgE therapy (off label use) in severe peanut allergy with recurrent anaphylaxis. Pneumologie 2008; 62:337-339.