Quantitative analysis of simvastatin and its β-hydroxy acid in human plasma using automated liquid-liquid extraction based on 96-well plate format and liquid chromatography-tandem mass spectrometry

Journal of Pharmaceutical and Biomedical Analysis

Volumn 34, Issue 1, 2004, Pages 175-187

  Zhang, Nanyan ^a   Yang, Amy ^a   Rogers, John Douglas ^a   Zhao, Jamie J ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Automated liquid liquid extraction; Human plasma; Liquid chromatography tandem mass spectrometry; Simvastatin

Indexed keywords

BETA HYDROXYACID; HYDROXYACID; ISOTOPE; SIMVASTATIN; SOLVENT; UNCLASSIFIED DRUG;

ACCURACY; ARTICLE; AUTOANALYSIS; AUTOMATION; CALIBRATION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; HUMAN; ISOTOPE LABELING; LIQUID; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; PRIORITY JOURNAL; QUALITY CONTROL; QUANTITATIVE ANALYSIS; REPRODUCIBILITY; SAMPLE; SEPARATION TECHNIQUE; SPIKE; STANDARD; TANDEM MASS SPECTROMETRY; TIME; VALIDATION PROCESS;

EID: 1642452675     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.japna.2003.08.016     Document Type: Article

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