Association analyses suggest multiple interaction effects of the methylenetetrahydrofolate reductase polymorphisms on timing of menarche and natural menopause in white women

Menopause

Volumn 17, Issue 1, 2010, Pages 185-190

  Liu, Pengyuan ^a   Lu, Yan ^a   Recker, Robert R ^b   Deng, Hong Wen ^c   Dvornyk, Volodymyr ^d  

^a WASHINGTON UNIVERSITY   (United States)

^b CREIGHTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF MISSOURI KANSAS CITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Age at menarche; Age at natural menopause; Association; Haplotypes; MTHFR; Polymorphisms

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2);

ADULT; ARTICLE; BREAST FEEDING; CAUCASIAN; ENZYME POLYMORPHISM; FEMALE; HAPLOTYPE; HUMAN; LIFESTYLE; MENARCHE; MENOPAUSE; SINGLE NUCLEOTIDE POLYMORPHISM;

AGING; BREAST FEEDING; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; HAPLOTYPES; HUMANS; MENARCHE; MENOPAUSE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 74549152666     PISSN: 10723714     EISSN: None     Source Type: Journal    
DOI: 10.1097/gme.0b013e3181aa2597     Document Type: Article

References (83)

1. Xu WH, Xiang YB, Ruan ZX, et al. Menstrual and reproductive factors and endometrial cancer risk: results from a population-based case-control study in urban Shanghai. Int J Cancer 2004;108:613-619.
2. Hsieh CC, Trichopoulos D, Katsouyanni K, Yuasa S. Age at menarche, age at menopause, height and obesity as risk factors for breast cancer: associations and interactions in an international case-control study. Int J Cancer 1990;46:796-800.
3. Petridou E, Syrigou E, Toupadaki N, Zavitsanos X, Willett W, Trichopoulos D. Determinants of age at menarche as early life predictors of breast cancer risk. Int J Cancer 1996;68:193-198.
4. Jordan SJ, Webb PM, Green AC. Height, age at menarche, and risk of epithelial ovarian cancer. Cancer Epidemiol Biomarkers Prev 2005; 14:2045-2048.
5. Chiaffarino F, Pelucchi C, Parazzini F, et al. Reproductive and hormonal factors and ovarian cancer. Ann Oncol 2001;12:337-341.
6. Harlow BL, Cohen LS, Otto MW, Spiegelman D, Cramer DW. Early life menstrual characteristics and pregnancy experiences among women with and without major depression: the Harvard study of moods and cycles. J Affect Disord 2004;79:167-176.
7. Laitinen J, Power C, Jarvelin MR. Family social class, maternal body mass index, childhood body mass index, and age at menarche as predictors of adult obesity. Am J Clin Nutr 2001;74:287-294.
8. Wang W, Zhao LJ, Liu YZ, Recker RR, Deng HW. Genetic and environmental correlations between obesity phenotypes and age at menarche. Int J Obes 2006;30:1595-1600.
9. Gerdhem P, Obrant KJ. Bone mineral density in old age: the influence of age at menarche and menopause. J Bone Miner Metab 2004;22:372-375.
10. Ito M, Yamada M, Hayashi K, Ohki M, Uetani M, Nakamura T. Relation of early menarche to high bone mineral density. Calcif Tissue Int 1995;57:11-14.
11. Rudra CL, Williams MA. BMI as a modifying factor in the relations between age at menarche, menstrual cycle characteristics, and risk of preeclampsia. Gynecol Endocrinol 2005;21:200-205.
12. Harlow BL, Signorello LB. Factors associated with early menopause. Maturitas 2000;35:3-9.
13. Kritz-Silverstein D, Barrett-Connor E. Early menopause, number of reproductive years, and bone mineral density in postmenopausal women. Am J Public Health 1993;83:983-988.
14. Jacobsen BK, Knutsen SF, Fraser GE. Age at natural menopause and total mortality and mortality from ischemic heart disease: the Adventist Health Study. J Clin Epidemiol 1999;52:303-307.
15. Cramer DW. Epidemiologic aspects of early menopause and ovarian cancer. Ann N Y Acad Sci 1990;592:363-375.
16. Schildkraut JM, Cooper GS, Halabi S, Calingaert B, Hartge P, Whittemore AS. Age at natural menopause and the risk of epithelial ovarian cancer. Obstet Gynecol 2001;98:85-90.
17. Velie EM, Nechuta S, Osuch JR. Lifetime reproductive and anthro-pometric risk factors for breast cancer in postmenopausal women. Breast Dis 2005;24:17-35.
18. Purdie DM, Green AC. Epidemiology of endometrial cancer. Best Pract Res Clin Obstet Gynaecol 2001;15:341-354.
19. Guo Y, Zhao LJ, Shen H, Guo Y, Deng HW. Genetic and environmental correlations between age at menarche and bone mineral density at different skeletal sites. Calcif Tissue Int 2005;77:356-360.
20. Loesch DZ, Huggins R, Rogucka E, Hoang NH, Hopper JL. Genetic correlates of menarcheal age: a multivariate twin study. Ann Hum Biol 1995;22:470-490.
21. de Bruin JP, Bovenhuis H, van Noord PA, et al. The role of genetic factors in age at natural menopause. Hum Reprod 2001;16:2014-2018.
22. Snieder H, MacGregor AJ, Spector TD. Genes control the cessation of a woman's reproductive life: a twin study of hysterectomy and age at menopause. J Clin Endocrinol Metab 1998;83:1875-1880.
23. Sharma K. Genetic basis of human female pelvic morphology: a twin study. Am J Phys Anthropol 2002;117:327-333.
24. van den Akker OB, Stein GS, Neale MC, Murray RM. Genetic and environmental variation in menstrual cycle: histories of two British twin samples. Acta Genet Med Gemellol (Roma) 1987;36:541-548.
25. Murabito JM, Yang Q, Fox C, Wilson PW, Cupples LA. Heritability of age at natural menopause in the Framingham Heart Study. Obstet Gynecol Surv 2005;60:656-657.
26. Dvornyk V, Liu Y, Lu Y, et al. Effect of menopause on gene expression profiles of circulating monocytes: a pilot in vivo microarray study. J Genet Genomics 2007;34:974-983.
27. Guo Y, Shen H, Xiao P, et al. Genomewide linkage scan for quantitative trait loci underlying variation in age at menarche. J Clin Endocrinol Metab 2006;91:1009-1014. (Pubitemid 43357773)
28. Murabito JM, Yang Q, Fox CS, Cupples LA. Genome-wide linkage analysis to age at natural menopause in a community-based sample: the Framingham Heart Study. Fertil Steril 2005;84:1674-1679. (Pubitemid 41785662)
29. Pan F, Xiao P, Guo Y, et al. Chromosomal regions 22q13 and 3p25 may harbor quantitative trait loci influencing both age at menarche and bone mineral density. Hum Genet 2008;123:419-427.
30. Sibani S, Christensen B, O'Ferrall E, et al. Characterization of six novel mutations in the methylenetetrahydrofolate reductase (MTHFR) gene in patients with homocystinuria. Hum Mutat 2000;15:280-287.
31. Hak AE, Polderman KH, Westendorp IC, et al. Increased plasma homocysteine after menopause. Atherosclerosis 2000;149:163-168.
32. Tallova J, Tomandl J, Bicikova M, Hill M. Changes of plasma total homocysteine levels during the menstrual cycle. Eur J Clin Invest 1999; 29:1041-1044.
33. Tallova J, Bicikova M, Hill M, Tomandl J, Valentova D. Homocysteine during the menstrual cycle in depressive women. Eur J Clin Invest 2003; 33:268-273.
34. Somekawa Y, Kobayashi K, Tomura S, Aso T, Hamaguchi H. Effects of hormone replacement therapy and methylenetetrahydrofolate reductase polymorphism on plasma folate and homocysteine levels in postmeno-pausal Japanese women. Fertil Steril 2002;77:481-486.
35. Weisberg IS, Jacques PF, Selhub J, et al. The 1298AYC polymorphism in methylenetetrahydrofolate reductase (MTHFR): in vitro expression and association with homocysteine. Atherosclerosis 2001; 156:409-415.
36. Kim YI. Folate, colorectal carcinogenesis, and DNA methylation: lessons from animal studies. Environ Mol Mutagen 2004;44:10-25.
37. Rao GG, Kurien A, Gossett D, Griffith WF, Coleman RL, Muller CY. A case-control study of methylenetetrahydrofolate reductase polymorphisms in cervical carcinogenesis. Gynecol Oncol 2006;101:250-254.
38. Piyathilake CJ, Macaluso M, Johanning GL, Whiteside M, Heimburger DC, Giuliano A. Methylenetetrahydrofolate reductase (MTHFR) polymorphism increases the risk of cervical intraepithelial neoplasia. Anticancer Res 2000;20:1751-1757.
39. Gershoni-Baruch R, Dagan E, Israeli D, Kasinetz L, Kadouri E, Friedman E. Association of the C677T polymorphism in the MTHFR gene with breast and/or ovarian cancer risk in Jewish women. Eur J Cancer 2000;36:2313-2316.
40. Lin WY, Chou YC, Wu MH, et al. The MTHFR C677T polymorphism, estrogen exposure and breast cancer risk: a nested case-control study in Taiwan. Anticancer Res 2004;24:3863-3868.
41. Xu WH, Shrubsole MJ, Xiang YB, et al. Dietary folate intake, MTHFR genetic polymorphisms, and the risk of endometrial cancer among Chinese women. Cancer Epidemiol Biomarkers Prev 2007;16: 281-287.
42. Esteller M, Garcia A, Martinez-Palones JM, Xercavins J, Reventos J. Germ line polymorphisms in cytochrome-P450 1A1 (C4887 CYP1A1) and methylenetetrahydrofolate reductase (MTHFR) genes and endome-trial cancer susceptibility. Carcinogenesis 1997;18:2307-2311.
43. Hong X, Hsu YH, Terwedow H, et al. Association of the methylenetet-rahydrofolate reductase C677T polymorphism and fracture risk in Chinese postmenopausal women. Bone 2007;40:737-742.
44. Abrahamsen B, Madsen JS, Tofteng CL, et al. A common methylenetet- rahydrofolate reductase (C677T) polymorphism is associated with low bone mineral density and increased fracture incidence after menopause: longitudinal data from the Danish osteoporosis prevention study. J Bone Miner Res 2003;18:723-729.
45. Dvornyk V, Long JR, Liu PY, et al. Predictive factors for age at menopause in Caucasian females. Maturitas 2006;54:19-26.
46. Long JR, Liu PY, Zhang YY, et al. Interaction effects between estrogen receptor > gene, vitamin D receptor gene, age, and sex on bone mineral density in Chinese. J Hum Genet 2003;48:514-519.
47. Deng HW, Xu FH, Liu YZ, et al. A whole-genome linkage scan suggests several genomic regions potentially containing QTLs underlying the variation of stature. Am J Med Genet 2002;113:29-39.
48. O'Connell JR, Weeks DE. PedCheck: a program for identification of genotype incompatibilities in linkage analysis. Am J Hum Genet 1998;63:259-266.
49. Purcell S, Neale B, Todd-Brown K, et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 2007;81:559-575.
50. Dvornyk V, Long JR, Liu PY, et al. Polymorphisms of the vitamin D receptor gene predict the onset of surgical menopause in Caucasian females. Gynecol Endocrinol 2006;22:552-556.
51. Iqbal MP, Frossard PM. Methylene tetrahydrofolate reductase gene and coronary artery disease. J Pak Med Assoc 2003;53:33-36.
52. Lin D, Li H, Tan W, Miao X, Wang L. Genetic polymorphisms in folate-metabolizing enzymes and risk of gastroesophageal cancers: a potential nutrient-gene interaction in cancer development. Forum Nutr 2007;60:140-145.
53. Schwahn B, Rozen R. Polymorphisms in the methylenetetrahydro-folate reductase gene: clinical consequences. Am J Pharmacogenomics 2001;1:189-201.
54. Frosst P, Blom HJ, Milos R, et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 1995;10:111-113.
55. Chatzikyriakidou A, Vakalis KV, Kolaitis N, et al. Distinct association of SLC19A1 polymorphism j43T9C with red cell folate levels and of MTHFR polymorphism 677C9T with plasma folate levels. Clin Biochem 2008;41:174-176.
56. Miyao M, Morita H, Hosoi T, et al. Association of methylenetetrahy- drofolate reductase (MTHFR) polymorphism with bone mineral density in postmenopausal Japanese women. Calcif Tissue Int 2000;66: 190-194. (Pubitemid 30091759)
57. Bi XH, Zhao HL, Zhang ZX, Zhang JW. Association of RFC1 A80G and MTHFR C677T polymorphisms with Alzheimer's disease [published online ahead of print February 5, 2008]. Neurobiol Aging. doi: 10.10161j. neurobiolaging.2007.12.010.
58. Gambacciani M, Mannella P. Homocysteine, menopause and cardiovascular disease. Menopause Int 2007;13:23-26.
59. Marchesoni D, Driul L, Plaino L, Villani MT, Becagli L, Mozzanega B. Menopause rather than estrogen modifies plasma homocysteine levels. Int J Gynaecol Obstet 2003;81:293-297.
60. Russo GT, Di BA, Alessi E, et al. Menopause modulates homocysteine levels in diabetic and non-diabetic women. J Endocrinol Invest 2008;31: 546-551.
61. Ebisch IM, Thomas CM, Peters WH, Braat DD, Steegers-Theunissen RP. The importance of folate, zinc and antioxidants in the pathogenesis and prevention of subfertility. Hum Reprod Update 2007;13:163-174.
62. Forges T, Monnier-Barbarino P, Alberto JM, Gueant-Rodriguez RM, Daval JL, Gueant JL. Impact of folate and homocysteine metabolism on human reproductive health. Hum Reprod Update 2007;13:225-238.
63. O'Callaghan P, Meleady R, Fitzgerald T, Graham I. Smoking and plasma homocysteine. Eur Heart J 2002;23:1580-1586.
64. Sakuta H, Suzuki T. Alcohol consumption and plasma homocysteine. Alcohol 2005;37:73-77.
65. Ramlau-Hansen CH, Moller UK, Moller J, Thulstrup AM. AmningVen risikofaktor for forhojet plasma-homocystein? [LactationVa risk factor for elevated plasma homocysteine?]. Ugeskr Laeger 2003;165: 2819-2823.
66. Milman N, Byg KE, Hvas AM, Bergholt T, Eriksen L. Erythrocyte folate, plasma folate and plasma homocysteine during normal pregnancy and postpartum: a longitudinal study comprising 404 Danish women. Eur J Haematol 2006;76:200-205.
67. Chiuve SE, Giovannucci EL, Hankinson SE, et al. Alcohol intake and methylenetetrahydrofolate reductase polymorphism modify the relation of folate intake to plasma homocysteine. Am J Clin Nutr 2005;82: 155-162.
68. Eastell R. Role of oestrogen in the regulation of bone turnover at the menarche. J Endocrinol 2005;185:223-234. (Pubitemid 40691789)
69. Zhang ZX, Lei SF, Deng FY, et al. Bivariate genome-wide linkage analysis for traits BMD and AAM: effect of menopause on linkage signals. Maturitas 2009;62:16-20.
70. He LN, Xiong DH, Liu YJ, Zhang F, Recker RR, Deng HW. Association study of the oestrogen signalling pathway genes in relation to age at natural menopause. J Genet 2007;86:269-276.
71. Long JR, Xu H, Zhao LJ, et al. The oestrogen receptor a gene is linked and/or associated with age of menarche in different ethnic groups. J Med Genet 2005;42:796-800.
72. Yang F, Xiong DH, Guo Y, et al. The chemokine (C-C-motif) receptor 3 (CCR3) gene is linked and associated with age at menarche in Caucasian females. Hum Genet 2007;121:35-42. (Pubitemid 46421138)
73. Zhang F, Xiong DH, Wang W, et al. HDC gene polymorphisms are associated with age at natural menopause in Caucasian women. Biochem Biophys Res Commun 2006;348:1378-1382.
74. Abrahamsen B, Madsen JS, Tofteng CL, et al. Are effects of MTHFR (C677T) genotype on BMD confined to women with low folate and riboflavin intake? Analysis of food records from the Danish osteoporosis prevention study. Bone 2005;36:577-583.
75. Reynolds RF, Obermeyer CM. Correlates of the age at natural menopause in Morocco. Ann Hum Biol 2003;30:97-108.
76. Parazzini F. Determinants of age at menopause in women attending menopause clinics in Italy. Maturitas 2007;56:280-287.
77. van Noord PA, Dubas JS, Dorland M, Boersma H, te Velde ER. Age at natural menopause in a population-based screening cohort: the role of menarche, fecundity, and lifestyle factors. Fertil Steril 1997;68:95-102.
78. Anderson CA, Zhu G, Falchi M, et al. A genome-wide linkage scan for age at menarche in three populations of European descent. J Clin Endocrinol Metab 2008;93:3965-3970.
79. Rothenbuhler A, Fradin D, Heath S, et al. Weight-adjusted genome scan analysis for mapping quantitative trait loci for menarchal age. J Clin Endocrinol Metab 2006;91:3534-3537.
80. van Asselt KM, Kok HS, Putter H, et al. Linkage analysis of extremely discordant and concordant sibling pairs identifies quantitative trait loci influencing variation in human menopausal age. Am J Hum Genet 2004; 74:444-453.
81. Mitchell ES, Farin FM, Stapleton PL, et al. Association of estrogen-related polymorphisms with age at menarche, age at final menstrual period, and stages of the menopausal transition. Menopause 2008;15:105-111.
82. Stavrou I, Zois C, Ioannidis JP, Tsatsoulis A. Association of polymorphisms of the oestrogen receptor a gene with the age of menarche. Hum Reprod 2002;17:1101-1105.
83. Weel AE, Uitterlinden AG, Westendorp IC, et al. Estrogen receptor polymorphism predicts the onset of natural and surgical menopause. J Clin Endocrinol Metab 1999;84:3146-3150.