Interaction effects between estrogen receptor α gene, vitamin D receptor gene, age, and sex on bone mineral density in Chinese

Journal of Human Genetics

Volumn 48, Issue 10, 2003, Pages 514-519

  Long, Jirong ^a,b   Liu, Pengyuan ^b   Zhang, Yuanyuan ^b   Shen, Hui ^b   Liu, Yongjun ^b   Dvornyk, Volodymyr ^b   Deng, Hong Wen ^a,b  

^a HUNAN NORMAL UNIVERSITY   (China)

^b CREIGHTON UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Age; Bone mineral density (BMD); ER gene; Interaction; Sex; VDR gene

Indexed keywords

ESTROGEN RECEPTOR ALPHA; VITAMIN D RECEPTOR;

ADULT; AGE DISTRIBUTION; AGED; ARTICLE; BONE DENSITY; BONE MINERAL; CHINESE; CONTROLLED STUDY; DNA POLYMORPHISM; FAMILY; FEMALE; FEMUR NECK; GENE FUNCTION; GENE INTERACTION; GENETIC ASSOCIATION; GENOTYPE ENVIRONMENT INTERACTION; HAPLOTYPE; HUMAN; LUMBAR SPINE; MAJOR CLINICAL STUDY; MALE; RECEPTOR GENE; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SEX RATIO; STATISTICAL SIGNIFICANCE;

AGE FACTORS; BONE DENSITY; CHINA; ESTROGEN RECEPTOR ALPHA; FEMALE; HUMANS; MALE; RECEPTORS, CALCITRIOL; RECEPTORS, ESTROGEN; REGRESSION ANALYSIS; SEX FACTORS;

EID: 0344873312     PISSN: 14345161     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10038-003-0068-5     Document Type: Article

References (35)

1. Brown MA, Haughton MA, Grant SF, Gunnell AS, Henderson NK, Eisman JA (2001) Genetic control of bone density and turnover: role of the collagen 1alpha1, estrogen receptor, and vitamin D receptor genes. J Bone Miner Res 16:758-764
2. Deng HW, Li J, Li JL, Johnson M, Gong G, Davis KM, Recker RR (1998) Change of bone mass in postmenopausal Caucasian women with and without hormone replacement therapy is associated with vitamin D receptor and estrogen receptor genotypes. Hum Genet 103:576-585
3. Deng HW, Shen H, Xu FH, Deng HY, Conway T, Zhang HT, Recker RR (2002a) Tests of linkage and/or association of genes for vitamin D receptor, osteocalcin, and parathyroid hormone with bone mineral density. J Bone Miner Res17:678-686
4. Deng HW, Livshits G, Yakovenko K, Xu FH, Conway T, Davies KM, Deng H, Recker RR (2002b) Evidence for a major gene for bone mineral density/content in human pedigrees identified via probands with extreme bone mineral density. Ann Hum Genet 66:61-74
5. Dennison EM, Arden NK, Keen RW, Syddall H, Day IN, Spector TD, Cooper C (2001) Birthweight, vitamin D receptor genotype and the programming of osteoporosis. Paediater Perinat Epidemiol 15:211-219
6. Drummond FJ, Wynne F, Mollov MG, Quane KA (2002) Osteoprotegrin, COLIA1 and VDR gene polymorphisms and the rate of bone loss in postmenopausal Irish women. J Bone Miner Res 17:S220 (Abstract)
7. Efstathiadou Z, Kranas V, loannidis JP, Georgiou I, Tsatsoulis A (2001) The Sp1 COLIA1 gene polymorphism, and not vitamin D receptor or estrogen receptor gene polymorphisms, determines bone mineral density in postmenopausal Greek women. Osteoporos Int 12:326-331
8. Ferrari SL, Rizzoli R, Slosman DO, Bonjour JP (1998) Do dietary calcium and age explain the controversy surrounding the relationship between bone mineral density and vitamin D receptor gene polymorphisms? J Bone Miner Res 13:363-370
9. Finkelstein JS, Lee ML, Sowers M, Ettinger B, Neer RM, Kelsey JL, Cauley JA, Huang MH, Greendale GA (2002) Ethnic variation in bone density in premenopausal and early perimenopausal women: effects of anthropometric and lifestyle factors. J Clin Endocrinol Metab 87:3057-3067
10. Gennari L, Becherini L, Masi L, Mansani R, Gonnelli S, Cepollaro C, Martini S, Montagnani A, Lentini G, Becorpi AM, Brandi ML (1998) Vitamin D and estrogen receptor allelic variants in Italian postmenopausal women: evidence of multiple gene contribution to bone mineral density. J Clin Endocrinol Metab 83:939-944
11. Giguere Y, Dodin S, Blanchet C, Morgan K, Rousseau F (2000) The association between heel ultrasound and hormone replacement therapy is modulated by a two-locus vitamin D and estrogen receptor genotype J Bone Miner Res 15:1076-1084
12. Graafmans WC, Lips P, Ooms ME, van Leeuwen JP, Pols HA, Uitterlinden AG (1997) The effect of vitamin D supplementation on the bone mineral density of the femoral neck is associated with vitamin D receptor genotype. J Bone Miner Res 12:1241-1245
13. Ho AY, Yeung SS, Kung AW (2000) PvuII polymorphisms of the estrogen receptor alpha and bone mineral density in healthy southern Chinese women. Calcif Tissue Int 66:405-408
14. Kanis JA, Melton LJ 3rd, Christiansen C, Johnston CC, Khaltaev N (1994) The diagnosis of osteoporosis. J Bone Miner Res 9:1137-1141
15. Karasik D, Ginsburg E, Livshits G, Pavlovsky O, Kobyliansky E (2000) Evidence of major gene control of cortical bone loss in humans. Gen Epidem 19:410-421
16. Kim JG, Lim KS, Kim EK, Choi YM, Lee JY (2001) Association of vitamin D receptor and estrogen receptor gene polymorphisms with bone mass in postmenopausal Korean women. Menopause 8:222-228
17. Lau EM, Young RP, Lam V, Li M, Woo J (2001) Estrogen receptor gene polymorphism and bone mineral density in postmenopausal Chinese women. Bone 29:96-98
18. Lau EM, Lam V, Li M, Ho K, Woo J. (2002) Vitamin D receptor start codon polymorphism (Fok I) and bone mineral density in Chinese men and women. Osteoporos Int 13:218-221
19. Lei SF, Deng FY, Liu XH, Huang QR, Qin Y, Zhou Q, Jiang DK, Li YM, Mo XY, Liu MY, Chen XD, Wu XS, Shen H, Dvornyk V, Zhao L, Recker RR, Deng HW (2003) Polymorphisms of four bone mineral density (BMD) candidate genes in Chinese populations and the comparison with the other populations of different ethnicity. J Bone Miner Metab 21:34-42
20. Liel Y, Kraus S, Levy J, Shany S (1992) Evidence that estrogen modulated activity increases the number of 1,25-dihydroxyvitamin D receptors in osteoblast-like cells. Endocrinology 130:2597-2601
21. Liu YZ, Liu YJ, Recker RR Deng HW (2003) Molecular studies of gene identification for osteoporosis: the 2002 update. J Endocrinol 177:147-196
22. Livshits G, Karasik D, Kobyliansky E (2002) Complex segregation analysis of the radiographic phalanges bone mineral density and their age-related changes. J Bone Miner Res 17:152-161
23. O'Connell JR, Weeks DE (1998) PedCheck: a program for identification of genotype incompatibilities in linkage analysis. Am J Hum Genet 63:259-266
24. Qin YJ, Shen H, Huang QR, Zhao LJ, Zhou Q, Li MX, He JW, Lu JH, Deng HW (2003) Estrogen receptor α gene polymorphisms and peak bone mass (PBM) in Chinese nuclear families. J Bone Miner Res 18:1028-1035
25. Ralston SH (2002) Genetic control of susceptibility to osteoporosis J Clin Endocrinol Metab 87:2460-2466
26. Rapuri PB, Gallagher JC, Kinyamu HK, Ryschon KL (2001) Caffeine intake increases the rate of bone loss in elderly women and interacts with viamin D receptor genotypes. Am J Clin Nutr 74:694-700
27. Recker RR, Deng HW (2002) Role of genetics in osteoporosis. Endocrine 17:55-66
28. Riggs BL, Nguyen TV, Melton LJ 3rd, Morrison NA, O'Fallon WM, Kelly PJ, Egan KS, Sambrook PN, Muhs JM, Eisman JA (1995) The contribution of vitamin D receptor gene alleles to the determination of bone mineral density in normal and osteoporotic women. J Bone Miner Res 10:991-996
29. Salmen T, Heikkinen AM, Mahonen A, Kroger H, Komulainen M, Saarikoski S, Honkanen R, Maenpaa PH (2000) Early postmenopausal bone loss is associated with PvuII estrogen receptor gene polymorphism in Finnish women: effect of hormone replacement therapy. J Bone Miner Res 15:315-321
30. Schaid DJ, Jacobsen SJ (1999) Biased tests of association: comparisons of allele frequencies when departing from Hardy-Weinberg proportions. Am J Epidemiol 149:706-711
31. Sobel E, Lange K (1996) Descent graphs in pedigree analysis: applications to haplotyping, location scores, and marker-sharing statistics. Am J Hum Genet 58:1323-1337
32. Tofteng CL, Jensen JE, Abrahamsen B, Odum L, Brot C (2002) Two polymorphisms in the Vitamin D receptor gene-association with bone mass and 5-year change in bone mass with or without hormone-replacement therapy in postmenopausal women: the Danish osteoporosis prevention study. J Bone Miner Res 17:1535-1544
33. Willing M, Sowers M, Aron D, Clark MK, Burns T, Bunten C, Crutchfield M, D'Agostino D, Jannausch M (1998) Bone mineral density and its change in white women: estrogen and vitamin D receptor genotypes and their interaction. J Bone Miner Res 13:695-705
34. Yamada Y, Ando F, Niino N, Ohta S, Shimokata H (2002) Association of polymorphisms of the estrogen receptor alpha gene with bone mineral density of the femoral neck in elderly Japanese women. J Mol Med 80:452-460
35. Zhao J, Zhou X, Meng X, Liu G, Xing X, Liu H, Xu L (1997) Polymorphisms of vitamin D receptor gene and its association with bone mineral density and osteocalcin in Chinese. Chin Med J 110:366-371