Menopause rather than estrogen modifies plasma homocysteine levels

International Journal of Gynecology and Obstetrics

Volumn 81, Issue 3, 2003, Pages 293-297

  Marchesoni, D ^a   Driul, L ^a   Plaino, L ^a   Villani, M T ^a   Becagli, L ^b   Mozzanega, B ^b  

^a UNIVERSITY OF UDINE   (Italy)

^b UNIVERSITY OF PADOVA   (Italy)

Author keywords

Cardiovascular risk; Estrogen replacement therapy; Homocysteine; Menopause

Indexed keywords

ESTROGEN; HOMOCYSTEINE;

ADULT; AGED; ARTICLE; BLOOD ANALYSIS; CONTROLLED STUDY; ESTROGEN THERAPY; FEMALE; HUMAN; HUMAN EXPERIMENT; HYSTERECTOMY; MENOPAUSE; NORMAL HUMAN; OVARIECTOMY; POSTMENOPAUSE; PREMENOPAUSE; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE; TREATMENT OUTCOME;

EID: 0037953095     PISSN: 00207292     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0020-7292(03)00005-5     Document Type: Article

References (21)

1. Eaker E.D., Chesebro J.H., Sacks F.M., Wenger N.K. Cardiovascular disease in women. Circulation. 88:1993;1999-2009.
2. Yaffe K., Sawaya G., Lieberburg I., Grady D. Estrogen therapy in postmenopausal women: effects on cognitive function and dementia. J Am Med Assoc. 279:1998;688-695.
3. Grady D., Rubin S.M., Petitti D.B., Fox D.B., Fox C.S., Black D., et al. Hormone therapy to prevent disease and prolong life in postmenopausal women. Ann Intern Med. 117:1992;1013-1016.
4. Risks and benefits of estrogen plus progestin in healthy postmenopausal women. Principal results from the Women's Health Initiative Randomized Controlled Trial. J Am Med Assoc Express. 288:2002;321-333.
5. Lobo R.A. Clinical review: effects of hormonal replacement on lipids and lipoproteins in postmenopausal women. J Clin Endocrinol Metab. 73:1991;925-930.
6. Clarkson T.B., Anthony M.S., Klein K.P. Hormone replacement therapy and coronary artery atherosclerosis: the monkey model. Br J Obstet Gynaecol. 103:1996;53-57.
7. Nasr A., Breckwoldt M. Estrogen replacement therapy and cardiovascular protection: lipid mechanisms are the tip of an iceberg. Gynecol Endocrinol. 12:(1):1998;43-59.
8. Verhoef P. Hyperhomocysteinemia and risk of vascular disease in women. Semin Thromb Hemost. 26:(3):2000;325-334.
9. Stampfer M.J., Malinov M.R., Willet W.C. A prospective study of plasma homocysteine and risk of myocardial infarction in US physicians. J Am Med Assoc. 268:1992;877-881.
10. Selhub J., Jacques P.F., Wilson P.W., Rusch D., Rosenberg I.H. V status and intake as primary determinants of homocysteinemia in an elderly population. J Am Med Assoc. 270:1993;2693-2698.
11. Van Der Mooren M.J., Wouters M.G.A.J., Blom H.J. Hormone replacement therapy may reduce high serum homocysteine in postmenopausal women. Eur J Clin Invest. 24:1994;733-736.
12. Stamler J.S., Osbore J.A., Jaraki O., Rabbani L.E. Adverse vascular effects of homocysteine are modulated by endothelial derived relaxing factor and related oxides of nitrogen. J Clin Invest. 91:1992;308-318.
13. Leino A. Fully automated measurement of total homocysteine in plasma and serum on the Abbott IMX Analyser. Clin Chem. 45:1999;569-571.
14. Wouters M.G., Moorrees M.T., Van Der Mooren M.J., Blon H.J., Boers G.H., Schellekens L.A. Plasma homocysteine and menopause status. Eur J Clin Invest. 25:1995;801-805.
15. Kim M.H., Kim E., Passen El., Meyer J., Kang S.S. Cortisol and estradiol: non-genetic factors for hyperhomocysteinemia. Metabolism. 46:1997;247-249.
16. Hak A.E., Polderman K.H., Westendorp J.C., Jakobs C., Hofman A., Witteman J.C. Increased plasma homocysteine after menopause. Atherosclerosis. 149:(1):2000;163-168.
17. Walsh B.W., Paul S., Wild R.A., Dean R.A., Tracy R.P., Cox D.A. The effects of hormone replacement therapy and Raloxifene on C-reactive protein an homocysteine in healthy postmenopausal women: a randomized, controlled trial. J Clin Endocrinol Metab. 85:(1):2000;214-218.
18. Blom H.J., Boers G.H.J., Elzen J.P.A.M., Van Roessel J.J.M., Trijbels J.M.F., Tangerman A. Difference between premenopausal women and young men in the transamination pathway of methionine catabolism and the protection against vascular disease. Eur J Clin Invest. 18:1988;633-638.
19. Eviö S., Tiitinen A., Turpeinen U., Ylikorkala O. Failure of the combination of sequential oral and transdermal estradiol plus norethisterone acetate to affect plasma homocysteine levels. Fertil Steril. 74:(6):2000;1080-1083.
20. Mijatovic V., Netelenbos C., Van der Mooren M.J., De Valk de Roogw, Jakobs C., Kenemans P. Randomized, double-blind, placebo-controlled study of the effects of Raloxifene and conjugated equine estrogen on plasma homocysteine levels in healthy postmenopausal women. Fertil Steril. 70:1998;1085-1089.
21. Somekawa Y., Kobayashi K., Tomura S., Aso T., Hamaguchi H. Effects of hormone replacement therapy and methylenetetrahydrofolate reductase polymorphism on plasma folate and homocysteine levels in postmenopausal Japanese women. Fertil Steril. 77:(3):2002;481-486.