Variable expression of cysteinyl leukotriene type I receptor splice variants in asthmatic females with different promoter haplotypes

BMC Immunology

Volumn 10, Issue , 2009, Pages

  Sokolowska, Milena ^a   Wodz Naskiewicz, Karolina ^a   Cieslak, Malgorzata ^a   Seta, Karolina ^a   Bednarek, Andrzej K ^a   Pawliczak, Rafal ^a  

^a MEDICAL UNIVERSITY OF LODZ   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE; CORTICOSTEROID; CYTIDINE; GENOMIC DNA; GUANOSINE; LEUKOTRIENE RECEPTOR; MONTELUKAST; PEPTIDOLEUKOTRIENE RECEPTOR 1; RNA; THYMIDINE; UNCLASSIFIED DRUG; ZAFIRLUKAST; LEUKOTRIENE D4 RECEPTOR;

ADULT; AGED; ARTICLE; ASTHMA; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENE LOCUS; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; HAPLOTYPE; HETEROZYGOTE; HOMOZYGOTE; HUMAN; HUMAN CELL; INFECTION SENSITIVITY; MALE; NUCLEOTIDE SEQUENCE; PROMOTER REGION; RESPIRATORY TRACT INFECTION; SINGLE NUCLEOTIDE POLYMORPHISM; ALTERNATIVE RNA SPLICING; BIOSYNTHESIS; GENETICS; IMMUNOLOGY; MIDDLE AGED;

ADULT; AGED; ALTERNATIVE SPLICING; ASTHMA; FEMALE; HAPLOTYPES; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS, GENETIC; RECEPTORS, LEUKOTRIENE;

EID: 74549125733     PISSN: None     EISSN: 14712172     Source Type: Journal    
DOI: 10.1186/1471-2172-10-63     Document Type: Article

References (54)

1. Chanez P, Wenzel SE, Anderson GP, Anto JM, Bel EH, Boulet LP, Brightling CE, Busse WW, Castro M, Dahlen B, et al. Severe asthma in adults: what are the important questions?. J Allergy Clin Immunol 2007, 119(6):1337-1348. 10.1016/j.jaci.2006.11.702, 17416409.
2. Funk CD. Prostaglandins and leukotrienes: advances in eicosanoid biology. Science 2001, 294(5548):1871-1875. 10.1126/science.294.5548.1871, 11729303.
3. Lewis RA, Austen KF, Soberman RJ. Leukotrienes and other products of the 5-lipoxygenase pathway. Biochemistry and relation to pathobiology in human diseases. N Engl J Med 1990, 323(10):645-655.
4. Lam BK, Frank Austen K. Leukotriene C4 synthase. A pivotal enzyme in the biosynthesis of the cysteinyl leukotrienes. Am J Respir Crit Care Med 2000, 161(2 Pt 2):S16-19.
5. Hedqvist P, Dahlen SE, Gustafsson L, Hammarstrom S, Samuelsson B. Biological profile of leukotrienes C4 and D4. Acta Physiol Scand 1980, 110(3):331-333. 10.1111/j.1748-1716.1980.tb06676.x, 6894214.
6. Peters-Golden M, Canetti C, Mancuso P, Coffey MJ. Leukotrienes: underappreciated mediators of innate immune responses. J Immunol 2005, 174(2):589-594.
7. Kanaoka Y, Boyce JA. Cysteinyl leukotrienes and their receptors: cellular distribution and function in immune and inflammatory responses. J Immunol 2004, 173(3):1503-1510.
8. Holgate ST, Peters-Golden M, Panettieri RA, Henderson WR. Roles of cysteinyl leukotrienes in airway inflammation, smooth muscle function, and remodeling. J Allergy Clin Immunol 2003, 111(1 Suppl):S18-34. discussion S34-16, 10.1067/mai.2003.25, 12532084.
9. Lynch KR, O'Neill GP, Liu Q, Im DS, Sawyer N, Metters KM, Coulombe N, Abramovitz M, Figueroa DJ, Zeng Z, et al. Characterization of the human cysteinyl leukotriene CysLT1 receptor. Nature 1999, 399(6738):789-793. 10.1038/21658, 10391245.
10. Sarau HM, Ames RS, Chambers J, Ellis C, Elshourbagy N, Foley JJ, Schmidt DB, Muccitelli RM, Jenkins O, Murdock PR, et al. Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptor. Mol Pharmacol 1999, 56(3):657-663.
11. Heise CE, O'Dowd BF, Figueroa DJ, Sawyer N, Nguyen T, Im DS, Stocco R, Bellefeuille JN, Abramovitz M, Cheng R, et al. Characterization of the human cysteinyl leukotriene 2 receptor. J Biol Chem 2000, 275(39):30531-30536. 10.1074/jbc.M003490200, 10851239.
12. Nothacker HP, Wang Z, Zhu Y, Reinscheid RK, Lin SH, Civelli O. Molecular cloning and characterization of a second human cysteinyl leukotriene receptor: discovery of a subtype selective agonist. Mol Pharmacol 2000, 58(6):1601-1608.
13. Takasaki J, Kamohara M, Matsumoto M, Saito T, Sugimoto T, Ohishi T, Ishii H, Ota T, Nishikawa T, Kawai Y, et al. The molecular characterization and tissue distribution of the human cysteinyl leukotriene CysLT(2) receptor. Biochem Biophys Res Commun 2000, 274(2):316-322. 10.1006/bbrc.2000.3140, 10913337.
14. Ciana P, Fumagalli M, Trincavelli ML, Verderio C, Rosa P, Lecca D, Ferrario S, Parravicini C, Capra V, Gelosa P, et al. The orphan receptor GPR17 identified as a new dual uracil nucleotides/cysteinyl-leukotrienes receptor. Embo J 2006, 25(19):4615-4627. 10.1038/sj.emboj.7601341, 1589991, 16990797.
15. Woszczek G, Chen LY, Nagineni S, Kern S, Barb J, Munson PJ, Logun C, Danner RL, Shelhamer JH. Leukotriene D(4) induces gene expression in human monocytes through cysteinyl leukotriene type I receptor. J Allergy Clin Immunol 2008, 121(1):215-221. 10.1016/j.jaci.2007.09.013, 18028998.
16. Figueroa DJ, Breyer RM, Defoe SK, Kargman S, Daugherty BL, Waldburger K, Liu Q, Clements M, Zeng Z, O'Neill GP, et al. Expression of the cysteinyl leukotriene 1 receptor in normal human lung and peripheral blood leukocytes. Am J Respir Crit Care Med 2001, 163(1):226-233.
17. Mita H, Hasegawa M, Saito H, Akiyama K. Levels of cysteinyl leukotriene receptor mRNA in human peripheral leucocytes: significantly higher expression of cysteinyl leukotriene receptor 2 mRNA in eosinophils. Clin Exp Allergy 2001, 31(11):1714-1723. 10.1046/j.1365-2222.2001.01184.x, 11696047.
18. Zhu J, Qiu YS, Figueroa DJ, Bandi V, Galczenski H, Hamada K, Guntupalli KK, Evans JF, Jeffery PK. Localization and upregulation of cysteinyl leukotriene-1 receptor in asthmatic bronchial mucosa. Am J Respir Cell Mol Biol 2005, 33(6):531-540. 10.1165/rcmb.2005-0124OC, 16123393.
19. Klotsman M, York TP, Pillai SG, Vargas-Irwin C, Sharma SS, Oord EJ, Anderson WH. Pharmacogenetics of the 5-lipoxygenase biosynthetic pathway and variable clinical response to montelukast. Pharmacogenet Genomics 2007, 17(3):189-196. 10.1097/FPC.0b013e3280120043, 17460547.
20. Salvi SS, Krishna MT, Sampson AP, Holgate ST. The anti-inflammatory effects of leukotriene-modifying drugs and their use in asthma. Chest 2001, 119(5):1533-1546. 10.1378/chest.119.5.1533, 11348965.
21. Drazen JM, Silverman EK, Lee TH. Heterogeneity of therapeutic responses in asthma. Br Med Bull 2000, 56(4):1054-1070. 10.1258/0007142001903535, 11359637.
22. Duroudier NP, Sayers I, Castagna CC, Fenech AG, Halapi E, Swan C, Hall IP. Functional polymorphism and differential regulation of CYSLTR1 transcription in human airway smooth muscle and monocytes. Cell Biochem Biophys 2007, 47(1):119-130.
23. Woszczek G, Pawliczak R, Qi HY, Nagineni S, Alsaaty S, Logun C, Shelhamer JH. Functional characterization of human cysteinyl leukotriene 1 receptor gene structure. J Immunol 2005, 175(8):5152-5159.
24. Kim SH, Oh JM, Kim YS, Palmer LJ, Suh CH, Nahm DH, Park HS. Cysteinyl leukotriene receptor 1 promoter polymorphism is associated with aspirin-intolerant asthma in males. Clin Exp Allergy 2006, 36(4):433-439. 10.1111/j.1365-2222.2006.02457.x, 16630147.
25. Zhang J, Migita O, Koga M, Shibasaki M, Arinami T, Noguchi E. Determination of structure and transcriptional regulation of CYSLTR1 and an association study with asthma and rhinitis. Pediatr Allergy Immunol 2006, 17(4):242-249. 10.1111/j.1399-3038.2005.00347.x, 16771777.
26. Sokolowska M, Wodz K, Cieslak M, Kowalski ML, Pawliczak R. Promoter polymorphisms of cysteinyl leukotriene type 1 receptor in patients with different asthma phenotypes [abstract]. XX Word Allergy Congress Abstract Book: 2007; Bangkok, Thailand 2007, WAO abstractbook.
27. Global Strategy for Asthma Management and Prevention, Global Initiative for Asthma (GINA). 2008, Date last updated: December 2008. Date last accessed: March 2009., http://www.ginasthma.org
28. Bousquet J, Khaltaev N, Cruz AA, Denburg J, Fokkens WJ, Togias A, Zuberbier T, Baena-Cagnani CE, Canonica GW, van Weel C, et al. Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen). Allergy 2008, 63(Suppl 86):8-160. 10.1111/j.1398-9995.2007.01620.x, 18331513.
29. DeVault KR, Castell DO. Updated guidelines for the diagnosis and treatment of gastroesophageal reflux disease. Am J Gastroenterol 2005, 100(1):190-200. 10.1111/j.1572-0241.2005.41217.x, 15654800.
30. Pfaffl MW, Horgan GW, Dempfle L. Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. Nucleic Acids Res 2002, 30(9):e36. 10.1093/nar/30.9.e36, 113859, 11972351.
31. Barrett JC, Fry B, Maller J, Daly MJ. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005, 21(2):263-265. 10.1093/bioinformatics/bth457, 15297300.
32. Stephens M, Smith NJ, Donnelly P. A new statistical method for haplotype reconstruction from population data. Am J Hum Genet 2001, 68(4):978-989. 10.1086/319501, 1275651, 11254454.
33. Figueroa DJ, Borish L, Baramki D, Philip G, Austin CP, Evans JF. Expression of cysteinyl leukotriene synthetic and signalling proteins in inflammatory cells in active seasonal allergic rhinitis. Clin Exp Allergy 2003, 33(10):1380-1388. 10.1046/j.1365-2222.2003.01786.x, 14519144.
34. Robbiani DF, Finch RA, Jager D, Muller WA, Sartorelli AC, Randolph GJ. The leukotriene C(4) transporter MRP1 regulates CCL19 (MIP-3beta, ELC)-dependent mobilization of dendritic cells to lymph nodes. Cell 2000, 103(5):757-768. 10.1016/S0092-8674(00)00179-3, 11114332.
35. Machida I, Matsuse H, Kondo Y, Kawano T, Saeki S, Tomari S, Obase Y, Fukushima C, Kohno S. Cysteinyl leukotrienes regulate dendritic cell functions in a murine model of asthma. J Immunol 2004, 172(3):1833-1838.
36. Thivierge M, Stankova J, Rola-Pleszczynski M. Toll-like receptor agonists differentially regulate cysteinyl-leukotriene receptor 1 expression and function in human dendritic cells. J Allergy Clin Immunol 2006, 117(5):1155-1162. 10.1016/j.jaci.2005.12.1342, 16675346.
37. Baenkler M, Leykauf M, John S. Functional analysis of eicosanoids from white blood cells in sepsis and SIRS. J Physiol Pharmacol 2006, 57(Suppl 12):25-33.
38. Kott KS, Salt BH, McDonald RJ, Jhawar S, Bric JM, Joad JP. Effect of secondhand cigarette smoke, RSV bronchiolitis and parental asthma on urinary cysteinyl LTE4. Pediatr Pulmonol 2008, 43(8):760-766. 10.1002/ppul.20853, 18615667.
39. Fullmer JJ, Khan AM, Elidemir O, Chiappetta C, Stark JM, Colasurdo GN. Role of cysteinyl leukotrienes in airway inflammation and responsiveness following RSV infection in BALB/c mice. Pediatr Allergy Immunol 2005, 16(7):593-601. 10.1111/j.1399-3038.2005.00248.x, 16238585.
40. Matsuse H, Kondo Y, Saeki S, Nakata H, Fukushima C, Mizuta Y, Kohno S. Naturally occurring parainfluenza virus 3 infection in adults induces mild exacerbation of asthma associated with increased sputum concentrations of cysteinyl leukotrienes. Int Arch Allergy Immunol 2005, 138(3):267-272. 10.1159/000088728, 16215328.
41. Bisgaard H. A randomized trial of montelukast in respiratory syncytial virus postbronchiolitis. Am J Respir Crit Care Med 2003, 167(3):379-383. 10.1164/rccm.200207-747OC, 12406832.
42. Fitzgerald DA, Mellis CM. Leukotriene receptor antagonists in virus-induced wheezing: evidence to date. Treat Respir Med 2006, 5(6):407-417. 10.2165/00151829-200605060-00006, 17154670.
43. Neugebauer KM. On the importance of being co-transcriptional. J Cell Sci 2002, 115(Pt 20):3865-3871. 10.1242/jcs.00073, 12244124.
44. Expert-Bezancon A, Le Caer JP, Marie J. Heterogeneous nuclear ribonucleoprotein (hnRNP) K is a component of an intronic splicing enhancer complex that activates the splicing of the alternative exon 6A from chicken beta-tropomyosin pre-mRNA. J Biol Chem 2002, 277(19):16614-16623. 10.1074/jbc.M201083200, 11867641.
45. Young JI, Hong EP, Castle JC, Crespo-Barreto J, Bowman AB, Rose MF, Kang D, Richman R, Johnson JM, Berget S, et al. Regulation of RNA splicing by the methylation-dependent transcriptional repressor methyl-CpG binding protein 2. Proc Natl Acad Sci USA 2005, 102(49):17551-17558. 10.1073/pnas.0507856102, 1266160,1266160, 16251272.
46. Bres V, Gomes N, Pickle L, Jones KA. A human splicing factor, SKIP, associates with P-TEFb and enhances transcription elongation by HIV-1 Tat. Genes Dev 2005, 19(10):1211-1226. 10.1101/gad.1291705, 1132007, 15905409.
47. Garcia-Blanco MA, Baraniak AP, Lasda EL. Alternative splicing in disease and therapy. Nat Biotechnol 2004, 22(5):535-546. 10.1038/nbt964, 15122293.
48. Caceres JF, Kornblihtt AR. Alternative splicing: multiple control mechanisms and involvement in human disease. Trends Genet 2002, 18(4):186-193. 10.1016/S0168-9525(01)02626-9, 11932019.
49. Tucker JK, Tamba K, Lee YJ, Shen LL, Warnock DG, Oh Y. Cloning and functional studies of splice variants of the alpha-subunit of the amiloride-sensitive Na+ channel. Am J Physiol 1998, 274:C1081-1089.
50. The ENFUMOSA cross-sectional European multicentre study of the clinical phenotype of chronic severe asthma. European Network for Understanding Mechanisms of Severe Asthma. Eur Respir J 2003, 22(3):470-477. 10.1183/09031936.03.00261903, 14516137.
51. Pergola C, Dodt G, Rossi A, Neunhoeffer E, Lawrenz B, Northoff H, Samuelsson B, Radmark O, Sautebin L, Werz O. ERK-mediated regulation of leukotriene biosynthesis by androgens: a molecular basis for gender differences in inflammation and asthma. Proc Natl Acad Sci USA 2008, 105(50):19881-19886. 10.1073/pnas.0809120105, 2597692,2597692, 19064924.
52. de Oliveira AP, Domingos HV, Cavriani G, Damazo AS, Dos Santos Franco AL, Oliani SM, Oliveira-Filho RM, Vargaftig BB, de Lima WT. Cellular recruitment and cytokine generation in a rat model of allergic lung inflammation are differentially modulated by progesterone and estradiol. Am J Physiol Cell Physiol 2007, 293(3):C1120-1128. 10.1152/ajpcell.00286.2006, 17634417.
53. Piccinni MP, Giudizi MG, Biagiotti R, Beloni L, Giannarini L, Sampognaro S, Parronchi P, Manetti R, Annunziato F, Livi C, et al. Progesterone favors the development of human T helper cells producing Th2-type cytokines and promotes both IL-4 production and membrane CD30 expression in established Th1 cell clones. J Immunol 1995, 155(1):128-133.
54. Capra V, Thompson MD, Sala A, Cole DE, Folco G, Rovati GE. Cysteinyl-leukotrienes and their receptors in asthma and other inflammatory diseases: critical update and emerging trends. Med Res Rev 2007, 27(4):469-527. 10.1002/med.20071, 16894531.