Functional polymorphism and differential regulation of CYSLTR1 transcription in human airway smooth muscle and monocytes

Cell Biochemistry and Biophysics

Volumn 47, Issue 1, 2007, Pages 119-129

  Duroudier, Nathalie P ^a   Sayers, Ian ^a   Castagna, Charlotte Carabott ^b   Fenech, Anthony G ^b   Halapi, Eva ^c   Swan, Caroline ^a   Hall, Ian P ^a  

^a QUEEN S MEDICAL CENTRE   (United Kingdom)

^b UNIVERSITY OF MALTA   (Malta)

^c DECODE GENETICS   (Iceland)

Author keywords

Airway smooth muscle; CLTR1; CYSLTR1; Cysteinyl leukotriene; Peripheral blood mononuclear cells; Receptor; THP1; Transcription

Indexed keywords

EID: 34147119483     PISSN: 10859195     EISSN: None     Source Type: Journal    
DOI: 10.1385/CBB:47:1:119     Document Type: Article

References (38)

1. Barnes, P. J. (2002) Asthma and COPD: Basic Mechanisms and Clinical Management Academic.
2. Brink, C., et al. (2003) International Union of Pharmacology XXXVII. Nomenclature for Leukotriene and Lipoxin Receptors. Pharmacol. Rev. 55(1), 195-227.
3. Hamid, Q., et al. (2003) Inflammatory cells in asthma: mechanisms and implications for therapy. J. Allergy Clin. Immunol. 111(1 Suppl), S5-S12; discussion S12-17.
4. Parameswaran, K., et al. (2002) Cysteinyl leukotrienes promote human airway smooth muscle migration. Am. J. Respir. Crit. Care Med. 166(5), 738-742.
5. Barnes, P. J. (2003) Anti-leukotrienes: here to stay? Curr. Opin. Pharmacol. 3(3), 257-263.
6. Cowburn, A. S., et al. (1998) Overexpression of leukotriene C4 synthase in bronchial biopsies from patients with aspirin-intolerant asthma. J. Clin. Invest. 101(4), 834-846.
7. Sanak, M. and Szczeklik, A. (2001) Leukotriene C4 synthase polymorphism and aspirin-induced asthma. J. Allergy Clin. Immunol. 107(3), 561-512.
8. Van Sambeek, R., et al. (2000) 5′ flanking region polymorphism of the gene encoding leukotriene C4 synthase does not correlate with the aspirin-intolerant asthma phenotype in the United States. J. Allergy Clin. Immunol. 106(1 Pt 1), 72-76.
9. Kawagishi, Y., et al. (2002) Leukotriene C4 synthase promoter polymorphism in Japanese patients with aspirin-induced asthma. J. Allergy Clin. Immunol. 109(6), 936-942.
10. Lynch, K. R., et al. (1999) Characterization of the human cysteinyl leukotriene CysLT1 receptor. Nature 399(6738), 789-793.
11. Sarau, H. M., et al. (1999) Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptor. Mol. Pharmacol. 56(3), 657-663.
12. Heise, C. E., et al. (2000) Characterization of the human cysteinyl leukotriene 2 receptor. J. Biol. Chem. 275(39), 30,531-30,536.
13. Mellor, E. A., et al. (2001) Cysteinyl leukotriene receptor 1 is also a pyrimidinergic receptor and is expressed by human mast cells. Proc. Natl. Acad. Sci. USA 98(14), 7964-7969.
14. Walch, L., et al. (2002) Pharmacological evidence for a novel cysteinyl-leukotriene receptor subtype in human pulmonary artery smooth muscle. Br. J. Pharmacol. 137(8), 1339-1345.
15. Back, M., et al. (2000) Prostacyclin modulation of contractions of the human pulmonary artery by cysteinyl-leukotrienes. Eur. J. Pharmacol. 401(3), 389-395.
16. Saussy, D. L., Jr., et al. (1989) Mechanisms of leukotriene E4 partial agonist activity at leukotriene D4 receptors in differentiated U-937 cells. J. Biol. Chem. 264(33), 19,845-19,855.
17. Hoshino, M., Izumi, T., and Shimizu T., (1998) Leukotriene D4 activates mitogen-activated protein kinase through a protein kinase Calpha-Raf-1-dependent pathway in human monocytic leukemia THP-1 cells. J. Biol. Chem. 273(9), 4878-4882.
18. Gorenne, I., et al. (1998) Leukotriene D4 contractions in human airways are blocked by SK&F 96365, an inhibitor of receptor-mediated calcium entry. J. Pharmacol. Exp. Ther. 284(2), 549-552.
19. Accomazzo, M. R., et al. (2001) Leukotriene D4-induced activation of smooth-muscle cells from human bronchi is partly Ca2+-independent. Am. J. Respir. Crit. Care Med. 163(1), 266-272.
20. Thivierge, M., et al. (2000) IL-5 up-regulates cysteinyl leukotriene 1 receptor expression in HL-60 cells differentiated into eosinophils. J. Immunol. 165(9), 5221-5226.
21. Thivierge, M., Stankova, J., and Rola-Pleszczynski, M. (2001) IL-13 and IL-4 up-regulate cysteinyl leukotriene 1 receptor expression in human monocytes and macrophages. J. Immunol. 167(5), 2855-2860.
22. Espinosa, K., et al. (2003) CysLT1 receptor upregulation by TGF-beta and IL-13 is associated with bronchial smooth muscle cell proliferation in response to LTD4. J. Allergy Clin. Immunol. 111(5), 1032-1040.
23. Figueroa, D. J., et al. (2001) Expression of the cysteinyl leukotriene 1 receptor in normal human lung and peripheral blood leukocytes. Am. J. Respir. Crit. Care Med. 163(1), 226-233.
24. Shirasaki, H., et al. (2002) Expression and localization of the cysteinyl leukotriene 1 receptor in human nasal mucosa. Clin. Exp. Allergy 32(7), 1007-1012.
25. Jenkins, S. (2003) Leukotriene receptors are overexpressed in aspirin sensitive asthmatics. Thorax 58(2), 105.
26. Sousa, A. R., et al. (2002) Leukotriene-receptor expression on nasal mucosal inflammatory cells in aspirin-sensitive rhinosinusitis. N. Engl. J. Med. 347(19), 1493-1499.
27. Kemp, J. P. (2003) Recent advances in the management of asthma using leukotriene modifiers. Am. J. Respir. Med. 2(2), 139-156.
28. Kemp, J. P. (2000) Leukotriene receptor antagonists for the treatment of asthma. IDrugs 3(4), 430-441.
29. Drazen, J. M., et al. (1999) Pharmacogenetic association between ALOX5 promoter genotype and the response to anti-asthma treatment. Nat. Genet. 22(2), 168-170.
30. Asano, K., et al. (2002) Leukotriene C4 synthase gene A(-444)C polymorphism and clinical response to a CYS-LT(1) antagonist, pranlukast, in Japanese patients with moderate asthma. Pharmacogenetics 12(7), 565-570.
31. Sayers, I. and Hall, I. P. (2005) Pharmacogenetic approaches in the treatment of asthma. Curr. Allergy Asthma Rep. 5(2), 101-108.
32. Fukai, H., et al. (2004) Association between a polymorphism in cysteinyl leukotriene receptor 2 on chromosome 13q14 and atopic asthma. Pharmacogenetics 14(10), 683-690.
33. Park, J. S., et al. (2005) Association analysis of cysteinyl-leukotriene receptor 2 (CYSLTR2) polymorphisms with aspirin intolerance in asthmatics. Pharmacogenet. Genomics 15(7), 483-492.
34. Daykin, K., Widdop, S., and Hall, I. P. (1993) Control of histamine induced inositol phospholipid hydrolysis in cultured human tracheal smooth muscle cells. Eur. J. Pharmacol. 246(2), 135-140.
35. Laan, M., et al. (2005) X-chromosome as a marker for population history: linkage disequilibrium and haplotype study in Eurasian populations. Eur. J. Hum. Genet. 13(4), 452-462.
36. Oh, I. H. and Reddy, E. P. (1999) The myb gene family in cell growth, differentiation and apoptosis. Oncogene 18(19), 3017-3033.
37. Westin, E. H., et al. (1982) Differential expression of the amv gene in human hematopoietic cells. Proc. Natl. Acad. Sci. USA 79(7), 2194-218.
38. Lipsick, J. S. (1996) One billion years of Myb. Oncogene 13(2), 223-235.