The metabolism and transplacental transfer of oseltamivir in the ex vivo human model

Infectious Diseases in Obstetrics and Gynecology

Volumn 2008, Issue , 2008, Pages

  Worley, Kevin C ^a   Roberts, Scott W ^a   Bawdon, Roger E ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 ACETAMIDO 5 AMINO 3 (1 ETHYLPROPOXY) 1 CYCLOHEXENE 1 CARBOXYLIC ACID; CARBON 14; OSELTAMIVIR; PHENAZONE; ANTIVIRUS AGENT;

ARTICLE; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG METABOLISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; IN VIVO STUDY; MAXIMUM PLASMA CONCENTRATION; MOTHER FETUS RELATIONSHIP; PLACENTAL TRANSFER; PRIORITY JOURNAL; BIOLOGICAL MODEL; FEMALE; FETOMATERNAL TRANSFUSION; FETUS; METABOLISM; PERFUSION; PLACENTA; PREGNANCY;

ANTIPYRINE; ANTIVIRAL AGENTS; FEMALE; FETUS; HUMANS; MATERNAL-FETAL EXCHANGE; MODELS, BIOLOGICAL; OSELTAMIVIR; PERFUSION; PLACENTA; PREGNANCY;

EID: 47049102593     PISSN: 10647449     EISSN: 10980997     Source Type: Journal    
DOI: 10.1155/2008/927574     Document Type: Article

References (17)

1. Tamiflu (oseltamivir phosphate) prescribing information. Roche Pharmaceuticals, Nutley, NJ, USA, November 2006
2. Moscona A., Neuraminidase inhibitors for influenza The New England Journal of Medicine 2005 353 13 1363 1373
3. Fiore A. E., Shay D. K., Haber P., Prevention and control of influenza: Recommendations of the Advisory Committee on Immunization Practices (ACIP) MMWR Morbidity and Mortality Weekly Report 2007 56 RR-06 1 54
4. Roberts S., Hollier L. M., Sheffield J., Laibl V., Wendel G. D. Jr., Cost-effectiveness of universal influenza vaccination in a pregnant population Obstetrics & Gynecology 2006 107 6 1323 1329
5. Hartert T. V., Neuzil K. M., Shintani A. K., Maternal morbidity and perinatal outcomes among pregnant women with respiratory hospitalizations during influenza season American Journal of Obstetrics & Gynecology 2003 189 6 1705 1712
6. Cox S., Posner S. F., McPheeters M., Jamieson D. J., Kourtis A. P., Meikle S., Hospitalizations with respiratory illness among pregnant women during influenza season Obstetrics & Gynecology 2006 107 6 1315 1322
7. Shu Y., Yu H., Li D., Lethal avian influenza A (H5N1) infection in a pregnant woman in Anhui Province, China The New England Journal of Medicine 2006 354 13 1421 1422
8. Webster R. G., Govorkova E. A., H5N1 influenza-continuing evolution and spread The New England Journal of Medicine 2006 355 21 2174 2177
9. Ward P., Small I., Smith J., Suter P., Dutkowski R., Oseltamivir (Tamiflu ®) and its potential for use in the event of an influenza pandemic Journal of Antimicrobial Chemotherapy 2005 55 supplement 1 i5 i21
10. Schneider H., Huch A., Dual in vitro perfusion of an isolated lobe of human placenta: method and instrumentation Contributions to Gynecology and Obstetrics 1985 13 40 47
11. Sweeny D. J., Lynch G., Bidgood A. M., Lew W., Wang K.-Y., Cundy K. C., Metabolism of the influenza neuraminidase inhibitor prodrug oseltamivir in the rat Drug Metabolism and Disposition 2000 28 7 737 741
12. Briggs G. G., Freeman R. K., Yaffe S. J., Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk 2005 7th Philadelphia, Pa, USA Lippincott Williams & Wilkins
13. He G., Massarella J., Ward P., Clinical pharmacokinetics of the prodrug oseltamivir and its active metabolite Ro 64-0802 Clinical Pharmacokinetics 1999 37 6 471 484
14. Lindegardh N., Davies G. R., Hien T. T., Rapid degradation of oseltamivir phosphate in clinical samples by plasma esterases Antimicrobial Agents and Chemotherapy 2006 50 9 3197 3199
15. Perrotta C. A., Lewis P. R., A histochemical study of placental esterases in the guinea-pig and in the human Journal of Anatomy 1958 92 1 110 117
16. Cunningham F. G., Leveno K. J., Bloom S. L., Hauth J. C., Gilstrap L. C., Wenstrom K. D., Williams Obstetrics 2005 22nd New York, NY, USA McGraw-Hill
17. World Health Organization, Cumulative number of confirmed human cases of avian influenza A/(H5N1) reported to WHO. October 2007, http://www.who.int/csr/ disease/avian_influenza/en/