Guanidino- and Urea-modified dendrimers as potent solubilizers of misfolded prion protein aggregates under non-cytotoxic conditions. Dependence on dendrimer generation and surface charge

Biomacromolecules

Volumn 8, Issue 11, 2007, Pages 3578-3583

  Cordes, Henriette ^a   Boas, Ulrik ^a,b   Olsen, Panchale ^a   Heegaard, Peter M H ^a  

^a TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

AMINES; CYTOTOXICITY; PH; PROTEINS; SOLUBILITY;

AMINO-TERMINATED DENDRIMERS; GUANIDINO SURFACE GROUPS; PROTEASE-RESISTANT;

DENDRIMERS;

AMINE; DENDRIMER; GUANIDINE DERIVATIVE; PRION PROTEIN; SOLUBILIZER; UREA DERIVATIVE;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BRAIN CELL; CHEMICAL MODIFICATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG CYTOTOXICITY; DRUG SYNTHESIS; IN VITRO STUDY; INCUBATION TIME; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; PH; PRION DISEASE; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DEPLETION; PROTEIN FOLDING; PROTEIN STABILITY; SOLUBILIZATION; SURFACE CHARGE;

CELL LINE; CELL SURVIVAL; DENDRIMERS; GUANIDINES; KINETICS; MOLECULAR STRUCTURE; PRIONS; PROTEIN FOLDING; SOLUBILITY; SURFACE PROPERTIES; TITRIMETRY; UREA;

EID: 36649016409     PISSN: 15257797     EISSN: None     Source Type: Journal    
DOI: 10.1021/bm7006168     Document Type: Article

References (18)

1. Prusiner, S. B. Proc. Natl. Acad. Sci. U.S.A. 1998, 95, 13363-13383.
2. Taylor, D. M. Transfus. Clin. Biol. 2003, 10, 23-25.
3. Prusiner, S. B.; Groth, D. F.; McKinley, M. P.; Cochran, S. P.; Bowman, K. A.; Kasper, K. C. Proc. Natl. Acad. Sci. U.S.A. 1981, 78, 4606-4610.
4. Peretz, D.; Supattapone, S.; Giles, K.; Vergara; J. Freyman, Y.; Lessard, P.; Safar, J. G.; Glidden, D. V.; McCulloch C.; Nguyen, H. O.; Scott, M.; DeArmond, S. J.; Prusiner, S. B. J. Virol. 2006, 80, 322-331.
5. Soto, C.; Kascsak, R. J.; Saborio, G. P.; Aucouturier, P.; Wisniewski, T.; Prelli, F; Kascsak, R.; Mendez, E.; Harris, D. A.; Ironside, J.; Tagliavini, F.; Carp, R. I.; Frangione, B, Lancet 2000, 355, 192-197.
6. Supattapone, S.; Wille, H; Uyechi, L.; Safar, J.; Tremblay, P.; Szoka, F. C.; Cohen, F. E.; Prusiner, S. B.; Scott, M. R. J. Virol. 2001, 75, 3453-3461.
7. Supattapone, S.; Nguyen, H. O.; Cohen, F. E.; Prusiner, S. B.; Scott, M. R. Proc. Natl. Acad. Sci. U.S.A. 1999, 96, 14529-14534.
8. Supattapone, S.; Bosque, P.; Muramoto, T.; Wille, H.; Aagaard, C.; Peretz, D.; Nguyen, H. O.; Heinrich, C.; Torchia M.; Safar, J.; Cohen, F. E.; DeArmond, S. J.; Prusiner, S. B.; Scott, M. Cell 1999, 96, 869-878.
9. Solassol, J.; Crozet, C.; Perrier, V.; Leclaire, J.; Beranger, F.; Caminade, A. M.; Meunier, B.; Dormont, D.; Majoral, J. P.; Lehmann, S. J. Gen. Virol. 2004, 85, 1791-1799.
10. Boas, U.; Heegaard, P. M. H. Chem. Soc. Rev. 2004, 33, 43-63.
11. Boas, U.; Christensen, J. B.; Heegaard, P. M. H. Dendrimers in medicine and biotechnology; RSC Publishing: Cambridge, 2006.
12. Heegaard, P. M.; Pedersen; H. G.; Flink, J.; Boas, U. FEBS Lett. 2004, 577, 127-133.
13. Clarke, M. C.; Haig, D. A. Res. Vet. Sci. 1970, 11, 500-501.
14. Clarke, M. C.; Haig, D. A. Nature 1970, 225, 100-101.
15. Mange, A.; Nishida, N.; Milhavet, O.; McMahon, H. E.; Casanova, D.; Lehmann, S. J. Virol. 2000, 74, 3135-3140.
16. Fisher, D.; Li, Y.; Ahlemeyer, B.; Krieglstein, J.; Kissel, T. Biomater. 2003, 24, 1121-1131.
17. Fuchs, S.; Kapp, T.; Otto, H.; Schoneberg, T.; Franke, P.; Gust, R.; Schluter, A. D. Chemistry 2004, 10, 1167-1192.
18. Klajnert, B.; Cortijo-Arellano, M.; Cladera, J.; Bryszewska, M. Biochem. Biophys. Res. Commun. 2006, 345, 21-28.