Dendrimers destabilize proteins in a generation-dependent manner involving electrostatic interactions

Biopolymers

Volumn 89, Issue 6, 2008, Pages 522-529

  Giehm, Lise ^a,b   Christensen, Casper ^b   Boas, Ulrik ^c   Heegaard, Peter M H ^c   Otzen, Daniel E ^a,b  

^a AARHUS UNIVERSITY   (Denmark)

^b AALBORG UNIVERSITY   (Denmark)

^c TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

Author keywords

Aggregation; Cutinase; Denaturation; Insulin; Solubility; Thermal stability

Indexed keywords

CHEMICAL PROPERTIES; CHEMOTHERAPY; DRUG DELIVERY; DRUG DOSAGE; ELECTROSTATICS; FLOW INTERACTIONS; HORMONES; INSULIN; NITROGEN COMPOUNDS; PHOTORESISTS; PROPYLENE; PROTEINS; UREA;

AGGREGATION; ANTI-TUMOR ACTIVITIES; CHEMICAL-; CUTINASE; DENATURATION; DENDRIMER; ELECTROSTATIC INTERACTIONS; GUANIDINIUM; LOW CONCENTRATIONS; MICROLITER; MODE OF ACTION; PH-DEPENDENCE; PRION PROTEIN; PROPYLENE IMINE; SMALL MOLECULES; SOLUBILITY; SURFACE GROUPS; SURFACE IMMOBILIZATION; THERMAL STABILITY;

DENDRIMERS;

BUTANE; CUTINASE; DENDRIMER; EGG WHITE; GUANIDINE; HUMAN INSULIN; POLYPROPYLENE; UREA; POLYPROPYLENEIMINE; PROTEIN;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATION ANALYSIS; ELECTROSTATIC PRECIPITATION; PH; PROTEIN AGGREGATION; PROTEIN DENATURATION; PROTEIN INTERACTION; PROTEIN MODIFICATION; PROTEIN STABILITY; SOLUBILITY; SURFACE PROPERTY; THERMOSTABILITY; CHEMISTRY; ELECTRICITY; HUMAN;

DENDRIMERS; ELECTROSTATICS; HUMANS; HYDROGEN-ION CONCENTRATION; POLYPROPYLENES; PROTEINS;

EID: 44849085552     PISSN: 00063525     EISSN: 10970282     Source Type: Journal    
DOI: 10.1002/bip.20921     Document Type: Article

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