Toll-like receptor 4 mutation impairs the macrophage TNFα response to peptidoglycan

Biochemical and Biophysical Research Communications

Volumn 325, Issue 1, 2004, Pages 91-96

  Li, Qian ^a   Cherayil, Bobby J ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Inflammation; Lipopolysaccharide; Macrophage; Peptidoglycan; TNF ; Toll like receptors

Indexed keywords

LIGAND; MESSENGER RNA; PEPTIDOGLYCAN; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; BIOSYNTHESIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; MOUSE; MOUSE STRAIN; MUTATION; NONHUMAN; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; WILD TYPE;

ANIMALS; LIPOPOLYSACCHARIDES; MACROPHAGES, PERITONEAL; MICE; MICE, INBRED C3H; PEPTIDOGLYCAN; POINT MUTATION; RECEPTORS, CELL SURFACE; RNA, MESSENGER; TOLL-LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA; NEGIBACTERIA;

EID: 7444249575     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2004.10.008     Document Type: Article

References (31)

1. R. Medzhitov Toll-like receptors and innate immunity Nat. Rev. Immunol. 1 2001 135 145
2. J.L. Imler, and J.A. Hoffmann Toll signaling: the TIReless quest for specificity Nat. Immunol. 4 2003 105 106
3. M. Yamamoto, S. Sato, H. Hemmi, K. Hoshino, T. Kaisho, H. Sanjo, O. Takeuchi, M. Sugiyama, M. Okabe, K. Takeda, and S. Akira Role of adaptor TRIF in the MyD88-independent Toll-like receptor signaling pathway Science 301 2003 640 643
4. K. Hoebe, X. Du, P. Georgel, E. Janssen, K. Tabeta, S.O. Kim, J. Goode, P. Lin, N. Mann, S. Mudd, K. Crozat, S. Sovath, J. Han, and B. Beutler Identification of Lps2 as a key transducer of MyD88-independent TIR signalling Nature 424 2003 743 748
5. M. Yamamoto, S. Sato, H. Hemmi, S. Uematsu, K. Hoshino, T. Kaisho, O. Takeuchi, K. Takeda, and S. Akira TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway Nat. Immunol. 4 2003 1144 1150
6. K. Fitzgerald, D.C. Rowe, B.J. Barnes, D.R. Caffrey, A. Visintin, E. Latz, B. Monks, P.M. Pitha, and D.T. Golenbock LPS-TLR4 signaling to IRF-3/7 and NF-κB involves the Toll adaptors TRAM and TRIF J. Exp. Med. 198 2003 1043 1055
7. S. Sato, F. Nomura, T. Kawai, O. Takeuchi, P.F. Muhlradt, K. Takeda, and S. Akira Synergy and cross-tolerance between Toll-like receptor (TLR) 2- and TLR4-mediated signaling pathways J. Immunol. 165 2000 7096 7101
8. D.A. Hume, D.M. Underhill, M.J. Sweet, A.O. Ozinsky, F.Y. Liew, and A. Aderem Macrophages exposed continuously to lipopolysaccharide and other agonists that act via Toll-like receptors exhibit a sustained and additive activation state BMC Immunol. 2 2001 11
9. A.S. Cross Endotoxin tolerance-current concepts in historical perspective J. Endotoxin Res. 8 2002 83 98
10. B.J. Cherayil How not to get bugged by bugs: mechanisms of cellular tolerance to microorganisms Curr. Opin. Gastroenterol. 19 2003 572 577
11. A. Poltorak, X. He, I. Smirnova, M.Y. Liu, C.V. Huffel, X. Du, D. Birdwell, E. Alejos, M. Silva, C. Galanos, M. Freudenberg, P. Ricciardi-Castagnoli, B. Layton, and B. Beutler Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene Science 282 1998 2085 2088
12. Q. Li, and B.J. Cherayil Role of Toll-like receptor 4 in macrophage activation and tolerance during Salmonella enterica serovar Typhimurium infection Infect. Immun. 71 2003 4873 4882
13. M.C. Royle, S. Totemeyer, L.C. Alldridge, D.J. Maskell, and C.E. Bryant Stimulation of Toll-like receptor 4 by lipopolysaccharide during cellular invasion by live Salmonella typhimurium is a critical but not exclusive event leading to macrophage responses J. Immunol. 170 2003 5445 5454
14. A. Lembo, C. Kalis, C.J. Kirschning, V. Mitolo, E. Jirillo, H. Wagner, C. Galanos, and M.A. Freudenberg Differential contribution of Toll-like receptors 4 and 2 to the cytokine response to Salmonella enterica serovar Typhimurium and Staphylococcus aureus in mice Infect. Immun. 71 2003 6058 6062
15. D.S. Weiss, B. Raupach, K. Takeda, S. Akira, and A. Zychlinsky Toll-like receptors are temporally involved in host defense J. Immunol. 172 2004 4463 4469
16. O. Takeuchi, K. Hoshino, T. Kawai, H. Sanjo, H. Takada, T. Ogawa, K. Takeda, and S. Akira Differential roles of TLR2 and TLR4 in recognition of Gram-negative and Gram-positive bacterial cell wall components Immunity 11 1999 443 451
17. M.A. Dobrovolskaia, A.E. Medvedev, K.E. Thomas, N. Cuesta, V. Toshchakov, T. Ren, M.J. Cody, S.M. Michalek, N.R. Rice, and S.N. Vogel Induction of in vitro reprogramming by Toll-like receptor (TLR)2 and TLR4 agonists in murine macrophages: effects of TLR "homotolerance" versus "heterotolerance" on NF-κB signaling pathway components J. Immunol. 170 2003 508 519
18. A.J. Macpherson, and N.L. Harris Interactions between commensal intestinal bacteria and the immune system Nat. Rev. Immunol. 4 2004 478 485
19. C.D. Dumitru, J.D. Ceci, C. Tsatsanis, D. Kontoyiannis, K. Stamatakis, J.-H. Lin, C. Patriotis, N. Jenkins, N.G. Copeland, G. Kollias, and P.N. Tsichlis TNF-α induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway Cell 103 2000 1071 1083
20. D. Kontoyiannis, A. Kotlyarov, E. Carballo, L. Alexopoulou, P.J. Blackshear, M. Gaestel, R. Davis, R. Flavell, and G. Kollias Interleukin-10 targets p38 MAPK to modulate ARE-dependent TNF mRNA translation and limit intestinal pathology EMBO J. 20 2001 3760 3770
21. T. Zhang, V. Kruys, G. Huez, and C. Gueydan AU-rich element-mediated translational control: complexity and multiple activities of trans-activating factors Biochem. Soc. Trans. 30 2002 952 958
22. B. Abel, N. Thieblemont, V.J.F. Quesniaux, N. Brown, J. Mpagi, K. Miyake, F. Bihl, and B. Ryffel Toll-like receptor 4 expression is required to control chronic Mycobacterium tuberculosis infection in mice J. Immunol. 169 2002 3155 3162
23. M.G. Netea, C.A.A. Van der Graaf, A.G. Vonk, I. Verschueren, J. Van der Meer, and B.J. Kullberg The role of the Toll-like receptor (TLR) 2 and TLR4 in the host defense against disseminated candidiasis J. Infect. Dis. 185 2002 1483 1489
24. K.K. Yang, B.G. Dorner, U. Merkel, B. Ryffel, C. Schutt, D. Golenbock, M.W. Freeman, and R.S. Jack Neutrophil influx in response to peritoneal infection with Salmonella is delayed in lipopolysaccharide-binding protein or CD14-deficient mice J. Immunol. 169 2002 4475 4480
25. A.D. O'Brien, D.L. Rosenstreich, I. Scher, G.H. Campbell, R.P. MacDermott, and S.B. Formal Genetic control of susceptibility to Salmonella typhimurium in mice: role of the LPS gene J. Immunol. 124 1980 20 24
26. D.L. Weinstein, C.R. Lissner, R.N. Swanson, and A.D. O'Brien Macrophage defect and inflammatory cell recruitment dysfunction in Salmonella susceptible C3H/HeJ mice Cell. Immunol. 102 1986 68 77
27. A. Vazquez-Torres, B.A. Vallance, M.A. Bergman, B.B. Finlay, B.T. Cookson, J. Jones-Carson, and F.C. Fang Toll-like receptor 4 dependence of innate and adaptive immunity to Salmonella: importance of the Kupffer cell network J. Immunol. 172 2004 6202 6208
28. C.M. Fremond, D.M. Nicolle, D.S. Torres, and V.F. Quesniaux Control of Mycobacterium bovis BCG infection with increased inflammation in TLR4-deficient mice Microbes Infect. 5 2003 1070 1081
29. W. Levis, G.B. Schuller-Levis, and E. Park Deficient tumor necrosis factor-alpha production in lipoarabinomannan activated macrophages from Toll-like receptor 4-deficient mice: implications for mycobacterial susceptibility Int. J. Lepr. Other Mycobact. Dis. 71 2003 1 9
30. M.E. Bashir, S. Louie, H.N. Shi, and C. Nagler-Anderson Toll-like receptor 4 signaling by intestinal microbes influences susceptibility to food allergy J. Immunol. 172 2004 6978 6987
31. S. Rakoff-Nahoum, J. Paglino, F. Eslami-Varzaneh, S. Edberg, and R. Medzhitov Recognition of commensal microflora by Toll-like receptors is required for intestinal homeostasis Cell 118 2004 229 241