Endotoxin tolerance - Current concepts in historical perspective

Journal of Endotoxin Research

Volumn 8, Issue 2, 2002, Pages 83-98

  Cross, Alan S ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD14 ANTIGEN; COLONY STIMULATING FACTOR; CYTOKINE; ENDOGENOUS PYROGEN; ENDOTOXIN; GAMMA INTERFERON; INTERLEUKIN 10; LIPOPOLYSACCHARIDE; MURAMYL DIPEPTIDE; O ANTIGEN; PHOSPHORYL LIPID A; PROTEIN P50; RECOMBINANT INTERLEUKIN 1; RECOMBINANT TUMOR NECROSIS FACTOR ALPHA; TOLL LIKE RECEPTOR 4; TYPHOID VACCINE;

ANTIMICROBIAL ACTIVITY; BACTEREMIA; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DENDRITIC CELL; ENDOTHELIUM CELL; FEVER; GRANULOCYTOSIS; HOST RESISTANCE; HUMAN; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; IN VITRO STUDY; IN VIVO STUDY; INFECTION SENSITIVITY; INFLUENZA; KUPFFER CELL; MACROPHAGE FUNCTION; MICROBIAL IMMUNITY; NATURAL KILLER CELL; NONHUMAN; PATHOGENESIS; PLASMA CLEARANCE; RETICULOENDOTHELIAL SYSTEM; REVIEW; SEPSIS; T LYMPHOCYTE;

ANIMALS; DRUG TOLERANCE; ENDOTOXINS; HISTORY, 20TH CENTURY; HUMANS; LIPOPOLYSACCHARIDES; TOXICOLOGY;

EID: 0036099755     PISSN: 09680519     EISSN: None     Source Type: Journal    
DOI: 10.1179/096805102125000227     Document Type: Review

References (174)

1. Studies on the generalized Shwartzman reaction. I. General observations concerning the phenomenon
2. Approaches to the mechanisms of endotoxin action
3. Chemical treatment of tumors. VII. Nature of hemorrhage-producing fraction from Serratia marcescens (Bacillus prodigiosus) culture filtrate
4. Tolerance to bacterial pyrogens. I. Factors influencing its development
5. Endotoxin tolerance: Regulation of cytokine production and cellular changes in response to endotoxin application in cancer patients
6. Endotoxin (Salmonella abortus equi) in cancer patients. Clinical and immunological findings
7. Tolerance to bacterial pyrogens. II. Role of the reticulo-endothelial system
8. Temperature-elevating effect of a substance obtained from polymorphonuclear leukocytes
9. Further studies on the immunological properties of polysaccharides from Serratia marcescens (Bacillus prodigiosus). II. Nature of the antigenic action and the antibody response in mice
10. The effect of Mycobacterium tuberculosis (BCG) infection on the resistance of mice to bacterial endotoxin and Salmonella enteritidis infection
11. Investigations on the mechanism of stimulation of non-specific immunity by bacterial lipopolysaccharide
12. Stimulation of natural immunity to Escherichia coli infections
13. The influence of endotoxin on resistance to infection
14. Possible mechanisms whereby endotoxins evoke increased nonspecific resistance to infection
15. Mechanisms of endotoxin tolerance with special reference to man
16. Endotoxin tolerance and the induction of nonspecific resistance to Salmonella dublin and Streptococcus agalactiae infections in mice
17. Mechanisms of endotoxin tolerance. The role of the spleen
18. Induction of endotoxin tolerance with nonpyrogenic O-antigen oligosaccharide-protein conjugates
19. Resistance promoting activity of endotoxins and other microbial products. II. Protection against neurotoxic action of products of influenza virus
20. Relationship between vascular manifestations of shock produced by endotoxin, trauma and hemorrhage. II. Possible role of reticulo-endothelial system in resistance to each type of shock
21. Resistance to experimental infection and mobilization of granulocytes in irradiated mice treated with bacterial endotoxin
22. Mechanisms of endotoxin tolerance. I. Relationship between tolerance and reticuloendothelial system phagocytic activity in the rabbit
23. Biological effects of bacterial endotoxin in man
24. Mechanisms of endotoxin tolerance. IX. Effect of exchange transfusion
25. The hepatic uptake of bacterial endotoxin. I. The influence of humoral and cellular factors
26. The role of the liver in the production of fever and in pyrogenic tolerance
27. Mechanisms of endotoxin tolerance. VII. The role of the liver
28. The role of endotoxin tolerance during typhoid fever and tularemia in man. IV. Integrity of endotoxin tolerance mechanisms during infection
29. Endotoxin tolerance. II. Its occurrence in patients with pyelonephritis
30. Tolerance to the action of endotoxins of enteric bacilli in patients convalescent from typhoid and paratyphoid fevers
31. Influence of various disease states upon the febrile response to intravenous injection of typhoid bacterial pyrogen
32. The role of endotoxin during typhoid fever and tularemia in man. I. Acquisition of tolerance to endotoxin
33. Malaria induced endotoxin tolerance
34. Studies on cyclic neutropenia
35. Studies on the pathogenesis of fever. VII. Preliminary chemical characterization of leucocytic pyrogen
36. Release of endogenous pyrogen by human monocytes
37. Tolerance to the induction of interferons by endotoxin and viruses: Role of a humoral factor
38. Interferon appearance stimulated by endotoxin, bacteria or viruses in mice pre-treated with Escherichia coli endotoxin or infected with Mycobacterium tuberculosis
39. Toxic properties of a synthetic double-stranded RNA. Endotoxin-like properties of poly I:poly C, an interferon
40. Interferon tolerance and antiviral protection in mice given single or multiple injection of endotoxin or poly I:C
41. Tolerance to the granulocyte-releasing and colony-stimulating elevating effects of endotoxin
42. The synthesis and secretion of granulocyte-monocyte colony-stimulating activity (CSA) by isolated human monocyte kinetics of response to bacterial endotoxin
43. Early endotoxin tolerance is associated with alterations in both marrow-derived macrophages precursor pools
44. Recombinant interleukin-1 alpha and recombinant tumor necrosis factor alpha synergize in vivo to induce early endotoxin tolerance and associated hematopoietic changes
45. An interleukin-1 receptor antagonist blocks lipopolysaccharide-induced colony-stimulating factor production and early endotoxin tolerance
46. Lipid A-induced tolerance and hyperreactivity to hypothermia in mice
47. Induction of colony-stimulating activity (CSA) by a synthetic muramyl peptide (MDP): Synergism with LPS and activity in C3H/HeJ mice and in endotoxin-tolerized mice
48. Tolerance to pyrogens
49. Effects of bacterial constituents on resistance of mice to heterologous infection and on activity of their reticulo-endothelial system
50. Effect of zymosan on endotoxin toxicity in mice
51. Inverse relationship between the susceptibility of lipopolysaccharide (lipid A)-pretreated mice to the hypothermic and lethal affect of lipopolysaccharide
52. Adaptation to bacterial lipopolysaccharide controls lipopolysaccharide-induced tumor necrosis factor production in rabbit macrophages
53. Endotoxin tolerance: Independent regulation of interleukin-1 and tumor necrosis factor expression
54. Early downregulation of TNF production by LPS tolerance in human monocytes. Comparison with IL-1β, IL-6 and IL-8
55. Lipopolysaccharide tolerance in murine peritoneal macrophages induces downregulation of the lipopolysaccharide signal transduction pathway through mitogen-activated protein kinase and nuclear factor-kappaB lipopolysaccharide-incorporation steps
56. Endotoxin tolerance is associated with altered GTP-binding protein function
57. Tolerance to LPS decreases macrophage G protein content
58. Macrophage TNF secretion in endotoxin tolerance: Role of SAPK, p38, and MAPK
59. Impaired mitogen-activated protein kinase activation and altered cytokine secretion in endotoxin-tolerant human monocytes
60. Endotoxin tolerance: In vivo regulation of tumor necrosis factor and interleukin-1 synthesis is at the transcriptional level
61. Suppression of TNF-alpha mRNA expression in LPS-primed macrophages occurs at the level of nuclear factor-kappa B activation, but not at the level of protein kinase C or CD14 expression
62. The involvement of an LPS inducible I kappa B kinase in endotoxin tolerance
63. Induction of endotoxin tolerance depletes nuclear factor-kappaB and suppresses its activation in rat alveolar macrophages
64. Mechanism of endotoxin desensitization: Involvement of interleukin 10 and transforming growth factor beta
65. mRNA and protein stability regulate the differential expression of pro- and anti-inflammatory genes in endotoxin-tolerant THP-1 cells
66. NF-kappaB1 (p50) is upregulated in lipopolysaccharide tolerance and can block tumor necrosis factor gene expression
67. Inhibitory kappaB alpha control of nuclear factor-kappaB is dysregulated in endotoxin tolerant macrophages
68. A labile transcriptional repressor modulates endotoxin tolerance
69. Increased levels of myocardial IkappaB-alpha protein promote tolerance to endotoxin
70. Hyporesponsiveness to lipopolysaccharide alters the composition of NF-kappa B binding to the regulatory regions of inducible nitric oxide synthase gene
71. Lipopolysaccharide-triggered desensitization of TNF-alpha mRNA expression involves lack of phosphorylation of IkappaBalpha in a murine macrophage-like cell line, P388D1
72. Induction of tolerance to lipopolysaccharide (LPS)-D-galactosamine lethality by pretreatment with LPS is mediated by macrophages
73. Tumor necrosis factor (cachectin) is a endogenous pyrogen induces production of interleukin 1
74. Dysregulation of the in vitro cytokine production by monocytes during sepsis
75. Inhibition of the defense system stimulating interleukin 12 interferon γ pathway during critical illness
76. Differential expression of pro-inflammatory cytokines and their inhibitors during the course of meningococcal infections
77. Clinical and biological significance of interleukin-10 plasma levels in patients with septic shock
78. Reversal of defective IL-6 production in lipopolysaccharide-tolerant mice by phorbol myristate acetate
79. Cytokine synthesis in the liver of endotoxin-tolerant and normal rats during hemorrhagic shock
80. Effects of bacterial infection and irradiation on serum colony-stimulating factor levels in tolerant and nontolerant C mice
81. Time course of IL-6 and TNF alpha release during endotoxin-induced endotoxin tolerance in rats
82. Differential regulation of cytokine production in lipopolysaccharide tolerance in mice
83. In vitro desensitization to lipopolysaccharide suppresses tumor necrosis factor, interleukin-1 and interleukin-6 gene expression in a similar fashion
84. 2
85. Differential desensitization of lipopolysaccharide-inducible chemokine gene expression in human monocytes and macrophages
86. Improved innate immunity of endotoxin-tolerant mice increases resistance to Salmonella enterica serovar typhimurium infection despite attenuated cytokine response
87. Pretreatment of normal humans with monophosphoryl lipid A induces tolerance to endotoxin: A prospective, double-blind, randomized, controlled trial
88. Disociation of IFN-γ from IL-12 and IL-18 production during endotoxin tolerance
89. Potent suppression of IL-12 production from monocytes and dendritic cells during endotoxin tolerance
90. IL-12 suppression during experimental endotoxin tolerance: Dendritic cells loss and macrophage hyporesponsiveness
91. Cellular mechanisms that cause suppressed gamma interferon secretion in endotoxin-tolerant mice
92. Interleukin-10 is upregulated in LPS tolerance
93. Changes in endotoxin-induced production by whole blood after in vivo exposure of normal humans to endotoxin
94. Interleukin-10 is a central regulator of the response to LPS in murine models of endotoxic shock and the Shwartzman reaction but not endotoxin tolerance
95. Comparison of monocyte functions after LPS-or IL-10-induced re-orientation: Importance in clinical immunoparalysis
96. Tolerance to tumor necrosis factor in rats and the relationship endotoxin tolerance and toxicity
97. Inhibition of lipopolysaccharide-induced signal transduction in endotoxin-tolerized mouse macrophages: Dysregulation of cytokine, chemokine, and toll-like receptor 2 and 4 gene expression
98. Inhibition of lipopolysaccharide-induced in vitro desensitization by interferon-gamma
99. In vitro prevention and reversal of lipopolysaccharide desensitization by IFN-gamma, IL-12 and granulocyte-macrophage colony-stimulating factor
100. Granulocyte-macrophage colony-stimulating factor and IFN-gamma restore the systemic TNF-alpha response to endotoxin in lipopolysaccharide-desensitized mice
101. Restoration of normal febrile response to endotoxin in progen-tolerant rabbits by injection with human beta interferon
102. Protein kinase C regulates macrophages tumor necrosis factor secretion: Direct protein kinase C activation restores tumor necrosis factor production in endotoxin tolerance
103. Lipopolysaccharide induces hyporesponsiveness to its own action in RAW 264.7 cells
104. Lack of cross-tolerance between LPS and muramyl dipeptide in induction of circulating TNF-α and IL-6 in guinea pigs
105. Differential tolerance induction by lipoarabinomannan and lipopolysaccharide in human macrophages
106. Pre-exposure of murine macrophages to CpG oligonucleotide results in a biphasic tumor necrosis factor alpha response to subsequent lipopolysaccharide challenge
107. Induction of tolerance to lipopolysaccharide and mycobacterial components in Chinese hamster ovary/CD14 cells is not affected by overexpression of Toll-like receptors 2 or 4
108. Induction of cross-tolerance by lipopolysaccharide and highly purified lipoteichoic acid via different Toll-like receptors independent of paracrine mediators
109. Synergy and cross-tolerance between Toll-like receptor (TLR) 2- and TLR4-mediated signaling pathways
110. Endotoxin tolerance is not a LPS-specific phenomenon: Partial mimicry with IL-1, IL-10 and TGF-β
111. Epinephrine and endotoxin tolerance differentially modulate serum cytokine levels to high-dose lipopolysaccharide challenge in a murine model
112. Choice of bacteria in animal models of sepsis
113. Studies on the bacteremia of bacterial endocarditis
114. Serial quantitation of endotoxemia and bacteremia during therapy for gram-negative bacterial septicemia
115. Salmonellosis in mice infected with Mycobacterium tuberculosis BCG. I Role of endotoxin in infection
116. Bacterial DNA induces NK cells to produce interferon γ in vivo and increases the toxicity of lipopolysaccharides
117. Bacterial DNA and lipopolysaccharide induce synergistic production of TNF-α through a post-transcriptional mechanism
118. Role of Toll-like receptors in inflammatory response in macrophages
119. Centrally acting vasopressin contributes to endotoxin tolerance
120. Further studies on passive transfer of tolerance to pyrogenicity of bacterial endotoxin
121. Resistance to the action of enteric bacilli in man
122. Mechanism of endotoxin tolerance and reticuloendothelial system phagocytic activity in man
123. CD14 and tolerance to lipopolysaccharide: Biochemical and functional analysis
124. 51Cr-labeled lipid A before and after the induction of endotoxin tolerance
125. The kinetics of the production of granulocyte-monocyte colon stimulating activity (GM-CSA) by isolated human monocytes response to bacterial endotoxin
126. Cutting edge: Endotoxin tolerance in mouse peritoneal macrophages correlates with downregulation of surface Toll-like receptor 4 expression
127. Hypersensitivity to endotoxin and mechanisms of host-response
128. Use of mice tolerant to lipopolysaccharide to demonstrate requirement of co-operation between macrophages and lymphocyte to generate lipopolysaccharide-induced colony-stimulating factor in vivo
129. Induction of early-phase endotoxin tolerance in athymic (nude) mice, B-cell-deficient (xid) mice, and splenectomized mice
130. The immunosuppressive effects of the in vivo administration of endotoxin as influenced by macrophages
131. Phase II trial of intravenous endotoxin in patients with colorectal and non-small cell lung cancer
132. Impaired antigen presentation by human monocytes during endotoxin tolerance
133. LPS tolerance in human endothelial cells: Reduced PMN adhesion, E-selectin expression, and NF-kappaB mobilization
134. Tolerance to endotoxin-induced expression of the interleukin 1-β gene in blood neutrophils of humans with the sepsis syndrome
135. Reduced ex vivo interleukin-8 production by neutrophils in septic and nonseptic systemic inflammatory response syndrome
136. Intravenous endotoxin suppresses the cytokine response of peripheral blood mononuclear cells of healthy humans
137. Endotoxin tolerance in rats: Expression of TNF-alpha, IL-6 IL-10, VCAM-1 and HSP 70 in lung and liver during endotoxin shock
138. Pulmonary and hepatic gene expression following cecal ligation and puncture: Monophosphoryl lipid A prophylaxis attenuates sepsis-induced cytokine and chemokine expression and neutrophil infiltration
139. Independent down-regulation of central and peripheral tumor necrosis factor production as a result of lipopolysaccharide tolerance in mice
140. Does the formation of lipopolysaccharide tolerance require intact vagal innervation of the liver?
141. Mind over immunity
142. Tolerance to lipopolysaccharide is related to the nitric oxide pathway
143. Increased resistance to epinephrine infusion in endotoxin-tolerance state
144. Endotoxin fever and tolerance in totally adrenalectomized rats
145. Glucocorticoid-dependent and -independent mechanisms involved in lipopolysaccharide tolerance
146. Neutralization and lipoprotein binding of lipopolysaccharide tolerant rabbit serum
147. Plasma CD14 decreases monocyte response to LPS by transferring cell-bound LPS to plasma lipoproteins
148. Nuclear factor kappa B: A pivotal role in the systemic inflammatory response syndrome and new target for therapy
149. Administration of endotoxin associated with lipopolysaccharide tolerance protects mice against fungal infection
150. In vivo microscopic observations of the responses of Kupffer cells and the hepatic microcirculation to Mycobacterium bovis BCG alone and in combination with endotoxin
151. Early-phase endotoxin tolerance: Induction by a detoxified lipid derivative, monophosphoryl lipid A
152. Downregulation of the proinflammatory cytokine response to endotoxin by pretreatment with the nontoxic lipid A analog SDZ MRL 953 in cancer patients
153. E5531, a pure endotoxin antagonist of high potency
154. The importance of a lipopolysaccharide-initiated, cytokine-mediated host defense mechanism in mice against experimentally invasive Escherichia coli
155. Tolerance to lipopolysaccharide in human blood monocytes
156. Tolerance to lipopolysaccharide involves mobilization of nuclear factor kappa B with predominance of p50 homodimers
157. Effects of gamma interferon on release of tumor necrosis factor alpha from lipopolysaccharide-tolerant human monocyte-derived macrophages
158. Differential expression of interferon regulatory factor 1 (IRF-1), IRF-2, and interferon consensus sequence binding protein genes in lipopolysaccharide (LPS)-responsive and LPS hyporesponsive macrophages
159. Attenuation of the induction of nitric oxide synthase by endogenous glucocorticoids accounts for endotoxin tolerance in vivo
160. Pre-exposure of murine macrophages to lipopolysaccharide inhibits the induction of nitric oxide synthase and reduces leishmanicidal activity
161. Characterization of interleukin-1 receptor associated kinase in normal and endotoxin-tolerant cells
162. Endotoxin tolerance alters phospholipase C-gamma 1 and phosphatidylinositol-3′-kinase expression in peritoneal macrophages
163. Dissociation of lipopolysaccharide (LPS)-inducible gene expression in murine macrophages pretreated with smooth LPS versus monophosphoryl lipid A
164. Impaired activation of nuclear factor kappaB in endotoxin-tolerant rats is associated with down-regulation of chemokine gene expression and inhibition of neutrophilic lung inflammation
165. Molecular mechanism in tolerance to lipopolysaccharide
166. Regulation of an essential innate immune response by the p50 subunit of NF-κB
167. Independent signal transduction pathways for IL-1 and TNF in LPS-tolerant macrophages
168. Pre-exposure of murine macrophages to lipopolysaccharide inhibits the induction of nitric oxide synthase and reduces leishmanicidal activity
169. Lipopolysaccharide-induced selective priming effects on tumor necrosis factor alpha and nitric oxide production in mouse peritoneal macrophages
170. Increased nitric oxide synthesis during the development of endotoxin tolerance
171. Involvement of the membrane form of tumor necrosis factor alpha in lipopolysaccharide-induced priming of mouse peritoneal macrophages for enhanced nitric oxide response to lipopolysaccharide
172. The role of nuclear factor-kappa B in cytokine gene regulation
173. Induction of endotoxin tolerance in rat bone marrow cells by in vivo infusion of tumor necrosis factor