Expression of HIV-1 integrase in CEM cells inhibits HIV-1 replication

Journal of Gene Medicine

Volumn 6, Issue 3, 2004, Pages 268-277

  van Griensven, John ^a   Zhan, Xiaojing ^a   Van Maele, Bénédicte ^a   Pluymers, Wim ^a   Michiels, Martine ^a   De Clercq, Erik ^a   Cherepanov, Peter ^a   Debyser, Zeger ^a  

^a REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

Gene therapy; HIV 1; Integrase; Lentiviral vectors

Indexed keywords

INTEGRASE; RETROVIRUS VECTOR; SYNTHETIC DNA;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CELL LINE; CONTROLLED STUDY; ENZYME MECHANISM; FLOW CYTOMETRY; GENE EXPRESSION; GENE STRUCTURE; GENE TARGETING; GENETIC TRANSDUCTION; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IN VIVO STUDY; NONHUMAN; PLEIOTROPY; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY; VIRUS CELL INTERACTION; VIRUS DNA CELL DNA INTERACTION; VIRUS PARTICLE; VIRUS REPLICATION; WESTERN BLOTTING; ENZYMOLOGY; FLUORESCENT ANTIBODY TECHNIQUE; GENE THERAPY; GENE VECTOR; GENETICS; HUMAN; METABOLISM; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE;

HUMAN IMMUNODEFICIENCY VIRUS 1; MAMMALIA;

ACQUIRED IMMUNODEFICIENCY SYNDROME; CELL LINE; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; GENE THERAPY; GENES, SYNTHETIC; GENETIC VECTORS; HIV INTEGRASE; HIV-1; HUMANS; PROTEIN STRUCTURE, TERTIARY; TRANSDUCTION, GENETIC; VIRUS INTEGRATION; VIRUS REPLICATION;

EID: 7444236405     PISSN: 1099498X     EISSN: 15212254     Source Type: Journal    
DOI: 10.1002/jgm.520     Document Type: Article

References (45)

1. Richman DD. HIV chemotherapy. Nature 2001; 410: 995-1001.
2. Debyser Z, Cherepanov P, Van Maele B, et al. In search of authentic inhibitors of HIV-1 integration. Antivir Chem Chemother 2002; 13: 1-15.
3. Nair V. HIV integrase as a target for antiviral chemotherapy. Rev Med Virol 2002; 12: 179-193.
4. Engelman A. In vivo analysis of retroviral integrase structure and function. Adv Virus Res 1999; 52: 411-426.
5. Hazuda DJ, Felock P, Witmer M, et al. Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells. Science 2000; 287: 646-650.
6. Brown PO. Integration of retroviral DNA. Curr Topics Microbiol Immunol 1997; 157: 19-47.
7. van Gent DC, Vink C, Groeneger AA, et al. Complementation between HIV integrase proteins mutated in different domains. EMBO J 1993; 12: 3261-3267.
8. Engelman A, Bushman FD, Craigie R. Identification of discrete functional domains of HIV-1 integrase and their organization within an active multimeric complex. EMBO J 1993; 12: 3269-3275.
9. Wang JY, Ling H, Yang W, et al. Structure of a two-domain fragment of HIV-1 integrase: implications for domain organization in the intact protein. EMBO J 2001; 20: 7333-7343.
10. Bushman FD, Craigie R. Activities of human immunodeficiency virus (HIV) integration protein in vitro: specific cleavage and integration of HIV DNA. Proc Natl Acad Sci U S A 1991; 88: 1339-1343.
11. Sherman PA, Fyfe JA. Human immunodeficiency virus integration protein expressed in Escherichia coli possesses selective DNA cleaving activity. Proc Natl Acad Sci U S A 1990; 87: 5119-5123.
12. Miller MD, Farnet CM, Bushman FD. Human immunodeficiency virus type 1 preintegration complexes: studies of organization and composition. J Virol 1997; 71: 5382-5390.
13. Schroder AR, Shinn P, Chen H, et al. HIV-1 integration in the human genome favors active genes and local hotspots. Cell 2002; 110: 521-529.
14. Bukrinsky MI, Sharova N, Dempsey MP, et al. Active nuclear import of human immunodeficiency virus type 1 preintegration complexes. Proc Natl Acad Sci U S A 1992; 89: 6580-6584.
15. Gallay P, Swingler S, Song J, et al. HIV nuclear import is governed by the phosphotyrosine-mediated binding of matrix to the core domain of integrase. Cell 1995; 83: 569-576.
16. Greene WC, Peterlin BM. Charting HIV's remarkable voyage through the cell: basic science as a passport to future therapy. Nat Med 2002; 8: 673-680.
17. Zennou V, Petit C, Guetard D, et al. HIV-1 genome nuclear import is mediated by a central DNA flap. Cell 2000; 101 173-185.
18. Follenzi A, Ailles LE, et al. Gene transfer by lentiviral vectors is limited by nuclear translocation and rescued by HIV-1 pol sequences. Nat Genet 2000; 25: 217-222.
19. Wang W, Cote J, Xue Y, et al. Purification and biochemical heterogeneity of the mammalian SWI-SNF complex. EMBO J 1996; 15: 5370-5382.
20. Carlson M, Laurent BC. The SNF/SWI family of global transcriptional activators. Curr Opin Cell Biol 1994; 6: 396-402.
21. Turelli P, Doucas V, Craig E, et al. Cytoplasmic recruitment of INI1 and PML on incoming HIV preintegration complexes: interference with early steps of viral replication. Mol Cell 2001; 7: 1245-1254.
22. Cherepanov P, Maertens G, Proost P, et al. HIV-1 integrase forms stable tetramers and associates with LEDGF/p75 protein in human cells. J Biol Chem 2003; 278: 372-381.
23. Fatma N, Singh DP, Shinohara T, et al. Transcriptional regulation of the antioxidant protein 2 gene, a thiol-specific antioxidant, by lens epithelium-derived growth factor to protect cells from oxidative stress. J Biol Chem 2001; 276: 48 899-48 907.
24. Matsui H, Lin LR, Singh DP, et al. Lens epithelium-derived growth factor: increased survival and decreased DNA breakage of human RPE cells induced by oxidative stress. Invest Ophthalmol Vis Sci 2001; 42: 2935-2941.
25. Singh DP, Fatma N, Kimura A, et al. LEDGF binds to heat shock and stress-related element to activate the expression of stress-related genes. Biochem Biophys Res Commun 2001; 283: 943-955.
26. Farnet CM, Bushman FD. HIV-1 cDNA integration: requirement of HMG I(Y) protein for function of preintegration complexes in vitro. Cell 1997; 88: 483-492.
27. Lee MS, Craigie R. A previously unidentified host protein protects retroviral DNA from autointegration. Proc Natl Acad Sci U S A 1998; 95: 1528-1533.
28. Gao K, Gorelick RJ, Johnson DG, et al. Cofactors for human immunodeficiency virus type 1 cDNA integration in vitro. J Virol 2003; 77: 1598-15 603.
29. Buchschacher GL Jr, Wong-Staal F. Approaches to gene therapy for human immunodeficiency virus infection. Hum Gene Ther 2001; 12: 1013-1019.
30. Trono D, Feinberg MB, Baltimore D. HIV-1 Gag mutants can dominantly interfere with the replication of the wild-type virus. Cell 1989; 59: 113-120.
31. Malim MH, Freimuth WW, Liu J, et al. Stable expression of transdominant Rev protein in human T cells inhibits human immunodeficiency virus replication. J Exp Med 1992; 176: 1197-1201.
32. Cullen BR. Mechanism of action of regulatory proteins encoded by complex retroviruses. Microbiol Rev 1992; 56: 375-394.
33. Cherepanov P, Pluymers W, Claeys A, et al. High-level expression of active HIV-1 integrase from a synthetic gene in human cells. FASEB J 2000; 14: 1389-1399.
34. Naldini L, Blomer U, Gallay P, et al. In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science 1996; 272: 263-267.
35. Baekelandt V, Claeys A, Eggermont K, et al. Characterization of lentiviral vector-mediated gene transfer in adult mouse brain. Hum Gene Ther 2002; 13: 841-853.
36. Zufferey R, Dull T, Mandel RJ, et al. Self-inactivating lentivirus vector for safe and efficient in vivo gene delivery. J Virol 1998; 72: 9873-9880.
37. Abdallah B, Hassan A, Benoist C, et al. A powerful nonviral vector for in vivo gene transfer into the adult mammalian brain: polyethylenimine. Hum Gene Ther 1996; 7: 1947-1954.
38. Van Maele B, De Rijck J, De Clercq E, et al. Impact of the central polypurine tract on the kinetics of human immunodeficiency virus type 1 vector transduction. J Virol 2003; 77: 4685-4694.
39. Corbeau P, Wong-Staal F. Anti-HIV effects of HIV vectors. Virology 1998; 243: 268-274.
40. An DS, Morizono K, Li QX, et al. An inducible human immunodeficiency virus type 1 (HIV-1) vector which effectively suppresses HIV-1 replication. J Virol 1999; 73: 7671-7677.
41. Engelman A, Englund G, Orenstein JM, et al. Multiple effects of mutations in human immunodeficiency virus type 1 integrase on viral replication. J Virol 1995; 69: 2729-2736.
42. Yung E, Sorin M, Pal A, et al. Inhibition of HIV-1 virion production by a transdominant mutant of integrase interactor 1. Nat Med 2001; 7: 920-926.
43. Kitamura Y, Ishikawa T, Okui N, et al. Inhibition of replication of HIV-1 at both early and late stages of the viral life cycle by single-chain antibody against viral integrase. J Acquir Immune Defic Syndr Hum Retrovirol 1999; 20: 105-114.
44. van den Ent FM, Vos A, Plasterk RH. Dissecting the role of the N-terminal domain of human immunodeficiency virus integrase by trans-complementation analysis. J Virol 1999; 73: 3176-3183.
45. Zheng R, Jenkins TM, Craigie R. Zinc folds the N-terminal domain of HIV-1 integrase, promotes multimerization, and enhances catalytic activity. Proc Natl Acad Sci U S A 1996; 93: 13 659-13 664.