Modeling of drug delivery into tissues with a microneedle array using mixture theory

Biomechanics and Modeling in Mechanobiology

Volumn 9, Issue 1, 2010, Pages 77-86

  Zhang, Rumi ^a   Zhang, Peiyu ^a   Dalton, Colin ^a   Jullien, Graham A ^a  

^a UNIVERSITY OF CALGARY   (Canada)

Author keywords

Finite element method (FEM); Microelectromechanical systems (MEMS); Microfluidic; Microneedle

Indexed keywords

CAPILLARITY; CONTROLLED DRUG DELIVERY; ELECTROMECHANICAL DEVICES; FINITE ELEMENT METHOD; HISTOLOGY; MEMS; MICROCIRCULATION; MIXTURES; POROUS MATERIALS; TARGETED DRUG DELIVERY;

BIOLOGICAL TISSUES; CONSERVATION EQUATIONS; FINITE ELEMENT METHOD; FLUID SATURATED POROUS MEDIA; MICROELECTROMECHANICAL SYSTEM; MICRONEEDLE ARRAYS; MICRONEEDLES; MIXTURE THEORY; MULTIPHASE FLUIDS; TRANSIENT BEHAVIOR;

TISSUE;

ABSORPTION; ARTICLE; BIOLOGICAL MODEL; COMPUTER SIMULATION; DRUG DELIVERY SYSTEM; INSTRUMENTATION; METABOLISM; METHODOLOGY; NEEDLE; SCANNING ELECTRON MICROSCOPY; SKIN; SOLUTION AND SOLUBILITY;

ABSORPTION; COMPUTER SIMULATION; DRUG DELIVERY SYSTEMS; MICROSCOPY, ELECTRON, SCANNING; MODELS, BIOLOGICAL; NEEDLES; SKIN; SOLUTIONS;

EID: 74349115455     PISSN: 16177959     EISSN: 16822978     Source Type: Journal    
DOI: 10.1007/s10237-009-0160-7     Document Type: Article

References (44)

1. ES Almeida RL Spilker 1998 Finite element formulations for hyperelastic biphasic soft tissues Comput Methods Appl Mech Eng 151 3-4 513 538 0920.73350 10.1016/S0045-7825(97)82246-3
2. RJ Atkin RE Craine 1976 Continuum theories of mixtures: basic theory and historical development Q J Mech Appl Math 29 2 209 244 0339.76003 10.1093/qjmam/29.2.209 418619
3. J Brazzle I Papautsky AB Frazier 1999 Micromachined needle arrays for drug delivery or fluid extraction IEEE Eng Med Biol Mag 18 6 53 58 10.1109/51.805145
4. S Chandrasekaran AB Frazier 2003 Surface micromachined metallic microneedles J Microelectromech Syst 12 3 281 288 10.1109/JMEMS.2003.809951
5. Chen JK, Wise KD (1994) A multichannel neural probe for selective chemical delivery at the cellular level. Solid State Sensor and Actuator Workshop, pp 256-259
6. JK Chen KD Wise JF Hetke, et al. 1997 A multichannel neural probe for selective chemical delivery at the cellular level IEEE Trans Biomed Eng 44 8 760 769 10.1109/10.605435 (Pubitemid 27314086)
7. Davis S, Prausnitz M, Allen M (2003) Fabrication and characterization of laser micromachined hollow microneedles. In: Proceedings of transducers 03, international conference on solid-state sensors and actuators, pp 1435-1438
8. SP Davis BJ Landis ZH Adams, et al. 2004 Insertion of microneedles into skin: measurement and prediction of insertion force and needle fracture force J Biomech 37 8 1155 1163 10.1016/j.jbiomech.2003.12.010 (Pubitemid 38798369)
9. J Frauhammer H Klein G Eigenberger U Nowak 1998 Solving moving boundary problems with an adaptive moving grid method: Rotary heat exchangers with condensation and evaporation Chem Eng Sci 53 19 3393 3411 10.1016/S0009-2509(98) 00135-3 (Pubitemid 29151045)
10. Gardeniers H, Berenschot E, De Boer M et al (2002) Silicon micromachined hollow microneedles for transdermal liquid transfer. MEMS 2002, pp 141-144
11. H Gardeniers R Luttge E Berenschot, et al. 2003 A silicon micromachined hollow microneedles for transdermal liquid transport J Microelectromech Syst 12 6 855 862 10.1109/JMEMS.2003.820293
12. Griss P, Stemme G (2002) Novel, side opened out-of-plane microneedles for microfluidic transdermal interfacing. In: International conference on microelectromechanical systems (MEMS'02), pp 467-470
13. P Griss G Stemme 2003 Side-opened out-of-plane microneedles for microfluidic transdermal liquid transfer J Microelectromech Syst 12 3 296 301 10.1109/JMEMS.2003.809959
14. Henry S, Mcallister DV, Allen MG, Prausnitz MR (1998) Micromachined needles for the transdermal delivery of drugs. In: Proceedings of micro electro mechanical systems workshop (MEMS'98), pp 494-498
15. MH Holmes 1986 Finite deformation of soft tissue: analysis of a mixture model in uni-axial compression J Biomech Eng 108 4 372 381 10.1115/1.3138633
16. RK Jain 1987 Transport of molecules in the tumor interstitium: a review Cancer Res 47 12 3039 3501
17. S Kaushik AH Hord DD Denson, et al. 2001 Lack of pain associated with microfabricated microneedles Anesth Analg 92 2 502 504 10.1097/00000539- 200102000-00041
18. K Kim D Park H Lu, et al. 2004 A tapered hollow metallic microneedle array using backside exposure of SU-8 J Micromech Microeng 14 4 597 603 10.1088/0960-1317/14/4/021
19. SC Kuo Y Chou 2004 A novel polymer microneedle arrays and PDMS micromolding technique Tamkang J Sci Eng 7 2 95 98
20. MK Kwan MW Lai VC Mow 1990 A finite deformation theory for cartilage and other soft hydrated connective tissues I. Equilibrium results J Biomech 23 2 145 155 10.1016/0021-9290(90)90348-7 (Pubitemid 20104613)
21. R Langer 1998 Drug delivery and targeting Nature 392 6679 Suppl 5 10
22. M Lian N Islam J Wu 2007 AC electrothermal manipulation of conductive fluids and particles for lab-chip applications IET Nanobiotechnol 1 3 36 43 10.1049/iet-nbt:20060022 (Pubitemid 46738205)
23. Lin LW, Pisano AP, Muller RS (1993) Silicon processed microneedles. In: Technical digest, 7th international conference on solid-state sensors and actuators, transducers, vol 93, pp 237-240
24. YG Lv J Liu YH Gao, et al. 2006 Modeling of transdermal drug delivery with a microneedle array J Micromech Microeng 16 11 2492 2501 10.1088/0960-1317/16/11/034 (Pubitemid 44679475)
25. Ma B, Gan Z, Liu S (2005) Flexible silicon microneedles array for micro fluid transfer. In: 6th International conference on electronic packaging technology, pp 561-565
26. N Mills 1966 Incompressible mixtures of Newtonian fluids Int J Eng Sci 4 2 97 112 0141.42602 10.1016/0020-7225(66)90018-8
27. S Moon S Lee 2005 A novel fabrication method of a microneedle array using inclined deep X-ray exposure J Micromech Microeng 15 5 903 911 10.1088/0960-1317/15/5/002 (Pubitemid 41237418)
28. WE Morf OT Guenat NF de Rooij 2001 Partial electroosmotic pumping in complex capillary systems Part 1: principles and general theoretical approach Sens Actuators B 72 3 266 272 10.1016/S0925-4005(00)00673-0 (Pubitemid 32160792)
29. VC Mow, et al. 1980 Biphasic creep and stress relaxation of articular cartilage: theory and experiments ASME J Biomech Eng 102 1 73 84 10.1115/1.3138202
30. K Najafi KD Wise 1986 An implantable multielectrode array with on-chip signal processing IEEE J Solid-State Circuits 21 6 1035 1044 10.1109/JSSC.1986.1052646
31. K Najafi KD Wise T Mochizuki 1985 A high-yield IC-compatible multichannel recording array IEEE Trans Electron Devices 32 7 1206 1211 10.1109/T-ED.1985. 22102
32. PA Netti F Travascio RK Jain 2003 Coupled macromolecular transport and gel mechanics: poroviscoelastic approach AICHE J 49 6 1580 1596 10.1002/aic.690490621 (Pubitemid 36712618)
33. C Nicholson JM Phillips 1981 Ion diffusion modified by tortuosity and volume fraction in the extracellular environment of rat cerebellum J Physiol 321 225 257
34. Nield DA, Bejan A (1992) Convection in porous media. Springer, New York
35. CW Oomens DH van Campen HJ Grootenboer 1987 A mixture approach to the mechanics of skin J Biomech 20 9 877 885 10.1016/0021-9290(87)90147-3 (Pubitemid 18514458)
36. LR Petzold 1987 Observations on an adaptive moving grid method for one-dimensional systems of partial differential equations Appl Numer Math 3 4 347 360 0621.65123 10.1016/0168-9274(87)90039-0 899604 (Pubitemid 18498875)
37. MR Prausnitz 2004 Microneedles for transdermal drug delivery Adv Drug Deliv Rev 56 5 581 587 10.1016/j.addr.2003.10.023 (Pubitemid 38326934)
38. MR Prausnitz DV Mcallister S Kaushik, et al. 1999 Microfabricated microneedles for transdermal drug delivery ASME Bioeng Div 42 89 90 (Pubitemid 30852369)
39. MR Prausnitz S Mitragotri R Langer 2004 Current status and future potential of transdermal drug delivery Nat Rev Drug Discov 3 2 115 124 10.1038/nrd1304 (Pubitemid 38239773)
40. ML Reed WK Lye 2004 Microsystems for drug and gene delivery Proc IEEE 92 1 56 75 10.1109/JPROC.2003.820542 (Pubitemid 40890772)
41. B Stoeber D Liepmann 2005 Arrays of hollow out-of-plane microneedles for drug delivery J Microelectromech Syst 14 3 472 479 10.1109/JMEMS.2005.844843 (Pubitemid 41005066)
42. JK Suh RL Spilker MH Holmes 1991 A penalty finite element analysis for nonlinear mechanics of biphasic hydrated soft tissue under large deformation Int J Numer Methods Eng 32 7 1411 1439 0763.73057 10.1002/nme.1620320704
43. JD Zahn A Deshmukh AP Pisano, et al. 2004 Continuous on-chip micropumping for microneedle enhanced drug delivery Biomed Microdevices 6 3 183 190 10.1023/B:BMMD.0000042047.83433.96 (Pubitemid 39256164)
44. P Zhang C Dalton GA Jullien 2009 Design and fabrication of MEMS-badsed microneedle arrays for medical applications Microsyst Technol 15 7 1073 1082 10.1007/s00542-009-0883-5