Endothelial nitric oxide synthase Glu298Asp, 4b/a, and -786T>C gene polymorphisms and the risk of ischemic stroke

Acta Neurologica Scandinavica

Volumn 121, Issue 2, 2010, Pages 114-119

  Saidi, S ^a   Mallat, S G ^b   Almawi, W Y ^c   Mahjoub, T ^a  

^a UNIVERSITY OF MONASTIR   (Tunisia)

^b SAINT JOSEPH UNIVERSITY   (Lebanon)

^c ARABIAN GULF UNIVERSITY   (Bahrain)

Author keywords

Endothelial nitric oxide synthase; Ischemic stroke; Polymorphisms

Indexed keywords

ASPARTIC ACID; DNA; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GLUTAMIC ACID;

ADULT; ARTICLE; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; DNA POLYMORPHISM; EXON; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENOTYPE; HAPLOTYPE; HUMAN; INTRON; MAJOR CLINICAL STUDY; MALE; PATHOGENESIS; POLYMERASE CHAIN REACTION; PREVALENCE; PROMOTER REGION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; RISK FACTOR;

BRAIN ISCHEMIA; CASE-CONTROL STUDIES; EXONS; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HAPLOTYPES; HUMANS; INTRONS; MALE; MIDDLE AGED; MUTATION, MISSENSE; NITRIC OXIDE SYNTHASE TYPE III; POINT MUTATION; POLYMORPHISM, GENETIC; PROMOTER REGIONS, GENETIC; REPETITIVE SEQUENCES, NUCLEIC ACID; RETROSPECTIVE STUDIES; RISK FACTORS; STROKE;

EID: 74349112288     PISSN: 00016314     EISSN: 16000404     Source Type: Journal    
DOI: 10.1111/j.1600-0404.2009.01192.x     Document Type: Article

References (34)

1. Flemming KD, Brown RD Jr., Petty GW, Huston J III., Kallmes DF, Piepgras DG. Evaluation and management of transient ischemic attack and minor cerebral infarction. Mayo Clin Proc 2004 79 : 1071 1086.
2. Domingues-Montanari S, Mendioroz M, del Rio-Espinola A, Fernández-Cadenas I, Montaner J. Genetics of stroke: a review of recent advances. Expert Rev Mol Diagn 2008 8 : 495 513.
3. Szentirmai O, Carter BS. Genetic and cellular therapies for cerebral infarction. Neurosurgery 2008 62 : 1465 1479.
4. Radomski MW, Palmer RM, Moncada S. Endogeneous nitric oxide inhibits human platelet adhesion to vascular endothelium. Lancet 1987 2 : 1057 1058. (Pubitemid 17154788)
5. Yetik-Anacak G, Catravas JD. Nitric oxide and the endothelium: history and impact on cardiovascular disease. Vascul Pharmacol 2006 45 : 268 276.
6. Puddu GM, Cravero E, Arnone G, Muscari A, Puddu P. Molecular aspects of atherogenesis: new insights and unsolved questions. J Biomed Sci 2005 12 : 839 853.
7. Chatterjee A, Catravas JD. Endothelial nitric oxide (NO) and its pathophysiologic regulation. Vascul Pharmacol 2008 49 : 134 140.
8. Schulz E, Jansen T, Wenzel P, Daiber A, Münzel T. Nitric oxide, tetrahydrobiopterin, oxidative stress, and endothelial dysfunction in hypertension. Antioxid Redox Signal 2008 10 : 1115 1126.
9. Yoon Y, Song J, Hong SH, Kim JQ. Plasma nitric oxide concentrations and nitric oxide synthase gene polymorphisms in coronary artery disease. Clin Chem 2000 46 : 1626 1630.
10. Ichihara S, Yamada Y, Fujimura T, Nakashima N, Yokota M. Association of a polymorphism of the endothelial constitutive nitric oxide synthase gene with myocardial infarction in the Japanese population. Am J Cardiol 1998 81 : 83 6.
11. Ezzidi I, Mtiraoui N, Mohamed MB, Mahjoub T, Kacem M, Almawi WY. Association of endothelial nitric oxide synthase Glu298Asp, 4b/a, and -786T>C gene variants with diabetic nephropathy. J Diabetes Complications 2008 22 : 331 338.
12. Thameem F, Puppala S, Arar NH et al. Endothelial nitric oxide synthase (eNOS) gene polymorphisms and their association with type 2 diabetes-related traits in Mexican Americans. Diab Vasc Dis Res 2008 5 : 109 113.
13. Szolnoki Z, Havasi V, Bene J et al. Endothelial nitric oxide synthase gene interactions and the risk of ischaemic stroke. Acta Neurol Scand 2005 111 : 29 33.
14. Grewal RP, Dutra AV, Liao YC, Juo SH, Papamitsakis NI. The intron 4c allele of the NOS3 gene is associated with ischemic stroke in African Americans. BMC Med Genet 2007 8 : 76.
15. Hassan A, Gormley K, O'Sullivan M et al. Endothelial nitric oxide gene haplotypes and risk of cerebral small-vessel disease. Stroke 2004 35 : 654 659.
16. Hou L, Osei-Hyiaman D, Yu H et al. Association of a 27-bp repeat polymorphism in ecNOS gene with ischemic stroke in Chinese patients. Neurology 2001 56 : 490 496.
17. Howard TD, Giles WH, Xu J et al. Promoter polymorphisms in the nitric oxide synthase 3 gene are associated with ischemic stroke susceptibility in young black women. Stroke 2005 36 : 1848 1851.
18. MacLeod MJ, Dahiyat MT, Cumming A, Meiklejohn D, Shaw D, St Clair D. No association between Glu/Asp polymorphism of NOS3 gene and ischemic stroke. Neurology 1999 53 : 418 420.
19. Markus HS, Ruigrok Y, Ali N, Powell JF. Endothelial nitric oxide synthase exon 7 polymorphism, ischemic cerebrovascular disease, and carotid atheroma. Stroke 1998 29 : 1908 1911.
20. Yahashi Y, Kario K, Shimada K, Matsuo M. The 27-bp repeat polymorphism in intron 4 of the endothelial cell nitric oxide synthase gene and ischemic stroke in a Japanese population. Blood Coagul Fibrinolysis 1998 9 : 405 409.
21. Adams HP Jr., Bendixen BH, Kappelle LJ et al. Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. Stroke 1993 24 : 35 41.
22. Leeson CP, Hingorani AD, Mullen MJ et al. Glu298Asp endothelial nitric oxide synthase gene polymorphism interacts with environmental and dietary factors to influence endothelial function. Circ Res 2002 90 : 1153 1158.
23. Persu A, Stoenoiu MS, Messiaen T et al. Modifier effect of eNOS in autosomal dominant polycystic kidney disease. Hum Mol Genet 2002 11 : 229 241.
24. Berger K, Stögbauer F, Stoll M et al. The glu298asp polymorphism in the nitric oxide synthase 3 gene is associated with the risk of ischemic stroke in two large independent case-control studies. Hum Genet 2007 121 : 169 178.
25. Khurana VG, Meissner I, Sohni YR et al. The presence of tandem endothelial nitric oxide synthase gene polymorphisms identifying brain aneurysms more prone to rupture. J Neurosurg 2005 102 : 526 531.
26. Guldiken B, Sipahi T, Guldiken S et al. Glu298Asp polymorphism of the endothelial nitric oxide synthase gene in Turkish patients with ischemic stroke. Mol Biol Rep 2009 36 : 1539 1543.
27. Cheng J, Liu J, Li X et al. Effect of polymorphisms of endothelial nitric oxide synthase on ischemic stroke: a case-control study in a Chinese popuation. Clin Chim Acta 2008 392 : 46 51.
28. Nakayama M, Yoshimura M, Sakamoto T et al. A -786T>C polymorphism in the endothelial nitric oxide synthase gene reduces serum nitrite/nitrate levels from the heart due to an intracoronary injection of acetylcholine. Pharmacogenet Genomics 2006 16 : 339 345.
29. Ko NU, Rajendran P, Kim H et al. Endothelial nitric oxide synthase polymorphism (-786T->C) and increased risk of angiographic vasospasm after aneurysmal subarachnoid hemorrhage. Stroke 2008 39 : 1103 1108.
30. Marroni AS, Metzger IF, Souza-Costa DC et al. Consistent interethnic differences in the distribution of clinically relevant endothelial nitric oxide synthase genetic polymorphisms. Nitric Oxide 2005 12 : 177 182.
31. Tanus-Santos JE, Desai M, Flockhart DA. Effects of ethnicity on the distribution of clinically relevant endothelial nitric oxide variants. Pharmacogenetics 2001 11 : 719 725.
32. Tsukada T, Yokoyama K, Arai T et al. Evidence of association of the ecNOS gene polymorphism with plasma NO metabolite levels in humans. Biochem Biophys Res Commun 1998 245 : 190 193.
33. Li R, Lyn D, Lapu-Bula R et al. Relation of endothelial nitric oxide synthase gene to plasma nitric oxide level, endothelial function, and blood pressure in African Americans. Am J Hypertens 2004 17 : 560 567.
34. Salimi S, Firoozrai M, Nourmohammadi I et al. Lack of evidence for contribution of intron4a/b polymorphism of endothelial nitric oxide synthase (NOS3) gene to plasma nitric oxide levels. Acta Cardiol 2008 63 : 229 234.