A -786T>C polymorphism in the endothelial nitric oxide synthase gene reduces serum nitrite/nitrate levels from the heart due to an intracoronary injection of acetylcholine

Pharmacogenetics and Genomics

Volumn 16, Issue 5, 2006, Pages 339-345

  Nakayama, Masafumi ^a   Yoshimura, Michihiro ^a,f   Sakamoto, Tomohiro ^a   Abe, Koji ^a   Yamamuro, Megumi ^a   Shono, Makoto ^a   Suzuki, Satoru ^a   Nishijima, Tsunenori ^a   Miyamoto, Yoshihiro ^b   Saito, Yoshihiko ^c   Nakao, Kazuwa ^d   Yasue, Hirofumi ^e   Ogawa, Hisao ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

^b NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

^c NARA MEDICAL UNIVERSITY   (Japan)

^d KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^e Kumamoto Aging Research Institute   (Japan)

^f KUMAMOTO UNIV SCHOOL OF MEDICINE   (Japan)

Author keywords

Acetylcholene; Coronary vasospasm; Endothelium derived nitric oxide; Genetic polymorphism

Indexed keywords

ACETYLCHOLINE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; LACTIC ACID; NITRATE; NITRITE;

ADULT; AGED; AORTA; ARTICLE; BLOOD LEVEL; BLOOD SAMPLING; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; CORONARY ARTERY SPASM; CORONARY SINUS; FEMALE; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENOTYPE; HUMAN; LACTATE BLOOD LEVEL; LEFT ANTERIOR DESCENDING CORONARY ARTERY; MALE; PRIORITY JOURNAL; PROVOCATION TEST;

ACETYLCHOLINE; AGED; CORONARY VASOSPASM; FEMALE; HUMANS; MALE; MIDDLE AGED; NITRATES; NITRIC OXIDE SYNTHASE TYPE III; NITRITES; POLYMORPHISM, GENETIC; VASODILATOR AGENTS;

EID: 33645912077     PISSN: 17446872     EISSN: 17446880     Source Type: Journal    
DOI: 10.1097/01.fpc.0000199499.08725.d5     Document Type: Article

References (38)

1. Yasue H, Omote S, Takizawa A, Nagao M. Coronary arterial spasm in ischemic heart disease and its pathogenesis. A review. Circ Res 1983; 52 (Suppl 1):147-152.
2. Yasue H, Horio Y, Nakamura N, Fujii H, Imoto N, Sonoda R, et al. Induction of coronary artery spasm by acetylcholine in patients with variant angina: possible role of the parasympathetic nervous system in the pathogenesis of coronary artery spasm. Circulation 1986; 74:955-963.
3. Okumura K, Yasue H, Horio Y, Takaoka K, Matsuyama K, Kugiyama K, et al. Multivessel coronary spasm in patients with variant angina: a study with intracoronary injection of acetylcholine. Circulation 1988; 77:535-542.
4. Moncada S, Palmer RM, Higgs EA. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev 1991; 43:109-142.
5. Furchgott RF. Role of endothelium in response of vascular smooth muscle. Circ Res 1983; 53:557-573.
6. Kugiyama K, Yasue H, Okumura K, Ogawa H, Fujimoto K, Nakao K, et al. Nitric oxide activity is deficient in spasm arteries of patients with coronary spastic angina. Circulation 1996; 94:266-272.
7. Motoyama T, Kawano H, Kugiyama K, Okumura K, Ohgushi M, Yoshimura M, et al. Flow-mediated, endothelium-dependent dilation of the brachial arteries is impaired in patients with coronary spastic angina. Am Heart J 1997; 133:263-267.
8. Nakayama M, Yasue H, Yoshimura M, Shimasaki Y, Kugiyama K, Ogawa H, et al. T-786>C mutation in the 5′-flanking region of the endothelial nitric oxide synthase gene is associated with coronary spasm. Circulation 1999; 99:2864-2870.
9. Nakayama M, Yoshimura M, Sakamoto T, Shimasaki Y, Nakamura S, Ito T, et al. Synergistic interaction of T-786>C polymorphism in the endothelial nitric oxide synthase gene and smoking for an enhanced risk for coronary spasm. Pharmacogenetics 2003; 13:683-688.
10. Miyamoto Y, Saito Y, Nakayama M, Shimasaki Y, Yoshimura T, Yoshimura M, et al. Replication protein A1 reduced transcription of the endothelial nitric oxide Synthase gene containing a -786T>C mutation associated with coronary spastic angina. Hum Mol Genet 2000; 9:2629-2637.
11. 15N] nitrate in biological fluids. Annal Biochem 1982; 126:131-138.
12. Bergmeyer HU. Methods of enzymatic analysis. New York, New York: Academic Press; 1963. pp. 266-270.
13. Marietta MA, Yoon PS, Iyengar R, Leaf CD, Wishnok JS. Macrophage oxidation of L-arginine to nitrite and nitrate: nitric oxide is an intermediate. Biochemistry 1988; 27:8706-8711.
14. Shultz PJ, Raij L. Endogenously synthesized nitric oxide prevents endotoxin-induced glomerular thrombosis. J Clin Invest 1991; 90:1718-1725.
15. Naber CK, Frey UH, Oldenburg O, Brauck K, Eggebrecht H, Schmermund A, et al. Relevance of the NOS3 T-786C and G894T variants for cholinergic and adrenergic coronary vasomotor responses in man. Basic Res Cardiol 2005; 100:1-8.
16. Yoshimura M, Nakayama M, Shimasaki Y, Ogawa H, Kugiyama K, Nakamura S, et al. A T-786>C mutation in the 5′-flanking region of the endothelial nitric oxide synthase gene and coronary arterial vasomotility. Am J Cardiol 2000; 85:710-714.
17. Node K, Kitakaze M, Sato H, Koretsune Y, Karita M, Kosaka H, et al. Increased release of nitric oxide in ischemic hearts after exercise in patients with effort angina. J Am Coll Cardiol 1998; 32:63-68.
18. Han TH, Qamirani E, Nelson AG, Hyduke DR, Chaudhuri G, Kuo L, et al. Regulation of nitric oxide consumption by hypoxic red blood cells. Proc Natl Acad Sci USA 2003; 100:12504-12509.
19. Nakayama M, Yasue H, Yoshimura M, Shimasaki Y, Ogawa H, Kugiyama K, et al. T-786>C mutation in the 5′-flanking region of the endothelial nitric oxide synthase gene is associated with myocardial infarction, especially without coronary organic stenosis. Am J Cardiol 2000; 86:628-634.
20. Yasue H, Kugiyama K. Coronary artery spasm: Japanese view. Coronary Artery Dis 1990; 1:668-673.
21. Zeiher AM, Drexler H, Wollschlanger H, Just H. Modulation of coronary vasomotor tone in humans. Progressive endothelial dysfunction with different early stages of coronary atherosclerosis. Circulation 1991; 83:391-401.
22. Miwa K, Miyagi Y, Igawa A, Nakagawa K, Inoue H. Vitamin E deficiency in variant angina. Circulation 1996; 94:14-18.
23. Kugiyama K, Motoyama T, Hirashima O, Ohgushi M, Soejima H, Misumi K, et al. Vitamin C attenuates abnormal vasomotor reactivity in spasm coronary arteries in patients with coronary spastic angina. J Am Coll Cardiol 1998; 32:103-109.
24. Motoyama T, Kawano H, Kugiyama K, Hirashima O, Ohgushi M, Tsunoda R, et al. Vitamin E administration improves impairment of endothelium-dependent vasodilation in patients with coronary spastic angina. J Am Coll Cardiol 1998; 32:1672-1679.
25. Nagassaki S, Metzger IF, Souza-Costa DC, Marroni AS, Uzuelli JA, Tanus-Santos JE. eNOS genotype is without effect on circulating nitrite/ nitrate level in healthy male population. Thromb Res 2005; 115:375-379.
26. Metzger IF, Souza-Costa DC, Marroni AS, Nagassaki S, Desta Z, Flockhart DA, et al. Endothelial nitric oxide synthase gene haplotypes associated with circulating concentrations of nitric oxide products in healthy men. Pharmacogenet Genomomics 2005; 15:565-570.
27. Schmidt HW, Walter U. NO at work. Review. Cell 1994; 78:919-925.
28. Loscalzo J, Welch G. Nitric oxide and its role in the cardiovascular system. Prog Cardiovasc Dis 1995; 38:87-104.
29. Cooke JP, Tsao PS. Is NO an endogenous antiatherogenic molecule? Arterioscler Thromb 1994; 14:653-655.
30. Lefer AM. Nitric Oxide: nature's naturally occurring leukocyte inhibitor. Circulation 1997; 95:553-554.
31. Garg UC, Hassid A. Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells. J Clin Invest 1989; 83:1774-1777.
32. Tanus-Santos JE, Desai M, Deak LR, Pezzullo JC, Abernethy DR, Flockhart DA, et al. Effects of endothelial nitric oxide synthase gene polymorphisms on platelet function, nitric oxide release, and interactions with estradiol. Pharmacogenetics 2002; 12:407-413.
33. Rossi GP, Cesari M, Zanchetta M, Colonna S, Maiolino G, Pedon L, et al. The T-786C endothelial nitric oxide synthase genotype is a novel risk factor for coronary artery disease in Caucasian patients of the GENICA study. J Am Coll Cardiol 2003; 41:930-937.
34. Bredt DS, Snyder SH. Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme. Proc Natl Acad Sci USA 1990; 87:682-685.
35. Bredt DS, Hwang PM, Glatt CE, Lowenstein C, Reed RR, Snyder SH. Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase. Nature 1991; 351:714-718.
36. Stuehr DJ, Cho HJ, Kwon NS, Weise MF, Nathan CF. Purification and characterization of the cytokine-induced macrophage nitric oxide synthase: an FAD- and FMN-containing flavoprotein. Proc Natl Acad Sci USA 1991; 88:7773-7777.
37. Lyons CR, Orloff GJ, Cunningham JM. Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line. J Biol Chem 1992; 267:6370-6374.
38. Wilcox JN, Subramanian RR, Sundell CL, Tracey WR, Pollock JS, Harrison DG, et al. Expression of multiple isoforms of nitric oxide synthase in normal and atherosclerotic vessels. Arterioscler Thromb Vasc Biol 1997; 17:2479-2488.