Innate signaling regulates cross-priming at the level of DC licensing and not antigen presentation

European Journal of Immunology

Volumn 40, Issue 1, 2010, Pages 103-112

  Keller, Susanne A ^a   Schwarz, Katrin ^a   Manolova, Vania ^a   Von Allmen, Caroline E ^a   Kinzler, Matthias G ^a   Bauer, Monika ^a   Muntwiler, Simone ^a   Saudan, Philippe ^a   Bachmann, Martin F ^a  

^a CYTOS BIOTECHNOLOGY AG   (Switzerland)

Author keywords

Antigen presentation processing; Cross presentation priming; DC

Indexed keywords

ALPHA INTERFERON RECEPTOR; BETA INTERFERON RECEPTOR; DENDRITIC CELL LYSOSOME ASSOCIATED MEMBRANE PROTEIN; LIGAND; MYELOID DIFFERENTIATION FACTOR 88; PEPTIDE; TOLL LIKE RECEPTOR; VIRUS PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL ACTIVATION; CELLULAR IMMUNITY; CONTROLLED STUDY; CPG ISLAND; CROSS PRESENTATION; DENDRITIC CELL; FEMALE; IMMUNOSTIMULATION; INNATE IMMUNITY; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; VIRUS LIKE AGENT; ANIMAL; ANTIGEN PRESENTATION; C57BL MOUSE; ELECTRON MICROSCOPY; IMMUNOLOGY; METABOLISM; SIGNAL TRANSDUCTION; ULTRASTRUCTURE; VIRION;

ANIMALS; ANTIGEN PRESENTATION; CROSS-PRIMING; DENDRITIC CELLS; IMMUNITY, INNATE; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MICE; MICE, INBRED C57BL; MICROSCOPY, ELECTRON; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTORS; VIRAL PROTEINS; VIRION;

EID: 74249107488     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.200939559     Document Type: Article

References (41)

1. Bevan, M. J., Immunology. Stimulating killer cells. Nature 1989. 342: 478-479.
2. Sigal, L. J., Crotty, S., Andino, R. and Rock, K. L., Cytotoxic T-cell immunity to virus-infected non-haematopoietic cells requires presentation of exogenous antigen. Nature 1999. 398: 77-80.
3. Yewdell, J., Anton, L. C., Bacik, I., Schubert, U., Snyder, H. L. and Bennink, J. R., Generating MHC class I ligands from viral gene products. Immunol. Rev. 1999. 172: 97-108.
4. Storni, T., Lechner, F., Erdmann, I., Bachi, T., Jegerlehner, A., Dumrese, T., Kundig, T. M. et al., Critical role for activation of antigen-presenting cells in priming of cytotoxic T cell responses after vaccination with virus-like particles. J. Immunol. 2002. 168: 2880-2886.
5. Rock, K. L., Rothstein, L., Gamble, S. and Fleischacker, C., Characterization of antigen-presenting cells that present exogenous antigens in association with class I MHC molecules. J. Immunol. 1993. 150: 438-446.
6. Regnault, A., Lankar, D., Lacabanne, V., Rodriguez, A., Thery, C., Rescigno, M., Saito, T. et al., Fcgamma receptor-mediated induction of dendritic cell maturation and major histocompatibility complex class I-restricted antigen presentation after immune complex internalization. J. Exp Med. 1999. 189: 371-380.
7. Ruedl, C., Storni, T., Lechner, F., Bachi, T. and Bachmann, M. F., Cross-presentation of virus-like particles by skin-derived CD8(-) dendritic cells: a dispensable role for TAP. Eur. J. Immunol. 2002. 32: 818-825.
8. Rock, K. L., A new foreign policy: MHC class I molecules monitor the outside world. Immunol. Today 1996. 17: 131-137.
9. Keller, S. A., von Allmen, C. E., Hinton, H. J., Bauer, M., Muntwiler, S., Dietmeier, K., Saudan, P. and Bachmann, M. F., Follicular and marginal zone B cells fail to cross-present MHC class I-restricted epitopes derived from viral particles. J. Immunol. 2009. 182: 6261-6266.
10. Banchereau, J. and Steinman, R. M., Dendritic cells and the control of immunity. Nature 1998. 392: 245-252.
11. Geijtenbeek, T. B., van Vliet, S. J., Engering, A., t Hart, B. A. and van Kooyk, Y., Self- and nonself-recognition by C-type lectins on dendritic cells. Annu. Rev. Immunol. 2004. 22: 33-54.
12. Inohara, N. and Nunez, G., NODs: intracellular proteins involved in inflammation and apoptosis. Nat. Rev. Immunol. 2003.3:371-382.
13. Pulendran, B., Palucka, K. and Banchereau, J., Sensing pathogens and tuning immune responses. Science 2001. 293: 253-256.
14. Rogers, N. C., Slack, E. C., Edwards, A. D., Nolte,M. A., Schulz,O., Schweighoffer,E., Williams,D. L. et al., Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectins. Immunity 2005. 22: 507-517.
15. Takeda, K., Kaisho, T. and Akira, S., Toll-like receptors. Annu. Rev. Immunol. 21: 335-376.
16. Banchereau, J., Briere, F., Caux, C., Davoust, J., Lebecque, S., Liu, Y. J., Pulendran, B. and Palucka, K., 2000. Immunobiology of dendritic cells. Annu. Rev. Immunol. 2003. 18: 767-811.
17. Macagno, A., Napolitani, G., Lanzavecchia, A. and Sallusto, F., Duration, combination and timing: the signal integration model of dendritic cell activation. Trends Immunol. 2007. 28: 227-233.
18. Marsland, B. J., Battig, P., Bauer, M., Ruedl, C., Lassing, U., Beerli, R. R., Dietmeier, K. et al., CCL19 and CCL21 induce a potent proinflammatory differentiation program in licensed dendritic cells. Immunity 2005. 22:493-505.
19. Ishii, K. J. and Akira, S., Toll or toll-free adjuvant path toward the optimal vaccine development. J. Clin. Immunol. 2007. 27: 363-371.
20. Steinman, R. M., Hawiger, D. and Nussenzweig, M. C., Tolerogenic dendritic cells. Annu. Rev. Immunol. 2003. 21: 685-711.
21. Iwasaki, A. and Medzhitov, R., Toll-like receptor control of the adaptive immune responses. Nat. Immunol. 2004. 5: 987-995.
22. Blander, J. M. and Medzhitov, R., Toll-dependent selection of microbial antigens for presentation by dendritic cells. Nature 2006. 440: 808-812.
23. Kadowaki, N., Antonenko, S., Lau, J. Y. and Liu, Y. J., Natural interferon alpha/beta-producing cells link innate and adaptive immunity. J. Exp. Med. 2000. 192: 219-226.
24. Tough,D. F., Type I interferon as a link between innate and adaptive immunity through dendritic cell stimulation. Leuk. Lymphoma 2004. 45: 257-264.
25. Cho, H. J., Hayashi, T., Datta, S. K., Takabayashi, K., Van Uden, J. H., Horner, A., Corr, M. and Raz, E., IFN-alpha beta promote priming of antigen-specific CD8+ and CD4+ T lymphocytes by immunostimulatory DNA-based vaccines. J. Immunol. 2002. 168: 4907-4913.
26. Durand, V., Wong, S. Y., Tough, D. F. and Le Bon, A., Shaping of adaptive immune responses to soluble proteins by TLR agonists: a role for IFN-alpha/ beta. Immunol. Cell Biol. 2004. 82: 596-602.
27. Le Bon, A., Durand, V., Kamphuis, E., Thompson, C., Bulfone-Paus, S., Rossmann, C., Kalinke, U. and Tough, D. F., Direct stimulation of T cells by type I IFN enhances the CD8+ T cell response during cross-priming. J. Immunol. 2006. 176: 4682-4689.
28. Le Bon, A., Etchart, N., Rossmann, C., Ashton, M., Hou, S., Gewert, D., Borrow, P. and Tough, D. F., Cross-priming of CD8+ T cells stimulated by virus-induced type I interferon. Nat. Immunol. 2003.4: 1009-1015.
29. van Boxel-Dezaire, A. H., Rani, M. R. and Stark, G. R., Complex modulation of cell type-specific signaling in response to type I interferons. Immunity 2006. 25: 361-372.
30. Storni, T. and Bachmann, M. F., Loading of MHC class I and II presentation pathways by exogenous antigens: a quantitative in vivo comparison. J. Immunol. 2004. 172: 6129-6135.
31. Bachmann, M. F., Schwarz, K., Wolint, P., Meijerink, E., Martin, S., Manolova, V. and Oxenius, A., 2004 Cutting edge: distinct roles for T help and CD40/CD40 ligand in regulating differentiation of proliferationcompetent memory CD8+ T cells. J. Immunol. 2004. 173: 2217-2221.
32. Storni, T., Ruedl, C., Schwarz, K., Schwendener, R. A., Renner, W. A. and Bachmann, M. F., Nonmethylated CG motifs packaged into virus-like particles induce protective cytotoxic T cell responses in the absence of systemic side effects. J. Immunol. 2004. 172: 1777-1785.
33. Schwarz, K., Storni, T., Manolova, V., Didierlaurent, A., Sirard, J. C., Rothlisberger, P. and Bachmann, M. F., Role of Toll-like receptors in costimulating cytotoxic T cell responses. Eur. J. Immunol. 2003. 33: 1465-1470.
34. Akira, S., Takeda, K. and Kaisho, T., Toll-like receptors: critical proteins linking innate and acquired immunity. Nat. Immunol. 2001. 2: 675-680.
35. Bachmann, M. F., Lutz, M. B., Layton, G. T., Harris, S. J., Fehr, T., Rescigno, M. and Ricciardi-Castagnoli, P., Dendritic cells process exogenous viral proteins and virus-like particles for class I presentation to CD8+ cytotoxic T lymphocytes. Eur. J. Immunol. 1996. 26: 2595-2600.
36. Honda, K., Sakaguchi, S., Nakajima, C., Watanabe, A., Yanai, H., Matsumoto, M., Ohteki, T. et al., Selective contribution of IFN-alpha/beta signaling to the maturation of dendritic cells induced by double-stranded RNA or viral infection. Proc. Natl. Acad. Sci. USA 2003. 100: 10872-10877.
37. Datta, S. K., Redecke, V., Prilliman, K. R., Takabayashi, K., Corr, M., Tallant, T., DiDonato, J. et al., subset of Toll-like receptor ligands induces cross-presentation by bone marrow-derived dendritic cells. J. Immunol. 2003. 170: 4102-4110.
38. Oxenius, A., Bachmann, M. F., Zinkernagel, R. M. and Hengartner, H., Virus-specific MHC-class II-restricted TCR-transgenic mice: effects on humoral and cellular immune responses after viral infection. Eur. J. Immunol. 1998. 28: 390-400.
39. Pircher, H., Moskophidis, D., Rohrer, U., Burki, K., Hengartner, H. and Zinkernagel, R. M., Viral escape by selection of cytotoxic T cell-resistant virus variants in vivo. Nature 1990. 346: 629-633.
40. Schwarz, K., Meijerink, E., Speiser, D. E., Tissot, A. C., Cielens, I., Renhof, R., Dishlers, A. et al., Efficient homologous prime-boost strategies for T cell vaccination based on virus-like particles. Eur. J. Immunol. 2005. 35: 816-821.
41. Bachmann, M. F., Hengartner, H. and Zinkernagel, R. M., Immunization with recombinant protein: conditions for cytotoxic T cell and/or antibody induction. Med. Microbiol. Immunol. 1994. 183: 315-324.