Cat's claw: An Amazonian vine decreases inflammation in osteoarthritis

Complementary Therapies in Clinical Practice

Volumn 13, Issue 1, 2007, Pages 25-28

  Hardin, Sonya R ^a  

^a UNIVERSITY OF NORTH CAROLINA AT CHARLOTTE   (United States)

Author keywords

Cat's claw; Osteoarthritis; Uncaria guianesis; Uncaria tomentosa

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PLANT MEDICINAL PRODUCT; SCAVENGER;

ARTICLE; DRUG ANTAGONISM; HUMAN; INFLAMMATION; OSTEOARTHRITIS; PATHOPHYSIOLOGY; PHYTOTHERAPY; UNCARIA TOMENTOSA;

CAT'S CLAW; FREE RADICAL SCAVENGERS; HUMANS; INFLAMMATION; NF-KAPPA B; OSTEOARTHRITIS; PHYTOTHERAPY; PLANT PREPARATIONS;

EID: 33845932706     PISSN: 17443881     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ctcp.2006.10.003     Document Type: Article

References (15)

1. Tierney L., McPhee S.J., and Papadakis M.A. Current Medical Diagnosis & Treatment (2005), Lange Medical Books/McGraw Hill, New York, NY p. 781-4
2. Kumar V., Abbas A., and Fausto N. Robbins and Cotran Pathologic Basis of Disease. 7th ed (2005), Elsevier Inc, St. Louis, MO p.48-86; 1304-05
3. van der Kraan P.M., and van den Berg W.B. Anabolic and destructive mediators in osteoarthritis. Curr Opin Clin Nutr Metab Care 3 (2000) 205-211
4. Beg A.A., and Baltimore D. An essential role for NF-κB in preventing TNFα-induced cell death. Science 274 (1996) 782-784
5. Miller MJS, Mehta K, Kunte S, Raut V, Dhumale J, Shukla A, et al. Early relief of osteoarthritis symptoms with a natural mineral supplement and a herbomineral combination: a randomized controlled trial. J Inflammation 2005;2:11. Accessed at 〈www.pubmedcentral.gov/articlerender.fcg?tool=pubmed&pubmedid=16242032〉 (Retrieved on 24.04.06).
6. Blanco F.J., Geng Y., and Lotz M. Differentiation-dependent effects of IL-1 and TGF-beta on human articular chondrocyte proliferation are related to inducible nitric oxide synthase expression. J Immunol 154 8 (1995) 4018-4026
7. Aggarwal B.B., and Shishodia S. Suppression of the nuclear factor-κB ActivationPathway by spice-derived phytochemicals: reasoning for seasoning. Ann NY Acad Sci 1030 (2004) 434-441
8. Cerri R., Aquino R., De Simone F., and Pizza C. New quinovic acid glycoside from uncaria tomentosa. J Nat Prod 51 2 (1988) 257-261
9. Sandoval M., Chaarbonnett R.M., Okuhama N.N., Roberts J., Krenova Z., Trentacosti A.M., et al. Cat's claw inhibits TNFα production and scavenges free radicals: role in cytoprotection. Free Rad Biol Med 29 1 (2000) 71-78
10. Sandoval M., Okuhama N.N., Zhang X.-J., Condezo L.A., Lao J., Angeles F.M., et al. Antiinflammatory and antioxidant activities of cat's claw (Uncaria tomentosa and Uncaria guianensis) are independent of their alkaloid content. Phytomedicine 9 (2002) 325-337
11. Desmarchelier C., Mongelli E., Coussio J., and Ciccia G. Evaluation of the in vitro antioxidant activity in extracts of Uncaria tomentosa (Willd.)DC. Phytotherpay Res 11 3 (1998) 254-256
12. Sandoval-Chacon M., Thompson J.H., Zhang X.-J., Liu X., Mannick E.E., Sadowska-Krowicka H., et al. Antiinflammatory action of cat's claw: the role of NF-κB. Aliment Pharmacol Therapy 12 (1998) 1279-1289
13. Piscoya J., Rodriguez Z., Bustamante S.A., Okuhama N.N., Miller M.J.S., and Sandoval M. Efficacy and safety of freeze-dried cat's claw in osteoarthritis of the knee: mechanisms of action of the species Uncaria guianensis. Inflammation Res 50 (2001) 442-448
14. Lemaire I., Assinewe V., Cano P., Awang D.V.C., and Arnason J.T. Stimulation of interleukin-1 and -6 production in alveolar macrophages by neotorpical liana, Uncaria tomentosa (Uña de Gato). J Ethnopharmacol 64 (1999) 109-115
15. Winyard P.G., and Blake D.R. Antioxidants, redox-regulated transcription factors. Adv Pharmacol 18 (1997) 403-431