Adjuvantive effects of anti-4-1BB agonist Ab and 4-1BBL DNA for a HIV-1 Gag DNA vaccine: Different effects on cellular and humoral immunity

Vaccine

Volumn 28, Issue 5, 2010, Pages 1300-1309

  Ganguly, Sumita ^a   Liu, Jinyan ^a   Pillai, Vinod B ^a   Mittler, Robert S ^a   Amara, Rama Rao ^a  

^a EMORY UNIVERSITY   (United States)

Author keywords

4 1BB; DNA vaccines; Vaccine adjuvant

Indexed keywords

4 1BB AGONIST ANTIBODY; 4 1BBL DNA VACCINE; ANTIBODY; ANTIGEN; DNA VACCINE; HIV 1 GAG DNA VACCINE; HUMAN IMMUNODEFICIENCY VIRUS 1 VACCINE; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; IMMUNOGLOBULIN G; PLASMID DNA; UNCLASSIFIED DRUG;

ARTICLE; CELLULAR IMMUNITY; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG EFFECT; EMBRYO; FEMALE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMORAL IMMUNITY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PLASMID; PRIORITY JOURNAL;

4-1BB LIGAND; ADJUVANTS, IMMUNOLOGIC; AIDS VACCINES; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD137; CELL LINE; FEMALE; GAG GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; HUMANS; IMMUNITY, CELLULAR; IMMUNITY, HUMORAL; MICE; MICE, INBRED BALB C; PLASMIDS; VACCINES, DNA;

EID: 74149084929     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vaccine.2009.11.020     Document Type: Article

References (34)

1. Vinay D.S., and Kwon B.S. Role of 4-1BB in immune responses. Semin Immunol 10 6 (1998 Dec) 481-489
2. Watts T.H. TNF/TNFR family members in costimulation of T cell responses. Annu Rev Immunol 23 (2005) 23-68
3. Wilcox R.A., Chapoval A.I., Gorski K.S., Otsuji M., Shin T., Flies D.B., et al. Cutting edge: expression of functional CD137 receptor by dendritic cells. J Immunol 168 May (9) (2002) 4262-4267
4. Cannons J.L., Lau P., Ghumman B., DeBenedette M.A., Yagita H., Okumura K., et al. 4-1BB ligand induces cell division, sustains survival, and enhances effector function of CD4 and CD8 T cells with similar efficacy. J Immunol 167 August (3) (2001) 1313-1324
5. Shuford W.W., Klussman K., Tritchler D.D., Loo D.T., Chalupny J., Siadak A.W., et al. 4-1BB costimulatory signals preferentially induce CD8+ T cell proliferation and lead to the amplification in vivo of cytotoxic T cell responses. J Exp Med 186 July (1) (1997) 47-55
6. Tan J.T., Whitmire J.K., Murali-Krishna K., Ahmed R., Altman J.D., Mittler R.S., et al. 4-1BB costimulation is required for protective anti-viral immunity after peptide vaccination. J Immunol 164 March (5) (2000) 2320-2325
7. Wiethe C., Dittmar K., Doan T., Lindenmaier W., and Tindle R. Provision of 4-1BB ligand enhances effector and memory CTL responses generated by immunization with dendritic cells expressing a human tumor-associated antigen. J Immunol 170 March (6) (2003) 2912-2922
8. Myers L., Lee S.W., Rossi R.J., Lefrancois L., Kwon B.S., Mittler R.S., et al. Combined CD137 (4-1BB) and adjuvant therapy generates a developing pool of peptide-specific CD8 memory T cells. Int Immunol 18 2 (2006 Feb) 325-333
9. Melero I., Shuford W.W., Newby S.A., Aruffo A., Ledbetter J.A., Hellstrom K.E., et al. Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors. Nat Med 3 June (6) (1997) 682-685
10. Miller R.E., Jones J., Le T., Whitmore J., Boiani N., Gliniak B., et al. 4-1BB-specific monoclonal antibody promotes the generation of tumor-specific immune responses by direct activation of CD8 T cells in a CD40-dependent manner. J Immunol 169 August (4) (2002) 1792-1800
11. Halstead E.S., Mueller Y.M., Altman J.D., and Katsikis P.D. In vivo stimulation of CD137 broadens primary antiviral CD8+ T cell responses. Nat Immunol 3 June (6) (2002) 536-541
12. Bukczynski J., Wen T., Ellefsen K., Gauldie J., and Watts T.H. Costimulatory ligand 4-1BBL (CD137L) as an efficient adjuvant for human antiviral cytotoxic T cell responses. Proc Natl Acad Sci USA 101 February (5) (2004) 1291-1296
13. Sun Y., Lin X., Chen H.M., Wu Q., Subudhi S.K., Chen L., et al. Administration of agonistic anti-4-1BB monoclonal antibody leads to the amelioration of experimental autoimmune encephalomyelitis. J Immunol 168 February (3) (2002) 1457-1465
14. Foell J., Strahotin S., O'Neil S.P., McCausland M.M., Suwyn C., Haber M., et al. CD137 costimulatory T cell receptor engagement reverses acute disease in lupus-prone NZB x NZW F1 mice. J Clin Invest 111 May (10) (2003) 1505-1518
15. Seo S.K., Choi J.H., Kim Y.H., Kang W.J., Park H.Y., Suh J.H., et al. 4-1BB-mediated immunotherapy of rheumatoid arthritis. Nat Med 10 October (10) (2004) 1088-1094
16. Smith J.M., Amara R.R., Campbell D., Xu Y., Patel M., Sharma S., et al. DNA/MVA vaccine for HIV type 1: effects of codon-optimization and the expression of aggregates or virus-like particles on the immunogenicity of the DNA prime. AIDS Res Hum Retroviruses 20 December (12) (2004) 1335-1347
17. Robinson H.L., Sharma S., Zhao J., Kannanganat S., Lai L., Chennareddi L., et al. Immunogenicity in macaques of the clinical product for a clade B DNA/MVA HIV vaccine: elicitation of IFN-gamma, IL-2, and TNF-alpha coproducing CD4 and CD8 T cells. AIDS Res Hum Retroviruses 23 December (12) (2007) 1555-1562
18. Stone G.W., Barzee S., Snarsky V., Kee K., Spina C.A., Yu X.F., et al. Multimeric soluble CD40 ligand and GITR ligand as adjuvants for human immunodeficiency virus DNA vaccines. J Virol 80 February (4) (2006) 1762-1772
19. Liu J., Wyatt L.S., Amara R.R., Moss B., and Robinson H.L. Studies on in vitro expression and in vivo immunogenicity of a recombinant MVA HIV vaccine. Vaccine 24 April (16) (2006) 3332-3339
20. Locksley R.M., Killeen N., and Lenardo M.J. The TNF and TNF receptor superfamilies: integrating mammalian biology. Cell 104 February (4) (2001) 487-501
21. Haswell L.E., Glennie M.J., and Al-Shamkhani A. Analysis of the oligomeric requirement for signaling by CD40 using soluble multimeric forms of its ligand, CD154. Eur J Immunol 31 October (10) (2001) 3094-3100
22. Schneider P., Holler N., Bodmer J.L., Hahne M., Frei K., Fontana A., et al. Conversion of membrane-bound Fas(CD95) ligand to its soluble form is associated with downregulation of its proapoptotic activity and loss of liver toxicity. J Exp Med 187 April (8) (1998) 1205-1213
23. Gramaglia I., Cooper D., Miner K.T., Kwon B.S., and Croft M. Co-stimulation of antigen-specific CD4 T cells by 4-1BB ligand. Eur J Immunol 30 February (2) (2000) 392-402
24. Cooper D., Bansal-Pakala P., and Croft M. 4-1BB (CD137) controls the clonal expansion and survival of CD8 T cells in vivo but does not contribute to the development of cytotoxicity. Eur J Immunol 32 February (2) (2002) 521-529
25. Tan J.T., Whitmire J.K., Ahmed R., Pearson T.C., and Larsen C.P. 4-1BB ligand, a member of the TNF family, is important for the generation of antiviral CD8 T cell responses. J Immunol 163 November (9) (1999) 4859-4868
26. Bertram E.M., Lau P., and Watts T.H. Temporal segregation of 4-1BB versus CD28-mediated costimulation: 4-1BB ligand influences T cell numbers late in the primary response and regulates the size of the T cell memory response following influenza infection. J Immunol 168 April (8) (2002) 3777-3785
27. Harrison J.M., Bertram E.M., Boyle D.B., Coupar B.E., Ranasinghe C., and Ramshaw I.A. 4-1BBL coexpression enhances HIV-specific CD8 T cell memory in a poxvirus prime-boost vaccine. Vaccine 24 November (47-48) (2006) 6867-6874
28. Munks M.W., Mourich D.V., Mittler R.S., Weinberg A.D., and Hill A.B. 4-1BB and OX40 stimulation enhance CD8 and CD4 T-cell responses to a DNA prime, poxvirus boost vaccine. Immunology 112 August (4) (2004) 559-566
29. Calarota S.A., Hokey D.A., Dai A., Jure-Kunkel M.N., Balimane P., and Weiner D.B. Augmentation of SIV DNA vaccine-induced cellular immunity by targeting the 4-1BB costimulatory molecule. Vaccine 26 June (25) (2008) 3121-3134
30. Sun Y., Chen H.M., Subudhi S.K., Chen J., Koka R., Chen L., et al. Costimulatory molecule-targeted antibody therapy of a spontaneous autoimmune disease. Nat Med 8 December (12) (2002) 1405-1413
31. Zheng G., Wang B., and Chen A. The 4-1BB costimulation augments the proliferation of CD4+CD25+ regulatory T cells. J Immunol 173 August (4) (2004) 2428-2434
32. Myers L., Takahashi C., Mittler R.S., Rossi R.J., and Vella A.T. Effector CD8 T cells possess suppressor function after 4-1BB and Toll-like receptor triggering. Proc Natl Acad Sci USA 100 April (9) (2003) 5348-5353
33. Sun Y., Blink S.E., Chen J.H., and Fu Y.X. Regulation of follicular dendritic cell networks by activated T cells: the role of CD137 signaling. J Immunol 175 July (2) (2005) 884-890
34. Kienzle G., and von Kempis J. CD137 (ILA/4-1BB), expressed by primary human monocytes, induces monocyte activation and apoptosis of B lymphocytes. Int Immunol 12 January (1) (2000) 73-82