Cholinergic agonist physostigmine suppresses excessive superoxide anion radical generation in blood, oxidative stress, early inflammation, and endothelial injury in rats with forebrain ischemia/reperfusion

Brain Research

Volumn 1313, Issue , 2010, Pages 242-249

  Kutsuna, Satoshi ^a   Tsuruta, Ryosuke ^a   Fujita, Motoki ^a   Todani, Masaki ^a   Yagi, Takeshi ^a   Ogino, Yasuaki ^a   Igarashi, Masatsugu ^b   Takahashi, Koshiro ^b   Izumi, Tomonori ^a   Kasaoka, Shunji ^a   Yuasa, Makoto ^b   Maekawa, Tsuyoshi ^a  

^a YAMAGUCHI UNIVERSITY HOSPITAL   (Japan)

^b TOKYO UNIVERSITY OF SCIENCE   (Japan)

Author keywords

Cholinergic anti inflammatory pathway; Electrochemical sensor; Forebrain ischemia reperfusion; High mobility group box 1 (HMGB1) protein; Physostigmine; Superoxide anion radical (O2 radical dot )

Indexed keywords

HIGH MOBILITY GROUP B1 PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; MALONALDEHYDE; PHYSOSTIGMINE; SUPEROXIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; BLOOD LEVEL; BRAIN ISCHEMIA; BRAIN LEVEL; CHOLINERGIC STIMULATION; CONTROLLED STUDY; DRUG MECHANISM; ENCEPHALITIS; ENDOTHELIUM INJURY; FOREBRAIN; FOREBRAIN ISCHEMIA; JUGULAR VEIN; MALE; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RAT; REPERFUSION INJURY; VASCULAR ENDOTHELIUM;

ANIMALS; BRAIN ISCHEMIA; CHOLINERGIC AGONISTS; ELECTRICITY; ENCEPHALITIS; ENDOTHELIUM, VASCULAR; HMGB1 PROTEIN; JUGULAR VEINS; MALE; MALONDIALDEHYDE; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; PHYSOSTIGMINE; PROSENCEPHALON; RATS; RATS, WISTAR; REPERFUSION INJURY; SUPEROXIDES; TIME FACTORS;

RATTUS; RATTUS NORVEGICUS;

EID: 74149083854     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2009.11.077     Document Type: Article

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