메뉴 건너뛰기




Volumn 32, Issue 4, 2009, Pages 429-437

Acute toxicity of two Alzheimer's disease radiopharmaceuticals: FDDNP and IMPY

Author keywords

Alzheimers disease; FDDNP; IMPY; Toxicity

Indexed keywords

2 [1 [6 [(2 FLUOROETHYL)METHYLAMINO] 2 NAPHTHYL]ETHYLIDENE]MALONONITRILE; 6 IODO 2 (4' DIMETHYLAMINO)PHENYLIMIDAZO[1,2 A]PYRIDINE; IMIDAZO[1,2 A]PYRIDINE DERIVATIVE; MALONONITRILE; UNCLASSIFIED DRUG; 2,3 DIHYDRO 1H IMIDAZO[1,2 B]PYRAZOLE; 2,3-DIHYDRO-1H-IMIDAZO(1,2-B)PYRAZOLE; AMYLOID BETA PROTEIN; DIAGNOSTIC AGENT; FLUORESCENT DYE; FLUORODEOXYGLUCOSE F 18; PYRAZOLE DERIVATIVE; RADIOPHARMACEUTICAL AGENT;

EID: 74049151575     PISSN: 01480545     EISSN: 15256014     Source Type: Journal    
DOI: 10.1080/01480540903127324     Document Type: Article
Times cited : (4)

References (19)
  • 1
    • 0035893245 scopus 로고    scopus 로고
    • Binding characteristics of radiofluorinated 6-dialkylamino-2- naphthylethylidene derivatives as positron emission tomography imaging probes for beta-amyloid plaques in Alzheimer's disease
    • Agdeppa, E. D., Kepe. V., Liu, J., Flores-Torres, S., Satyamurthy, N., Petric, A., et al. (2001). Binding characteristics of radiofluorinated 6-dialkylamino-2-naphthylethylidene derivatives as positron emission tomography imaging probes for beta-amyloid plaques in Alzheimer's disease. J Neurosci 21:RC189.
    • (2001) J Neurosci , vol.21
    • Agdeppa, E.D.1    Kepe., V.2    Liu, J.3    Flores-Torres, S.4    Satyamurthy, N.5    Petric, A.6
  • 2
    • 0345415139 scopus 로고    scopus 로고
    • 2-dialkylamino-6-acylmalononitrile substituted naphthalenes (DDNP analogs): Novel diagnostic and therapeutic tools in Alzheimer's disease
    • Agdeppa, E. D., Kepe, V., Liu, J., Small, G. W., Huang, S. C., Petric, A., et al. (2003b). 2-dialkylamino-6-acylmalononitrile substituted naphthalenes (DDNP analogs): novel diagnostic and therapeutic tools in Alzheimer's disease. Mol Imaging Biol 5:404-417.
    • (2003) Mol Imaging Biol , vol.5 , pp. 404-417
    • Agdeppa, E.D.1    Kepe, V.2    Liu, J.3    Small, G.W.4    Huang, S.C.5    Petric, A.6
  • 3
    • 0037475148 scopus 로고    scopus 로고
    • In vitro detection of (S)-naproxen and ibuprofen binding to plaques in the Alzheimer's brain using the positron emission tomography molecular imaging probe 2-(1-[6-[(2-[(18)F]fluoroethyl)(methyl) amino]- 2-naphthyl]ethylidene) malononitrile
    • Agdeppa, E. D., Kepe, V., Petri, A., Satyamurthy, N., Liu, J., Huang, S. C., et al. (2003a). In vitro detection of (S)-naproxen and ibuprofen binding to plaques in the Alzheimer's brain using the positron emission tomography molecular imaging probe 2-(1-[6-[(2-[(18)F]fluoroethyl)(methyl) amino]- 2-naphthyl]ethylidene)malononitrile. Neuroscience 117:723-730.
    • (2003) Neuroscience , vol.117 , pp. 723-730
    • Agdeppa, E.D.1    Kepe, V.2    Petri, A.3    Satyamurthy, N.4    Liu, J.5    Huang, S.C.6
  • 4
    • 33744900621 scopus 로고    scopus 로고
    • Brain pathology and neuronal losses in the living brain of Alzheimer's patients
    • DOI 10.1016/j.ics.2005.11.102, PII S0531513105016961, Functional and Molecular Imaging of Stroke and Dementia: Updates in Diagnosis, Treatment, and Monitoring. Proceedings of the International Symposium on Functional and Molecular Imaging of Stroke
    • Barrio, J. R. Kepe, V., Satyamurthy, N., Huang, S. C., Small, G. W. (2006). Brain pathology and neuronal losses in the living brain of Alzheimer's patients. Int Congr Series 1290:150-155. (Pubitemid 43850885)
    • (2006) International Congress Series , vol.1290 , pp. 150-155
    • Barrio, J.R.1    Kepe, V.2    Satyamurthy, N.3    Huang, S.-C.4    Small, G.W.5
  • 5
    • 85047691873 scopus 로고    scopus 로고
    • Anti-Aβ antibody treatment promotes the rapid recovery of amyloid-associated neuritic dystrophy in PDAPP transgenic mice
    • Brendza, R. P., Bacskai, B. J., Cirrito, J. R., Simmons, K. A., Skoch, J. M., Klunk, W. E., et al. (2005). Anti-Aβ antibody treatment promotes the rapid recovery of amyloid-associated neuritic dystrophy in PDAPP transgenic mice. J Clin Invest 15:428-433.
    • (2005) J Clin Invest , vol.15 , pp. 428-433
    • Brendza, R.P.1    Bacskai, B.J.2    Cirrito, J.R.3    Simmons, K.A.4    Skoch, J.M.5    Klunk, W.E.6
  • 6
    • 0029027171 scopus 로고
    • Beta-amyloid (1-40) effects on behavior and memory
    • Cleary, J., Hittner, J. M., Semotuk, M., Mantyh, P., O'Hare, E. (1995). Beta-amyloid (1-40) effects on behavior and memory. Brain Res 682(1-2):69-74.
    • (1995) Brain Res , vol.682 , Issue.1-2 , pp. 69-74
    • Cleary, J.1    Hittner, J.M.2    Semotuk, M.3    Mantyh, P.4    O'Hare, E.5
  • 7
    • 0034988318 scopus 로고    scopus 로고
    • Correlation between cognitive deficits and Abeta deposits in transgenic APP+PS1 mice
    • Gordon, M. N., King, D. L., Diamond, D. M., Jantzen, P. T., Boyett, K. V., Hope, C. E., et al. (2001). Correlation between cognitive deficits and Abeta deposits in transgenic APP+PS1 mice. Neurobiol Aging 22:377-385.
    • (2001) Neurobiol Aging , vol.22 , pp. 377-385
    • Gordon, M.N.1    King, D.L.2    Diamond, D.M.3    Jantzen, P.T.4    Boyett, K.V.5    Hope, C.E.6
  • 8
    • 0035902875 scopus 로고    scopus 로고
    • Uncharged thioflavin-T derivatives bind to amyloid-beta protein with high affinity and readily enter the brain
    • Klunk, W. E., Wang, Y., Huang, G. F., Debnath, M. L., Holt, D. P., Mathis, C. A. (2001). Uncharged thioflavin-T derivatives bind to amyloid-beta protein with high affinity and readily enter the brain. Life Sci 69:1471-1484.
    • (2001) Life Sci , vol.69 , pp. 1471-1484
    • Klunk, W.E.1    Wang, Y.2    Huang, G.F.3    Debnath, M.L.4    Holt, D.P.5    Mathis, C.A.6
  • 10
    • 5444264488 scopus 로고    scopus 로고
    • Binding of two potential imaging agents targeting amyloid plaques in postmortem brain tissues of patients with Alzheimer's disease
    • Kung, M. P., Hou, C., Zhuang, Z. P., Skovronsky, D., Kung. H. F. (2004a). Binding of two potential imaging agents targeting amyloid plaques in postmortem brain tissues of patients with Alzheimer's disease. Brain Res 1025(1-2):98-105.
    • (2004) Brain Res , vol.1025 , Issue.1-2 , pp. 98-105
    • Kung, M.P.1    Hou, C.2    Zhuang, Z.P.3    Skovronsky, D.4    Kung., H.F.5
  • 11
    • 3943100779 scopus 로고    scopus 로고
    • Characterization of IMPY as a potential imaging agent for beta-amyloid plaques in double transgenic PSAPP mice
    • Kung, M. P., Hou, C., Zhuang, Z. P., Cross, A. J., Maier, D. L., Kung, H. F. (2004b). Characterization of IMPY as a potential imaging agent for beta-amyloid plaques in double transgenic PSAPP mice. Eur J Nucl Med Mol Imaging 31:1136-1145.
    • (2004) Eur J Nucl Med Mol Imaging , vol.31 , pp. 1136-1145
    • Kung, M.P.1    Hou, C.2    Zhuang, Z.P.3    Cross, A.J.4    Maier, D.L.5    Kung, H.F.6
  • 12
    • 0037195577 scopus 로고    scopus 로고
    • IMPY: An improved thioflavin- T derivative for in vivo labeling of beta-amyloid plaques
    • Kung, M. P., Hou, C., Zhuang, Z. P., Zhang, B., Skovronsky, D., Trojanowski, J. Q., et al. (2002). IMPY: an improved thioflavin- T derivative for in vivo labeling of beta-amyloid plaques. Brain Res 956:202-210.
    • (2002) Brain Res , vol.956 , pp. 202-210
    • Kung, M.P.1    Hou, C.2    Zhuang, Z.P.3    Zhang, B.4    Skovronsky, D.5    Trojanowski, J.Q.6
  • 14
    • 0142011533 scopus 로고    scopus 로고
    • Dimethylaminofluorenes: Ligands for detecting beta-amyloid plaques in the brain
    • Lee, C. W., Kung, M. P., Hou, C., Kung, H. F. (2003). Dimethylaminofluorenes: ligands for detecting beta-amyloid plaques in the brain. Nucl Med Biol 30:573-580.
    • (2003) Nucl Med Biol , vol.30 , pp. 573-580
    • Lee, C.W.1    Kung, M.P.2    Hou, C.3    Kung, H.F.4
  • 15
    • 33846021298 scopus 로고    scopus 로고
    • High-yield, automated radiosynthesis of 2-(1-{6-[(2-[18F]fluoroethyl) (methyl)amino]- 2-naphthyl}ethylidene)malononitrile ([18F]FDDNP) ready for animal or human administration
    • Liu, J., Kepe, V., Zabjek, A., Petric, A., Padgett, H. C., Satyamurthy, N., et al. (2007). High-yield, automated radiosynthesis of 2-(1-{6-[(2-[18F] fluoroethyl) (methyl)amino]- 2-naphthyl}ethylidene)malononitrile ([18F]FDDNP) ready for animal or human administration. Mol Imaging Biol 9:6-16.
    • (2007) Mol Imaging Biol , vol.9 , pp. 6-16
    • Liu, J.1    Kepe, V.2    Zabjek, A.3    Petric, A.4    Padgett, H.C.5    Satyamurthy, N.6
  • 16
    • 0035823325 scopus 로고    scopus 로고
    • Progressive brain dysfunction following intracerebroventricular infusion of beta(1-42)-amyloid peptide
    • Nakamura, S., Murayama, N., Noshita, T., Annoura, H., Ohno, T. (2001). Progressive brain dysfunction following intracerebroventricular infusion of beta(1-42)-amyloid peptide. Brain Res 912:128-136.
    • (2001) Brain Res , vol.912 , pp. 128-136
    • Nakamura, S.1    Murayama, N.2    Noshita, T.3    Annoura, H.4    Ohno, T.5
  • 17
    • 0042697305 scopus 로고    scopus 로고
    • Triple-transgenic model of Alzheimer's disease with plaques and tangles: Intracellular Abeta and synaptic dysfunction
    • Oddo, S., Caccamo, A., Shepherd, J. D., Murphy, M. P., Golde, T. E., Kayed, R., et al. (2003). Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction. Neuron 39:409-421.
    • (2003) Neuron , vol.39 , pp. 409-421
    • Oddo, S.1    Caccamo, A.2    Shepherd, J.D.3    Murphy, M.P.4    Golde, T.E.5    Kayed, R.6
  • 18
    • 0034616277 scopus 로고    scopus 로고
    • Tracking Alzheimer's disease in transgenic mice using fluorodeoxyglucose autoradiography
    • Reiman, E. M., Uecker, A., Gonzalez-Lima, F., Minear, D., Chen, K., Callaway, N. L., et al. (2000). Tracking Alzheimer's disease in transgenic mice using fluorodeoxyglucose autoradiography. Neuroreport 11:987-991
    • (2000) Neuroreport , vol.11 , pp. 987-991
    • Reiman, E.M.1    Uecker, A.2    Gonzalez-Lima, F.3    Minear, D.4    Chen, K.5    Callaway, N.L.6
  • 19
    • 0034701238 scopus 로고    scopus 로고
    • The origins of Alzheimer's disease: A is for amyloid
    • Selkoe, D. J. (2000). The origins of Alzheimer's disease: a is for amyloid. JAMA 283:1615-1617.
    • (2000) JAMA , vol.283 , pp. 1615-1617
    • Selkoe, D.J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.